cancer symbol gene Drug ps.twosided fcs nMut clust.name nMut.prop adjp color BLCA ERBB2 ERBB2 17-AAG 0.619621845294696 -0.0141124695661654 22 310 0.054320987654321 0.816774250615736 0 BLCA ERBB2 ERBB2 AEW541 0.514014799909094 -0.0138467551642536 22 310 0.054320987654321 0.722419772169928 0 BLCA ERBB2 ERBB2 AZD0530 0.190081967485601 -0.0610046905437844 22 310 0.054320987654321 0.475204918714002 0 BLCA ERBB2 ERBB2 AZD6244 0.951649749836438 0.0115095924271216 22 310 0.054320987654321 0.990629855225245 0 BLCA ERBB2 ERBB2 Erlotinib 0.0181415236792116 -0.0794799532569297 22 310 0.054320987654321 0.0974267012402104 1 BLCA ERBB2 ERBB2 Irinotecan 0.179199597946917 0.166727734655546 22 310 0.054320987654321 0.498486128871455 0 BLCA ERBB2 ERBB2 L685458 0.22880056357942 0.0313286681913 22 310 0.054320987654321 0.474945983684696 0 BLCA ERBB2 ERBB2 Lapatinib 0.681763182028522 0.0402117465426701 22 310 0.054320987654321 0.852203977535653 0 BLCA ERBB2 ERBB2 LBW242 0.41508489006953 -0.0255347948903464 22 310 0.054320987654321 1 0 BLCA ERBB2 ERBB2 Nilotinib 0.097377155046489 0.0512688126746038 22 310 0.054320987654321 0.382213281247524 0 BLCA ERBB2 ERBB2 Nutlin3 0.361988150428941 0.0256365190956513 22 310 0.054320987654321 0.640100997709713 0 BLCA ERBB2 ERBB2 Paclitaxel 0.179865874175688 -0.144856171569015 22 310 0.054320987654321 0.44966468543922 0 BLCA ERBB2 ERBB2 Panobinostat 0.104201457336179 0.0970840340168451 22 310 0.054320987654321 0.308351251300938 0 BLCA ERBB2 ERBB2 PD0325901 0.951649749836438 0.0280931209814614 22 310 0.054320987654321 0.982965157298728 0 BLCA ERBB2 ERBB2 PD0332991 0.547697930083039 0.0277327707353544 22 310 0.054320987654321 0.728588989560006 0 BLCA ERBB2 ERBB2 PF2341066 0.385164885190077 0.0110639436338842 22 310 0.054320987654321 0.58941749340588 0 BLCA ERBB2 ERBB2 PHA665752 0.019815138712525 0.0389270850231042 22 310 0.054320987654321 0.0993065239080255 2 BLCA ERBB2 ERBB2 PLX4720 0.596615914116106 0.0413704681677907 22 310 0.054320987654321 0.852629509131721 0 BLCA ERBB2 ERBB2 RAF265 0.388548357172623 0.0559774773926225 22 310 0.054320987654321 0.695549528271979 0 BLCA ERBB2 ERBB2 Sorafenib 0.0527156656361239 0.0558318078194875 22 310 0.054320987654321 0.228949479597925 0 BLCA ERBB2 ERBB2 TAE684 0.354460923167594 0.0453013508441311 22 310 0.054320987654321 0.64629317885846 0 BLCA ERBB2 ERBB2 TKI258 0.446336482749713 0.0552688706961555 22 310 0.054320987654321 0.779744457815764 0 BLCA ERBB2 ERBB2 Topotecan 0.152256312598666 0.133391411372189 22 310 0.054320987654321 0.426315514646521 0 BLCA ERBB2 ERBB2 ZD6474 0.958199243917864 0.0120269985608146 22 310 0.054320987654321 0.978442889916129 0 BLCA FGFR3 FGFR3 17-AAG 9.42138169837156e-06 0.177459082803221 34 248:249 0.0839506172839506 0.000341525086565969 2 BLCA FGFR3 FGFR3 AEW541 0.262864936331641 -0.0281533117823304 34 248:249 0.0839506172839506 0.568886802508775 0 BLCA FGFR3 FGFR3 AZD0530 0.00383208801044433 0.118923485591995 34 248:249 0.0839506172839506 0.0370435174342952 2 BLCA FGFR3 FGFR3 AZD6244 0.0717326945713314 0.100810311163312 34 248:249 0.0839506172839506 0.236391834382797 0 BLCA FGFR3 FGFR3 Erlotinib 4.67338134538775e-08 0.186006953390571 34 248:249 0.0839506172839506 6.77640295081224e-06 2 BLCA FGFR3 FGFR3 Irinotecan 0.693539754414282 -0.0360635966796732 34 248:249 0.0839506172839506 0.852231054153143 0 BLCA FGFR3 FGFR3 L685458 0.0980509912164244 -0.0334328534128657 34 248:249 0.0839506172839506 0.355434843159538 0 BLCA FGFR3 FGFR3 Lapatinib 0.00283164552250051 0.130205860543035 34 248:249 0.0839506172839506 0.0342157167302145 2 BLCA FGFR3 FGFR3 LBW242 0.166192240992689 -0.0180750880217015 34 248:249 0.0839506172839506 1 0 BLCA FGFR3 FGFR3 Nilotinib 0.0365829150439192 -0.045642158518602 34 248:249 0.0839506172839506 0.259813085953551 0 BLCA FGFR3 FGFR3 Nutlin3 0.0319780965559904 -0.0369124709957054 34 248:249 0.0839506172839506 0.15456080002062 1 BLCA FGFR3 FGFR3 Paclitaxel 0.074098784398511 0.177708519344731 34 248:249 0.0839506172839506 0.254461241349235 0 BLCA FGFR3 FGFR3 Panobinostat 4.01108018788984e-07 -0.222762204477495 34 248:249 0.0839506172839506 5.81606627244027e-05 1 BLCA FGFR3 FGFR3 PD0325901 0.0192590591197621 0.175121541190338 34 248:249 0.0839506172839506 0.109286101344252 2 BLCA FGFR3 FGFR3 PD0332991 0.0287087546340097 -0.0551305988733011 34 248:249 0.0839506172839506 0.138758980731047 1 BLCA FGFR3 FGFR3 PF2341066 0.131569220978163 -0.0292721201538015 34 248:249 0.0839506172839506 0.334693632312871 0 BLCA FGFR3 FGFR3 PHA665752 0.504656990185282 -0.011471914390192 34 248:249 0.0839506172839506 0.696907272160628 0 BLCA FGFR3 FGFR3 PLX4720 0.954733353739912 -0.0170252659268731 34 248:249 0.0839506172839506 0.978697382843298 0 BLCA FGFR3 FGFR3 RAF265 0.201972691680741 -0.0459206531890968 34 248:249 0.0839506172839506 0.459753779127033 0 BLCA FGFR3 FGFR3 Sorafenib 0.0101939850144982 -0.0477082386147699 34 248:249 0.0839506172839506 0.0821182126167911 1 BLCA FGFR3 FGFR3 TAE684 0.00211001169553569 -0.085750018545542 34 248:249 0.0839506172839506 0.0339946328725194 1 BLCA FGFR3 FGFR3 TKI258 0.00658252234020241 -0.126438523389116 34 248:249 0.0839506172839506 0.0530258744071861 1 BLCA FGFR3 FGFR3 Topotecan 0.00334148564856438 -0.200321488338603 34 248:249 0.0839506172839506 0.0372704168493719 1 BLCA FGFR3 FGFR3 ZD6474 0.396345367680112 0.0283919625357545 34 248:249 0.0839506172839506 0.739978986852158 0 BLCA FGFR3 FGFR3 17-AAG 0.000438800985923679 0.249727871886279 10 373:375 0.0246913580246914 0.00908944899413335 2 BLCA FGFR3 FGFR3 AEW541 0.408806468150413 0.02084720107681 10 373:375 0.0246913580246914 0.666033009907976 0 BLCA FGFR3 FGFR3 AZD0530 0.0108668681439728 0.179729718626951 10 373:375 0.0246913580246914 0.0750331371845741 2 BLCA FGFR3 FGFR3 AZD6244 0.0395962359189076 0.20255066407358 10 373:375 0.0246913580246914 0.16538682214573 2 BLCA FGFR3 FGFR3 Erlotinib 0.0040262791296177 0.192066998784826 10 373:375 0.0246913580246914 0.0583810473794567 2 BLCA FGFR3 FGFR3 Irinotecan 0.637088326283217 -0.0782776582708129 10 373:375 0.0246913580246914 0.831248558064582 0 BLCA FGFR3 FGFR3 L685458 0.0146721881374702 -0.0729057680618541 10 373:375 0.0246913580246914 0.101307965711104 1 BLCA FGFR3 FGFR3 Lapatinib 0.000127011872383703 0.276220077301652 10 373:375 0.0246913580246914 0.00306945358260616 2 BLCA FGFR3 FGFR3 LBW242 0.0222092405536636 -0.06451266036064 10 373:375 0.0246913580246914 1 0 BLCA FGFR3 FGFR3 Nilotinib 0.00617824540630737 -0.105268327499179 10 373:375 0.0246913580246914 0.0995383982127298 1 BLCA FGFR3 FGFR3 Nutlin3 0.0100192738110994 -0.0776156376370065 10 373:375 0.0246913580246914 0.0854585119182008 1 BLCA FGFR3 FGFR3 Paclitaxel 0.750353743048449 -0.0165009789031805 10 373:375 0.0246913580246914 0.895898230167188 0 BLCA FGFR3 FGFR3 Panobinostat 0.000204766080582245 -0.291165300933829 10 373:375 0.0246913580246914 0.00722317728540929 1 BLCA FGFR3 FGFR3 PD0325901 0.00617824540630737 0.387151510981581 10 373:375 0.0246913580246914 0.0746537986595474 2 BLCA FGFR3 FGFR3 PD0332991 0.0664505753129879 -0.0809596059174718 10 373:375 0.0246913580246914 0.240883335509581 0 BLCA FGFR3 FGFR3 PF2341066 0.0414372365800699 -0.0673719485085812 10 373:375 0.0246913580246914 0.200279976803671 0 BLCA FGFR3 FGFR3 PHA665752 0.242936235328589 -0.0293764775839586 10 373:375 0.0246913580246914 0.48254457702254 0 BLCA FGFR3 FGFR3 PLX4720 0.396472069494308 -0.0772240202848564 10 373:375 0.0246913580246914 0.769266275380849 0 BLCA FGFR3 FGFR3 RAF265 0.419558433385029 -0.0625691759692868 10 373:375 0.0246913580246914 0.703927107918497 0 BLCA FGFR3 FGFR3 Sorafenib 0.0326546303548931 -0.0764401066967512 10 373:375 0.0246913580246914 0.175367459313315 1 BLCA FGFR3 FGFR3 TAE684 0.000438800985923679 -0.186490469756805 10 373:375 0.0246913580246914 0.0106043571598222 1 BLCA FGFR3 FGFR3 TKI258 0.019606677703729 -0.212481154492689 10 373:375 0.0246913580246914 0.104392576358009 1 BLCA FGFR3 FGFR3 Topotecan 0.0118828633140369 -0.29181546624364 10 373:375 0.0246913580246914 0.074913703501537 1 BLCA FGFR3 FGFR3 ZD6474 0.144508137046722 0.0961562641492215 10 373:375 0.0246913580246914 0.501815000527511 0 BLCA NFE2L2 NFE2L2 17-AAG 0.382833990972332 0.0665059001973307 12 24:29:30:31:34 0.0296296296296296 0.693886608637352 0 BLCA NFE2L2 NFE2L2 AEW541 0.00891078073302038 -0.0790035084199583 12 24:29:30:31:34 0.0296296296296296 0.0680033266467345 1 BLCA NFE2L2 NFE2L2 AZD0530 0.401541421795139 0.0488916949705225 12 24:29:30:31:34 0.0296296296296296 0.701488026027652 0 BLCA NFE2L2 NFE2L2 AZD6244 0.0226130460476501 -0.190598744890464 12 24:29:30:31:34 0.0296296296296296 0.136900600982901 1 BLCA NFE2L2 NFE2L2 Erlotinib 0.00502631595775484 0.126702055781814 12 24:29:30:31:34 0.0296296296296296 0.0607346511562043 2 BLCA NFE2L2 NFE2L2 Irinotecan 0.844307292903159 0.0428374692073468 12 24:29:30:31:34 0.0296296296296296 0.936443495026048 0 BLCA NFE2L2 NFE2L2 L685458 0.895491974981918 -0.020932377524526 12 24:29:30:31:34 0.0296296296296296 0.940915480959262 0 BLCA NFE2L2 NFE2L2 Lapatinib 0.109374921403151 -0.0805906478449845 12 24:29:30:31:34 0.0296296296296296 0.318780105662015 0 BLCA NFE2L2 NFE2L2 LBW242 0.0872182853242452 -0.0470534004698466 12 24:29:30:31:34 0.0296296296296296 1 0 BLCA NFE2L2 NFE2L2 Nilotinib 0.521403173911427 0.00188278236110329 12 24:29:30:31:34 0.0296296296296296 0.752634187514088 0 BLCA NFE2L2 NFE2L2 Nutlin3 0.0634646895169632 -0.0457454433112745 12 24:29:30:31:34 0.0296296296296296 0.205681521991773 0 BLCA NFE2L2 NFE2L2 Paclitaxel 0.000286393385612174 0.536159048561946 12 24:29:30:31:34 0.0296296296296296 0.00692117348562754 2 BLCA NFE2L2 NFE2L2 Panobinostat 0.0280438217806157 -0.172455135988606 12 24:29:30:31:34 0.0296296296296296 0.168888463846555 1 BLCA NFE2L2 NFE2L2 PD0325901 0.194743295415195 -0.171249264054278 12 24:29:30:31:34 0.0296296296296296 0.448151505729182 0 BLCA NFE2L2 NFE2L2 PD0332991 0.0255430797182069 -0.0843705593648857 12 24:29:30:31:34 0.0296296296296296 0.132276662826429 1 BLCA NFE2L2 NFE2L2 PF2341066 0.705083252854297 0.00143327252588288 12 24:29:30:31:34 0.0296296296296296 0.811495252300017 0 BLCA NFE2L2 NFE2L2 PHA665752 0.74999867371102 -0.00429541979127368 12 24:29:30:31:34 0.0296296296296296 0.877092920919321 0 BLCA NFE2L2 NFE2L2 PLX4720 0.486548988189406 0.0121661365897214 12 24:29:30:31:34 0.0296296296296296 0.791842381808024 0 BLCA NFE2L2 NFE2L2 RAF265 0.000498349707509306 0.213707092375929 12 24:29:30:31:34 0.0296296296296296 0.00996836092647044 2 BLCA NFE2L2 NFE2L2 Sorafenib 0.114657842203916 0.042595450200968 12 24:29:30:31:34 0.0296296296296296 0.36142145912104 0 BLCA NFE2L2 NFE2L2 TAE684 0.333880106375645 -0.0396150029000879 12 24:29:30:31:34 0.0296296296296296 0.632438523508005 0 BLCA NFE2L2 NFE2L2 TKI258 0.091133573445043 -0.141919488612677 12 24:29:30:31:34 0.0296296296296296 0.29713894935857 0 BLCA NFE2L2 NFE2L2 Topotecan 0.856540215107432 -0.00591484991766444 12 24:29:30:31:34 0.0296296296296296 0.940917023721381 0 BLCA NFE2L2 NFE2L2 ZD6474 0.262800742314323 0.0542995137049691 12 24:29:30:31:34 0.0296296296296296 0.614614639283497 0 BLCA PIK3CA PIK3CA 17-AAG 0.0496524516291113 0.0634493060371604 50 542:545:546 0.123456790123457 0.205703013892033 0 BLCA PIK3CA PIK3CA AEW541 0.127066186561816 -0.026283205837071 50 542:545:546 0.123456790123457 0.373852057889815 0 BLCA PIK3CA PIK3CA AZD0530 0.350934562516559 0.0245625381625285 50 542:545:546 0.123456790123457 0.66085079954417 0 BLCA PIK3CA PIK3CA AZD6244 0.328319077448721 -0.0256814248978057 50 542:545:546 0.123456790123457 0.601762645640106 0 BLCA PIK3CA PIK3CA Erlotinib 0.742730378475766 0.023572377996804 50 542:545:546 0.123456790123457 0.852277706263159 0 BLCA PIK3CA PIK3CA Irinotecan 0.689939206147532 0.033436680165758 50 542:545:546 0.123456790123457 0.852231054153143 0 BLCA PIK3CA PIK3CA L685458 0.245746672459295 0.00691749010290937 50 542:545:546 0.123456790123457 0.474945983684696 0 BLCA PIK3CA PIK3CA Lapatinib 0.1618710427333 0.0588795030855791 50 542:545:546 0.123456790123457 0.372560336449659 0 BLCA PIK3CA PIK3CA LBW242 0.841613938688185 0.00549052411910367 50 542:545:546 0.123456790123457 1 0 BLCA PIK3CA PIK3CA Nilotinib 0.0882536374853235 0.0274053555679273 50 542:545:546 0.123456790123457 0.376587874898145 0 BLCA PIK3CA PIK3CA Nutlin3 0.609017146012483 0.00286411490389771 50 542:545:546 0.123456790123457 0.816230497417743 0 BLCA PIK3CA PIK3CA Paclitaxel 0.625272260817946 0.0201095990973812 50 542:545:546 0.123456790123457 0.877715146851436 0 BLCA PIK3CA PIK3CA Panobinostat 0.249285928880602 0.0419979040615148 50 542:545:546 0.123456790123457 0.495156982023114 0 BLCA PIK3CA PIK3CA PD0325901 0.398241203120637 -0.0464033897240756 50 542:545:546 0.123456790123457 0.641610827249915 0 BLCA PIK3CA PIK3CA PD0332991 0.889267315657353 -0.000751362152852209 50 542:545:546 0.123456790123457 0.96226687142027 0 BLCA