TissGeneSummary for SLC22A14 |
Gene summary |
Basic gene information | Gene symbol | SLC22A14 |
Gene name | solute carrier family 22, member 14 | |
Synonyms | OCTL2|OCTL4|ORCTL4 | |
Cytomap | UCSC genome browser: 3p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_004803.3, | |
Description | ORCTL-4organic cation transporter-like 4organic cationic transporter-like 4solute carrier family 22 (organic cation transporter), member 14solute carrier family 22 member 14 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604048 | |
HGNC : HGNC | ||
Ensembl : ENSG00000144671 | ||
HPRD : 06811 | ||
Vega : OTTHUMG00000131082 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC22A14 | |
BioGPS: 9389 | ||
Pathway | NCI Pathway Interaction Database: SLC22A14 | |
KEGG: SLC22A14 | ||
REACTOME: SLC22A14 | ||
Pathway Commons: SLC22A14 | ||
Context | iHOP: SLC22A14 | |
ligand binding site mutation search in PubMed: SLC22A14 | ||
UCL Cancer Institute: SLC22A14 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC22A14 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for SLC22A14 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for SLC22A14 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for SLC22A14 |
TissGeneSNV for SLC22A14 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E172K | SKCM | 2 |
p.S554F | SKCM | 2 |
p.W438* | MESO | 1 |
p.P422L | SKCM | 1 |
p.H109Q | HNSC | 1 |
p.L199F | SKCM | 1 |
p.P321S | SKCM | 1 |
p.P96L | MESO | 1 |
p.P472L | STAD | 1 |
p.V59M | SKCM | 1 |
p.M326I | SKCM | 1 |
p.D163G | READ | 1 |
p.P349L | SKCM | 1 |
p.L466P | DLBC | 1 |
p.E35K | SKCM | 1 |
p.G460E | COAD | 1 |
p.S168A | SKCM | 1 |
p.R39C | HNSC | 1 |
p.D370N | COAD | 1 |
p.V90L | LUAD | 1 |
p.S519F | SKCM | 1 |
p.F89I | BRCA | 1 |
p.R241C | SKCM | 1 |
p.R268Q | UCEC | 1 |
p.L20S | BLCA | 1 |
p.P76S | SKCM | 1 |
p.P560R | COAD | 1 |
p.A290T | SARC | 1 |
p.I533V | LUSC | 1 |
p.I160N | COAD | 1 |
p.V547I | UCEC | 1 |
p.K112E | BRCA | 1 |
p.G107D | BRCA | 1 |
p.P458S | SKCM | 1 |
p.E261A | COAD | 1 |
p.I542N | OV | 1 |
p.L506I | STAD | 1 |
p.S590* | BLCA | 1 |
p.E488D | BLCA | 1 |
p.Q67H | HNSC | 1 |
p.P349S | SKCM | 1 |
p.G225S | SKCM | 1 |
p.S399I | UCEC | 1 |
p.A503T | PRAD | 1 |
p.R241H | HNSC | 1 |
p.W323R | SARC | 1 |
p.K165N | ESCA | 1 |
p.A341T | READ | 1 |
p.G148V | LUAD | 1 |
p.A526T | UCEC | 1 |
p.R268Q | HNSC | 1 |
p.V414M | UVM | 1 |
p.P541H | LIHC | 1 |
p.F242S | SKCM | 1 |
p.W315X | SKCM | 1 |
p.T205S | LUAD | 1 |
p.G250S | HNSC | 1 |
p.V391I | COAD | 1 |
p.D370N | STAD | 1 |
p.R167Q | SKCM | 1 |
p.A503T | STAD | 1 |
p.K165* | SKCM | 1 |
p.P359L | PRAD | 1 |
p.P136T | CESC | 1 |
p.W323L | UCEC | 1 |
p.T390I | SKCM | 1 |
p.G525R | SKCM | 1 |
p.P162S | SKCM | 1 |
p.S522L | SARC | 1 |
p.G27E | SKCM | 1 |
p.K165N | LUAD | 1 |
Top |
TissGeneCNV for SLC22A14 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for SLC22A14 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for SLC22A14 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for SLC22A14 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for SLC22A14 |
TissGeneDrug for SLC22A14 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for SLC22A14 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |