TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CEP170

Gene summary

Basic gene information	Gene symbol	CEP170
	Gene name	centrosomal protein 170kDa
	Synonyms	FAM68A\|KAB\|KIAA0470
	Cytomap	UCSC genome browser: 1q44
	Type of gene	protein-coding
	RefGenes	NM_001042404.1, NM_001042405.1,NM_014812.2,
	Description	KARP-1-binding proteinXRCC5 binding proteincentrosomal protein of 170 kDa
	Modification date	20141207
dbXrefs	MIM : 613023
	HGNC : HGNC
	Ensembl : ENSG00000143702
	HPRD : 17172
	Vega : OTTHUMG00000039862
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CEP170
	BioGPS: 9859
Pathway	NCI Pathway Interaction Database: CEP170
	KEGG: CEP170
	REACTOME: CEP170
	Pathway Commons: CEP170
Context	iHOP: CEP170
	ligand binding site mutation search in PubMed: CEP170
	UCL Cancer Institute: CEP170
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	TGCT
Reference showing the relevant tissue of CEP170
Description by TissGene annotations	Cancer gene TissgsLTS Fused withOncogene Fused withTSGene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for CEP170

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KIRC	1.975220034	0.959475589	1.015744444	7.13E-26	9.24E-25

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TissGene-miRNA for CEP170

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for CEP170

TissGeneSNV for CEP170

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E539K	UCEC	5
p.E539K	ESCA	2
p.G1140R	BRCA	1
p.D406H	BRCA	1
p.S1177C	BLCA	1
p.E417K	UCEC	1
p.E505*	HNSC	1
p.T640I	COAD	1
p.E1167V	COAD	1
p.I1400S	LGG	1
p.R1054W	UCEC	1
p.R643Q	BRCA	1
p.R1448Q	SKCM	1
p.Q785R	BRCA	1
p.R1142*	UCEC	1
p.E755K	STAD	1
p.Q1044E	UCEC	1
p.R37H	READ	1
p.T565I	OV	1
p.P171L	LUAD	1
p.K1481R	UCEC	1
p.R470K	BLCA	1
p.D360V	LIHC	1
p.E1577K	LUSC	1
p.K308N	LUAD	1
p.R1403W	STAD	1
p.W1450C	LUAD	1
p.R1357C	UCEC	1
p.S1350Y	READ	1
p.R393C	STAD	1
p.S996F	SKCM	1
p.R1208L	LUAD	1
p.S5F	SKCM	1
p.V363L	HNSC	1
p.V361F	LUAD	1
p.R1006C	UCEC	1
p.A1502D	ESCA	1
p.A591D	THYM	1
p.L645H	SKCM	1
p.A1562V	STAD	1
p.Q783R	UCEC	1
p.K987T	KIRP	1
p.R1284G	COAD	1
p.R431K	BLCA	1
p.P1370S	SKCM	1
p.V1358G	SKCM	1
p.L1544F	BRCA	1
p.S1087I	LUSC	1
p.A423S	LUSC	1
p.G574S	HNSC	1
p.A169V	UCEC	1
p.V584F	SKCM	1
p.P180A	HNSC	1
p.E513K	BLCA	1
p.V1355G	ESCA	1
p.D495E	HNSC	1
p.S1085L	BLCA	1
p.R545Q	COAD	1
p.R1357C	SKCM	1
p.R1448W	UCEC	1
p.T682S	READ	1
p.D318E	CESC	1
p.R985K	LUAD	1
p.R995C	SKCM	1
p.K445R	UCEC	1
p.D375N	CESC	1
p.R20*	BLCA	1
p.R1164C	LUAD	1
p.S359I	ACC	1
p.Y923H	UCEC	1
p.H307Q	ESCA	1
p.E558D	COAD	1
p.P289S	SKCM	1
p.S356R	PRAD	1
p.G435C	LUAD	1
p.R1014X	LIHC	1
p.T458P	ESCA	1
p.H1221D	CESC	1
p.A659V	SKCM	1
p.Y687C	LUAD	1
p.S1133C	BLCA	1
p.K542E	UCEC	1
p.R349I	LUAD	1
p.S1085L	CESC	1
p.L346V	UCEC	1
p.I272L	LIHC	1
p.D1025N	BLCA	1
p.T377K	THYM	1
p.E102K	UCEC	1
p.S785*	BLCA	1
p.G1382S	STAD	1
p.V486F	SKCM	1
p.I1147V	BRCA	1
p.T684A	UCEC	1
p.S450L	UCEC	1
p.R1154L	UCEC	1
p.Q586H	LUSC	1
p.P1246S	SKCM	1
p.E417K	BRCA	1
p.R995H	PAAD	1
p.D1043N	LIHC	1
p.S450L	COAD	1
p.E1577K	STAD	1
p.R909C	UCEC	1
p.P171S	LUAD	1
p.S566T	UCEC	1
p.R626I	LUSC	1
p.S724R	PRAD	1
p.E513*	LUAD	1
p.N508D	STAD	1
p.P329R	BRCA	1
p.I1206F	UCEC	1
p.R388W	HNSC	1
p.G439W	ACC	1
p.K1155E	COAD	1
p.T377M	LUAD	1
p.R1403W	PRAD	1
p.D1118A	LGG	1
p.A1119V	UCEC	1
p.P723S	COAD	1
p.S452Y	UCEC	1
p.R956*	OV	1
p.E187D	KIRC	1
p.S1279C	HNSC	1
p.E507D	HNSC	1
p.E1062D	KIRC	1
p.I167T	UCEC	1
p.S952T	KIRC	1
p.T1090A	SKCM	1
p.R172C	LUAD	1
p.K246I	HNSC	1
p.A757V	SKCM	1
p.S464L	BLCA	1
p.D998N	SKCM	1
p.F606L	GBM	1
p.D1290H	CESC	1
p.S724C	LUAD	1
p.Q1390*	CESC	1
p.T1130A	LGG	1
p.E206K	HNSC	1
p.S466R	STAD	1
p.T484P	STAD	1
p.L32R	CESC	1
p.A1119D	PRAD	1
p.E679D	LUAD	1
p.M1T	HNSC	1
p.D1563Y	LUAD	1
p.L720F	KIRP	1
p.V1234G	SKCM	1
p.T682A	UCEC	1
p.L904I	UCEC	1
p.R1299Q	LUAD	1
p.R995H	LGG	1
p.K409Q	UCEC	1
p.A224V	TGCT	1
p.Q753K	LUSC	1
p.S415Y	UCEC	1
p.S1207C	BLCA	1
p.R37C	STAD	1
p.V1355G	UCEC	1
p.N1380K	STAD	1
p.P683L	BLCA	1
p.I1566V	HNSC	1

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TissGeneCNV for CEP170

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for CEP170

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	FusionScan	LGG	TCGA-DU-6399-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	LGG	TCGA-S9-A6U6-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	LGG	TCGA-FG-A711-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	LGG	TCGA-HT-7485-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	LGG	TCGA-DU-A7TI-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	BRCA	TCGA-BH-A203-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	ESCA	TCGA-VR-A8EP-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	ESCA	TCGA-LN-A8HZ-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	ESCA	TCGA-LN-A5U5-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	ESCA	TCGA-Z6-A8JD-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
Chimerdb3.0	FusionScan	LUSC	TCGA-85-6798-01A	CEP170-RAD51B	In-Frame	chr1:243349080	chr14:68758600
TCGAfusionPortal	PRADA	GBM	TCGA-06-2561-01A	CEP170-C1orf100	CDS-5UTR	Chr1:243349561	Chr1:244527990
TCGAfusionPortal	PRADA	HNSC	TCGA-BA-4074-01A	SDCCAG8-CEP170	Out-of-frame	Chr1:243419542	Chr1:243336148
TCGAfusionPortal	PRADA	LUAD	TCGA-44-8119-01A	CEP170-RGS7	In-frame	Chr1:243385026	Chr1:240990472
TCGAfusionPortal	PRADA	LUAD	TCGA-73-4662-01A	CEP170-SDCCAG8	NA	Chr1:243418349	Chr1:243468015
TCGAfusionPortal	PRADA	PRAD	TCGA-YL-A8HM-01A	CEP170-IFI16	5UTR-5UTR	Chr1:243418342	Chr1:158979793

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TissGeneNet for CEP170

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
CEP170, VAV2, SIRT7, KIAA1967, PPP1CA, YWHAZ, YWHAG, BEGAIN, MYC, DISC1, MYH9, RUNX1T1, SERPINB6, CCDC120, LMO3, AIMP2, HERC2, TNKS2, ABI3, NEURL4, C19orf25 (tumor)	CEP170, SIRT7, PPP1CA, YWHAZ, YWHAG, BEGAIN, YWHAQ, DISC1, MYH9, RUNX1T1, SERPINB6, SNAPIN, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, NEURL4, CENPO, C19orf25 (normal)

COAD (tumor)	COAD (normal)
CEP170, VAV2, SIRT7, PPP1CA, YWHAZ, YWHAG, DISC1, RALYL, RUNX1T1, SERPINB6, SNAPIN, CCDC120, LMO3, AIMP2, HERC2, TNKS2, C1orf216, ABI3, NEURL4, CENPO, C19orf25 (tumor)	CEP170, SIRT7, PPP1CA, KIAA0101, YWHAG, MYC, DISC1, MYH9, RALYL, RUNX1T1, SNAPIN, CCDC120, LMO3, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, NEURL4, C19orf25 (normal)

HNSC (tumor)	HNSC (normal)
CEP170, SIRT7, PPP1CA, YWHAZ, KIAA0101, YWHAG, BEGAIN, YWHAQ, DISC1, MYH9, RUNX1T1, SERPINB6, CCDC120, LMO3, HERC2, NDEL1, TNKS2, C1orf216, NEURL4, CENPO, C19orf25 (tumor)	CEP170, VAV2, SIRT7, PPP1CA, KIAA0101, YWHAG, BEGAIN, YWHAQ, DISC1, MYH9, RUNX1T1, SERPINB6, CCDC120, LMO3, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, CENPO, C19orf25 (normal)