PIK3CA PIK3CA PF2341066 0.164045876144593 0.0165404419650835 50 542:545:546 0.123456790123457 0.37628443227733 0 BLCA PIK3CA PIK3CA PHA665752 0.000912166090971948 0.0353741543944771 50 542:545:546 0.123456790123457 0.0132264083190932 2 BLCA PIK3CA PIK3CA PLX4720 0.824725192730625 0.00154733275920205 50 542:545:546 0.123456790123457 0.927016689503416 0 BLCA PIK3CA PIK3CA RAF265 0.59595006237024 0.0159054389269513 50 542:545:546 0.123456790123457 0.807595878912942 0 BLCA PIK3CA PIK3CA Sorafenib 0.0471903107321952 0.0268872875385706 50 542:545:546 0.123456790123457 0.221896308143565 0 BLCA PIK3CA PIK3CA TAE684 0.951104747060724 0.00168582954753105 50 542:545:546 0.123456790123457 0.984846233442031 0 BLCA PIK3CA PIK3CA TKI258 0.82247929756319 -0.00709505002178057 50 542:545:546 0.123456790123457 0.959342395190069 0 BLCA PIK3CA PIK3CA Topotecan 0.391826866970352 0.0504204625640279 50 542:545:546 0.123456790123457 0.70141846556421 0 BLCA PIK3CA PIK3CA ZD6474 0.432941291396056 0.0263584510701338 50 542:545:546 0.123456790123457 0.745518132812309 0 BLCA RXRA RXRA 17-AAG 0.661205791980234 -0.00727398518578504 14 427 0.0345679012345679 0.819443075531059 0 BLCA RXRA RXRA AEW541 0.124912802766968 0.0610836947655916 14 427 0.0345679012345679 0.373852057889815 0 BLCA RXRA RXRA AZD0530 0.183770593446707 0.0660804427958375 14 427 0.0345679012345679 0.469722052336024 0 BLCA RXRA RXRA AZD6244 0.0252783476078087 0.174454663292339 14 427 0.0345679012345679 0.138184273413645 2 BLCA RXRA RXRA Erlotinib 0.316899504728648 -0.0473727364907515 14 427 0.0345679012345679 0.560371075434804 0 BLCA RXRA RXRA Irinotecan 0.642067851746436 -0.0505438241019798 14 427 0.0345679012345679 0.831248558064582 0 BLCA RXRA RXRA L685458 0.927852297230315 -0.00764283990354153 14 427 0.0345679012345679 0.954174348215572 0 BLCA RXRA RXRA Lapatinib 0.727157640915499 0.0158656446117604 14 427 0.0345679012345679 0.8569095338034 0 BLCA RXRA RXRA LBW242 0.939371567174048 -0.00105575836209271 14 427 0.0345679012345679 1 0 BLCA RXRA RXRA Nilotinib 0.954749933336669 0.00892084964828554 14 427 0.0345679012345679 0.98401675142912 0 BLCA RXRA RXRA Nutlin3 0.687661893443436 -0.00917177231483768 14 427 0.0345679012345679 0.882398004861046 0 BLCA RXRA RXRA Paclitaxel 0.304227355644745 -0.130826948308688 14 427 0.0345679012345679 0.642119687127053 0 BLCA RXRA RXRA Panobinostat 0.459255470435691 0.0505566302067235 14 427 0.0345679012345679 0.716043475410486 0 BLCA RXRA RXRA PD0325901 0.0492192304653669 0.223747458074153 14 427 0.0345679012345679 0.198244122707728 2 BLCA RXRA RXRA PD0332991 0.828904923350588 0.00504691090961373 14 427 0.0345679012345679 0.928689602392617 0 BLCA RXRA RXRA PF2341066 0.550098673714986 -0.0144446574657791 14 427 0.0345679012345679 0.700263659046377 0 BLCA RXRA RXRA PHA665752 0.709107559171327 -0.00901207553400074 14 427 0.0345679012345679 0.877092920919321 0 BLCA RXRA RXRA PLX4720 0.589430156709026 0.00784988568218348 14 427 0.0345679012345679 0.852629509131721 0 BLCA RXRA RXRA RAF265 0.487559254532259 -0.0520879310788831 14 427 0.0345679012345679 0.745662374723171 0 BLCA RXRA RXRA Sorafenib 0.408237741126445 -0.0223157122880645 14 427 0.0345679012345679 0.721813757748919 0 BLCA RXRA RXRA TAE684 0.916348128215587 -0.0125995631858937 14 427 0.0345679012345679 0.984846233442031 0 BLCA RXRA RXRA TKI258 0.774778928626671 0.00949940225844559 14 427 0.0345679012345679 0.944058358410649 0 BLCA RXRA RXRA Topotecan 0.709107559171327 -0.0595282930924999 14 427 0.0345679012345679 0.881352745205969 0 BLCA RXRA RXRA ZD6474 0.652478296206936 0.0395524037632913 14 427 0.0345679012345679 0.876012527314868 0 BLCA TP53 TP53 17-AAG 0.00394986097615079 -0.124677986895172 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0409092743958475 1 BLCA TP53 TP53 AEW541 0.281010640596788 -0.0459191637049995 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.582093469807632 0 BLCA TP53 TP53 AZD0530 0.00559804741629104 -0.109866530613117 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0477480514918942 1 BLCA TP53 TP53 AZD6244 0.00701827882035209 -0.188370843015323 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0726893163536467 1 BLCA TP53 TP53 Erlotinib 0.0720171753412799 -0.0545562194374123 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.219864241851032 0 BLCA TP53 TP53 Irinotecan 0.250501498540457 0.127199267064586 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.576551068069306 0 BLCA TP53 TP53 L685458 0.325470627728029 0.00324710441558218 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.568593265308002 0 BLCA TP53 TP53 Lapatinib 0.138649112607541 -0.0691007787797575 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.340747819120228 0 BLCA TP53 TP53 LBW242 0.75421079217436 0.00675879977224891 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 1 0 BLCA TP53 TP53 Nilotinib 0.0222298425112159 0.0599817522013312 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.189607480242724 2 BLCA TP53 TP53 Nutlin3 0.514678755498635 -0.00134134414515508 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.743373854209307 0 BLCA TP53 TP53 Paclitaxel 0.641640038387946 0.0743123812847939 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.877715146851436 0 BLCA TP53 TP53 Panobinostat 0.0569183068728025 0.0950852704277914 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.257911078017386 0 BLCA TP53 TP53 PD0325901 0.00745807012951878 -0.259203656987598 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0759942757476325 1 BLCA TP53 TP53 PD0332991 0.407909403997843 -0.0425518996720129 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.657187373107636 0 BLCA TP53 TP53 PF2341066 0.519056664247954 0.00445920593731319 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.690488223082141 0 BLCA TP53 TP53 PHA665752 0.0704255518357997 0.0240610838499344 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.237481512004441 0 BLCA TP53 TP53 PLX4720 0.743946934288222 -0.010393028528461 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.893116372848996 0 BLCA TP53 TP53 RAF265 0.0114023012144803 0.108613960388408 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0661333470439857 2 BLCA TP53 TP53 Sorafenib 0.00140540809976777 0.0577752943554404 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0291120249237609 2 BLCA TP53 TP53 TAE684 0.400282203250182 0.0186896811403121 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.64629317885846 0 BLCA TP53 TP53 TKI258 0.367033844472082 0.0162135939288264 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.729039828060985 0 BLCA TP53 TP53 Topotecan 0.0915434051389052 0.131144210684019 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.308692877793983 0 BLCA TP53 TP53 ZD6474 0.0309436970735161 0.0847738905204782 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.186951503152493 2 BLCA TP53 TP53 17-AAG 0.0236293903639482 -0.151279911986787 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.14276090011552 1 BLCA TP53 TP53 AEW541 0.141465414626761 -0.02205516831336 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.391975875337794 0 BLCA TP53 TP53 AZD0530 0.101744386418302 -0.0809944480301212 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.327843022903418 0 BLCA TP53 TP53 AZD6244 0.0464475384424374 -0.153792880988694 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.182024137139282 1 BLCA TP53 TP53 Erlotinib 0.0227145377423459 -0.162454873902935 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.109786932421339 1 BLCA TP53 TP53 Irinotecan 0.154141011158256 0.144927759706216 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.465634304540565 0 BLCA TP53 TP53 L685458 0.431232744385441 -0.00132375082978831 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.694763865954322 0 BLCA TP53 TP53 Lapatinib 0.0413126706768911 -0.134370876035528 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.166398256893034 1 BLCA TP53 TP53 LBW242 0.12770728469926 0.0271206778775512 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 1 0 BLCA TP53 TP53 Nilotinib 0.673820376903196 -0.00523529905702824 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.847965386361886 0 BLCA TP53 TP53 Nutlin3 0.310781828210941 0.016795941597383 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.579680916393002 0 BLCA TP53 TP53 Paclitaxel 0.344335707792752 -0.13344858383634 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.657917533572212 0 BLCA TP53 TP53 Panobinostat 0.039469996664498 0.11081659641003 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.19734998332249 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192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.715801914724046 0 BLCA TP53 TP53 TAE684 0.11242654487424 0.046118758314043 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.346847851207762 0 BLCA TP53 TP53 TKI258 0.559735217763508 0.0394362872776519 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.863421346550092 0 BLCA TP53 TP53 Topotecan 0.534609708427416 0.0399712560584464 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.799087021720268 0 BLCA TP53 TP53 ZD6474 0.590621889396484 -0.0328062028886387 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.838351456165102 0 BLCA TP53 TP53 17-AAG 0.0258649530703574 -0.0663057554154265 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.144246853661609 1 BLCA TP53 TP53 AEW541 0.510936410119918 -0.000233311112496359 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.722419772169928 0 BLCA TP53 TP53 AZD0530 0.113845447631876 -0.0457225338785447 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.351225317162171 0 BLCA TP53 TP53 AZD6244 0.0128139358728028 -0.125977237755792 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.115873204402054 1 BLCA TP53 TP53 Erlotinib 0.0282400594564217 -0.0596853685854593 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.127962769411911 1 BLCA TP53 TP53 Irinotecan 0.086572466692725 0.1569778451258 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.38039417183167 0 BLCA TP53 TP53 L685458 0.24217594290856 -0.000823822070520286 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.474945983684696 0 BLCA TP53 TP53 Lapatinib 0.213123979511107 -0.0394053721856833 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.423328452453569 0 BLCA TP53 TP53 LBW242 0.37069061269395 -0.0208251947510256 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 1 0 BLCA TP53 TP53 Nilotinib 0.323818125016081 0.0141649923944562 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.643200385305914 0 BLCA TP53 TP53 Nutlin3 0.59657373420991 -0.0164501735896868 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.816230497417743 0 BLCA TP53 TP53 Paclitaxel 0.767148401778674 -0.08092434624559 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.897068695628288 0 BLCA TP53 TP53 Panobinostat 0.046292139485066 0.0540312594863277 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.216527749204341 0 BLCA TP53 TP53 PD0325901 0.00580298728325766 -0.193697363126893 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.0746537986595474 1 BLCA TP53 TP53 PD0332991 0.40330656429895 -0.0301097035388342 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.657072492397166 0 BLCA TP53 TP53 PF2341066 0.913511305620344 0.00468120765155855 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.939770585322949 0 BLCA TP53 TP53 PHA665752 0.812922965468878 0.00179187359469968 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.906721769176825 0 BLCA TP53 TP53 PLX4720 0.0746908556653458 -0.0579765357847686 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.331576984443117 0 BLCA TP53 TP53 RAF265 0.0371436704635206 0.0748502097213624 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.141732426768697 2 BLCA TP53 TP53 Sorafenib 0.0041546038231821 0.0483045692929976 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.0463398118739542 2 BLCA TP53 TP53 TAE684 0.0939556789683265 0.0468641901292322 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.319828070469847 0 BLCA TP53 TP53 TKI258 0.659821960431653 -0.0431302283470238 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.89531411341033 0 BLCA TP53 TP53 Topotecan 0.268924724517359 0.064574822963162 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.603174324143118 0 BLCA TP53 TP53 ZD6474 0.159997801490325 0.0504688388666776 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.522950688624405 0 BLCA TP53 TP53 17-AAG 0.0108727418956952 -0.101601206456906 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0829761881513581 1 BLCA TP53 TP53 AEW541 0.591420166893579 -0.0145915319643438 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.752244949119026 0 BLCA TP53 TP53 AZD0530 0.0088124055430145 -0.0882167310574753 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0672525686177422 1 BLCA TP53 TP53 AZD6244 0.0594832931596326 -0.0878315863556014 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.208684481937948 0 BLCA TP53 TP53 Erlotinib 0.00195321810815901 -0.116049872107231 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0354020782103821 1 BLCA TP53 TP53 Irinotecan 0.000701088531977431 0.234802426128389 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0145225481623896 2 BLCA TP53 TP53 L685458 0.288324656930324 0.0166823141487036 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.535988144293551 0 BLCA TP53 TP53 Lapatinib 0.569950819154407 -0.0461723015322717 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.765211747938787 0 BLCA TP53 TP53 LBW242 0.29189763929046 -0.0192607928811164 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 1 0 BLCA TP53 TP53 Nilotinib 0.120766092742517 0.0408402817876529 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.407234498782906 0 BLCA TP53 TP53 Nutlin3 0.861586260960824 -0.00531119122514867 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.917341274328711 0 BLCA TP53 TP53 Paclitaxel 0.30556040283977 -0.067788609522343 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.642119687127053 0 BLCA TP53 TP53 Panobinostat 0.014568445525893 0.0769919813400683 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.105621230062724 2 BLCA TP53 TP53 PD0325901 0.0206877118913573 -0.158823322371072 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.111100674972104 1 BLCA TP53 TP53 PD0332991 0.434414316962753 -0.0249805297657438 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.692198636918672 0 BLCA TP53 TP53 PF2341066 0.291001616696044 0.0175556437490102 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.534116891404131 0 BLCA TP53 TP53 PHA665752 0.193324218146031 0.0183657072112899 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.412235465164331 0 BLCA TP53 TP53 PLX4720 0.247747286466935 -0.0181880578562424 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.565201900745044 0 BLCA TP53 TP53 RAF265 0.00423360379927922 0.0990749406012197 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0341040306053048 2 BLCA TP53 TP53 Sorafenib 0.00180382822415321 0.0600596417473581 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0309840576886325 2 BLCA TP53 TP53 TAE684 0.250159852994123 0.0331331151133216 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.518188266916398 0 BLCA TP53 TP53 TKI258 0.383330384284019 0.0416036348655393 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.74110540961577 0 BLCA TP53 TP53 Topotecan 0.0905282969230282 0.122991979217408 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.308692877793983 0 BLCA TP53 TP53 ZD6474 0.783879653746656 -0.0192129616412287 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.927179961391957 0 BLCA TP53 TP53 17-AAG 0.154458896570702 -0.0772016109188169 13 331:336:337 0.0320987654320988 0.379487919519414 0 BLCA TP53 TP53 AEW541 0.500440556674436 0.0177023249898609 13 331:336:337 0.0320987654320988 0.722419772169928 0 BLCA TP53 TP53 AZD0530 0.00199832600913289 -0.211049420719033 13 331:336:337 0.0320987654320988 0.022581280277263 1 BLCA TP53 TP53 AZD6244 0.220082024126051 -0.103495614379143 13 331:336:337 0.0320987654320988 0.490952207665806 0 BLCA TP53 TP53 Erlotinib 0.021201052338846 -0.174344960092838 13 331:336:337 0.0320987654320988 0.10600526169423 1 BLCA TP53 TP53 Irinotecan 0.526492754617902 0.133223469130458 13 331:336:337 0.0320987654320988 0.771125751713089 0 BLCA TP53 TP53 L685458 0.0920866600050119 0.0440670938529509 13 331:336:337 0.0320987654320988 0.353387640335593 0 BLCA TP53 TP53 Lapatinib 0.739582418025516 0.0220839980203589 13 331:336:337 0.0320987654320988 0.8569095338034 0 BLCA TP53 TP53 LBW242 0.702596259098226 -0.00748141931767843 13 331:336:337 0.0320987654320988 1 0 BLCA TP53 TP53 Nilotinib 0.250165943274456 0.0627485267428598 13 331:336:337 0.0320987654320988 0.566782215231189 0 BLCA TP53 TP53 Nutlin3 0.235668808679319 0.0250336417357008 13 331:336:337 0.0320987654320988 0.488171103692875 0 BLCA TP53 TP53 Paclitaxel 0.132372240804207 -0.266013262078076 13 331:336:337 0.0320987654320988 0.391713773808368 0 BLCA TP53 TP53 Panobinostat 0.00485545298657364 0.199983010900266 13 331:336:337 0.0320987654320988 0.0502886202180841 2 BLCA TP53 TP53 PD0325901 0.133531347409233 -0.176301634352797 13 331:336:337 0.0320987654320988 0.379647948516447 0 BLCA TP53 TP53 PD0332991 0.119063512263108 0.0533152335498601 13 331:336:337 0.0320987654320988 0.319707579225012 0 BLCA TP53 TP53 PF2341066 0.0105902722728442 0.0685006007211539 13 331:336:337 0.0320987654320988 0.0883764757820365 2 BLCA TP53 TP53 PHA665752 0.0760083532097656 0.0502950767132219 13 331:336:337 0.0320987654320988 0.250482073077637 0 BLCA TP53 TP53 PLX4720 0.40850691865052 -0.0449853888416348 13 331:336:337 0.0320987654320988 0.769266275380849 0 BLCA TP53 TP53 RAF265 0.964171249218997 0.0346008823129635 13 331:336:337 0.0320987654320988 0.988055037433057 0 BLCA TP53 TP53 Sorafenib 0.0280506470072113 0.0869385710697184 13 331:336:337 0.0320987654320988 0.15643630061714 2 BLCA TP53 TP53 TAE684 0.0635695295226547 0.101022694126139 13 331:336:337 0.0320987654320988 0.256043938355137 0 BLCA TP53 TP53 TKI258 0.836298051364956 -0.00366576194671486 13 331:336:337 0.0320987654320988 0.959342395190069 0 BLCA TP53 TP53 Topotecan 0.00648608993543202 0.285288478553077 13 331:336:337 0.0320987654320988 0.0553225318022143 2 BLCA TP53 TP53 ZD6474 0.191156459416677 -0.0720509380806429 13 331:336:337 0.0320987654320988 0.546043030477178 0 CESC MAPK1 MAPK1 17-AAG 0.0992569873871938 0.0716801587578488 10 321:322 0.0352112676056338 0.301807385453539 0 CESC MAPK1 MAPK1 AEW541 0.365588583751959 0.0280190317788274 10 321:322 0.0352112676056338 0.660796770817279 0 CESC MAPK1 MAPK1 AZD0530 0.367699730592155 0.0699533100655541 10 321:322 0.0352112676056338 0.674891910580538 0 CESC MAPK1 MAPK1 AZD6244 0.969861895394689 -0.061414345558398 10 321:322 0.0352112676056338 0.990629855225245 0 CESC MAPK1 MAPK1 Erlotinib 0.203852667252115 0.113030804243251 10 321:322 0.0352112676056338 0.447858132599344 0 CESC MAPK1 MAPK1 Irinotecan 0.409242454313337 0.0858048723397702 10 321:322 0.0352112676056338 0.690049518412545 0 CESC MAPK1 MAPK1 L685458 0.500246795800478 0.0124428770423387 10 321:322 0.0352112676056338 0.712950676140981 0 CESC MAPK1 MAPK1 Lapatinib 0.739829235015148 0.037076216088836 10 321:322 0.0352112676056338 0.8569095338034 0 CESC MAPK1 MAPK1 LBW242 0.206697923283503 0.0393533116796294 10 321:322 0.0352112676056338 1 0 CESC MAPK1 MAPK1 Nilotinib 0.931859524683679 -0.00736605078338093 10 321:322 0.0352112676056338 0.98401675142912 0 CESC MAPK1 MAPK1 Nutlin3 0.0282846592878222 0.0442673946210949 10 321:322 0.0352112676056338 0.15456080002062 2 CESC MAPK1 MAPK1 Paclitaxel 0.296502750897475 0.25396599238527 10 321:322 0.0352112676056338 0.641685057912446 0 CESC MAPK1 MAPK1 Panobinostat 0.247960033695451 0.0848902922076098 10 321:322 0.0352112676056338 0.495156982023114 0 CESC MAPK1 MAPK1 PD0325901 0.319134288367226 -0.156076242687697 10 321:322 0.0352112676056338 0.565530852379404 0 CESC MAPK1 MAPK1 PD0332991 0.651708857122357 0.00452524847624314 10 321:322 0.0352112676056338 0.807673369937964 0 CESC MAPK1 MAPK1 PF2341066 0.120418723497791 0.0399263084478025 10 321:322 0.0352112676056338 0.334693632312871 0 CESC MAPK1 MAPK1 PHA665752 0.282026341014981 0.019020074928587 10 321:322 0.0352112676056338 0.53108856424899 0 CESC MAPK1 MAPK1 PLX4720 0.136385630458271 0.077034294039428 10 321:322 0.0352112676056338 0.42991122644455 0 CESC MAPK1 MAPK1 RAF265 0.187377988285582 -0.0507337164947341 10 321:322 0.0352112676056338 0.447045820425066 0 CESC MAPK1 MAPK1 Sorafenib 0.523272889513048 -0.0263547697143999 10 321:322 0.0352112676056338 0.807176265738212 0 CESC MAPK1 MAPK1 TAE684 0.0992569873871938 0.0763977201716615 10 321:322 0.0352112676056338 0.319828070469847 0 CESC MAPK1 MAPK1 TKI258 0.274970932043971 0.103555849965774 10 321:322 0.0352112676056338 0.628916494647843 0 CESC MAPK1 MAPK1 Topotecan 0.212474702040483 0.148571842980918 10 321:322 0.0352112676056338 0.540505820980176 0 CESC MAPK1 MAPK1 ZD6474 0.922379761588922 0.01811071288363 10 321:322 0.0352112676056338 0.96509326057909 0 CESC PIK3CA PIK3CA 17-AAG 0.464047359944862 0.0142367504424086 59 542:545 0.207746478873239 0.729176211192437 0 CESC PIK3CA PIK3CA AEW541 0.522132840307603 -0.00657067582530801 59 542:545 0.207746478873239 0.722419772169928 0 CESC PIK3CA PIK3CA AZD0530 0.547937409781851 -0.0153254530462643 59 542:545 0.207746478873239 0.771368198236586 0 CESC PIK3CA PIK3CA AZD6244 0.619221441858533 0.000885679615067803 59 542:545 0.207746478873239 0.801670616691851 0 CESC PIK3CA PIK3CA Erlotinib 0.946077942773201 -0.00929830646544283 59 542:545 0.207746478873239 0.963255612068181 0 CESC PIK3CA PIK3CA Irinotecan 0.756014391710609 -0.0169595810138818 59 542:545 0.207746478873239 0.896514602339079 0 CESC PIK3CA PIK3CA L685458 0.388916980088616 0.0108039519321947 59 542:545 0.207746478873239 0.640829114918742 0 CESC PIK3CA PIK3CA Lapatinib 0.122638675551532 0.0362188353435742 59 542:545 0.207746478873239 0.324316390107145 0 CESC PIK3CA PIK3CA LBW242 0.953883287416058 -0.00303313020474527 59 542:545 0.207746478873239 1 0 CESC PIK3CA PIK3CA Nilotinib 0.361477821111856 -0.0261150004436098 59 542:545 0.207746478873239 0.679345452090186 0 CESC PIK3CA PIK3CA Nutlin3 0.726394055619507 -0.00564989760893231 59 542:545 0.207746478873239 0.895167134863111 0 CESC PIK3CA PIK3CA Paclitaxel 0.194031166985072 0.0152008228800096 59 542:545 0.207746478873239 0.473658090899305 0 CESC PIK3CA PIK3CA Panobinostat 0.177107262399895 0.0485240632798281 59 542:545 0.207746478873239 0.420992672917783 0 CESC PIK3CA PIK3CA PD0325901 0.151568997022879 -0.0605146148138296 59 542:545 0.207746478873239 0.406990825339212 0 CESC PIK3CA PIK3CA PD0332991 0.914915736106173 -0.00930473677159205 59 542:545 0.207746478873239 0.965946950720715 0 CESC PIK3CA PIK3CA PF2341066 0.550552118146807 -0.00953674089650725 59 542:545 0.207746478873239 0.700263659046377 0 CESC PIK3CA PIK3CA PHA665752 0.260066830571049 0.00872273118302347 59 542:545 0.207746478873239 0.502795872437361 0 CESC PIK3CA PIK3CA PLX4720 0.123114459296922 -0.0357762625952426 59 542:545 0.207746478873239 0.415153409257063 0 CESC PIK3CA PIK3CA RAF265 0.000549978533874231 -0.0670214460953595 59 542:545 0.207746478873239 0.00996836092647044 1 CESC PIK3CA PIK3CA Sorafenib 0.613702439661484 -0.00861469531939846 59 542:545 0.207746478873239 0.831376335950175 0 CESC PIK3CA PIK3CA TAE684 0.900932413564695 -0.00854598892970482 59 542:545 0.207746478873239 0.984846233442031 0 CESC PIK3CA PIK3CA TKI258 0.823923025082331 0.0100432161753865 59 542:545 0.207746478873239 0.959342395190069 0 CESC PIK3CA PIK3CA Topotecan 0.452169953367241 -0.0596913791891551 59 542:545 0.207746478873239 0.745156389465223 0 CESC PIK3CA PIK3CA ZD6474 0.510728032144442 -0.0113184708344176 59 542:545 0.207746478873239 0.7962963942037 0 COAD APC APC 17-AAG 0.77094092821643 0.0302496525734819 17 211:213:216 0.0636704119850187 0.916717368708119 0 COAD APC APC AEW541 0.0353845652778186 0.0357932086546668 17 211:213:216 0.0636704119850187 0.183241498760132 2 COAD APC APC AZD0530 0.388441890938428 0.0387207669146621 17 211:213:216 0.0636704119850187 0.686878953488684 0 COAD APC APC AZD6244 0.17136558370848 0.125167480053534 17 211:213:216 0.0636704119850187 0.435929993644379 0 COAD APC APC Erlotinib 0.754191394309232 0.00552109915514687 17 211:213:216 0.0636704119850187 0.854357438865927 0 COAD APC APC Irinotecan 0.899458316141774 -0.0145222111562386 17 211:213:216 0.0636704119850187 0.947844676277817 0 COAD APC APC L685458 0.762552261876624 -0.0214619713887653 17 211:213:216 0.0636704119850187 0.863828734157113 0 COAD APC APC Lapatinib 0.294077663338279 -0.0290844526517249 17 211:213:216 0.0636704119850187 0.520015380293298 0 COAD APC APC LBW242 0.125367597259604 -0.0433433573394152 17 211:213:216 0.0636704119850187 1 0 COAD APC APC Nilotinib 0.925596975088143 -0.0147549167942738 17 211:213:216 0.0636704119850187 0.98401675142912 0 COAD APC APC Nutlin3 0.0690215292252448 -0.043263348508621 17 211:213:216 0.0636704119850187 0.217567863862185 0 COAD APC APC Paclitaxel 0.5865545690809 0.0479069931364222 17 211:213:216 0.0636704119850187 0.867861352211536 0 COAD APC APC Panobinostat 0.838938297247601 -0.0418073170450608 17 211:213:216 0.0636704119850187 0.921561008340168 0 COAD APC APC PD0325901 0.112385720789775 0.174708666236131 17 211:213:216 0.0636704119850187 0.338581381117707 0 COAD APC APC PD0332991 0.672307453461351 -0.000359360511494433 17 211:213:216 0.0636704119850187 0.819198157578957 0 COAD APC APC PF2341066 0.737556700081941 0.00746399888203064 17 211:213:216 0.0636704119850187 0.829036600867298 0 COAD APC APC PHA665752 0.220573882445522 -0.0220208250720698 17 211:213:216 