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| TissGeneSummary for ADIPOQ |
 Gene summary |
| Basic gene information | Gene symbol | ADIPOQ |
| Gene name | adiponectin, C1Q and collagen domain containing | |
| Synonyms | ACDC|ACRP30|ADIPQTL1|ADPN|APM-1|APM1|GBP28 | |
| Cytomap | UCSC genome browser: 3q27 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001177800.1, NM_004797.3, | |
| Description | 30 kDa adipocyte complement-related proteinadipocyte complement-related 30 kDa proteinadiponectinadipose most abundant gene transcript 1 proteinadipose specific collagen-like factorgelatin-binding protein 28 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 605441 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000181092 | ||
| HPRD : 05671 | ||
| Vega : OTTHUMG00000156521 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADIPOQ | |
| BioGPS: 9370 | ||
| Pathway | NCI Pathway Interaction Database: ADIPOQ | |
| KEGG: ADIPOQ | ||
| REACTOME: ADIPOQ | ||
| Pathway Commons: ADIPOQ | ||
| Context | iHOP: ADIPOQ | |
| ligand binding site mutation search in PubMed: ADIPOQ | ||
| UCL Cancer Institute: ADIPOQ | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASARC | |
| Reference showing the relevant tissue of ADIPOQ | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0001934 | positive regulation of protein phosphorylation | 18431508 | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway | 12070119 | GO:0010739 | positive regulation of protein kinase A signaling | 10982546 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 11222466 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 10604883 | GO:0010875 | positive regulation of cholesterol efflux | 18703020 | GO:0010906 | regulation of glucose metabolic process | 17327472 | GO:0014912 | negative regulation of smooth muscle cell migration | 12070119 | GO:0030853 | negative regulation of granulocyte differentiation | 10961870 | GO:0031953 | negative regulation of protein autophosphorylation | 12070119 | GO:0032270 | positive regulation of cellular protein metabolic process | 18703020 | GO:0032720 | negative regulation of tumor necrosis factor production | 10961870 | GO:0032757 | positive regulation of interleukin-8 production | 19524870 | GO:0033034 | positive regulation of myeloid cell apoptotic process | 10961870 | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 10604883 | GO:0034383 | low-density lipoprotein particle clearance | 11222466 | GO:0034612 | response to tumor necrosis factor | 10604883 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 10982546 | GO:0045599 | negative regulation of fat cell differentiation | 12021245 | GO:0045650 | negative regulation of macrophage differentiation | 10961870 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process | 11222466 | GO:0045776 | negative regulation of blood pressure | 17327472 | GO:0045892 | negative regulation of transcription, DNA-templated | 18431508 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 12070119 | GO:0050765 | negative regulation of phagocytosis | 10961870 | GO:0050805 | negative regulation of synaptic transmission | 17327472 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12070119 | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production | 19524870 | GO:0072659 | protein localization to plasma membrane | 18431508 | GO:0090317 | negative regulation of intracellular protein transport | 18431508 | GO:1900121 | negative regulation of receptor binding | 12070119 | GO:2000279 | negative regulation of DNA biosynthetic process | 12070119 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | 18431508 | GO:2000534 | positive regulation of renal albumin absorption | 18431508 | GO:0001934 | positive regulation of protein phosphorylation | 18431508 | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway | 12070119 | GO:0010739 | positive regulation of protein kinase A signaling | 10982546 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 11222466 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway | 10604883 | GO:0010875 | positive regulation of cholesterol efflux | 18703020 | GO:0010906 | regulation of glucose metabolic process | 17327472 | GO:0014912 | negative regulation of smooth muscle cell migration | 12070119 | GO:0030853 | negative regulation of granulocyte differentiation | 10961870 | GO:0031953 | negative regulation of protein autophosphorylation | 12070119 | GO:0032270 | positive regulation of cellular protein metabolic process | 18703020 | GO:0032720 | negative regulation of tumor necrosis factor production | 10961870 | GO:0032757 | positive regulation of interleukin-8 production | 19524870 | GO:0033034 | positive regulation of myeloid cell apoptotic process | 10961870 | GO:0034115 | negative regulation of heterotypic cell-cell adhesion | 10604883 | GO:0034383 | low-density lipoprotein particle clearance | 11222466 | GO:0034612 | response to tumor necrosis factor | 10604883 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 10982546 | GO:0045599 | negative regulation of fat cell differentiation | 12021245 | GO:0045650 | negative regulation of macrophage differentiation | 10961870 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process | 11222466 | GO:0045776 | negative regulation of blood pressure | 17327472 | GO:0045892 | negative regulation of transcription, DNA-templated | 18431508 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 12070119 | GO:0050765 | negative regulation of phagocytosis | 10961870 | GO:0050805 | negative regulation of synaptic transmission | 17327472 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 12070119 | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production | 19524870 | GO:0072659 | protein localization to plasma membrane | 18431508 | GO:0090317 | negative regulation of intracellular protein transport | 18431508 | GO:1900121 | negative regulation of receptor binding | 12070119 | GO:2000279 | negative regulation of DNA biosynthetic process | 12070119 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | 18431508 | GO:2000534 | positive regulation of renal albumin absorption | 18431508 |
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| TissGeneExp for ADIPOQ |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -1.011414282 | 4.307355485 | -5.318769767 | 2.17E-13 | 9.96E-12 |
| BRCA | 4.396515685 | 10.53711569 | -6.1406 | 1.96E-32 | 2.96E-31 |
| THCA | -2.148314124 | 0.777207909 | -2.925522034 | 2.48E-12 | 2.04E-11 |
| ESCA | -2.223343246 | 1.791984027 | -4.015327273 | 0.00238 | 0.025059155 |
| KIRP | -2.740526201 | -0.812291826 | -1.928234375 | 0.00321 | 0.007882607 |
| BLCA | -1.584115017 | 2.35159551 | -3.935710526 | 0.000532 | 0.004333949 |
| KICH | -2.660580701 | -0.549416701 | -2.111164 | 0.00176 | 0.00365258 |
| STAD | -0.511876201 | 2.816726924 | -3.328603125 | 0.000148 | 0.001091318 |
| COAD | -0.399723316 | 3.445676684 | -3.8454 | 9.78E-05 | 0.000356539 |
| KIRC | -2.52207759 | -1.104397034 | -1.417680556 | 0.000111 | 0.000232044 |
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| TissGene-miRNA for ADIPOQ |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ADIPOQ |
| TissGeneSNV for ADIPOQ |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R221C | COAD | 1 |
| p.G60D | HNSC | 1 |
| p.G199S | PRAD | 1 |
| p.G118E | SKCM | 1 |
| p.G69R | SKCM | 1 |
| p.A35V | DLBC | 1 |
| p.G223* | LUSC | 1 |
| p.D209N | HNSC | 1 |
| p.I74T | LUAD | 1 |
| p.S174N | LIHC | 1 |
| p.M168V | STAD | 1 |
| p.G24W | UCEC | 1 |
| p.Y143D | COAD | 1 |
| p.G75V | STAD | 1 |
| p.G102R | SKCM | 1 |
| p.Y111H | DLBC | 1 |
| p.G148S | SKCM | 1 |
| p.N192K | LIHC | 1 |
| p.G148V | OV | 1 |
| p.R55C | UCEC | 1 |
| p.G15V | LUAD | 1 |
| p.E82K | SKCM | 1 |
