TissGeneSummary for LDHAL6B |
Gene summary |
Basic gene information | Gene symbol | LDHAL6B |
Gene name | lactate dehydrogenase A-like 6B | |
Synonyms | LDH6B|LDHAL6|LDHL | |
Cytomap | UCSC genome browser: 15q22.2 | |
Type of gene | protein-coding | |
RefGenes | NM_033195.2, | |
Description | L-lactate dehydrogenase A-like 6Blactate dehydrogenase A-like 6 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000171989 | ||
HPRD : 13981 | ||
Vega : OTTHUMG00000132714 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LDHAL6B | |
BioGPS: 92483 | ||
Pathway | NCI Pathway Interaction Database: LDHAL6B | |
KEGG: LDHAL6B | ||
REACTOME: LDHAL6B | ||
Pathway Commons: LDHAL6B | ||
Context | iHOP: LDHAL6B | |
ligand binding site mutation search in PubMed: LDHAL6B | ||
UCL Cancer Institute: LDHAL6B | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of LDHAL6B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for LDHAL6B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for LDHAL6B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for LDHAL6B |
TissGeneSNV for LDHAL6B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G152R | SKCM | 2 |
p.R148L | GBM | 1 |
p.G117D | STAD | 1 |
p.R155H | UCEC | 1 |
p.I255T | HNSC | 1 |
p.K356R | SKCM | 1 |
p.G25W | STAD | 1 |
p.T350A | READ | 1 |
p.A51V | STAD | 1 |
p.E64K | COAD | 1 |
p.R9W | COAD | 1 |
p.R206H | HNSC | 1 |
p.T154M | ESCA | 1 |
p.C23S | LUSC | 1 |
p.Q12K | LIHC | 1 |
p.R13* | KIRC | 1 |
p.D266N | SKCM | 1 |
p.L57I | UCEC | 1 |
p.E104K | HNSC | 1 |
p.D307N | CESC | 1 |
p.L140I | LUAD | 1 |
p.G236* | HNSC | 1 |
p.L352F | STAD | 1 |
p.R13X | KIRC | 1 |
p.V279A | LIHC | 1 |
p.G25R | COAD | 1 |
p.K277R | STAD | 1 |
p.D307Y | ESCA | 1 |
p.R161Q | SKCM | 1 |
p.I170N | COAD | 1 |
p.E274Q | HNSC | 1 |
p.S79L | READ | 1 |
p.A136T | PAAD | 1 |
p.L222F | HNSC | 1 |
p.G252A | BLCA | 1 |
p.R155S | LUAD | 1 |
p.V47M | STAD | 1 |
p.R60H | HNSC | 1 |
p.E346G | SKCM | 1 |
p.P30L | COAD | 1 |
p.P203S | LUAD | 1 |
p.W276* | SKCM | 1 |
p.G268V | THYM | 1 |
p.A136G | BLCA | 1 |
p.R148H | STAD | 1 |
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TissGeneCNV for LDHAL6B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LDHAL6B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for LDHAL6B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LDHAL6B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LDHAL6B |
TissGeneDrug for LDHAL6B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for LDHAL6B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1458155 | Mammary Neoplasms | 1 | CTD_human |