KICH (tumor)	KICH (normal)
CEP170, KIAA1967, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, MYC, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, SNAPIN, CCDC120, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, C19orf25 (tumor)	CEP170, VAV2, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, MYC, DISC1, RUNX1T1, SERPINB6, SNAPIN, CCDC120, AIMP2, NDEL1, TNKS2, C1orf216, ABI3, NEURL4, CENPO, C19orf25 (normal)

KIRC (tumor)	KIRC (normal)
CEP170, VAV2, SIRT7, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, MYC, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, SNAPIN, AIMP2, NDEL1, TNKS2, C1orf216, NEURL4, C19orf25 (tumor)	CEP170, VAV2, SIRT7, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, MYC, DISC1, MYH9, RUNX1T1, SERPINB6, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, CENPO, C19orf25 (normal)

KIRP (tumor)	KIRP (normal)
CEP170, KIAA1967, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, MYC, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, CCDC120, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, NEURL4, CENPO (tumor)	CEP170, SIRT7, KIAA1967, PPP1CA, YWHAZ, YWHAG, YWHAQ, MYC, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, SNAPIN, AIMP2, HERC2, NDEL1, TNKS2, NEURL4, CENPO, C19orf25 (normal)

LIHC (tumor)	LIHC (normal)
CEP170, SIRT7, PPP1CA, YWHAZ, YWHAG, YWHAQ, MYC, DISC1, MYH9, RUNX1T1, SERPINB6, SNAPIN, CCDC120, LMO3, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, C19orf25 (tumor)	CEP170, SIRT7, KIAA1967, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, DISC1, MYH9, RUNX1T1, SERPINB6, CCDC120, LMO3, AIMP2, HERC2, NDEL1, TNKS2, NEURL4, CENPO, C19orf25 (normal)

LUAD (tumor)	LUAD (normal)
CEP170, VAV2, KIAA1967, PPP1CA, YWHAZ, KIAA0101, BEGAIN, YWHAQ, DISC1, MYH9, RUNX1T1, SERPINB6, SNAPIN, CCDC120, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, NEURL4, C19orf25 (tumor)	CEP170, SIRT7, PPP1CA, YWHAG, BEGAIN, YWHAQ, MYC, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, SNAPIN, CCDC120, HERC2, NDEL1, TNKS2, C1orf216, ABI3, CENPO, C19orf25 (normal)

LUSC (tumor)	LUSC (normal)
CEP170, VAV2, SIRT7, PPP1CA, YWHAZ, YWHAG, YWHAQ, MYC, DISC1, RUNX1T1, SERPINB6, SNAPIN, CCDC120, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, NEURL4, CENPO, C19orf25 (tumor)	CEP170, VAV2, SIRT7, KIAA1967, PPP1CA, YWHAZ, KIAA0101, MYC, DISC1, MYH9, RUNX1T1, SERPINB6, CCDC120, LMO3, AIMP2, HERC2, TNKS2, C1orf216, ABI3, NEURL4, C19orf25 (normal)

PRAD (tumor)	PRAD (normal)
CEP170, SIRT7, KIAA1967, PPP1CA, YWHAG, YWHAQ, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, CCDC120, LMO3, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, CENPO, C19orf25 (tumor)	CEP170, SIRT7, KIAA1967, PPP1CA, YWHAZ, YWHAG, BEGAIN, YWHAQ, MYC, DISC1, MYH9, RUNX1T1, SERPINB6, SNAPIN, CCDC120, AIMP2, HERC2, TNKS2, NEURL4, CENPO, C19orf25 (normal)

STAD (tumor)	STAD (normal)
CEP170, VAV2, SIRT7, PPP1CA, KIAA0101, YWHAG, YWHAQ, DISC1, RALYL, RUNX1T1, SERPINB6, SNAPIN, CCDC120, LMO3, AIMP2, HERC2, TNKS2, C1orf216, NEURL4, CENPO, C19orf25 (tumor)	CEP170, SIRT7, PPP1CA, YWHAZ, KIAA0101, YWHAG, YWHAQ, DISC1, MYH9, RALYL, RUNX1T1, SERPINB6, CCDC120, LMO3, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, C19orf25 (normal)

THCA (tumor)	THCA (normal)
CEP170, SIRT7, PPP1CA, KIAA0101, YWHAG, YWHAQ, DISC1, MYH9, RUNX1T1, SERPINB6, SNAPIN, CCDC120, AIMP2, HERC2, NDEL1, TNKS2, C1orf216, ABI3, NEURL4, CENPO, C19orf25 (tumor)	CEP170, SIRT7, PPP1CA, YWHAZ, YWHAG, BEGAIN, YWHAQ, MYC, DISC1, MYH9, RUNX1T1, SERPINB6, SNAPIN, AIMP2, HERC2, NDEL1, TNKS2, ABI3, NEURL4, CENPO, C19orf25 (normal)

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TissGeneProg for CEP170

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for CEP170

TissGeneDrug for CEP170

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for CEP170

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0026769	Multiple Sclerosis	1	GAD
umls:C0040336	Tobacco Use Disorder	1	GAD