| p.G51R | STAD | 1 |
| p.G5* | LUAD | 1 |
| p.G38C | READ | 1 |
| p.K172N | LUAD | 1 |
| p.G54D | COAD | 1 |
| p.P47L | LIHC | 1 |
| p.G54S | SKCM | 1 |
| p.L205M | LUSC | 1 |
| p.V110A | BLCA | 1 |
| p.P95L | BLCA | 1 |
| p.G48D | LUAD | 1 |
| p.P53T | STAD | 1 |
| p.G15C | COAD | 1 |
| p.P155S | LUAD | 1 |
| p.L73F | SKCM | 1 |
| p.A41V | STAD | 1 |
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| TissGeneCNV for ADIPOQ |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ADIPOQ |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BU615971 | ADIPOQ-PCNT | chr3:186576252 | chr21:47851502 | |
| Chimerdb3.0 | ChiTaRs | NA | CA427200 | ADIPOQ-PCNT | chr3:186576252 | chr21:47851520 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-D8-A1XW-01A | LPP-ADIPOQ | 5'UTR-5'UTR | chr3:188059507 | chr3:186570839 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-D8-A1XW-01A | LPP-ADIPOQ | 5'UTR-5'UTR | chr3:187943315 | chr3:186570839 |
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| TissGeneNet for ADIPOQ |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| COAD (tumor) | COAD (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| KICH (tumor) | KICH (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| STAD (tumor) | STAD (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| THCA (tumor) | THCA (normal) |
| ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (tumor) | ADIPOQ, NR5A2, CEBPA, PPARG, AP2B1, C1QA, ADIPOR2, CDH13 (normal) |
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| TissGeneProg for ADIPOQ |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ADIPOQ |
| TissGeneDrug for ADIPOQ |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ADIPOQ |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 138 | BeFree,CTD_human,GAD,LHGDN,RGD |
| umls:C0028754 | Obesity | 113 | BeFree,CTD_human,GAD,RGD |
| umls:C0524620 | Metabolic Syndrome X | 68 | BeFree,CTD_human,GAD,LHGDN |
| umls:C1956346 | Coronary Artery Disease | 45 | BeFree,GAD,LHGDN |
| umls:C0011849 | Diabetes Mellitus | 41 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0010054 | Coronary Arteriosclerosis | 31 | BeFree,GAD |
| umls:C0010068 | Coronary heart disease | 31 | BeFree,GAD,LHGDN |
| umls:C0011847 | Diabetes | 29 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 23 | BeFree,GAD,LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 22 | BeFree,GAD,LHGDN |
| umls:C0021655 | Insulin Resistance | 22 | CTD_human,GAD,RGD |
| umls:C0020538 | Hypertensive disease | 17 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0004153 | Atherosclerosis | 16 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0011881 | Diabetic Nephropathy | 14 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0085207 | Gestational Diabetes | 14 | BeFree,CTD_human,LHGDN,RGD |
| umls:C1527249 | Colorectal Cancer | 14 | BeFree,GAD |
| umls:C0009402 | Colorectal Carcinoma | 13 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 13 | BeFree,CTD_human,GAD,LHGDN,RGD |
| umls:C0029928 | Ovarian Diseases | 12 | BeFree |
| umls:C0015695 | Fatty Liver | 11 | BeFree,GAD,LHGDN,RGD |
| umls:C0025517 | Metabolic Diseases | 11 | BeFree,LHGDN |
| umls:C0027051 | Myocardial Infarction | 11 | BeFree,GAD,LHGDN,RGD |
| umls:C0271650 | Impaired glucose tolerance | 10 | BeFree,LHGDN |
| umls:C2675519 | Hypoadiponectinemia | 10 | BeFree |
| umls:C0497406 | Overweight | 9 | BeFree,GAD |
| umls:C0021368 | Inflammation | 8 | CTD_human,GAD,LHGDN |
| umls:C0242339 | Dyslipidemias | 8 | BeFree,LHGDN |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 7 | BeFree,CTD_human,RGD |
| umls:C0003873 | Rheumatoid Arthritis | 6 | BeFree,CTD_human,LHGDN |
| umls:C0007102 | Malignant tumor of colon | 6 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 6 | BeFree,GAD,LHGDN |
| umls:C0028756 | Obesity, Morbid | 6 | BeFree,GAD |
| umls:C0699790 | Colon Carcinoma | 6 | BeFree |
| umls:C0003850 | Arteriosclerosis | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 5 | BeFree,GAD |
| umls:C0020456 | Hyperglycemia | 5 | BeFree,GAD |
| umls:C0022658 | Kidney Diseases | 5 | BeFree,LHGDN |
| umls:C0024117 | Chronic Obstructive Airway Disease | 5 | BeFree,LHGDN |
| umls:C0032914 | Pre-Eclampsia | 5 | GAD,LHGDN |
| umls:C0042373 | Vascular Diseases | 5 | BeFree,GAD,LHGDN |
| umls:C0033578 | Prostatic Neoplasms | 4 | BeFree,LHGDN |
| umls:C0311277 | Obesity, Abdominal | 4 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree,GAD |
| umls:C0518010 | body mass | 4 | GAD |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0948008 | Ischemic stroke | 4 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 4 | LHGDN |
| umls:C2239176 | Liver carcinoma | 4 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 4 | BeFree |
| umls:C0003125 | Anorexia Nervosa | 3 | BeFree,LHGDN |
| umls:C0007103 | Malignant neoplasm of endometrium | 3 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 3 | BeFree,LHGDN |
| umls:C0018802 | Congestive heart failure | 3 | BeFree |
| umls:C0020459 | Hyperinsulinism | 3 | BeFree,GAD,RGD |
| umls:C0020474 | Hyperlipidemia, Familial Combined | 3 | BeFree,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 3 | BeFree,GAD |
| umls:C0085580 | Essential Hypertension | 3 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C1384514 | Conn Syndrome | 3 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 3 | BeFree |
| umls:C3714619 | Insulin resistance syndrome | 3 | BeFree |
| umls:C0001430 | Adenoma | 2 | BeFree |
| umls:C0003851 | Arteriosclerosis Obliterans | 2 | LHGDN |
| umls:C0007785 | Cerebral Infarction | 2 | BeFree |
| umls:C0011884 | Diabetic Retinopathy | 2 | BeFree,GAD,LHGDN |
| umls:C0014175 | Endometriosis | 2 | LHGDN |
| umls:C0020452 | Hyperemia | 2 | CTD_human,LHGDN |
| umls:C0020473 | Hyperlipidemia | 2 | LHGDN,RGD |
| umls:C0023787 | Lipodystrophy | 2 | BeFree,LHGDN |
| umls:C0023890 | Liver Cirrhosis | 2 | BeFree,GAD,LHGDN |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0024115 | Lung diseases | 2 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 2 | BeFree,LHGDN |
| umls:C0032897 | Prader-Willi Syndrome | 2 | BeFree,LHGDN |
| umls:C0033687 | Proteinuria | 2 | GAD,LHGDN |
| umls:C0036341 | Schizophrenia | 2 | BeFree,GAD |
| umls:C0038356 | Stomach Neoplasms | 2 | LHGDN |
| umls:C0151744 | Myocardial Ischemia | 2 | CTD_human,LHGDN |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0520679 | Sleep Apnea, Obstructive | 2 | LHGDN |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | GAD |
| umls:C0600518 | Choroidal Neovascularization | 2 | RGD |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C0993582 | Arthritis, Experimental | 2 | CTD_human,RGD |
| umls:C1136321 | HIV-Associated Lipodystrophy Syndrome | 2 | GAD,LHGDN |
| umls:C1565489 | Renal Insufficiency | 2 | LHGDN |
| umls:C2316810 | Chronic kidney disease stage 5 | 2 | BeFree |
| umls:C2362324 | Pediatric Obesity | 2 | BeFree,GAD |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002962 | Angina Pectoris | 1 | LHGDN |
| umls:C0002963 | Angina Pectoris, Variant | 1 | LHGDN |
| umls:C0003123 | Anorexia | 1 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | LHGDN |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | LHGDN |
| umls:C0007193 | Cardiomyopathy, Dilated | 1 | BeFree,GAD |
| umls:C0007642 | Cellulitis | 1 | GAD |
| umls:C0008031 | Chest Pain | 1 | LHGDN |
| umls:C0009319 | Colitis | 1 | RGD |
| umls:C0010346 | Crohn Disease | 1 | CTD_human |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
| umls:C0014859 | Esophageal Neoplasms | 1 | GAD |
| umls:C0015934 | Fetal Growth Retardation | 1 | RGD |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | LHGDN |
| umls:C0018801 | Heart failure | 1 | CTD_human,GAD |
| umls:C0019158 | Hepatitis | 1 | BeFree |
| umls:C0019159 | Hepatitis A | 1 | BeFree |
| umls:C0019337 | Heroin Dependence | 1 | CTD_human |
| umls:C0019693 | HIV Infections | 1 | BeFree,GAD |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | LHGDN |
| umls:C0020550 | Hyperthyroidism | 1 | RGD |
| umls:C0020615 | Hypoglycemia | 1 | LHGDN |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0022408 | Arthropathy | 1 | LHGDN |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | LHGDN |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| umls:C0023895 | Liver diseases | 1 | LHGDN |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree,GAD |
| umls:C0024299 | Lymphoma | 1 | GAD |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | RGD |
| umls:C0025286 | Meningioma | 1 | BeFree |
| umls:C0026766 | Multiple Organ Failure | 1 | GAD |
| umls:C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| umls:C0030305 | Pancreatitis | 1 | GAD |
| umls:C0032962 | Pregnancy Complications | 1 | GAD |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 1 | BeFree |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0043094 | Weight Gain | 1 | CTD_human |
| umls:C0043119 | Werner Syndrome | 1 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 1 | LHGDN |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | LHGDN |
| umls:C0206081 | Hyperandrogenism | 1 | GAD |
| umls:C0221032 | Familial generalized lipodystrophy | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree |
| umls:C0239981 | Hypoalbuminemia | 1 | LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242656 | Disease Progression | 1 | LHGDN |
| umls:C0243026 | Sepsis | 1 | RGD |
| umls:C0264716 | Chronic heart failure | 1 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | BeFree |
| umls:C0280253 | stage, gastric cancer | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0333186 | Restenosis | 1 | BeFree |
| umls:C0342335 | Insulin resistance in diabetes | 1 | BeFree |
| umls:C0376618 | Endotoxemia | 1 | RGD |
| umls:C0393735 | Headache Disorders | 1 | LHGDN |
| umls:C0409959 | Osteoarthritis, Knee | 1 | BeFree |
| umls:C0429087 | Electrocardiogram: P-R interval | 1 | GAD |
| umls:C0431122 | Atypical meningioma | 1 | BeFree |
| umls:C0455825 | Left ventricular mass | 1 | GAD |
| umls:C0524910 | Hepatitis C, Chronic | 1 | LHGDN |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0740394 | Hyperuricemia | 1 | LHGDN |
| umls:C0751633 | Carotid Artery Plaque | 1 | BeFree |
| umls:C0751955 | Brain Infarction | 1 | RGD |
| umls:C0853897 | Diabetic Cardiomyopathies | 1 | RGD |
| umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
| umls:C0920563 | Insulin Sensitivity | 1 | GAD |
| umls:C0948480 | Coronary Restenosis | 1 | CTD_human |
| umls:C1096293 | Macroangiopathy | 1 | BeFree |
| umls:C1257958 | Glucose Metabolism Disorders | 1 | GAD |
| umls:C1262477 | Weight decreased | 1 | CTD_human |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1527336 | Sjogren's Syndrome | 1 | LHGDN |
| umls:C1837173 | CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 5 | 1 | BeFree |
| umls:C1847529 | ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 3 | 1 | CTD_human |
| umls:C1847530 | ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 2 | 1 | CTD_human |
| umls:C1857941 | Brooke-Spiegler syndrome | 1 | BeFree |
| umls:C1962972 | Proteinuria Adverse Event | 1 | GAD |
| umls:C2267227 | Bulimia Nervosa | 1 | LHGDN |
| umls:C2675517 | ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1 | 1 | UNIPROT |
| umls:C2711227 | Steatohepatitis | 1 | BeFree |
| umls:C2911645 | Weight Loss Adverse Event | 1 | GAD |
| umls:C2936179 | Obesity, Visceral | 1 | BeFree |
| umls:C3665365 | Arteriosclerotic cardiovascular disease, NOS | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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