TissGeneSummary for DMKN |
Gene summary |
Basic gene information | Gene symbol | DMKN |
Gene name | dermokine | |
Synonyms | UNQ729|ZD52F10 | |
Cytomap | UCSC genome browser: 19q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001035516.3, NM_001126056.2,NM_001126057.2,NM_001126058.2,NM_001126059.2, NM_001190347.1,NM_001190348.1,NM_001190349.1,NM_033317.4, NR_033746.1, | |
Description | epidermis-specific secreted protein SK30/SK89 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000161249 | ||
HPRD : 12387 | ||
Vega : OTTHUMG00000048101 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DMKN | |
BioGPS: 93099 | ||
Pathway | NCI Pathway Interaction Database: DMKN | |
KEGG: DMKN | ||
REACTOME: DMKN | ||
Pathway Commons: DMKN | ||
Context | iHOP: DMKN | |
ligand binding site mutation search in PubMed: DMKN | ||
UCL Cancer Institute: DMKN | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of DMKN | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DMKN |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.430321629 | 1.202324205 | -2.632645833 | 6.09E-12 | 2.42E-11 |
PRAD | -1.388550688 | 0.55843585 | -1.946986538 | 5.05E-12 | 1.83E-10 |
COAD | -0.425487227 | -1.577179534 | 1.151692308 | 0.00864 | 0.019435565 |
LIHC | -4.413697073 | -3.000801073 | -1.412896 | 0.0089 | 0.019043256 |
KICH | 0.589672927 | 1.994104927 | -1.404432 | 0.00419 | 0.008044216 |
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TissGene-miRNA for DMKN |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DMKN |
TissGeneSNV for DMKN |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S282N | ACC | 3 |
p.S276G | PAAD | 3 |
p.G110E | LUAD | 2 |
p.G270S | COAD | 2 |
p.S276G | COAD | 2 |
p.S281N | ACC | 2 |
p.G288S | PAAD | 2 |
p.S276N | PAAD | 2 |
p.G228R | KIRC | 1 |
p.S276G | PRAD | 1 |
p.G147D | SKCM | 1 |
p.R297I | BLCA | 1 |
p.N292S | LIHC | 1 |
p.L11V | CESC | 1 |
p.S457L | CESC | 1 |
p.S68I | LUAD | 1 |
p.S274G | COAD | 1 |
p.R122* | UCEC | 1 |
p.A211T | READ | 1 |
p.S276N | OV | 1 |
p.V91A | COAD | 1 |
p.G288S | DLBC | 1 |
p.N198T | KIRC | 1 |
p.I121M | OV | 1 |
p.K422I | COAD | 1 |
p.A117T | STAD | 1 |
p.A328V | CESC | 1 |
p.S305F | SKCM | 1 |
p.E112Q | CESC | 1 |
p.G199R | HNSC | 1 |
p.P352S | SKCM | 1 |
p.S393C | LIHC | 1 |
p.S274G | PAAD | 1 |
p.D427Y | LGG | 1 |
p.P171T | LIHC | 1 |
p.S296G | LGG | 1 |
p.G36R | LUAD | 1 |
p.P188L | SKCM | 1 |
p.Q116K | LUSC | 1 |
p.S281N | STAD | 1 |
p.D428N | READ | 1 |
p.S219L | BRCA | 1 |
p.D119Y | READ | 1 |
p.G347S | BRCA | 1 |
p.D409G | BRCA | 1 |
p.G249C | SKCM | 1 |
p.A141V | HNSC | 1 |
p.W361* | SKCM | 1 |
p.S276N | BRCA | 1 |
p.A437T | UCEC | 1 |
p.P404H | THYM | 1 |
p.G124R | PCPG | 1 |
p.L95S | SKCM | 1 |
p.P451A | LUAD | 1 |
p.A38D | THYM | 1 |
p.G149D | STAD | 1 |
p.V120F | PRAD | 1 |
p.E29K | SKCM | 1 |
p.G124R | UCEC | 1 |
p.E395D | COAD | 1 |
p.A337G | SARC | 1 |
p.P384S | SKCM | 1 |
p.A441S | BRCA | 1 |
p.S248I | DLBC | 1 |
p.E349K | CESC | 1 |
p.G196X | COAD | 1 |
p.G147S | SKCM | 1 |
p.G190V | LIHC | 1 |
p.Q160* | SKCM | 1 |
p.A46T | SKCM | 1 |
p.G156V | SKCM | 1 |
p.E37K | KIRP | 1 |
p.I113S | SKCM | 1 |
p.V173F | KIRC | 1 |
p.G270S | KIRC | 1 |
p.G270S | PAAD | 1 |
p.L128F | CESC | 1 |
p.G271S | KIRP | 1 |
p.Q162X | LIHC | 1 |
p.A191T | KIRC | 1 |
p.A415P | SARC | 1 |
p.A415V | ESCA | 1 |
p.W172L | LUAD | 1 |
p.G369C | LUAD | 1 |
p.S276N | STAD | 1 |
p.S276G | KIRP | 1 |
p.A70T | COAD | 1 |
p.G82E | SKCM | 1 |
p.G158E | BLCA | 1 |
p.M186R | LUAD | 1 |
p.G100W | HNSC | 1 |
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TissGeneCNV for DMKN |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DMKN |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChimerDB 2.0 | NA | NA | DMKN-BRD8 | chr19:40692679 | chr5:137534705 | |
Chimerdb3.0 | ChiTaRs | NA | BG993061 | ZNF703-DMKN | chr8:37554897 | chr19:36003644 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-2H-A9GN-01A | NR1D1-DMKN | Out-of-Frame | chr17:38253317 | chr19:35990931 |
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TissGeneNet for DMKN |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DMKN |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DMKN |
TissGeneDrug for DMKN |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DMKN |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
umls:C0022572 | keratoacanthoma | 1 | BeFree |
umls:C0037274 | Dermatologic disorders | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |