TissGeneSummary for SLC22A8 |
Gene summary |
Basic gene information | Gene symbol | SLC22A8 |
Gene name | solute carrier family 22 (organic anion transporter), member 8 | |
Synonyms | OAT3 | |
Cytomap | UCSC genome browser: 11q11 | |
Type of gene | protein-coding | |
RefGenes | NM_001184732.1, NM_001184733.1,NM_001184736.1,NM_004254.3, | |
Description | hOAT3organic anion transporter 3solute carrier family 22 member 8 | |
Modification date | 20141222 | |
dbXrefs | MIM : 607581 | |
HGNC : HGNC | ||
Ensembl : ENSG00000149452 | ||
Vega : OTTHUMG00000167768 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC22A8 | |
BioGPS: 9376 | ||
Pathway | NCI Pathway Interaction Database: SLC22A8 | |
KEGG: SLC22A8 | ||
REACTOME: SLC22A8 | ||
Pathway Commons: SLC22A8 | ||
Context | iHOP: SLC22A8 | |
ligand binding site mutation search in PubMed: SLC22A8 | ||
UCL Cancer Institute: SLC22A8 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC22A8 | Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK. J Biol Chem. 2002 Jul 26;277(30):26934-43. Epub 2002 May 13 (pmid:12011098) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC22A8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 0.766092169 | 8.166760169 | -7.400668 | 1.58E-09 | 9.57E-09 |
KIRP | 3.423928669 | 10.56957554 | -7.145646875 | 9.27E-10 | 8.73E-09 |
KIRC | 2.798830057 | 8.952993946 | -6.154163889 | 2.86E-15 | 1.46E-14 |
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TissGene-miRNA for SLC22A8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC22A8 |
TissGeneSNV for SLC22A8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A531V | SKCM | 2 |
p.G456E | SKCM | 2 |
p.G338S | CESC | 1 |
p.A208D | LUSC | 1 |
p.P52L | SKCM | 1 |
p.M1I | LUSC | 1 |
p.L532I | UCEC | 1 |
p.R207W | STAD | 1 |
p.L121M | SARC | 1 |
p.M31V | KIRP | 1 |
p.G363D | SKCM | 1 |
p.R324H | STAD | 1 |
p.G141X | SKCM | 1 |
p.S4* | LUAD | 1 |
p.R325H | LIHC | 1 |
p.R149C | SARC | 1 |
p.A213P | OV | 1 |
p.R513W | STAD | 1 |
p.G68E | UCEC | 1 |
p.G289E | SKCM | 1 |
p.T466K | LUSC | 1 |
p.I441M | LUAD | 1 |
p.L159Q | ESCA | 1 |
p.E505K | BLCA | 1 |
p.V413I | SKCM | 1 |
p.F223L | READ | 1 |
p.G166A | OV | 1 |
p.E258* | UCEC | 1 |
p.L138I | PRAD | 1 |
p.G540D | STAD | 1 |
p.G221D | SKCM | 1 |
p.N81S | KIRC | 1 |
p.P517S | LGG | 1 |
p.R149H | BLCA | 1 |
p.D142N | SKCM | 1 |
p.R236H | THYM | 1 |
p.E287K | SKCM | 1 |
p.S270L | SKCM | 1 |
p.P517S | ESCA | 1 |
p.G68R | SKCM | 1 |
p.K309R | LGG | 1 |
p.Q533* | PAAD | 1 |
p.S252L | SKCM | 1 |
p.Y342H | LUAD | 1 |
p.G479W | KIRP | 1 |
p.R291K | SKCM | 1 |
p.R236C | UCEC | 1 |
p.L516F | UCEC | 1 |
p.S259Y | BLCA | 1 |
p.G352R | STAD | 1 |
p.V242E | LUAD | 1 |
p.M1I | LIHC | 1 |
p.V21I | BLCA | 1 |
p.T313N | LUAD | 1 |
p.E304K | HNSC | 1 |
p.N102S | HNSC | 1 |
p.Q89K | PRAD | 1 |
p.R513W | UCEC | 1 |
p.C428Y | LIHC | 1 |
p.C329S | LIHC | 1 |
p.P531S | SKCM | 1 |
p.E288Q | BLCA | 1 |
p.S144F | SKCM | 1 |
p.R149H | GBM | 1 |
p.R205Q | STAD | 1 |
p.P80L | UCEC | 1 |
p.R454H | COAD | 1 |
p.K515N | BLCA | 1 |
p.Q38X | COAD | 1 |
p.P66L | SKCM | 1 |
p.G11E | SKCM | 1 |
p.A526T | LIHC | 1 |
p.L532I | LUSC | 1 |
p.R529K | SKCM | 1 |
p.G456R | SARC | 1 |
p.L26F | SARC | 1 |
p.V410M | PRAD | 1 |
p.G289R | SKCM | 1 |
p.P233S | SKCM | 1 |
p.S500L | UCEC | 1 |
p.W510* | LUAD | 1 |
p.I224S | CESC | 1 |
p.S270L | UCEC | 1 |
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TissGeneCNV for SLC22A8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC22A8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC22A8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC22A8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC22A8 |
TissGeneDrug for SLC22A8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00493 | Cefotaxime | Small molecule | Approved | |
DB01032 | Probenecid | Inhibitor | Small molecule | Approved |
DB01212 | Ceftriaxone | Small molecule | Approved | |
DB01053 | Benzylpenicillin | Small molecule | Approved|Vet_approved |
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TissGeneDisease for SLC22A8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
umls:C0021400 | Influenza | 1 | CTD_human |
umls:C0022658 | Kidney Diseases | 1 | BeFree |
umls:C0022660 | Kidney Failure, Acute | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0028860 | Oculocerebrorenal Syndrome | 1 | BeFree |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0221238 | Mesangial proliferative glomerulonephritis | 1 | BeFree |