TissGeneSummary for NUP155 |
Gene summary |
Basic gene information | Gene symbol | NUP155 |
Gene name | nucleoporin 155kDa | |
Synonyms | ATFB15|N155 | |
Cytomap | UCSC genome browser: 5p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001278312.1, NM_004298.3,NM_153485.2, | |
Description | 155 kDa nucleoporinnuclear pore complex protein Nup155nucleoporin 155kD | |
Modification date | 20141207 | |
dbXrefs | MIM : 606694 | |
HGNC : HGNC | ||
Ensembl : ENSG00000113569 | ||
HPRD : 05984 | ||
Vega : OTTHUMG00000090803 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NUP155 | |
BioGPS: 9631 | ||
Pathway | NCI Pathway Interaction Database: NUP155 | |
KEGG: NUP155 | ||
REACTOME: NUP155 | ||
Pathway Commons: NUP155 | ||
Context | iHOP: NUP155 | |
ligand binding site mutation search in PubMed: NUP155 | ||
UCL Cancer Institute: NUP155 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NUP155 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006998 | nuclear envelope organization | 19070573 | GO:0006998 | nuclear envelope organization | 19070573 |
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TissGeneExp for NUP155 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.193422452 | -1.17848272 | 1.371905172 | 9.50E-19 | 1.47E-17 |
LUSC | 1.046101086 | -0.959724404 | 2.00582549 | 6.55E-25 | 1.42E-23 |
BLCA | 0.2246112 | -0.83320459 | 1.057815789 | 2.58E-05 | 0.000390335 |
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TissGene-miRNA for NUP155 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-98-5p | MIMAT0000096 | 0.024 | -0.26 | 78 |
ACC | hsa-miR-98-5p | MIMAT0000096 | 0.024 | -0.26 | 78 |
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TissGeneMut for NUP155 |
TissGeneSNV for NUP155 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P440S | SKCM | 3 |
p.R410I | LUAD | 1 |
p.F1192I | STAD | 1 |
p.R252K | STAD | 1 |
p.E1388Q | BLCA | 1 |
p.P942S | READ | 1 |
p.E1086K | LUAD | 1 |
p.D1007N | LUSC | 1 |
p.A1372V | THYM | 1 |
p.H160Y | LIHC | 1 |
p.T56I | SKCM | 1 |
p.S1309L | BLCA | 1 |
p.G611S | ACC | 1 |
p.C1201Y | THYM | 1 |
p.A168V | THCA | 1 |
p.R162* | STAD | 1 |
p.E832Q | CESC | 1 |
p.A555D | ESCA | 1 |
p.P1338A | HNSC | 1 |
p.H99Y | STAD | 1 |
p.Q905* | SKCM | 1 |
p.L1039I | ESCA | 1 |
p.L588V | BLCA | 1 |
p.G754E | BLCA | 1 |
p.W1221* | LUSC | 1 |
p.A115V | SKCM | 1 |
p.E762* | OV | 1 |
p.K1318Q | LGG | 1 |
p.K231E | LGG | 1 |
p.E1015* | LUAD | 1 |
p.Y1084D | MESO | 1 |
p.L264I | BLCA | 1 |
p.H625Y | STAD | 1 |
p.V174A | COAD | 1 |
p.G716S | PAAD | 1 |
p.L1123V | OV | 1 |
p.E694V | BLCA | 1 |
p.V911A | STAD | 1 |
p.A463V | UCEC | 1 |
p.S1238L | SKCM | 1 |
p.T56A | STAD | 1 |
p.R1310W | COAD | 1 |
p.S406* | CESC | 1 |
p.A851T | BRCA | 1 |
p.E713Q | BLCA | 1 |
p.F965L | KIRP | 1 |
p.Q1172H | STAD | 1 |
p.A989T | UCEC | 1 |
p.E1061Q | BLCA | 1 |
p.I81M | CESC | 1 |
p.I1109S | UCEC | 1 |
p.A8T | BLCA | 1 |
p.A115P | HNSC | 1 |
p.L1141F | SKCM | 1 |
p.C102S | LGG | 1 |
p.F227L | BLCA | 1 |
p.R86K | LUAD | 1 |
p.Y576C | HNSC | 1 |
p.V1282A | STAD | 1 |
p.E536K | BLCA | 1 |
p.S1236G | LUAD | 1 |
p.T1234A | STAD | 1 |
p.D335Y | LUAD | 1 |
p.L476X | COAD | 1 |
p.R1074T | LUSC | 1 |
p.A316S | LUSC | 1 |
p.A937V | LUSC | 1 |
p.E699A | LGG | 1 |
p.K876N | BRCA | 1 |
p.T1277S | BLCA | 1 |
p.Q963H | HNSC | 1 |
p.K1197E | LUAD | 1 |
p.Q35E | PAAD | 1 |
p.D853V | LUAD | 1 |
p.R1066* | HNSC | 1 |
p.I673N | BRCA | 1 |
p.A936V | UCEC | 1 |
p.P589L | BLCA | 1 |
p.A17V | BLCA | 1 |
p.D429Y | COAD | 1 |
p.Q320H | LUAD | 1 |
p.L1390R | LIHC | 1 |
p.E694Q | BLCA | 1 |
p.K498N | COAD | 1 |
p.A360S | STAD | 1 |
p.Y926* | OV | 1 |
p.E1200K | SKCM | 1 |
p.E774D | BRCA | 1 |
p.L837F | OV | 1 |
p.A770D | STAD | 1 |
p.E534Q | LUAD | 1 |
p.L1251F | SKCM | 1 |
p.S1133* | HNSC | 1 |
p.T570A | UCEC | 1 |
p.S1366C | BLCA | 1 |
p.P999T | COAD | 1 |
p.W1314C | SKCM | 1 |
p.E892G | LGG | 1 |
p.S933C | CESC | 1 |
p.E1145Q | CESC | 1 |
p.R693I | BLCA | 1 |
p.E142K | BLCA | 1 |
p.Q1340H | STAD | 1 |
p.D203G | LIHC | 1 |
p.S1382F | COAD | 1 |
p.V366A | CESC | 1 |
p.L117I | BLCA | 1 |
p.S908C | SKCM | 1 |
p.C356S | STAD | 1 |
p.Q757L | KIRC | 1 |
p.P278S | SKCM | 1 |
p.R1316T | LUSC | 1 |
p.Q33R | LIHC | 1 |
p.G306R | SARC | 1 |
p.P55S | SKCM | 1 |
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TissGeneCNV for NUP155 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NUP155 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A43E-01A | NUP155-MARCH6 | Out-of-Frame | chr5:37364348 | chr5:10402495 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1FM-01A | NIPBL-NUP155 | In-Frame | chr5:37027514 | chr5:37310845 |
TCGAfusionPortal | PRADA | BLCA | TCGA-E5-A2PC-01A | NUP155-TRIO | Out-of-frame | Chr5:37314300 | Chr5:14531853 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A04Q-01A | C5orf42-NUP155 | Out-of-frame | Chr5:37221426 | Chr5:37304945 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A15K-01A | NUP155-ZFYVE26 | Out-of-frame | Chr5:37370923 | Chr14:68244965 |
TCGAfusionPortal | PRADA | OV | TCGA-25-2397-01A | PRRC2B-NUP155 | 5UTR-CDS | Chr9:134269650 | Chr5:37293087 |
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TissGeneNet for NUP155 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NUP155 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NUP155 |
TissGeneDrug for NUP155 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NUP155 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004238 | Atrial Fibrillation | 1 | LHGDN |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree,LHGDN |
umls:C0017178 | Gastrointestinal Diseases | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0035869 | Rotavirus Infections | 1 | BeFree |
umls:C0232197 | Fibrillation | 1 | BeFree |
umls:C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | BeFree |
umls:C4014269 | ATRIAL FIBRILLATION, FAMILIAL, 15 | 1 | UNIPROT |