TissGeneSummary for CLDN1 |
Gene summary |
Basic gene information | Gene symbol | CLDN1 |
Gene name | claudin 1 | |
Synonyms | CLD1|ILVASC|SEMP1 | |
Cytomap | UCSC genome browser: 3q28-q29 | |
Type of gene | protein-coding | |
RefGenes | NM_021101.4, | |
Description | claudin-1senescence-associated epithelial membrane protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603718 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163347 | ||
HPRD : 04760 | ||
Vega : OTTHUMG00000156214 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CLDN1 | |
BioGPS: 9076 | ||
Pathway | NCI Pathway Interaction Database: CLDN1 | |
KEGG: CLDN1 | ||
REACTOME: CLDN1 | ||
Pathway Commons: CLDN1 | ||
Context | iHOP: CLDN1 | |
ligand binding site mutation search in PubMed: CLDN1 | ||
UCL Cancer Institute: CLDN1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTExTiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCASKCM | |
Reference showing the relevant tissue of CLDN1 | ||
Description by TissGene annotations | Cancer gene Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CLDN1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 4.918513264 | 2.134707382 | 2.783805882 | 1.09E-11 | 4.51E-11 |
THCA | 4.711570858 | 1.3048234 | 3.406747458 | 5.29E-22 | 3.00E-20 |
COAD | 2.761835134 | -1.875003327 | 4.636838462 | 2.06E-22 | 2.26E-19 |
STAD | 2.936809894 | -0.493574481 | 3.430384375 | 3.46E-09 | 2.16E-07 |
KICH | -0.728781481 | 2.096710519 | -2.825492 | 4.27E-08 | 2.09E-07 |
KIRP | 3.692194269 | 1.680556769 | 2.0116375 | 2.65E-06 | 1.22E-05 |
ESCA | 3.46965961 | 0.027886883 | 3.441772727 | 0.000335 | 0.007384544 |
LIHC | 4.690208519 | 5.701066519 | -1.010858 | 0.000396 | 0.001180558 |
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TissGene-miRNA for CLDN1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CLDN1 |
TissGeneSNV for CLDN1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E160K | SKCM | 2 |
p.L174F | SKCM | 1 |
p.V211M | THYM | 1 |
p.P151H | THYM | 1 |
p.P151T | SARC | 1 |
p.L73V | BLCA | 1 |
p.I95V | LIHC | 1 |
p.A124T | LUAD | 1 |
p.R188Q | SKCM | 1 |
p.A157V | UCEC | 1 |
p.Q61* | UCEC | 1 |
p.G17R | SKCM | 1 |
p.G141D | SKCM | 1 |
p.A124T | STAD | 1 |
p.V211L | BLCA | 1 |
p.V100I | ACC | 1 |
p.A124T | PRAD | 1 |
p.A124T | LGG | 1 |
p.V211M | UCEC | 1 |
p.A119V | SKCM | 1 |
p.P196S | BLCA | 1 |
p.G10R | LUSC | 1 |
p.C54R | STAD | 1 |
p.M105T | STAD | 1 |
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TissGeneCNV for CLDN1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CLDN1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG289620 | FADS1-CLDN1 | chr11:61569290 | chr3:190024204 | |
Chimerdb3.0 | ChiTaRs | NA | AI133078 | CLDN1-C3 | chr3:190024282 | chr19:6717313 | |
Chimerdb3.0 | ChiTaRs | NA | BQ022914 | CLDN1-PARD3 | chr3:190025563 | chr10:35084174 | |
Chimerdb3.0 | ChiTaRs | NA | R27501 | PARD3-CLDN1 | chr10:35084275 | chr3:190025441 | |
Chimerdb3.0 | FusionScan | LUSC | TCGA-56-7223-01A | PPP1R2-CLDN1 | Out-of-Frame | chr3:195256594 | chr3:190030825 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A4A2-01A | LPP-CLDN1 | In-Frame | chr3:188124101 | chr3:190030825 |
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TissGeneNet for CLDN1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CLDN1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CLDN1 |
TissGeneDrug for CLDN1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CLDN1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 15 | BeFree |
umls:C0678222 | Breast Carcinoma | 15 | BeFree |
umls:C0019196 | Hepatitis C | 13 | BeFree,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 13 | BeFree |
umls:C0007102 | Malignant tumor of colon | 9 | BeFree |
