TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC22A14
check button Gene summary
Basic gene informationGene symbolSLC22A14
Gene namesolute carrier family 22, member 14
SynonymsOCTL2|OCTL4|ORCTL4
CytomapUCSC genome browser: 3p21.3
Type of geneprotein-coding
RefGenesNM_004803.3,
DescriptionORCTL-4organic cation transporter-like 4organic cationic transporter-like 4solute carrier family 22 (organic cation transporter), member 14solute carrier family 22 member 14
Modification date20141207
dbXrefs MIM : 604048
HGNC : HGNC
Ensembl : ENSG00000144671
HPRD : 06811
Vega : OTTHUMG00000131082
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC22A14
BioGPS: 9389
PathwayNCI Pathway Interaction Database: SLC22A14
KEGG: SLC22A14
REACTOME: SLC22A14
Pathway Commons: SLC22A14
ContextiHOP: SLC22A14
ligand binding site mutation search in PubMed: SLC22A14
UCL Cancer Institute: SLC22A14
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of SLC22A14
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for SLC22A14

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR


Top
TissGene-miRNA for SLC22A14

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for SLC22A14
TissGeneSNV for SLC22A14

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E172KSKCM2
p.S554FSKCM2
p.W438*MESO1
p.P422LSKCM1
p.H109QHNSC1
p.L199FSKCM1
p.P321SSKCM1
p.P96LMESO1
p.P472LSTAD1
p.V59MSKCM1
p.M326ISKCM1
p.D163GREAD1
p.P349LSKCM1
p.L466PDLBC1
p.E35KSKCM1
p.G460ECOAD1
p.S168ASKCM1
p.R39CHNSC1
p.D370NCOAD1
p.V90LLUAD1
p.S519FSKCM1
p.F89IBRCA1
p.R241CSKCM1
p.R268QUCEC1
p.L20SBLCA1
p.P76SSKCM1
p.P560RCOAD1
p.A290TSARC1
p.I533VLUSC1
p.I160NCOAD1
p.V547IUCEC1
p.K112EBRCA1
p.G107DBRCA1
p.P458SSKCM1
p.E261ACOAD1
p.I542NOV1
p.L506ISTAD1
p.S590*BLCA1
p.E488DBLCA1
p.Q67HHNSC1
p.P349SSKCM1
p.G225SSKCM1
p.S399IUCEC1
p.A503TPRAD1
p.R241HHNSC1
p.W323RSARC1
p.K165NESCA1
p.A341TREAD1
p.G148VLUAD1
p.A526TUCEC1
p.R268QHNSC1
p.V414MUVM1
p.P541HLIHC1
p.F242SSKCM1
p.W315XSKCM1
p.T205SLUAD1
p.G250SHNSC1
p.V391ICOAD1
p.D370NSTAD1
p.R167QSKCM1
p.A503TSTAD1
p.K165*SKCM1
p.P359LPRAD1
p.P136TCESC1
p.W323LUCEC1
p.T390ISKCM1
p.G525RSKCM1
p.P162SSKCM1
p.S522LSARC1
p.G27ESKCM1
p.K165NLUAD1


Top
TissGeneCNV for SLC22A14

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for SLC22A14

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


Top
TissGeneNet for SLC22A14

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


Top
TissGeneProg for SLC22A14

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for SLC22A14
TissGeneDrug for SLC22A14

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for SLC22A14

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020503Hyperparathyroidism, Secondary1GAD
umls:C0040336Tobacco Use Disorder1GAD