TissGeneSummary for SPAG6 |
Gene summary |
Basic gene information | Gene symbol | SPAG6 |
Gene name | sperm associated antigen 6 | |
Synonyms | CT141|Repro-SA-1|pf16 | |
Cytomap | UCSC genome browser: 10p12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001253854.1, NM_001253855.1,NM_012443.3,NM_172242.2, | |
Description | axoneme central apparatus proteinprotein PF16 homologsperm flagellar proteinsperm-associated antigen 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605730 | |
HGNC : HGNC | ||
Ensembl : ENSG00000077327 | ||
HPRD : 09305 | ||
Vega : OTTHUMG00000017808 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPAG6 | |
BioGPS: 9576 | ||
Pathway | NCI Pathway Interaction Database: SPAG6 | |
KEGG: SPAG6 | ||
REACTOME: SPAG6 | ||
Pathway Commons: SPAG6 | ||
Context | iHOP: SPAG6 | |
ligand binding site mutation search in PubMed: SPAG6 | ||
UCL Cancer Institute: SPAG6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPAG6 | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPAG6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -3.315531099 | -1.245487099 | -2.070044 | 2.47E-05 | 7.23E-05 |
KIRC | -3.079543988 | -1.032710655 | -2.046833333 | 4.28E-16 | 2.34E-15 |
LUSC | -1.016662943 | 2.826252744 | -3.842915686 | 3.29E-11 | 1.31E-10 |
PRAD | 1.43302567 | 0.380306439 | 1.052719231 | 0.00285 | 0.007993554 |
LUAD | 1.257725935 | 3.154974211 | -1.897248276 | 7.68E-05 | 0.000198003 |
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TissGene-miRNA for SPAG6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPAG6 |
TissGeneSNV for SPAG6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P330S | SKCM | 2 |
p.S385Y | STAD | 1 |
p.Q473* | SARC | 1 |
p.E418X | THYM | 1 |
p.V245F | LIHC | 1 |
p.Q19E | LUSC | 1 |
p.E170* | LUAD | 1 |
p.S320P | READ | 1 |
p.R108X | THYM | 1 |
p.A451S | LUAD | 1 |
p.M217V | BRCA | 1 |
p.A320S | LUAD | 1 |
p.L505V | HNSC | 1 |
p.R310W | BRCA | 1 |
p.Y342N | HNSC | 1 |
p.G543V | LUAD | 1 |
p.H189Q | PRAD | 1 |
p.A177V | READ | 1 |
p.L525H | HNSC | 1 |
p.S265L | SKCM | 1 |
p.E494* | THYM | 1 |
p.S198F | KICH | 1 |
p.Y266N | HNSC | 1 |
p.L429V | HNSC | 1 |
p.S469F | SKCM | 1 |
p.R185M | LUAD | 1 |
p.E560K | SKCM | 1 |
p.A232S | KIRP | 1 |
p.N156D | UCEC | 1 |
p.Y266X | READ | 1 |
p.K405N | UCEC | 1 |
p.T387A | COAD | 1 |
p.L497V | ESCA | 1 |
p.R310L | LUAD | 1 |
p.L396I | READ | 1 |
p.G243A | THCA | 1 |
p.D165H | LUSC | 1 |
p.I474T | UCEC | 1 |
p.L421I | UCEC | 1 |
p.L421V | ESCA | 1 |
p.R448L | LUAD | 1 |
p.V396A | LUAD | 1 |
p.A431S | LUAD | 1 |
p.G543S | LUAD | 1 |
p.Q292H | BLCA | 1 |
p.R261M | LUAD | 1 |
p.G531S | HNSC | 1 |
p.P330Q | LUAD | 1 |
p.T129M | ESCA | 1 |
p.A371S | UCEC | 1 |
p.E458K | COAD | 1 |
p.L449H | HNSC | 1 |
p.D262E | LUSC | 1 |
p.G44R | UCEC | 1 |
p.H399Y | SKCM | 1 |
p.A202V | ESCA | 1 |
p.E459K | SKCM | 1 |
p.R372L | LUAD | 1 |
p.A368G | LUAD | 1 |
p.E254K | SKCM | 1 |
p.R347L | COAD | 1 |
p.V476M | SKCM | 1 |
p.R386L | LUAD | 1 |
p.R447* | UCEC | 1 |
p.E346G | LIHC | 1 |
p.V324A | LIHC | 1 |
p.Q58E | LUSC | 1 |
p.P517T | LUAD | 1 |
p.L393I | PAAD | 1 |
p.Q485R | PRAD | 1 |
p.E327K | SKCM | 1 |
p.Q59R | UCEC | 1 |
p.V577M | SKCM | 1 |
p.V169F | LIHC | 1 |
p.S167L | SKCM | 1 |
p.Q253R | LUAD | 1 |
p.D123N | UCEC | 1 |
p.L317I | PAAD | 1 |
p.R524Q | PAAD | 1 |
p.A250S | THYM | 1 |
p.R448Q | PAAD | 1 |
p.A308S | KIRP | 1 |
p.V241M | STAD | 1 |
p.Y151C | UCEC | 1 |
p.S268R | BLCA | 1 |
p.H298Y | SKCM | 1 |
p.S410F | SKCM | 1 |
p.V248A | LIHC | 1 |
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TissGeneCNV for SPAG6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPAG6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CN357114 | GFM2-SPAG6 | chr5:74062864 | chr10:22699957 | |
Chimerdb3.0 | ChiTaRs | NA | BM979038 | AGBL4-SPAG6 | chr1:50321725 | chr10:22705847 | |
TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A2I1-01A | KIAA1217-SPAG6 | In-frame | Chr10:24669996 | Chr10:22653782 |
TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A2I1-01A | SPAG6-PLXDC2 | Out-of-frame | Chr10:22657607 | Chr10:20568632 |
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TissGeneNet for SPAG6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPAG6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPAG6 |
TissGeneDrug for SPAG6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPAG6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0024530 | Malaria | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0242596 | Neoplasm, Residual | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C2939461 | Myeloid neoplasm | 1 | BeFree |