umls:C0596263 | Carcinogenesis | 8 | BeFree |
umls:C0699790 | Colon Carcinoma | 8 | BeFree |
umls:C1458155 | Mammary Neoplasms | 8 | BeFree,CTD_human,LHGDN |
umls:C1527249 | Colorectal Cancer | 8 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 7 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 6 | BeFree,LHGDN |
umls:C0178874 | Tumor Progression | 5 | BeFree |
umls:C0001418 | Adenocarcinoma | 4 | BeFree,LHGDN |
umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 4 | BeFree |
umls:C0042769 | Virus Diseases | 4 | BeFree |
umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 4 | BeFree |
umls:C1843355 | ICHTHYOSIS, LEUKOCYTE VACUOLES, ALOPECIA, AND SCLEROSING CHOLANGITIS | 4 | BeFree,CLINVAR,CTD_human,ORPHANET |
umls:C2239176 | Liver carcinoma | 4 | BeFree,LHGDN |
umls:C0009404 | Colorectal Neoplasms | 3 | LHGDN |
umls:C0023903 | Liver neoplasms | 3 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0009375 | Colonic Neoplasms | 2 | BeFree,LHGDN |
umls:C0017636 | Glioblastoma | 2 | BeFree,LHGDN |
umls:C0022104 | Irritable Bowel Syndrome | 2 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 2 | LHGDN |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0339273 | Corneal dystrophy, Lattice type 3 | 2 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
umls:C0432306 | Ichthyosis Bullosa of Siemens | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C1621958 | Glioblastoma Multiforme | 2 | BeFree |
umls:C0001430 | Adenoma | 1 | LHGDN |
umls:C0007095 | Carcinoid Tumor | 1 | LHGDN |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
umls:C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
umls:C0008031 | Chest Pain | 1 | BeFree |
umls:C0008313 | Cholangitis, Sclerosing | 1 | BeFree |
umls:C0008370 | Cholestasis | 1 | BeFree |
umls:C0008373 | Cholesteatoma | 1 | BeFree |
umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
umls:C0011616 | Contact Dermatitis | 1 | BeFree,CTD_human |
umls:C0012746 | Dissociative disorder | 1 | LHGDN |
umls:C0014175 | Endometriosis | 1 | CTD_human |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree,LHGDN |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0018922 | hemangiopericytoma | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0020757 | Ichthyoses | 1 | BeFree |
umls:C0020758 | Congenital ichthyosis | 1 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | LHGDN |
umls:C0025286 | Meningioma | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0151546 | Oral Cavity Carcinoma | 1 | BeFree |
umls:C0206624 | Hepatoblastoma | 1 | BeFree |
umls:C0206687 | Carcinoma, Endometrioid | 1 | BeFree |
umls:C0206692 | Carcinoma, Lobular | 1 | BeFree |
umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0267841 | Acalculous Cholecystitis | 1 | LHGDN |
umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
umls:C0346153 | Breast Cancer, Familial | 1 | BeFree |
umls:C0348898 | Irritable bowel syndrome with diarrhea | 1 | BeFree |
umls:C0442874 | Neuropathy | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0566602 | Primary sclerosing cholangitis | 1 | BeFree |
umls:C0677055 | CARCINOMA OF VULVA | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0850666 | Helicobacter pylori infection | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
umls:C1153706 | Endometrial adenocarcinoma | 1 | BeFree |
umls:C1260325 | Dendritic Cell Sarcoma, Follicular | 1 | LHGDN |
umls:C1290884 | Inflammatory disorder | 1 | BeFree |
umls:C1336076 | Sporadic Breast Carcinoma | 1 | BeFree |
umls:C1858051 | NORTH AMERICAN INDIAN CHILDHOOD CIRRHOSIS | 1 | BeFree |
umls:C2004489 | Regurgitation | 1 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
umls:C3714514 | Infection | 1 | LHGDN |