TissGeneSummary for OPALIN |
Gene summary |
Basic gene information | Gene symbol | OPALIN |
Gene name | oligodendrocytic myelin paranodal and inner loop protein | |
Synonyms | HTMP10|TMEM10|TMP10 | |
Cytomap | UCSC genome browser: 10q23-q24 | |
Type of gene | protein-coding | |
RefGenes | NM_001040102.2, NM_001040103.2,NM_001284320.1,NM_001284321.1,NM_001284322.1, NM_001284323.1,NM_001284324.1,NM_001284326.1,NM_001284327.1, NM_033207.4,NR_104296.1,NR_104297.1, | |
Description | opalintransmembrane protein 10transmembrane protein TMP10 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000197430 | ||
HPRD : 15521 | ||
Vega : OTTHUMG00000018831 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OPALIN | |
BioGPS: 93377 | ||
Pathway | NCI Pathway Interaction Database: OPALIN | |
KEGG: OPALIN | ||
REACTOME: OPALIN | ||
Pathway Commons: OPALIN | ||
Context | iHOP: OPALIN | |
ligand binding site mutation search in PubMed: OPALIN | ||
UCL Cancer Institute: OPALIN | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of OPALIN | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OPALIN |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for OPALIN |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
THYM | hsa-miR-125b-5p | MIMAT0000423 | 0.0015 | -0.29 | 122 |
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TissGeneMut for OPALIN |
TissGeneSNV for OPALIN |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R45Q | SKCM | 2 |
p.S63L | SKCM | 2 |
p.G120E | SARC | 1 |
p.A11T | READ | 1 |
p.G11E | SKCM | 1 |
p.A24V | THYM | 1 |
p.M125T | LUAD | 1 |
p.M125T | PAAD | 1 |
p.G31E | SKCM | 1 |
p.A34E | LUSC | 1 |
p.D117N | HNSC | 1 |
p.M115T | LUAD | 1 |
p.M115I | SKCM | 1 |
p.P69H | LUAD | 1 |
p.H91D | CESC | 1 |
p.P18L | SKCM | 1 |
p.S82F | BRCA | 1 |
p.G130A | LIHC | 1 |
p.P28L | SKCM | 1 |
p.A34V | THYM | 1 |
p.D67G | LIHC | 1 |
p.D57G | LIHC | 1 |
p.R68K | BRCA | 1 |
p.K12I | SKCM | 1 |
p.D107N | HNSC | 1 |
p.G21E | SKCM | 1 |
p.K22I | SKCM | 1 |
p.E71K | SKCM | 1 |
p.R127T | LUSC | 1 |
p.X142C | COAD | 1 |
p.S73L | SKCM | 1 |
p.S16T | LIHC | 1 |
p.E61K | SKCM | 1 |
p.E116K | SKCM | 1 |
p.M115T | PAAD | 1 |
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TissGeneCNV for OPALIN |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OPALIN |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OPALIN |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OPALIN |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OPALIN |
TissGeneDrug for OPALIN |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OPALIN |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |