TissGeneSummary for GUCA1C |
Gene summary |
Basic gene information | Gene symbol | GUCA1C |
Gene name | guanylate cyclase activator 1C | |
Synonyms | GCAP3 | |
Cytomap | UCSC genome browser: 3q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_005459.3, | |
Description | GCAP 3guanylyl cyclase-activating protein 3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605128 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138472 | ||
HPRD : 05499 | ||
Vega : OTTHUMG00000159204 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GUCA1C | |
BioGPS: 9626 | ||
Pathway | NCI Pathway Interaction Database: GUCA1C | |
KEGG: GUCA1C | ||
REACTOME: GUCA1C | ||
Pathway Commons: GUCA1C | ||
Context | iHOP: GUCA1C | |
ligand binding site mutation search in PubMed: GUCA1C | ||
UCL Cancer Institute: GUCA1C | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADUVM | |
Reference showing the relevant tissue of GUCA1C | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GUCA1C |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -0.81501705 | 0.793311075 | -1.608328125 | 8.56E-08 | 5.23E-07 |
KICH | -1.692939925 | 0.770252075 | -2.463192 | 2.05E-14 | 3.48E-13 |
KIRC | -1.37905837 | 0.778384686 | -2.157443056 | 1.60E-25 | 1.97E-24 |
ESCA | -1.874063925 | 1.737326984 | -3.611390909 | 0.00596 | 0.044183467 |
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TissGene-miRNA for GUCA1C |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GUCA1C |
TissGeneSNV for GUCA1C |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E39K | SKCM | 7 |
p.Q170* | SKCM | 2 |
p.Q126K | HNSC | 1 |
p.G150E | SARC | 1 |
p.V169F | LUAD | 1 |
p.E133K | SKCM | 1 |
p.T157A | UCEC | 1 |
p.E87Q | BRCA | 1 |
p.G180R | SKCM | 1 |
p.P15S | SKCM | 1 |
p.K41N | UCEC | 1 |
p.M28I | SKCM | 1 |
p.F26C | READ | 1 |
p.A160S | GBM | 1 |
p.Q127* | STAD | 1 |
p.M190T | UCEC | 1 |
p.S107Y | COAD | 1 |
p.M1T | COAD | 1 |
p.N67S | LUAD | 1 |
p.P31S | SKCM | 1 |
p.E29* | LUAD | 1 |
p.S107Y | THYM | 1 |
p.M89I | SKCM | 1 |
p.Q163* | SKCM | 1 |
p.T63A | LUSC | 1 |
p.H38N | UCEC | 1 |
p.L93I | SKCM | 1 |
p.G150R | SARC | 1 |
p.F26L | READ | 1 |
p.F175V | ESCA | 1 |
p.D143N | PAAD | 1 |
p.M28I | LUAD | 1 |
p.R187* | BLCA | 1 |
p.R187* | SKCM | 1 |
p.E191K | SKCM | 1 |
p.W95* | STAD | 1 |
p.W22X | STAD | 1 |
p.K141N | LUAD | 1 |
p.E149* | UCEC | 1 |
p.P31L | SARC | 1 |
p.W22* | STAD | 1 |
p.M159V | DLBC | 1 |
p.G4V | BLCA | 1 |
p.D193N | SKCM | 1 |
p.H20N | LUAD | 1 |
p.D164Y | LUAD | 1 |
p.F155C | STAD | 1 |
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TissGeneCNV for GUCA1C |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GUCA1C |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for GUCA1C |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GUCA1C |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GUCA1C |
TissGeneDrug for GUCA1C |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GUCA1C |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |