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| TissGeneSummary for CDHR1 |
 Gene summary |
| Basic gene information | Gene symbol | CDHR1 |
| Gene name | cadherin-related family member 1 | |
| Synonyms | CORD15|PCDH21|PRCAD|RP65 | |
| Cytomap | UCSC genome browser: 10q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001171971.2, NM_033100.3, | |
| Description | MT-protocadherinphotoreceptor cadherinprotocadherin-21 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609502 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000148600 | ||
| HPRD : 15106 | ||
| Vega : OTTHUMG00000018634 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDHR1 | |
| BioGPS: 92211 | ||
| Pathway | NCI Pathway Interaction Database: CDHR1 | |
| KEGG: CDHR1 | ||
| REACTOME: CDHR1 | ||
| Pathway Commons: CDHR1 | ||
| Context | iHOP: CDHR1 | |
| ligand binding site mutation search in PubMed: CDHR1 | ||
| UCL Cancer Institute: CDHR1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMUVM | |
| Reference showing the relevant tissue of CDHR1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CDHR1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 1.91542248 | -1.376655298 | 3.292077778 | 1.32E-17 | 8.36E-17 |
| KICH | -3.678946353 | -1.558138353 | -2.120808 | 1.66E-07 | 7.33E-07 |
| PRAD | -1.448040661 | 0.511861262 | -1.959901923 | 1.11E-12 | 6.07E-11 |
| LUSC | 0.939738901 | -1.584247373 | 2.523986275 | 1.52E-08 | 4.70E-08 |
| LIHC | -2.720240353 | -1.701586353 | -1.018654 | 0.00216 | 0.005470194 |
| KIRP | 0.449954772 | -1.186951478 | 1.63690625 | 0.00178 | 0.004581814 |
| STAD | -2.774760853 | -0.597601478 | -2.177159375 | 0.00055 | 0.00326372 |
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| TissGene-miRNA for CDHR1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CDHR1 |
| TissGeneSNV for CDHR1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E722K | COAD | 3 |
| p.S634F | SKCM | 2 |
| p.G165S | UCEC | 1 |
| p.A722T | PAAD | 1 |
| p.A159S | KIRC | 1 |
| p.E506X | ESCA | 1 |
| p.P350L | UCEC | 1 |
| p.E483Q | MESO | 1 |
| p.S68F | UVM | 1 |
| p.G248D | STAD | 1 |
| p.P482S | UCEC | 1 |
| p.E615Q | THCA | 1 |
| p.D568Y | UCS | 1 |
| p.V814I | HNSC | 1 |
| p.A222D | ESCA | 1 |
| p.S634F | STAD | 1 |
| p.N570S | GBM | 1 |
| p.S357R | SKCM | 1 |
| p.A270T | READ | 1 |
| p.A456S | STAD | 1 |
| p.V491M | LUAD | 1 |
| p.A106S | UCEC | 1 |
| p.D84N | KIRP | 1 |
| p.P746R | LUAD | 1 |
| p.R185S | ACC | 1 |
| p.E237K | BRCA | 1 |
| p.D473N | STAD | 1 |
| p.A212T | LGG | 1 |
| p.A212T | PRAD | 1 |
| p.E598D | TGCT | 1 |
| p.G88E | LUAD | 1 |
| p.V337I | STAD | 1 |
| p.R185H | LUAD | 1 |
| p.M687I | SARC | 1 |
| p.R636C | HNSC | 1 |
| p.D467N | SKCM | 1 |
| p.R78T | LUSC | 1 |
| p.E424D | BLCA | 1 |
| p.E615K | LUSC | 1 |
| p.G51C | THYM | 1 |
| p.K728N | BLCA | 1 |
| p.P133L | THYM | 1 |
| p.E602K | SKCM | 1 |
| p.S579N | LUAD | 1 |
| p.V656L | LUAD | 1 |
| p.R191P | LUAD | 1 |
| p.P774S | SKCM | 1 |
| p.G329E | SARC | 1 |
| p.S284N | SKCM | 1 |
| p.T626M | PRAD | 1 |
| p.E317K | LUAD | 1 |
| p.N129S | LIHC | 1 |
| p.R726H | LUAD | 1 |
| p.N425K | STAD | 1 |
| p.A801T | PAAD | 1 |
| p.Q193* | HNSC | 1 |
| p.V183M | BRCA | 1 |
| p.G31A | LUAD | 1 |
| p.R684W | STAD | 1 |
| p.V811M | SARC | 1 |
| p.E506K | SKCM | 1 |
| p.N30S | COAD | 1 |
| p.R78G | BRCA | 1 |
| p.D345N | COAD | 1 |
| p.V731E | SARC | 1 |
| p.R280Q | UCEC | 1 |
| p.G276D | HNSC | 1 |
| p.L606P | LIHC | 1 |
| p.E314K | SKCM | 1 |
| p.K213N | STAD | 1 |
| p.D184E | LUAD | 1 |
| p.Q581H | BLCA | 1 |
| p.R738W | STAD | 1 |
| p.G513R | SKCM | 1 |
| p.L397F | SARC | 1 |
| p.G390E | PAAD | 1 |
| p.T259S | BLCA | 1 |
| p.P774L | PAAD | 1 |
| p.G355E | SKCM | 1 |
| p.R726C | STAD | 1 |
| p.S152C | HNSC | 1 |
| p.A806T | COAD | 1 |
| p.L346P | KIRP | 1 |
| p.P402L | LUAD | 1 |
| p.E257K | UCEC | 1 |
| p.K659N | STAD | 1 |
| p.R407Q | UCEC | 1 |
| p.D621N | UCEC | 1 |
| p.V320I | BRCA | 1 |
| p.E776K | BLCA | 1 |
| p.S366Y | LUAD | 1 |
| p.L734M | LUAD | 1 |
| p.E722K | DLBC | 1 |
| p.R726C | LUSC | 1 |
| p.V50A | LIHC | 1 |
| p.V247M | PRAD | 1 |
| p.D649Y | LUSC | 1 |
| p.P482S | SKCM | 1 |
| p.G404D | COAD | 1 |
| p.K508E | LUAD | 1 |
| p.S524F | SKCM | 1 |
| p.W652* | LGG | 1 |
| p.D467N | CESC | 1 |
| p.V83D | LUAD | 1 |
| p.V704M | SKCM | 1 |
| p.D214G | COAD | 1 |
| p.T831I | SKCM | 1 |
| p.R726H | STAD | 1 |
| p.A538S | LUAD | 1 |
| p.V409I | SKCM | 1 |
| p.R726C | BRCA | 1 |
| p.S637Y | LUAD | 1 |
| p.R280Q | BLCA | 1 |
| p.G300R | BLCA | 1 |
| p.P503L | SKCM | 1 |
| p.R743W | STAD | 1 |
| p.V559I | BLCA | 1 |
| p.V507L | LUAD | 1 |
| p.S624F | SKCM | 1 |
| p.P820L | UCEC | 1 |
| p.L788I | PAAD | 1 |
| p.G291E | PRAD | 1 |
| p.R204Q | SKCM | 1 |
| p.G215C | GBM | 1 |
| p.S720C | BLCA | 1 |
| p.D388N | STAD | 1 |
| p.A479D | LIHC | 1 |
| p.Q373* | LUSC | 1 |
| p.A456G | LUSC | 1 |
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| TissGeneCNV for CDHR1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CDHR1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CDHR1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| COAD (tumor) | COAD (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| KICH (tumor) | KICH (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| STAD (tumor) | STAD (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| THCA (tumor) | THCA (normal) |
| CDHR1, HNF4A, RYK (tumor) | CDHR1, HNF4A, RYK (normal) |
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| TissGeneProg for CDHR1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CDHR1 |
| TissGeneDrug for CDHR1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CDHR1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0035334 | Retinitis Pigmentosa | 4 | BeFree,GAD,ORPHANET |
| umls:C0035304 | Retinal Degeneration | 3 | BeFree |
| umls:C0854723 | Retinal Dystrophies | 3 | BeFree |
| umls:C0035309 | Retinal Diseases | 2 | BeFree |
| umls:C0007095 | Carcinoid Tumor | 1 | BeFree |
| umls:C0024437 | Macular degeneration | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C0339527 | Leber Congenital Amaurosis | 1 | GAD |
| umls:C3665346 | Unspecified visual loss | 1 | BeFree |
| umls:C3150912 | CONE-ROD DYSTROPHY 15 | 0 | CLINVAR,CTD_human |
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