0.0636704119850187 0.450467788092967 0 COAD APC APC PLX4720 0.21240603770129 -0.0610696911462595 17 211:213:216 0.0636704119850187 0.525535397237866 0 COAD APC APC RAF265 0.579016256050974 -0.0216563629113591 17 211:213:216 0.0636704119850187 0.805608273766497 0 COAD APC APC Sorafenib 0.737556700081941 -0.00619684551354782 17 211:213:216 0.0636704119850187 0.882361413084552 0 COAD APC APC TAE684 0.419370670072772 0.0247720255275878 17 211:213:216 0.0636704119850187 0.64629317885846 0 COAD APC APC TKI258 0.0124387406118827 -0.191190833285007 17 211:213:216 0.0636704119850187 0.0858865423201425 1 COAD APC APC Topotecan 0.934329159265052 -0.0145891399638463 17 211:213:216 0.0636704119850187 0.981722667343714 0 COAD APC APC ZD6474 0.890768190628903 -0.00373514428800781 17 211:213:216 0.0636704119850187 0.963890952546201 0 COAD APC APC 17-AAG 0.772049329397363 0.0272360096989406 12 874:876 0.0449438202247191 0.916717368708119 0 COAD APC APC AEW541 0.260548434056898 0.0144990641808691 12 874:876 0.0449438202247191 0.568886802508775 0 COAD APC APC AZD0530 0.238401113851509 -0.0543486255697303 12 874:876 0.0449438202247191 0.515942709081624 0 COAD APC APC AZD6244 0.126184673550019 -0.0475618325461089 12 874:876 0.0449438202247191 0.344101183665249 0 COAD APC APC Erlotinib 0.691006940061132 0.0162146127561529 12 874:876 0.0449438202247191 0.841983246292976 0 COAD APC APC Irinotecan 0.438477600591743 0.0793879399349451 12 874:876 0.0449438202247191 0.706436134286697 0 COAD APC APC L685458 0.163142576725968 -0.0409214332106329 12 874:876 0.0449438202247191 0.454916800485872 0 COAD APC APC Lapatinib 0.278066416419971 -0.0149919572784409 12 874:876 0.0449438202247191 0.510375068112605 0 COAD APC APC LBW242 0.0810006965457081 -0.0467186652481505 12 874:876 0.0449438202247191 1 0 COAD APC APC Nilotinib 0.193511723788658 -0.0523567049097892 12 874:876 0.0449438202247191 0.483779309471645 0 COAD APC APC Nutlin3 0.0208424932793164 -0.0608946335707793 12 874:876 0.0449438202247191 0.12592339689587 1 COAD APC APC Paclitaxel 0.919505600894139 -0.0280300932857722 12 874:876 0.0449438202247191 0.96746459691772 0 COAD APC APC Panobinostat 0.254882539754149 -0.0991593272421127 12 874:876 0.0449438202247191 0.499432003572319 0 COAD APC APC PD0325901 0.761760667487734 0.0356429844414867 12 874:876 0.0449438202247191 0.869726746344263 0 COAD APC APC PD0332991 0.207727869784786 -0.0552201310929749 12 874:876 0.0449438202247191 0.44956031520588 0 COAD APC APC PF2341066 0.613360395745478 0.0117473757556087 12 874:876 0.0449438202247191 0.762595823907022 0 COAD APC APC PHA665752 0.0786823158390558 -0.0322376061656215 12 874:876 0.0449438202247191 0.253531906592513 0 COAD APC APC PLX4720 0.021598735411327 -0.126062608499942 12 874:876 0.0449438202247191 0.16896858483428 1 COAD APC APC RAF265 0.700967522885139 0.0228234073841904 12 874:876 0.0449438202247191 0.880427302904542 0 COAD APC APC Sorafenib 0.487731520083406 0.0120729705825766 12 874:876 0.0449438202247191 0.797869324557991 0 COAD APC APC TAE684 0.18443960996047 -0.0545577111517033 12 874:876 0.0449438202247191 0.431350700714002 0 COAD APC APC TKI258 0.104452392583926 -0.1597911135298 12 874:876 0.0449438202247191 0.32224674307807 0 COAD APC APC Topotecan 0.407294909837418 -0.104442152207147 12 874:876 0.0449438202247191 0.720216608858849 0 COAD APC APC ZD6474 0.315461523979264 0.0164114732028007 12 874:876 0.0449438202247191 0.703721861184512 0 COAD APC APC 17-AAG 0.238401113851509 -0.0727817580031593 12 935:940:941:943 0.0449438202247191 0.540127523569825 0 COAD APC APC AEW541 0.622854832556943 -0.00280540732508339 12 935:940:941:943 0.0449438202247191 0.785338701919624 0 COAD APC APC AZD0530 0.163142576725968 0.0609058382429031 12 935:940:941:943 0.0449438202247191 0.441521231682424 0 COAD APC APC AZD6244 0.530954012983493 0.0675323993385111 12 935:940:941:943 0.0449438202247191 0.764276215065453 0 COAD APC APC Erlotinib 0.462739122413669 0.0217626566318914 12 935:940:941:943 0.0449438202247191 0.684665028061041 0 COAD APC APC Irinotecan 0.254882539754149 -0.133550798355321 12 935:940:941:943 0.0449438202247191 0.577468254130494 0 COAD APC APC L685458 0.180023383850848 -0.042515755365836 12 935:940:941:943 0.0449438202247191 0.45880039290054 0 COAD APC APC Lapatinib 0.00310057032363832 -0.0815413749590235 12 935:940:941:943 0.0449438202247191 0.0345832843790428 1 COAD APC APC LBW242 0.027592498408361 -0.0625310182443107 12 935:940:941:943 0.0449438202247191 1 0 COAD APC APC Nilotinib 0.322001217604516 -0.0468522743863838 12 935:940:941:943 0.0449438202247191 0.643200385305914 0 COAD APC APC Nutlin3 0.0858037879700263 -0.0471945283053521 12 935:940:941:943 0.0449438202247191 0.248830985113076 0 COAD APC APC Paclitaxel 0.414964027975207 -0.0906276029941715 12 935:940:941:943 0.0449438202247191 0.733777854346403 0 COAD APC APC Panobinostat 0.0742075324677739 -0.14143084368473 12 935:940:941:943 0.0449438202247191 0.286545176672071 0 COAD APC APC PD0325901 0.159115067218572 0.143972905597549 12 935:940:941:943 0.0449438202247191 0.41199437047666 0 COAD APC APC PD0332991 0.496221362106932 -0.0364696935336344 12 935:940:941:943 0.0449438202247191 0.70712568686602 0 COAD APC APC PF2341066 0.0583412089794693 -0.0377825610995716 12 935:940:941:943 0.0449438202247191 0.22261777110587 0 COAD APC APC PHA665752 0.0155795423317107 -0.046520710667987 12 935:940:941:943 0.0449438202247191 0.0919743048739549 1 COAD APC APC PLX4720 0.539825980571037 -0.039901551042632 12 935:940:941:943 0.0449438202247191 0.823944917713688 0 COAD APC APC RAF265 0.198168806766658 -0.0442661737496672 12 935:940:941:943 0.0449438202247191 0.459753779127033 0 COAD APC APC Sorafenib 0.315461523979264 -0.0195327153045182 12 935:940:941:943 0.0449438202247191 0.636793644603903 0 COAD APC APC TAE684 0.0720493919907818 -0.0791506416148375 12 935:940:941:943 0.0449438202247191 0.272788326236856 0 COAD APC APC TKI258 0.0882902405265887 -0.152976250634868 12 935:940:941:943 0.0449438202247191 0.29713894935857 0 COAD APC APC Topotecan 0.0208424932793164 -0.276370581798936 12 935:940:941:943 0.0449438202247191 0.111931908351884 1 COAD APC APC ZD6474 0.919505600894139 -0.0104495929063886 12 935:940:941:943 0.0449438202247191 0.96509326057909 0 COAD APC APC 17-AAG 0.0803105272354535 -0.105234582149686 11 1367:1370:1374:1378 0.0411985018726592 0.273753844028507 0 COAD APC APC AEW541 0.024798758456277 0.0395374171832659 11 1367:1370:1374:1378 0.0411985018726592 0.143832799046407 2 COAD APC APC AZD0530 0.0606090987425165 0.0872039993235774 11 1367:1370:1374:1378 0.0411985018726592 0.237522143720673 0 COAD APC APC AZD6244 0.368532624474633 0.115929659981583 11 1367:1370:1374:1378 0.0411985018726592 0.627350862443665 0 COAD APC APC Erlotinib 0.297951819463539 -0.0346815667220742 11 1367:1370:1374:1378 0.0411985018726592 0.546873592686242 0 COAD APC APC Irinotecan 0.537891359968971 -0.0797957661230546 11 1367:1370:1374:1378 0.0411985018726592 0.775836485622651 0 COAD APC APC L685458 0.368532624474633 -0.0345962491427022 11 1367:1370:1374:1378 0.0411985018726592 0.628673300574374 0 COAD APC APC Lapatinib 0.0213821758787866 -0.0642986961096128 11 1367:1370:1374:1378 0.0411985018726592 0.114830203793484 1 COAD APC APC LBW242 0.124422730581605 -0.0497930455733728 11 1367:1370:1374:1378 0.0411985018726592 1 0 COAD APC APC Nilotinib 0.585616219348979 -0.0281045525188529 11 1367:1370:1374:1378 0.0411985018726592 0.815453138326596 0 COAD APC APC Nutlin3 0.096128222147203 -0.0447558714729461 11 1367:1370:1374:1378 0.0411985018726592 0.273305729634205 0 COAD APC APC Paclitaxel 0.407432552703485 -0.0886158023751475 11 1367:1370:1374:1378 0.0411985018726592 0.729354569654387 0 COAD APC APC Panobinostat 0.284998599825797 -0.111286039215691 11 1367:1370:1374:1378 0.0411985018726592 0.510182678700501 0 COAD APC APC PD0325901 0.304573691746489 0.156718122761574 11 1367:1370:1374:1378 0.0411985018726592 0.560524963866979 0 COAD APC APC PD0332991 0.859498280408231 -0.0196458344604604 11 1367:1370:1374:1378 0.0411985018726592 0.937046997437545 0 COAD APC APC PF2341066 0.368532624474633 0.027498118331892 11 1367:1370:1374:1378 0.0411985018726592 0.588703668570395 0 COAD APC APC PHA665752 0.016381885354572 -0.0460488974995514 11 1367:1370:1374:1378 0.0411985018726592 0.0919743048739549 1 COAD APC APC PLX4720 0.215312136570953 -0.0646271061937214 11 1367:1370:1374:1378 0.0411985018726592 0.525535397237866 0 COAD APC APC RAF265 0.03935746982736 -0.08281687935941 11 1367:1370:1374:1378 0.0411985018726592 0.146329054486338 1 COAD APC APC Sorafenib 0.135178592961605 -0.0247170211091511 11 1367:1370:1374:1378 0.0411985018726592 0.408351999571515 0 COAD APC APC TAE684 0.7715858921717 0.023772916210548 11 1367:1370:1374:1378 0.0411985018726592 0.917048806269644 0 COAD APC APC TKI258 0.150620129058694 -0.136616296662554 11 1367:1370:1374:1378 0.0411985018726592 0.436798374270213 0 COAD APC APC Topotecan 0.383806943634189 -0.11866197645125 11 1367:1370:1374:1378 0.0411985018726592 0.695650085336968 0 COAD APC APC ZD6474 0.615163571560141 -0.0331262149952947 11 1367:1370:1374:1378 0.0411985018726592 0.84149733845491 0 COAD APC APC 17-AAG 0.840028963990846 -0.00814648734910461 22 1444:1447:1450:1451 0.0823970037453183 0.918827868253112 0 COAD APC APC AEW541 0.00296334942147788 0.0505946833205317 22 1444:1447:1450:1451 0.0823970037453183 0.0332670521950657 2 COAD APC APC AZD0530 0.82537760174561 0.00956679203670197 22 1444:1447:1450:1451 0.0823970037453183 0.934998064477449 0 COAD APC APC AZD6244 0.862108768965352 0.0229977525073437 22 1444:1447:1450:1451 0.0823970037453183 0.936322591467579 0 COAD APC APC Erlotinib 0.335879445693152 0.0217969865021903 22 1444:1447:1450:1451 0.0823970037453183 0.56712243933804 0 COAD APC APC Irinotecan 0.508034465865333 -0.0679910862057005 22 1444:1447:1450:1451 0.0823970037453183 0.759432964437869 0 COAD APC APC L685458 0.862108768965352 -0.0215872397890312 22 1444:1447:1450:1451 0.0823970037453183 0.939893018796812 0 COAD APC APC Lapatinib 0.490151844783214 -0.0153481123766286 22 1444:1447:1450:1451 0.0823970037453183 0.710521423319666 0 COAD APC APC LBW242 0.0664338269976416 -0.0418708014705502 22 1444:1447:1450:1451 0.0823970037453183 1 0 COAD APC APC Nilotinib 0.508034465865333 -0.0309227824404701 22 1444:1447:1450:1451 0.0823970037453183 0.744090884348215 0 COAD APC APC Nutlin3 0.122482644471228 -0.0368905685766074 22 1444:1447:1450:1451 0.0823970037453183 0.317142561577287 0 COAD APC APC Paclitaxel 0.563667059636239 -0.058080408550623 22 1444:1447:1450:1451 0.0823970037453183 0.851372121325569 0 COAD APC APC Panobinostat 0.602317136692288 -0.0712985927773628 22 1444:1447:1450:1451 0.0823970037453183 0.797983324486845 0 COAD APC APC PD0325901 0.438596524349664 0.112973229111887 22 1444:1447:1450:1451 0.0823970037453183 0.683833290652702 0 COAD APC APC PD0332991 0.988763757717443 -0.0151054657457061 22 1444:1447:1450:1451 0.0823970037453183 0.9909205500128 0 COAD APC APC PF2341066 0.466844998376471 -0.00915874953041762 22 1444:1447:1450:1451 0.0823970037453183 0.659603683825225 0 COAD APC APC PHA665752 0.0440231868035308 -0.0316620009238296 22 1444:1447:1450:1451 0.0823970037453183 0.17584271195418 1 COAD APC APC PLX4720 0.767426246856724 -0.0327023743021511 22 1444:1447:1450:1451 0.0823970037453183 0.900349517718861 0 COAD APC APC RAF265 0.0245387999823882 -0.0708469105745149 22 1444:1447:1450:1451 0.0823970037453183 0.104650764630773 1 COAD APC APC Sorafenib 0.0536847055608928 -0.0301842664514258 22 1444:1447:1450:1451 0.0823970037453183 0.228949479597925 0 COAD APC APC TAE684 0.67609637179785 -0.0207055345620701 22 1444:1447:1450:1451 0.0823970037453183 0.854392864300874 0 COAD APC APC TKI258 0.0799481184109461 -0.128410507854168 22 1444:1447:1450:1451 0.0823970037453183 0.276011361180647 0 COAD APC APC Topotecan 0.45542620534219 -0.0918587796014627 22 1444:1447:1450:1451 0.0823970037453183 0.745156389465223 0 COAD APC APC ZD6474 0.0849208699551205 0.0554497880854781 22 1444:1447:1450:1451 0.0823970037453183 0.410193048864343 0 COAD BRAF BRAF 17-AAG 0.332893650387277 0.0342230549686251 38 594:597:600 0.142322097378277 0.643594390748735 0 COAD BRAF BRAF AEW541 0.000373419787274809 -0.0463651882435059 38 594:597:600 0.142322097378277 0.00902431152580788 1 COAD BRAF BRAF AZD0530 0.00544655623701415 -0.0729656801300447 38 594:597:600 0.142322097378277 0.0477480514918942 1 COAD BRAF BRAF AZD6244 0.0141322658531801 -0.11039138089165 38 594:597:600 0.142322097378277 0.115873204402054 1 COAD BRAF BRAF Erlotinib 0.0103034122988557 -0.0394508857838574 38 594:597:600 0.142322097378277 0.078631304386004 1 COAD BRAF BRAF Irinotecan 0.782935783119768 -0.00691275894679233 38 594:597:600 0.142322097378277 0.915510956568343 0 COAD BRAF BRAF L685458 0.238980551760375 0.0249558951915655 38 594:597:600 0.142322097378277 0.474945983684696 0 COAD BRAF BRAF Lapatinib 0.0674748551288101 0.0295141868169257 38 594:597:600 0.142322097378277 0.219896843644694 0 COAD BRAF BRAF LBW242 0.0446952039598886 0.0275622303551522 38 594:597:600 0.142322097378277 1 0 COAD BRAF BRAF Nilotinib 0.676450685116226 0.0268468715085483 38 594:597:600 0.142322097378277 0.847965386361886 0 COAD BRAF BRAF Nutlin3 0.0404270136928633 0.0340256072280024 38 594:597:600 0.142322097378277 0.166547664528704 2 COAD BRAF BRAF Paclitaxel 0.733411384974734 -0.0245485968225756 38 594:597:600 0.142322097378277 0.892078030448865 0 COAD BRAF BRAF Panobinostat 0.0291187006631991 0.0887572109575148 38 594:597:600 0.142322097378277 0.168888463846555 2 COAD BRAF BRAF PD0325901 0.00175945391756989 -0.159771077965043 38 594:597:600 0.142322097378277 0.0500603406468697 1 COAD BRAF BRAF PD0332991 0.930526816870246 0.0220928442095802 38 594:597:600 0.142322097378277 0.965946950720715 0 COAD BRAF BRAF PF2341066 0.80264779222022 0.000680862979062558 38 594:597:600 0.142322097378277 0.868536790089044 0 COAD BRAF BRAF PHA665752 0.00257680273177791 0.0358486481595321 38 594:597:600 0.142322097378277 0.0287412612390613 2 COAD BRAF BRAF PLX4720 0.39936285248683 0.0395319038717734 38 594:597:600 0.142322097378277 0.769266275380849 0 COAD BRAF BRAF RAF265 2.24146071902462e-05 0.0993433222961557 38 594:597:600 0.142322097378277 0.00230595717325751 2 COAD BRAF BRAF Sorafenib 0.00458027594985907 0.0371237386752915 38 594:597:600 0.142322097378277 0.0474385723378261 2 COAD BRAF BRAF TAE684 0.46325868378131 -0.016346373532935 38 594:597:600 0.142322097378277 0.671725091482899 0 COAD BRAF BRAF TKI258 0.0075829742452521 0.134927384882849 38 594:597:600 0.142322097378277 0.0578700666085029 2 COAD BRAF BRAF Topotecan 0.00969841812017782 0.194853767979191 38 594:597:600 0.142322097378277 0.0713415000667662 2 COAD BRAF BRAF ZD6474 0.73866889225493 0.017209600220836 38 594:597:600 0.142322097378277 0.910370895332992 0 COAD CTNNB1 CTNNB1 17-AAG 0.00741631675701572 0.165241018843643 12 41:45 0.0449438202247191 0.0707685949891351 2 COAD CTNNB1 CTNNB1 AEW541 0.454004822814538 -0.0226406204590857 12 41:45 0.0449438202247191 0.697808405271508 0 COAD CTNNB1 CTNNB1 AZD0530 0.0752328546740242 -0.0526967800713027 12 41:45 0.0449438202247191 0.274936700105795 0 COAD CTNNB1 CTNNB1 AZD6244 0.376410517466199 0.0254167031822168 12 41:45 0.0449438202247191 0.627350862443665 0 COAD CTNNB1 CTNNB1 Erlotinib 0.0101778532068034 0.0725405013387233 12 41:45 0.0449438202247191 0.078631304386004 2 COAD CTNNB1 CTNNB1 Irinotecan 0.13066442470835 0.133395558461929 12 41:45 0.0449438202247191 0.421029812949128 0 COAD CTNNB1 CTNNB1 L685458 0.0452126860395874 0.0474636707828454 12 41:45 0.0449438202247191 0.218527982524672 0 COAD CTNNB1 CTNNB1 Lapatinib 0.000115451020917028 0.107492638928316 12 41:45 0.0449438202247191 0.00306945358260616 2 COAD CTNNB1 CTNNB1 LBW242 0.0202254431409724 0.0617089546801267 12 41:45 0.0449438202247191 1 0 COAD CTNNB1 CTNNB1 Nilotinib 0.0259941927982561 0.0814285276339987 12 41:45 0.0449438202247191 0.209397664208174 0 COAD CTNNB1 CTNNB1 Nutlin3 0.0318385839658619 0.051305852027914 12 41:45 0.0449438202247191 0.15456080002062 2 COAD CTNNB1 CTNNB1 Paclitaxel 0.154552725650985 0.184168222291945 12 41:45 0.0449438202247191 0.400181164632015 0 COAD CTNNB1 CTNNB1 Panobinostat 0.0222426236449321 0.164686552965638 12 41:45 0.0449438202247191 0.140225236022398 2 COAD CTNNB1 CTNNB1 PD0325901 0.953825313410821 -0.0203128631638996 12 41:45 0.0449438202247191 0.982965157298728 0 COAD CTNNB1 CTNNB1 PD0332991 0.104525060795019 0.0448000330530174 12 41:45 0.0449438202247191 0.297179094417211 0 COAD CTNNB1 CTNNB1 PF2341066 0.451601079206647 0.0188225304164262 12 41:45 0.0449438202247191 0.659603683825225 0 COAD CTNNB1 CTNNB1 PHA665752 0.00344305033068492 0.0570748916473492 12 41:45 0.0449438202247191 0.0332828198632876 2 COAD CTNNB1 CTNNB1 PLX4720 0.0308958612084381 0.103396613263427 12 41:45 0.0449438202247191 0.172410275043407 2 COAD CTNNB1 CTNNB1 RAF265 0.0848640994591054 0.0647159343953652 12 41:45 0.0449438202247191 0.256360300449381 0 COAD CTNNB1 CTNNB1 Sorafenib 0.0695266176369454 0.0504146114499744 12 41:45 0.0449438202247191 0.258950503504941 0 COAD CTNNB1 CTNNB1 TAE684 0.944286139425373 -0.010539619940966 12 41:45 0.0449438202247191 0.984846233442031 0 COAD CTNNB1 CTNNB1 TKI258 0.0701425517508698 0.134930196144693 12 41:45 0.0449438202247191 0.257337606466146 0 COAD CTNNB1 CTNNB1 Topotecan 0.125657281813229 0.150539774293114 12 41:45 0.0449438202247191 0.404895685842627 0 COAD CTNNB1 CTNNB1 ZD6474 0.702931735020365 0.00751355763647021 12 41:45 0.0449438202247191 0.910045549803151 0 COAD KRAS KRAS 17-AAG 0.849123685144255 -0.00735051337420467 70 12:13 0.262172284644195 0.918827868253112 0 COAD KRAS KRAS AEW541 0.854824328223378 -0.0048171057871893 70 12:13 0.262172284644195 0.906068571639172 0 COAD KRAS KRAS AZD0530 0.290140811942927 0.0286355792702049 70 12:13 0.262172284644195 0.579750106765148 0 COAD KRAS KRAS AZD6244 0.274947256444689 0.0539914508005657 70 12:13 0.262172284644195 0.556849407821519 0 COAD KRAS KRAS Erlotinib 0.0137632810308025 0.0292810461560795 70 12:13 0.262172284644195 0.0907125340666528 2 COAD KRAS KRAS Irinotecan 0.891092506652639 -0.0292574597276647 70 12:13 0.262172284644195 0.947844676277817 0 COAD KRAS KRAS L685458 0.0209832575378389 -0.0278035395441291 70 12:13 0.262172284644195 0.138287293721145 1 COAD KRAS KRAS Lapatinib 0.00120004251609087 -0.0398686960297476 70 12:13 0.262172284644195 0.0187450052533217 1 COAD KRAS KRAS LBW242 0.00137381981313405 -0.0387596961404636 70 12:13 0.262172284644195 1 0 COAD KRAS KRAS Nilotinib 0.445965507940701 -0.0183621072870123 70 12:13 0.262172284644195 0.695322566144104 0 COAD KRAS KRAS Nutlin3 0.0795457755683985 -0.023894208922576 70 12:13 0.262172284644195 0.239649170276642 0 COAD KRAS KRAS Paclitaxel 0.253191555602198 -0.0600658269369321 70 12:13 0.262172284644195 0.588872462745123 0 COAD KRAS KRAS Panobinostat 0.00727662319677746 -0.0909607811843829 70 12:13 0.262172284644195 0.0674057128543235 1 COAD KRAS KRAS PD0325901 0.00518374001133924 0.118894073038394 70 12:13 0.262172284644195 0.0746537986595474 2 COAD KRAS KRAS PD0332991 0.0738962440313081 -0.0310239098631693 70 12:13 0.262172284644195 0.255117985346183 0 COAD KRAS KRAS PF2341066 0.24228720365578 -0.00860280744059416 70 12:13 0.262172284644195 0.494811894789973 0 COAD KRAS KRAS PHA665752 0.0914312003792747 -0.0132517825322728 70 12:13 0.262172284644195 0.260943971812122 0 COAD KRAS KRAS PLX4720 0.908356859950799 -0.0116954145821972 70 12:13 0.262172284644195 0.975642553280488 0 COAD KRAS KRAS RAF265 0.224238894594633 0.0227488134169003 70 12:13 0.262172284644195 0.500225226403412 0 COAD KRAS KRAS Sorafenib 0.90067797443267 -0.00701318301339915 70 12:13 0.262172284644195 0.972333716193179 0 COAD KRAS KRAS TAE684 0.0991227214317872 -0.0383347275830195 70 12:13 0.262172284644195 0.319828070469847 0 COAD KRAS KRAS TKI258 0.0646254681086114 -0.06839276463443 70 12:13 0.262172284644195 0.257337606466146 0 COAD KRAS KRAS Topotecan 0.00534131381768335 -0.150860365749909 70 12:13 0.262172284644195 0.0484056564727554 1 COAD KRAS KRAS ZD6474 0.142276287736539 0.0256806460294809 70 12:13 0.262172284644195 0.501815000527511 0 COAD KRAS KRAS 17-AAG 0.651706522901499 0.037282649485769 10 146 0.0374531835205993 0.819443075531059 0 COAD KRAS KRAS AEW541 0.640810707963545 -0.0184092348536076 10 146 0.0374531835205993 0.794167116706957 0 COAD KRAS KRAS AZD0530 0.122627341426899 0.0831759047621485 10 146 0.0374531835205993 0.362876826671436 0 COAD KRAS KRAS AZD6244 0.679269207761233 0.0839642310142503 10 146 0.0374531835205993 0.839296016389673 0 COAD KRAS KRAS Erlotinib 0.0727826455782725 0.045866720894469 10 146 0.0374531835205993 0.219864241851032 0 COAD KRAS KRAS Irinotecan 0.311161086004844 -0.075965792710682 10 146 0.0374531835205993 0.626643853759755 0 COAD KRAS KRAS L685458 0.364629643499856 -0.0110895342953339 10 146 0.0374531835205993 0.628673300574374 0 COAD KRAS KRAS Lapatinib 0.817014793842767 0.0055477714763883 10 146 0.0374531835205993 0.897478372024252 0 COAD KRAS KRAS LBW242 0.468756190742506 -0.0084629133744738 10 146 0.0374531835205993 1 0 COAD KRAS KRAS Nilotinib 0.924449535815123 0.00743888953771088 10 146 0.0374531835205993 0.98401675142912 0 COAD KRAS KRAS Nutlin3 0.441286314437236 -0.0143192341110949 10 146 0.0374531835205993 0.695505604276078 0 COAD KRAS KRAS Paclitaxel 0.846603407302822 0.0236722657154509 10 146 0.0374531835205993 0.926211653185911 0 COAD KRAS KRAS Panobinostat 0.521487898613341 0.0603585974082472 10 146 0.0374531835205993 0.755880715994261 0 COAD KRAS KRAS PD0325901 0.888384251224407 0.0814352744459739 10 146 0.0374531835205993 0.938433143098641 0 COAD KRAS KRAS PD0332991 0.9909205500128 -0.00282642196670824 10 146 0.0374531835205993 0.9909205500128 0 COAD KRAS KRAS PF2341066 0.206538512550487 -0.0151748318943735 10 146 0.0374531835205993 0.434030207533632 0 COAD KRAS KRAS PHA665752 0.840666938084631 -0.00324066595741357 10 146 0.0374531835205993 0.930509206276882 0 COAD KRAS KRAS PLX4720 0.613911638816948 -0.0230241136816777 10 146 0.0374531835205993 0.855934496427476 0 COAD KRAS KRAS RAF265 0.619251586075597 0.0148977815829292 10 146 0.0374531835205993 0.808932252080735 0 COAD KRAS KRAS Sorafenib 0.918425819439349 0.002788318785514 10 146 0.0374531835205993 0.972333716193179 0 COAD KRAS KRAS TAE684 0.360630096153509 0.0452281190085564 10 146 0.0374531835205993 0.64629317885846 0 COAD KRAS KRAS TKI258 0.356658190580394 0.0486855658242891 10 146 0.0374531835205993 0.724893380361625 0 COAD KRAS KRAS Topotecan 0.707267525649149 -0.0550865593146437 10 146 0.0374531835205993 0.881352745205969 0 COAD KRAS KRAS ZD6474 0.747131976169835 0.00107744370536711 10 146 0.0374531835205993 0.910370895332992 0 COAD PGM5 PGM5 17-AAG 0.0905627447179461 0.0902739359064868 13 98 0.048689138576779 0.285469521393526 0 COAD PGM5 PGM5 AEW541 0.00578111941150234 -0.0492067725999203 13 98 0.048689138576779 0.0558841543111893 1 COAD PGM5 PGM5 AZD0530 0.0898412645495754 -0.0629717996340633 13 98 0.048689138576779 0.310166270468772 0 COAD PGM5 PGM5 AZD6244 0.0645742782236478 -0.10492405678143 13 98 0.048689138576779 0.217750473079743 0 COAD PGM5 PGM5 Erlotinib 0.0302114780534433 -0.0631085170832381 13 98 0.048689138576779 0.128843068169096 1 COAD PGM5 PGM5 Irinotecan 0.504952612652586 0.0825169269881041 13 98 0.048689138576779 0.759432964437869 0 COAD PGM5 PGM5 L685458 0.158152155747559 0.0547082781521513 13 98 0.048689138576779 0.449648285948942 0 COAD PGM5 PGM5 Lapatinib 0.210658307978876 0.0350177774926905 13 98 0.048689138576779 0.423328452453569 0 COAD PGM5 PGM5 LBW242 0.000943026867246528 0.0758100531959415 13 98 0.048689138576779 1 0 COAD PGM5 PGM5 Nilotinib 0.00695145227362215 0.117571617029811 13 98 0.048689138576779 0.100022818944152 2 COAD PGM5 PGM5 Nutlin3 0.128138555160736 0.0461595163337714 13 98 0.048689138576779 0.325966499970293 0 COAD PGM5 PGM5 Paclitaxel 0.0651255847297623 0.184562419754873 13 98 0.048689138576779 0.23032218989794 0 COAD PGM5 PGM5 Panobinostat 0.0173103627548043 0.19098798315144 13 98 0.048689138576779 0.119523933306982 2 COAD PGM5 PGM5 PD0325901 0.037184774458884 -0.164827670886235 13 98 0.048689138576779 0.170654095142905 1 COAD PGM5 PGM5 PD0332991 0.64166465355168 0.0191771063352379 13 98 0.048689138576779 0.8020808169396 0 COAD PGM5 PGM5 PF2341066 0.647114329592461 0.0188017856174294 13 98 0.048689138576779 0.788500653705099 0 COAD PGM5 PGM5 PHA665752 0.00526533496939062 0.0567251133419834 13 98 0.048689138576779 0.0424151983645355 2 COAD PGM5 PGM5 PLX4720 0.128138555160736 0.105949213491197 13 98 0.048689138576779 0.415964523639009 0 COAD PGM5 PGM5 RAF265 0.00251050271108221 0.108796882102645 13 98 0.048689138576779 0.0242681928737947 2 COAD PGM5 PGM5 Sorafenib 0.00192314840825995 0.0787833466904955 13 98 0.048689138576779 0.0309840576886325 2 COAD PGM5 PGM5 TAE684 0.983329989584617 0.00704258685180092 13 98 0.048689138576779 0.987747066904885 0 COAD PGM5 PGM5 TKI258 0.00467921723900384 0.251340680406546 13 98 0.048689138576779 0.0399109705679739 2 COAD PGM5 PGM5 Topotecan 0.00984024015272679 0.269276974270957 13 98 0.048689138576779 0.0713415000667662 2 COAD PGM5 PGM5 ZD6474 0.195822328171126 -0.0509944307006109 13 98 0.048689138576779 0.546043030477178 0 COAD PIK3CA PIK3CA 17-AAG 0.0999086517363438 0.0637459392387014 37 542:545:546 0.138576779026217 0.301807385453539 0 COAD PIK3CA PIK3CA AEW541 0.397151806701145 0.00511916484763075 37 542:545:546 0.138576779026217 0.661919677835242 0 COAD PIK3CA PIK3CA AZD0530 0.995481067912487 0.00781084608420946 37 542:545:546 0.138576779026217 1 0 COAD PIK3CA PIK3CA AZD6244 0.831804588194645 0.0219231293044313 37 542:545:546 0.138576779026217 0.936322591467579 0 COAD PIK3CA PIK3CA Erlotinib 0.000289241198893097 0.053012709917069 37 542:545:546 0.138576779026217 0.00838799476789981 2 COAD PIK3CA PIK3CA Irinotecan 0.0970239756268847 0.067460708387626 37 542:545:546 0.138576779026217 0.390791012941619 0 COAD PIK3CA PIK3CA L685458 0.580805856948475 -0.00334223526292099 37 542:545:546 0.138576779026217 0.772631644564485 0 COAD PIK3CA PIK3CA Lapatinib 0.202547854888094 0.0174742828936323 37 542:545:546 0.138576779026217 0.423328452453569 0 COAD PIK3CA PIK3CA LBW242 0.712769842666873 -0.000185426244550313 37 542:545:546 0.138576779026217 1 0 COAD PIK3CA PIK3CA Nilotinib 0.436124129629107 -0.0155284224465305 37 542:545:546 0.138576779026217 0.687369552132832 0 COAD PIK3CA PIK3CA Nutlin3 0.860628768098827 -0.00677307883866085 37 542:545:546 0.138576779026217 0.917341274328711 0 COAD PIK3CA PIK3CA Paclitaxel 0.939053479340985 -0.000160739869882853 37 542:545:546 0.138576779026217 0.972591103603163 0 COAD PIK3CA PIK3CA Panobinostat 0.162685863307598 0.0152631228906808 37 542:545:546 0.138576779026217 0.406714658268995 0 COAD PIK3CA PIK3CA PD0325901 0.757572482729177 0.0383347397648 37 542:545:546 0.138576779026217 0.869726746344263 0 COAD PIK3CA PIK3CA PD0332991 0.0942062882018748 0.0226259847693313 37 542:545:546 0.138576779026217 0.297179094417211 0 COAD PIK3CA PIK3CA PF2341066 0.687595203529425 0.00734334379061174 37 542:545:546 0.138576779026217 0.810579711477778 0 COAD PIK3CA PIK3CA PHA665752 0.714882382196631 0.00300970918806609 37 542:545:546 0.138576779026217 0.877092920919321 0 COAD PIK3CA PIK3CA PLX4720 0.273113574136202 -0.0376118489921925 37 542:545:546 0.138576779026217 0.600022246208323 0 COAD PIK3CA PIK3CA RAF265 0.704341842323634 -0.00984535964595201 37 542:545:546 0.138576779026217 0.880427302904542 0 COAD PIK3CA PIK3CA Sorafenib 0.733991855760664 0.00370034192889673 37 542:545:546 0.138576779026217 0.882361413084552 0 COAD PIK3CA PIK3CA TAE684 0.630223639514 -0.00793398866733663 37 542:545:546 0.138576779026217 0.82326511468045 0 COAD PIK3CA PIK3CA TKI258 0.83401433734847 -0.000529312063253906 37 542:545:546 0.138576779026217 0.959342395190069 0 COAD PIK3CA PIK3CA Topotecan 0.869537111577 -0.0132680191209276 37 542:545:546 0.138576779026217 0.940917023721381 0 COAD PIK3CA PIK3CA ZD6474 0.409903057898916 0.0217841389992754 37 542:545:546 0.138576779026217 0.739978986852158 0 COAD SMAD4 SMAD4 17-AAG 0.957832223625417 0.0117528774188842 12 361:365 0.0449438202247191 0.984846233442031 0 COAD SMAD4 SMAD4 AEW541 0.894001424113667 -0.0105599423951406 12 361:365 0.0449438202247191 0.932591413643753 0 COAD SMAD4 SMAD4 AZD0530 0.59845333313622 -0.0250906333728942 12 361:365 0.0449438202247191 0.818638993441056 0 COAD SMAD4 SMAD4 AZD6244 1 -0.0672757618862105 12 361:365 0.0449438202247191 1 0 COAD SMAD4 SMAD4 Erlotinib 0.708144976937584 0.0127604346646224 12 361:365 0.0449438202247191 0.852277706263159 0 COAD SMAD4 SMAD4 Irinotecan 0.807834320994921 0.008609642986106 12 361:365 0.0449438202247191 0.922330523970579 0 COAD SMAD4 SMAD4 L685458 0.194812630376171 0.0283090250854907 12 361:365 0.0449438202247191 0.464414853606848 0 COAD SMAD4 SMAD4 Lapatinib 0.532683844145368 0.0225389409651471 12 361:365 0.0449438202247191 0.721861284122228 0 COAD SMAD4 SMAD4 LBW242 0.0224866246517473 0.0437679641102833 12 361:365 0.0449438202247191 1 0 COAD SMAD4 SMAD4 Nilotinib 0.078826667818477 0.0496229999737231 12 361:365 0.0449438202247191 0.357183338552474 0 COAD SMAD4 SMAD4 Nutlin3 0.664602474108817 0.0139323378083893 12 361:365 0.0449438202247191 0.860422845944451 0 COAD SMAD4 SMAD4 Paclitaxel 0.430181258958082 -0.10998847554435 12 361:365 0.0449438202247191 0.748298203965188 0 COAD SMAD4 SMAD4 Panobinostat 0.12312009947155 0.11462670485318 12 361:365 0.0449438202247191 0.330600267099532 0 COAD SMAD4 SMAD4 PD0325901 0.254300667318953 -0.138218928506055 12 361:365 0.0449438202247191 0.505117763852715 0 COAD SMAD4 SMAD4 PD0332991 0.261418040506118 0.0434188417528454 12 361:365 0.0449438202247191 0.512221588580807 0 COAD SMAD4 SMAD4 PF2341066 0.353164272500844 -0.0203783210900679 12 361:365 0.0449438202247191 0.588703668570395 0 COAD SMAD4 SMAD4 PHA665752 0.135948494820775 0.023148081285906 12 361:365 0.0449438202247191 0.334110707610379 0 COAD SMAD4 SMAD4 PLX4720 0.285494915161067 0.0393729349059344 12 361:365 0.0449438202247191 0.608775922034628 0 COAD SMAD4 SMAD4 RAF265 0.572280998170113 -0.0113632420770693 12 361:365 0.0449438202247191 0.805608273766497 0 COAD SMAD4 SMAD4 Sorafenib 0.59845333313622 0.0138285211171774 12 361:365 0.0449438202247191 0.831376335950175 0 COAD SMAD4 SMAD4 TAE684 0.768773204647664 -0.0237180598410485 12 361:365 0.0449438202247191 0.917048806269644 0 COAD SMAD4 SMAD4 TKI258 0.631158567106433 0.0437727696756298 12 361:365 0.0449438202247191 0.888524196411969 0 COAD SMAD4 SMAD4 Topotecan 0.984813444012505 0.00160527927808429 12 361:365 0.0449438202247191 1 0 COAD SMAD4 SMAD4 ZD6474 0.595518620586245 -0.00595474641702887 12 361:365 0.0449438202247191 0.838351456165102 0 COAD TP53 TP53 17-AAG 0.551842123224821 0.0450457507184954 11 173:175:176:177:179:181 0.0411985018726592 0.769395267957683 0 COAD TP53 TP53 AEW541 0.342069641148503 0.0278982474510696 11 173:175:176:177:179:181 0.0411985018726592 0.656586643346452 0 COAD TP53 TP53 AZD0530 1 0.0106198620430804 11 173:175:176:177:179:181 0.0411985018726592 1 0 COAD TP53 TP53 AZD6244 0.42016687824318 0.0646534077180414 11 173:175:176:177:179:181 0.0411985018726592 0.679057671028548 0 COAD TP53 TP53 Erlotinib 0.0164308621911168 -0.0857882173752855 11 173:175:176:177:179:181 0.0411985018726592 0.0972525230793827 1 COAD TP53 TP53 Irinotecan 0.79554745191456 -0.00616387564053156 11 173:175:176:177:179:181 0.0411985018726592 0.915510956568343 0 COAD TP53 TP53 L685458 0.984686652411814 -0.00245945074437681 11 173:175:176:177:179:181 0.0411985018726592 0.984686652411814 0 COAD TP53 TP53 Lapatinib 0.0682438480276635 -0.0531340456185083 11 173:175:176:177:179:181 0.0411985018726592 0.219896843644694 0 COAD TP53 TP53 LBW242 0.969378944969078 0.00672469975222212 11 173:175:176:177:179:181 0.0411985018726592 1 0 COAD TP53 TP53 Nilotinib 0.356897242737158 0.0383425057891748 11 173:175:176:177:179:181 0.0411985018726592 0.679345452090186 0 COAD TP53 TP53 Nutlin3 0.16117407176828 -0.0244391047670649 11 173:175:176:177:179:181 0.0411985018726592 0.355596392881227 0 COAD TP53 TP53 Paclitaxel 0.577790646923425 0.0477496544314926 11 173:175:176:177:179:181 0.0411985018726592 0.863707668081408 0 COAD TP53 TP53 Panobinostat 0.377286943933676 -0.0619833609417162 11 173:175:176:177:179:181 0.0411985018726592 0.614680976071719 0 COAD TP53 TP53 PD0325901 0.185383736008228 0.117646282036405 11 173:175:176:177:179:181 0.0411985018726592 0.448010695353218 0 COAD TP53 TP53 PD0332991 0.346967785092351 -0.0388642419013248 11 173:175:176:177:179:181 0.0411985018726592 0.612947242225836 0 COAD TP53 TP53 PF2341066 0.115516049773161 0.0264433735538052 11 173:175:176:177:179:181 0.0411985018726592 0.334693632312871 0 COAD TP53 TP53 PHA665752 0.409186887964802 -0.0167682345526157 11 173:175:176:177:179:181 0.0411985018726592 0.605429579131595 0 COAD TP53 TP53 PLX4720 0.495635327730771 -0.000786687726303859 11 173:175:176:177:179:181 0.0411985018726592 0.791842381808024 0 COAD TP53 TP53 RAF265 0.245555040345041 0.0513572479956164 11 173:175:176:177:179:181 0.0411985018726592 0.530713589453383 0 COAD TP53 TP53 Sorafenib 0.744203872909214 0.00479017314475805 11 173:175:176:177:179:181 0.0411985018726592 0.882361413084552 0 COAD TP53 TP53 TAE684 0.234044807098048 0.0564866152044918 11 173:175:176:177:179:181 0.0411985018726592 0.506514881033089 0 COAD TP53 TP53 TKI258 0.893121631259667 0.00710826077184223 11 173:175:176:177:179:181 0.0411985018726592 0.959342395190069 0 COAD TP53 TP53 Topotecan 0.322921985529354 0.114586004233197 11 173:175:176:177:179:181 0.0411985018726592 0.664101103395911 0 COAD TP53 TP53 ZD6474 0.0182348516446443 -0.104606366165288 11 173:175:176:177:179:181 0.0411985018726592 0.125907308974925 1 COAD TP53 TP53 17-AAG 0.675350312574514 0.0150471956870701 18 211:213:214:215:216:220 0.0674157303370786 0.822905843052979 0 COAD TP53 TP53 AEW541 0.0180992553344419 0.0454825104989938 18 211:213:214:215:216:220 0.0674157303370786 0.119290546522458 2 COAD TP53 TP53 AZD0530 0.807226110258596 -0.00510785335133113 18 211:213:214:215:216:220 0.0674157303370786 0.934998064477449 0 COAD TP53 TP53 AZD6244 0.864091318605778 0.0482528024455862 18 211:213:214:215:216:220 0.0674157303370786 0.936322591467579 0 COAD TP53 TP53 Erlotinib 0.054949956070507 -0.040021666865335 18 211:213:214:215:216:220 0.0674157303370786 0.194335210493256 1 COAD TP53 TP53 Irinotecan 0.334495388676243 0.0664579465054436 18 211:213:214:215:216:220 0.0674157303370786 0.631451679426195 0 COAD TP53 TP53 L685458 0.718438639886865 -0.0029819641385519 18 211:213:214:215:216:220 0.0674157303370786 0.840109699867705 0 COAD TP53 TP53 Lapatinib 0.230847294430513 -0.0336754428518995 18 211:213:214:215:216:220 0.0674157303370786 0.446304769232325 0 COAD TP53 TP53 LBW242 0.712999951518828 0.00419245641419552 18 211:213:214:215:216:220 0.0674157303370786 1 0 COAD TP53 TP53 Nilotinib 0.973852470527465 -0.0108798517909603 18 211:213:214:215:216:220 0.0674157303370786 0.987472784800576 0 COAD TP53 TP53 Nutlin3 0.156572990366627 -0.0256355914452018 18 211:213:214:215:216:220 0.0674157303370786 0.354735681299389 0 COAD TP53 TP53 Paclitaxel 0.523910359098328 -0.00960388927716682 18 211:213:214:215:216:220 0.0674157303370786 0.834802220541292 0 COAD TP53 TP53 Panobinostat 0.24533284577566 -0.0744648135454549 18 211:213:214:215:216:220 0.0674157303370786 0.495156982023114 0 COAD TP53 TP53 PD0325901 0.323667165733298 0.0746204317901529 18 211:213:214:215:216:220 0.0674157303370786 0.565530852379404 0 COAD TP53 TP53 PD0332991 0.915888162324319 -0.0081261854121939 18 211:213:214:215:216:220 0.0674157303370786 0.965946950720715 0 COAD TP53 TP53 PF2341066 0.0488088027490189 0.0360022826664632 18 211:213:214:215:216:220 0.0674157303370786 0.208155188194345 0 COAD TP53 TP53 PHA665752 0.468614938228102 -0.0104226416834163 18 211:213:214:215:216:220 0.0674157303370786 0.672764020228463 0 COAD TP53 TP53 PLX4720 0.577385381572999 -0.0328741371290062 18 211:213:214:215:216:220 0.0674157303370786 0.852629509131721 0 COAD TP53 TP53 RAF265 0.0463590615042209 -0.0602094830169144 18 211:213:214:215:216:220 0.0674157303370786 0.163952778490537 1 COAD TP53 TP53 Sorafenib 0.592403277126724 -0.00701046707297254 18 211:213:214:215:216:220 0.0674157303370786 0.831376335950175 0 COAD TP53 TP53 TAE684 0.392085055927459 0.0251900709085946 18 211:213:214:215:216:220 0.0674157303370786 0.64629317885846 0 COAD TP53 TP53 TKI258 0.767999665322683 -0.0455041718856675 18 211:213:214:215:216:220 0.0674157303370786 0.943728402303297 0 COAD TP53 TP53 Topotecan 0.841243225913599 -0.000451346603022706 18 211:213:214:215:216:220 0.0674157303370786 0.940917023721381 0 COAD TP53 TP53 ZD6474 0.0270620062006644 -0.0751776613998283 18 211:213:214:215:216:220 0.0674157303370786 0.178363222686197 1 COAD TP53 TP53 17-AAG 0.118492827374362 -0.0698385613673671 24 232:236:240:245:248 0.0898876404494382 0.336891371946715 0 COAD TP53 TP53 AEW541 0.709462822175839 0.0088546344048992 24 232:236:240:245:248 0.0898876404494382 0.843121071823001 0 COAD TP53 TP53 AZD0530 0.519871702642486 0.024485519772218 24 232:236:240:245:248 0.0898876404494382 0.769197927379189 0 COAD TP53 TP53 AZD6244 0.226237638061674 0.0559878401684242 24 232:236:240:245:248 0.0898876404494382 0.497037235135496 0 COAD TP53 TP53 Erlotinib 0.00227745340966152 -0.0639572273742897 24 232:236:240:245:248 0.0898876404494382 0.0366923049334356 1 COAD TP53 TP53 Irinotecan 0.855841643456288 -0.0196801581889985 24 232:236:240:245:248 0.0898876404494382 0.936443495026048 0 COAD TP53 TP53 L685458 0.0023246122868233 -0.0440073242285732 24 232:236:240:245:248 0.0898876404494382 0.0350547508782544 1 COAD TP53 TP53 Lapatinib 0.0268348522256091 -0.047706585990315 24 232:236:240:245:248 0.0898876404494382 0.121595424147291 1 COAD TP53 TP53 LBW242 0.0360020858823423 -0.0428790511695042 24 232:236:240:245:248 0.0898876404494382 1 0 COAD TP53 TP53 Nilotinib 0.164924465302862 -0.035056475344266 24 232:236:240:245:248 0.0898876404494382 0.451208442809717 0 COAD TP53 TP53 Nutlin3 0.00522551722403981 -0.0410873732939813 24 232:236:240:245:248 0.0898876404494382 0.0607502083038393 1 COAD TP53 TP53 Paclitaxel 0.335158642753833 -0.0835899520836074 24 232:236:240:245:248 0.0898876404494382 0.657917533572212 0 COAD TP53 TP53 Panobinostat 0.00327585636927345 -0.13176738339374 24 232:236:240:245:248 0.0898876404494382 0.047499917354465 1 COAD TP53 TP53 PD0325901 0.085205997412263 0.119877492756807 24 232:236:240:245:248 0.0898876404494382 0.294163562494717 0 COAD TP53 TP53 PD0332991 0.0210946378124275 -0.059819502837173 24 232:236:240:245:248 0.0898876404494382 0.117643172415461 1 COAD TP53 TP53 PF2341066 0.67763994128398 0.0103103479987241 24 232:236:240:245:248 0.0898876404494382 0.805391733493255 0 COAD TP53 TP53 PHA665752 0.00156532972547806 -0.0451572368680455 24 232:236:240:245:248 0.0898876404494382 0.0206338918358472 1 COAD TP53 TP53 PLX4720 0.0105041107935263 -0.0768789672976861 24 232:236:240:245:248 0.0898876404494382 0.0951935040663321 1 COAD TP53 TP53 RAF265 0.85101117697516 0.0161281587618161 24 232:236:240:245:248 0.0898876404494382 0.950250786733846 0 COAD TP53 TP53 Sorafenib 0.741800860796852 -0.00976341483924609 24 232:236:240:245:248 0.0898876404494382 0.882361413084552 0 COAD TP53 TP53 TAE684 0.380183148036832 -0.0235662626188962 24 232:236:240:245:248 0.0898876404494382 0.64629317885846 0 COAD TP53 TP53 TKI258 0.0430727171565199 -0.123602487713153 24 232:236:240:245:248 0.0898876404494382 0.2014691608934 0 COAD TP53 TP53 Topotecan 0.373532738319278 -0.0815068465152318 24 232:236:240:245:248 0.0898876404494382 0.685598064003738 0 COAD TP53 TP53 ZD6474 0.338255977993156 -0.0255093368591264 24 232:236:240:245:248 0.0898876404494382 0.720924573780434 0 COAD TP53 TP53 17-AAG 0.787695531383551 -0.0247803710115502 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.917343998023038 0 COAD TP53 TP53 AEW541 0.856078581479769 -0.00168075171069781 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.906068571639172 0 COAD TP53 TP53 AZD0530 0.712699956194916 -0.00129110128535648 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.890874945243645 0 COAD TP53 TP53 AZD6244 0.869038295016332 -0.00294506684479945 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.936322591467579 0 COAD TP53 TP53 Erlotinib 0.0114661196301293 -0.050949547664311 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.0791708260175595 1 COAD TP53 TP53 Irinotecan 0.973693698167269 -0.0231140999897264 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.993033309127887 0 COAD TP53 TP53 L685458 0.0926119333293279 -0.0297925470913064 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.353387640335593 0 COAD TP53 TP53 Lapatinib 0.0834086358116333 -0.0374324585906338 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.262918525927974 0 COAD TP53 TP53 LBW242 0.336149558233437 -0.0153486613333198 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 1 0 COAD TP53 TP53 Nilotinib 0.0448517502703137 -0.046112963896846 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.260140151567819 0 COAD TP53 TP53 Nutlin3 0.0491175209337295 -0.0305661466230456 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.187422119352389 1 COAD TP53 TP53 Paclitaxel 0.830278628430885 -0.0384158366421543 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.919010695591438 0 COAD TP53 TP53 Panobinostat 0.0215999247932683 -0.113971817017663 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.140225236022398 1 COAD TP53 TP53 PD0325901 0.808916339853021 -0.0242069316578357 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.896892141798002 0 COAD TP53 TP53 PD0332991 0.255256958228273 -0.036751165561272 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.512221588580807 0 COAD TP53 TP53 PF2341066 0.700444569100341 0.00649128406316812 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.811495252300017 0 COAD TP53 TP53 PHA665752 0.0884255911267541 -0.0227280104290588 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.260943971812122 0 COAD TP53 TP53 PLX4720 0.100319685556738 -0.0513577335345509 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.369577395380993 0 COAD TP53 TP53 RAF265 0.314526663287183 -0.0276351125242458 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.604919145727398 0 COAD TP53 TP53 Sorafenib 0.509561451948509 -0.0231148095195399 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.807176265738212 0 COAD TP53 TP53 TAE684 0.601586391064941 -0.0201266251902623 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.799532371542555 0 COAD TP53 TP53 TKI258 0.176369731662505 -0.0790603880529814 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.473025952631722 0 COAD TP53 TP53 Topotecan 0.085387035019615 -0.116878857907667 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.301978538484004 0 COAD TP53 TP53 ZD6474 0.00316382876743529 -0.0796742581821752 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.0352888593290859 1 ESCA TP53 TP53 17-AAG 0.157029483939068 -0.159589987089598 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.379487919519414 0 ESCA TP53 TP53 AEW541 0.0673013129514799 -0.132466236220149 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.271074732721238 0 ESCA TP53 TP53 AZD0530 0.51172233143489 0.102751021369781 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.764945753175866 0 ESCA TP53 TP53 AZD6244 0.564898868261456 -0.243405516267603 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.785588984525203 0 ESCA TP53 TP53 Erlotinib 0.107903813779689 0.167198130305005 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.289741722186202 0 ESCA TP53 TP53 Irinotecan 0.946709578845434 -0.128728488196862 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.973566588174383 0 ESCA TP53 TP53 L685458 0.182522690648922 -0.0795273675142972 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.45880039290054 0 ESCA TP53 TP53 Lapatinib 0.968010868326465 0.00986334396381894 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.994211181100197 0 ESCA TP53 TP53 LBW242 0.134268047298696 0.0650862309173919 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 1 0 ESCA TP53 TP53 Nilotinib 0.678372309089509 -0.0629365385422379 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.847965386361886 0 ESCA TP53 TP53 Nutlin3 0.841052672972386 -0.046155169542048 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.917341274328711 0 ESCA TP53 TP53 Paclitaxel 0.037319735921205 0.548231820294997 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.180378723619157 2 ESCA TP53 TP53 Panobinostat 0.120536982609182 -0.281732106618164 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.330600267099532 0 ESCA TP53 TP53 PD0325901 0.494581501411332 -0.245838345369928 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.739322862934465 0 ESCA TP53 TP53 PD0332991 0.0807834278433412 -0.137291959829486 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.27240923342522 0 ESCA TP53 TP53 PF2341066 0.231431080976819 -0.0556061425208203 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.479392953451982 0 ESCA TP53 TP53 PHA665752 0.0324478486917673 -0.0866019992185184 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.142573880615341 1 ESCA TP53 TP53 PLX4720 0.477745033481544 -0.068810515328481 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.791842381808024 0 ESCA TP53 TP53 RAF265 0.989334488868495 0.020660312514386 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.989334488868495 0 ESCA TP53 TP53 Sorafenib 0.51172233143489 -0.0502449745246321 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.807176265738212 0 ESCA TP53 TP53 TAE684 0.242210248949606 -0.124908349167929 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.516477736730777 0 ESCA TP53 TP53 TKI258 0.883087138555901 -0.0303574360532208 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.959342395190069 0 ESCA TP53 TP53 Topotecan 0.718012204870049 0.0133010417906343 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.882303133103026 0 ESCA TP53 TP53 ZD6474 0.0153173611949596 0.131344350350068 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.116895651224692 2 ESCA TP53 TP53 17-AAG 0.530911994497929 -0.0723862428978976 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.756002304022029 0 ESCA TP53 TP53 AEW541 0.0510276034885796 -0.108139248832935 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.231218828307626 0 ESCA TP53 TP53 AZD0530 0.546571497886747 0.113185165725015 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.771368198236586 0 ESCA TP53 TP53 AZD6244 0.896663587776713 -0.0957350025474 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.95600161932076 0 ESCA TP53 TP53 Erlotinib 0.361873658676374 0.0970853404004763 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.583018672311936 0 ESCA TP53 TP53 Irinotecan 0.280643211119428 -0.210401087739177 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.625841804288989 0 ESCA TP53 TP53 L685458 0.0974249137415543 -0.0754989763655013 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.355434843159538 0 ESCA TP53 TP53 Lapatinib 0.971745575865022 0.0350538074012017 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.994211181100197 0 ESCA TP53 TP53 LBW242 0.325444989485064 0.0344040805306671 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 1 0 ESCA TP53 TP53 Nilotinib 0.546571497886747 -0.0855239356888017 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.769445312559013 0 ESCA TP53 TP53 Nutlin3 0.485309867126256 -0.0283709994307741 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.74073611298218 0 ESCA TP53 TP53 Paclitaxel 0.0926042703973243 0.416592095617943 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.29205207901756 0 ESCA TP53 TP53 Panobinostat 0.325444989485064 -0.225464899770931 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.555170864415697 0 ESCA TP53 TP53 PD0325901 0.644945107437839 -0.124117231475626 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.825166897472712 0 ESCA TP53 TP53 PD0332991 0.546571497886747 -0.069582363080943 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.728588989560006 0 ESCA TP53 TP53 PF2341066 0.0712450742637398 -0.0697186181039875 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.258263394206057 0 ESCA TP53 TP53 PHA665752 0.130578502873626 -0.0569840506528285 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.334110707610379 0 ESCA TP53 TP53 PLX4720 0.822477050900027 -0.0455984071415453 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.927016689503416 0 ESCA TP53 TP53 RAF265 0.470584119949695 -0.0244213999997878 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.745662374723171 0 ESCA TP53 TP53 Sorafenib 0.187258201530577 -0.0638947533171618 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.502822948554327 0 ESCA TP53 TP53 TAE684 0.42789065634767 -0.0699743150414289 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.64629317885846 0 ESCA TP53 TP53 TKI258 0.628055764995427 0.00312175750849986 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.888524196411969 0 ESCA TP53 TP53 Topotecan 0.822477050900027 -0.0197092302027206 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.940917023721381 0 ESCA TP53 TP53 ZD6474 0.00796273771357656 0.166827891595174 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.0721623105292876 2 ESCA TP53 TP53 17-AAG 0.934817787660816 -0.0209810723540191 11 213:216:220:224 0.0601092896174863 0.982236081237814 0 ESCA TP53 TP53 AEW541 0.030564865348612 -0.15848601605415 11 213:216:220:224 0.0601092896174863 0.168867255122632 1 ESCA TP53 TP53 AZD0530 0.960863491060442 0.0749128608205314 11 213:216:220:224 0.0601092896174863 0.995180044312601 0 ESCA TP53 TP53 AZD6244 0.611649866933515 -0.254561129776931 11 213:216:220:224 0.0601092896174863 0.799002078426664 0 ESCA TP53 TP53 Erlotinib 0.216287894067126 0.138787171415981 11 213:216:220:224 0.0601092896174863 0.454518038257004 0 ESCA TP53 TP53 Irinotecan 0.28486592471085 -0.243485255136602 11 213:216:220:224 0.0601092896174863 0.625841804288989 0 ESCA TP53 TP53 L685458 0.107822210747029 -0.0855983572333075 11 213:216:220:224 0.0601092896174863 0.381322452641932 0 ESCA TP53 TP53 Lapatinib 0.75585669937237 0.0214687721506657 11 213:216:220:224 0.0601092896174863 0.8569095338034 0 ESCA TP53 TP53 LBW242 0.421321036874266 0.0347381528020256 11 213:216:220:224 0.0601092896174863 1 0 ESCA TP53 TP53 Nilotinib 0.960863491060442 -0.0500286840649231 11 213:216:220:224 0.0601092896174863 0.98401675142912 0 ESCA TP53 TP53 Nutlin3 0.40248703007978 -0.0540153423573978 11 213:216:220:224 0.0601092896174863 0.67329174137326 0 ESCA TP53 TP53 Paclitaxel 0.255901076387892 0.351989810234417 11 213:216:220:224 0.0601092896174863 0.588872462745123 0 ESCA TP53 TP53 Panobinostat 0.0751884047702931 -0.267026339381153 11 213:216:220:224 0.0601092896174863 0.286545176672071 0 ESCA TP53 TP53 PD0325901 0.658441339704835 -0.216936768452084 11 213:216:220:224 0.0601092896174863 0.825166897472712 0 ESCA TP53 TP53 PD0332991 0.115487069406457 -0.148245599043089 11 213:216:220:224 0.0601092896174863 0.319707579225012 0 ESCA TP53 TP53 PF2341066 0.270125637363745 -0.0471099929961852 11 213:216:220:224 0.0601092896174863 0.517986105871644 0 ESCA TP53 TP53 PHA665752 0.059713584365158 -0.0883995555879813 11 213:216:220:224 0.0601092896174863 0.211182188608486 0 ESCA TP53 