TissGeneSummary for DYRK1B |
Gene summary |
Basic gene information | Gene symbol | DYRK1B |
Gene name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | |
Synonyms | AOMS3|MIRK | |
Cytomap | UCSC genome browser: 19q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_004714.2, NM_006483.2,NM_006484.2, | |
Description | dual specificity tyrosine-phosphorylation-regulated kinase 1Bminibrain-related kinasemirk protein kinase | |
Modification date | 20141215 | |
dbXrefs | MIM : 604556 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105204 | ||
HPRD : 05188 | ||
Vega : OTTHUMG00000182584 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DYRK1B | |
BioGPS: 9149 | ||
Pathway | NCI Pathway Interaction Database: DYRK1B | |
KEGG: DYRK1B | ||
REACTOME: DYRK1B | ||
Pathway Commons: DYRK1B | ||
Context | iHOP: DYRK1B | |
ligand binding site mutation search in PubMed: DYRK1B | ||
UCL Cancer Institute: DYRK1B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADTGCT | |
Reference showing the relevant tissue of DYRK1B | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 11980910 | GO:0045893 | positive regulation of transcription, DNA-templated | 11980910 | GO:0006468 | protein phosphorylation | 11980910 | GO:0045893 | positive regulation of transcription, DNA-templated | 11980910 |
Top |
TissGeneExp for DYRK1B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.194700383 | 0.102876361 | -1.297576744 | 7.71E-06 | 4.52E-05 |
Top |
TissGene-miRNA for DYRK1B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for DYRK1B |
TissGeneSNV for DYRK1B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D608A | PAAD | 2 |
p.S486R | PRAD | 1 |
p.S234N | UCEC | 1 |
p.E327Q | BLCA | 1 |
p.R277H | COAD | 1 |
p.V101M | STAD | 1 |
p.A528V | SKCM | 1 |
p.A229S | MESO | 1 |
p.R358* | STAD | 1 |
p.D499Y | LUAD | 1 |
p.H205Q | BRCA | 1 |
p.E362* | UCEC | 1 |
p.I467F | LUAD | 1 |
p.R46H | STAD | 1 |
p.E112K | COAD | 1 |
p.S567N | UCEC | 1 |
p.P250R | COAD | 1 |
p.P564L | COAD | 1 |
p.P231L | SKCM | 1 |
p.R178Q | LUSC | 1 |
p.P529T | STAD | 1 |
p.A425V | STAD | 1 |
p.D320N | UCEC | 1 |
p.Q21R | THYM | 1 |
p.D608A | BLCA | 1 |
p.P614L | THCA | 1 |
p.P443L | SKCM | 1 |
p.A43T | HNSC | 1 |
p.F260L | BLCA | 1 |
p.G120C | STAD | 1 |
p.C301G | HNSC | 1 |
p.P4Q | THYM | 1 |
p.H523Q | LUAD | 1 |
p.S504I | PAAD | 1 |
p.L603P | MESO | 1 |
p.S263F | BLCA | 1 |
p.D608A | TGCT | 1 |
p.E283Q | BLCA | 1 |
p.Q72H | OV | 1 |
p.R358X | STAD | 1 |
p.S531F | LUAD | 1 |
p.P587L | STAD | 1 |
p.C458Y | HNSC | 1 |
p.G518E | LGG | 1 |
p.A583T | STAD | 1 |
p.G442C | LUAD | 1 |
p.T360M | COAD | 1 |
p.A138V | ESCA | 1 |
p.D133Y | LUAD | 1 |
p.S316C | LUSC | 1 |
p.Q132E | OV | 1 |
p.P515L | SKCM | 1 |
p.L603P | HNSC | 1 |
p.I100T | COAD | 1 |
p.L226P | LIHC | 1 |
p.R31W | UCEC | 1 |
p.R547* | PRAD | 1 |
p.R547* | SKCM | 1 |
p.A218T | PAAD | 1 |
p.I235T | THCA | 1 |
p.P24R | STAD | 1 |
p.A254D | HNSC | 1 |
p.G494V | ACC | 1 |
p.A293T | UCS | 1 |
p.I497V | LIHC | 1 |
p.D199Y | HNSC | 1 |
p.V125A | COAD | 1 |
p.A583S | LUSC | 1 |
p.D166Y | ESCA | 1 |
Top |
TissGeneCNV for DYRK1B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for DYRK1B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CN408345 | DYRK1B-SENP3 | chr19:40317450 | chr17:7468276 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A6FD-01A | NUP62-DYRK1B | 5'UTR-5'UTR | chr19:50430950 | chr19:40322608 |
Top |
TissGeneNet for DYRK1B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for DYRK1B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for DYRK1B |
TissGeneDrug for DYRK1B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for DYRK1B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0035412 | Rhabdomyosarcoma | 3 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | CTD_human |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C4014361 | ABDOMINAL OBESITY-METABOLIC SYNDROME 3 | 1 | UNIPROT |