TP53 PLX4720 0.75585669937237 -0.0880223562201068 11 213:216:220:224 0.0601092896174863 0.89835427384421 0 ESCA TP53 TP53 RAF265 0.908839186631505 0.0285449104645852 11 213:216:220:224 0.0601092896174863 0.9673168432365 0 ESCA TP53 TP53 Sorafenib 0.52266724197955 -0.0348097217310961 11 213:216:220:224 0.0601092896174863 0.807176265738212 0 ESCA TP53 TP53 TAE684 0.192382357680401 -0.136255968257072 11 213:216:220:224 0.0601092896174863 0.442784791486637 0 ESCA TP53 TP53 TKI258 0.908839186631505 -0.00880646077705305 11 213:216:220:224 0.0601092896174863 0.959342395190069 0 ESCA TP53 TP53 Topotecan 0.908839186631505 -0.0634562899850919 11 213:216:220:224 0.0601092896174863 0.96898295633506 0 ESCA TP53 TP53 ZD6474 0.0936671989475758 0.111024676794336 11 213:216:220:224 0.0601092896174863 0.410193048864343 0 ESCA TP53 TP53 17-AAG 0.65390107183771 -0.0651918725481666 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.819443075531059 0 ESCA TP53 TP53 AEW541 0.314956435323441 -0.0644909023051616 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.64322088904083 0 ESCA TP53 TP53 AZD0530 0.382350071949652 0.113348399874986 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.686878953488684 0 ESCA TP53 TP53 AZD6244 0.993499406844079 0.0458811877882161 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 1 0 ESCA TP53 TP53 Erlotinib 0.902728315090688 0.0284538838015354 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.934968612058213 0 ESCA TP53 TP53 Irinotecan 0.0618767962346085 -0.261780454986294 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.32043340907208 0 ESCA TP53 TP53 L685458 0.248937205241634 -0.055634623899588 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.474945983684696 0 ESCA TP53 TP53 Lapatinib 0.838582308326267 0.00358966931018156 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.914243869979765 0 ESCA TP53 TP53 LBW242 0.928586758884943 0.00584245664878846 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 1 0 ESCA TP53 TP53 Nilotinib 0.596124363190477 -0.0706097085166093 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.815453138326596 0 ESCA TP53 TP53 Nutlin3 0.607495867728389 -0.0230626980212409 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.816230497417743 0 ESCA TP53 TP53 Paclitaxel 0.738271473474923 0.070339837723167 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.892078030448865 0 ESCA TP53 TP53 Panobinostat 0.763012678592014 -0.116993772470506 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.875816151937502 0 ESCA TP53 TP53 PD0325901 0.993499406844079 0.037949894407614 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 1 0 ESCA TP53 TP53 PD0332991 0.68960316789087 -0.0556601969407796 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.826383961522117 0 ESCA TP53 TP53 PF2341066 0.477834707773516 -0.0234828502134584 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.659866977401522 0 ESCA TP53 TP53 PHA665752 0.291797748399302 -0.042109023089531 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.538412065726142 0 ESCA TP53 TP53 PLX4720 0.65390107183771 -0.0588741263540542 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.877019401596361 0 ESCA TP53 TP53 RAF265 0.607495867728389 -0.0228848309692191 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.808553891169371 0 ESCA TP53 TP53 Sorafenib 0.642166549147721 -0.0378948107219289 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.831376335950175 0 ESCA TP53 TP53 TAE684 0.677621926859314 -0.0376714132451144 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.854392864300874 0 ESCA TP53 TP53 TKI258 0.928586758884943 -0.037486296744728 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.961750571702263 0 ESCA TP53 TP53 Topotecan 0.77547495359227 -0.0457819205659535 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.93679525703097 0 ESCA TP53 TP53 ZD6474 0.176692696967295 0.0670090411202187 30 237:238:239:241:242:245:246:248:250:253:255 0.163934426229508 0.546043030477178 0 ESCA TP53 TP53 17-AAG 0.0466182364289904 -0.189720200579317 20 272:273:274:275:278:280:282:285 0.109289617486339 0.198813067123636 1 ESCA TP53 TP53 AEW541 0.000359879958166556 -0.190649443359424 20 272:273:274:275:278:280:282:285 0.109289617486339 0.00902431152580788 1 ESCA TP53 TP53 AZD0530 0.461644152222472 0.109491751069144 20 272:273:274:275:278:280:282:285 0.109289617486339 0.727615782349407 0 ESCA TP53 TP53 AZD6244 0.306047334753921 -0.348396660823148 20 272:273:274:275:278:280:282:285 0.109289617486339 0.577366362839037 0 ESCA TP53 TP53 Erlotinib 0.0945647901301961 0.172555221983672 20 272:273:274:275:278:280:282:285 0.109289617486339 0.268860677821146 0 ESCA TP53 TP53 Irinotecan 0.108681148764569 -0.263413852107249 20 272:273:274:275:278:280:282:285 0.109289617486339 0.41023116820951 0 ESCA TP53 TP53 L685458 0.00580555678455469 -0.0966301624864853 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0495179843388488 1 ESCA TP53 TP53 Lapatinib 0.991249570477997 0.00140265995333921 20 272:273:274:275:278:280:282:285 0.109289617486339 0.998133248050761 0 ESCA TP53 TP53 LBW242 0.238399193024327 0.0370463611286245 20 272:273:274:275:278:280:282:285 0.109289617486339 1 0 ESCA TP53 TP53 Nilotinib 0.700946314279567 -0.0668578327837079 20 272:273:274:275:278:280:282:285 0.109289617486339 0.857743649286645 0 ESCA TP53 TP53 Nutlin3 0.956268476172532 -0.0362392531742176 20 272:273:274:275:278:280:282:285 0.109289617486339 0.956268476172532 0 ESCA TP53 TP53 Paclitaxel 0.0576306175892071 0.461639944318815 20 272:273:274:275:278:280:282:285 0.109289617486339 0.214267680780385 0 ESCA TP53 TP53 Panobinostat 0.0859825687084628 -0.271781560387841 20 272:273:274:275:278:280:282:285 0.109289617486339 0.292935191977058 0 ESCA TP53 TP53 PD0325901 0.229654185888299 -0.401786411442527 20 272:273:274:275:278:280:282:285 0.109289617486339 0.475712242197191 0 ESCA TP53 TP53 PD0332991 0.0466182364289904 -0.141374998912046 20 272:273:274:275:278:280:282:285 0.109289617486339 0.187767896727878 1 ESCA TP53 TP53 PF2341066 0.0161642771643921 -0.0864673288585219 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0976591745348689 1 ESCA TP53 TP53 PHA665752 0.00196298183616346 -0.104527158649726 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0237193638536418 1 ESCA TP53 TP53 PLX4720 0.921369737739836 -0.0501633446056132 20 272:273:274:275:278:280:282:285 0.109289617486339 0.978697382843298 0 ESCA TP53 TP53 RAF265 0.422356264751098 0.0571312612540651 20 272:273:274:275:278:280:282:285 0.109289617486339 0.703927107918497 0 ESCA TP53 TP53 Sorafenib 0.316639439467172 -0.0535686952353683 20 272:273:274:275:278:280:282:285 0.109289617486339 0.636793644603903 0 ESCA TP53 TP53 TAE684 0.0353497108161146 -0.168244437034188 20 272:273:274:275:278:280:282:285 0.109289617486339 0.20706063802039 0 ESCA TP53 TP53 TKI258 0.545885904899297 0.0195120337864647 20 272:273:274:275:278:280:282:285 0.109289617486339 0.863421346550092 0 ESCA TP53 TP53 Topotecan 0.817817347238582 -0.0340962561020928 20 272:273:274:275:278:280:282:285 0.109289617486339 0.940917023721381 0 ESCA TP53 TP53 ZD6474 0.00118328027839505 0.162979927779846 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0190639600408091 2 GBM EGFR EGFR 17-AAG 0.00994777596108504 -0.215664875682569 12 289 0.08 0.0801348619087406 1 GBM EGFR EGFR AEW541 0.338489272712471 0.0278415099748091 12 289 0.08 0.656586643346452 0 GBM EGFR EGFR AZD0530 0.904324084714368 -0.00130865781550416 12 289 0.08 0.964169060908701 0 GBM EGFR EGFR AZD6244 0.12676217071654 -0.17964996829259 12 289 0.08 0.344101183665249 0 GBM EGFR EGFR Erlotinib 0.224227430818177 0.0242780723206669 12 289 0.08 0.464471106694795 0 GBM EGFR EGFR Irinotecan 0.347552622083784 -0.0722317664890548 12 289 0.08 0.637913040533528 0 GBM EGFR EGFR L685458 0.518588441128337 -0.0183127869180923 12 289 0.08 0.723031961188547 0 GBM EGFR EGFR Lapatinib 0.96094264914553 -0.00206919515361165 12 289 0.08 0.994211181100197 0 GBM EGFR EGFR LBW242 0.827318325130335 -0.00702606214769275 12 289 0.08 1 0 GBM EGFR EGFR Nilotinib 0.256279059170973 -0.0524311596695618 12 289 0.08 0.571699439689094 0 GBM EGFR EGFR Nutlin3 0.248895076680972 -0.0195222719866969 12 289 0.08 0.494380631763574 0 GBM EGFR EGFR Paclitaxel 0.0360080810945265 -0.171488854184935 12 289 0.08 0.180378723619157 1 GBM EGFR EGFR Panobinostat 0.260027553460473 -0.0576612216662529 12 289 0.08 0.502719936690248 0 GBM EGFR EGFR PD0325901 0.0881812588414951 -0.300629324629441 12 289 0.08 0.297355407721321 0 GBM EGFR EGFR PD0332991 0.772296494420371 -0.00731150787717849 12 289 0.08 0.874867122585577 0 GBM EGFR EGFR PF2341066 0.33401502174562 -0.039067399976344 12 289 0.08 0.576684487335405 0 GBM EGFR EGFR PHA665752 0.0881812588414951 -0.0484692629267361 12 289 0.08 0.260943971812122 0 GBM EGFR EGFR PLX4720 0.329579090993187 -0.064961585729358 12 289 0.08 0.682699545628745 0 GBM EGFR EGFR RAF265 0.0337080035592337 -0.0956027665356531 12 289 0.08 0.135768347669136 1 GBM EGFR EGFR Sorafenib 0.0608970651324189 -0.0471550389718315 12 289 0.08 0.245279845672243 0 GBM EGFR EGFR TAE684 0.0234509143402643 -0.0970900996641522 12 289 0.08 0.15748144968018 1 GBM EGFR EGFR TKI258 0.897274912204461 -0.000385928646545297 12 289 0.08 0.959342395190069 0 GBM EGFR EGFR Topotecan 1 0.000351851765339806 12 289 0.08 1 0 GBM EGFR EGFR ZD6474 0.799683107749203 -0.00739983371320119 12 289 0.08 0.935113311480923 0 GBM EGFR EGFR 17-AAG 0.400120752556247 -0.0756202696511408 12 596:598 0.08 0.703231692747136 0 GBM EGFR EGFR AEW541 0.820388008980545 -0.0119005510290104 12 596:598 0.08 0.887733293299843 0 GBM EGFR EGFR AZD0530 0.479038939967055 0.0195290661744068 12 596:598 0.08 0.738943045693861 0 GBM EGFR EGFR AZD6244 0.490168011345095 -0.0947798127234804 12 596:598 0.08 0.740357933802487 0 GBM EGFR EGFR Erlotinib 0.989344054361269 -0.00606382478198519 12 596:598 0.08 0.989344054361269 0 GBM EGFR EGFR Irinotecan 0.989344054361269 -0.0252033632774706 12 596:598 0.08 0.994408617783507 0 GBM EGFR EGFR L685458 0.876178176111138 0.00422648018526639 12 596:598 0.08 0.940915480959262 0 GBM EGFR EGFR Lapatinib 0.484586161094633 -0.0189323110672223 12 596:598 0.08 0.709747407663856 0 GBM EGFR EGFR LBW242 0.325181500896721 0.0345597992430987 12 596:598 0.08 1 0 GBM EGFR EGFR Nilotinib 0.621194005004606 0.0127938457211345 12 596:598 0.08 0.841313416915054 0 GBM EGFR EGFR Nutlin3 0.738461729286355 0.00412383161304619 12 596:598 0.08 0.89606661749022 0 GBM EGFR EGFR Paclitaxel 0.0496136805898035 -0.134266979297247 12 596:598 0.08 0.199832880153375 1 GBM EGFR EGFR Panobinostat 0.705126097562626 -0.0167417475211113 12 596:598 0.08 0.859187261735973 0 GBM EGFR EGFR PD0325901 0.530190470743002 -0.155084961623421 12 596:598 0.08 0.753982608416788 0 GBM EGFR EGFR PD0332991 0.479038939967055 -0.0152812069723939 12 596:598 0.08 0.70712568686602 0 GBM EGFR EGFR PF2341066 0.536040531095303 0.0163716950827776 12 596:598 0.08 0.693981044721598 0 GBM EGFR EGFR PHA665752 0.718396696781287 0.0091610579610179 12 596:598 0.08 0.877092920919321 0 GBM EGFR EGFR PLX4720 0.813471688659877 -0.0140474044194305 12 596:598 0.08 0.927016689503416 0 GBM EGFR EGFR RAF265 0.79281187469602 -0.0158131722286226 12 596:598 0.08 0.934249438301629 0 GBM EGFR EGFR Sorafenib 0.820388008980545 0.00188131836849226 12 596:598 0.08 0.917914256371406 0 GBM EGFR EGFR TAE684 0.462607238630308 -0.0450146006220173 12 596:598 0.08 0.671725091482899 0 GBM EGFR EGFR TKI258 0.731752784235908 0.0306272453949883 12 596:598 0.08 0.921239375376304 0 GBM EGFR EGFR Topotecan 0.640179707738047 -0.00924111364753522 12 596:598 0.08 0.842630498667059 0 GBM EGFR EGFR ZD6474 0.806569883076115 0.00627860745453546 12 596:598 0.08 0.935621064368293 0 GBM PTEN PTEN 17-AAG 0.0393729749787502 0.178009320859896 10 129:130:131:132:136 0.0666666666666667 0.184163915223186 2 GBM PTEN PTEN AEW541 0.197163890610003 -0.0503467613018269 10 129:130:131:132:136 0.0666666666666667 0.468668264564761 0 GBM PTEN PTEN AZD0530 0.463476613475646 -0.038841154594057 10 129:130:131:132:136 0.0666666666666667 0.727615782349407 0 GBM PTEN PTEN AZD6244 0.12457866347364 0.116433178344431 10 129:130:131:132:136 0.0666666666666667 0.344101183665249 0 GBM PTEN PTEN Erlotinib 0.456975190842192 -0.0162731608826927 10 129:130:131:132:136 0.0666666666666667 0.683107244042452 0 GBM PTEN PTEN Irinotecan 0.641525510256247 -0.061705429384689 10 129:130:131:132:136 0.0666666666666667 0.831248558064582 0 GBM PTEN PTEN L685458 0.885116480040425 -0.0113686174322759 10 129:130:131:132:136 0.0666666666666667 0.940915480959262 0 GBM PTEN PTEN Lapatinib 0.38306159172367 -0.0219919437336056 10 129:130:131:132:136 0.0666666666666667 0.61037286593332 0 GBM PTEN PTEN LBW242 0.111981573320185 0.0431082158514785 10 129:130:131:132:136 0.0666666666666667 1 0 GBM PTEN PTEN Nilotinib 0.524248640958089 0.0105786721177421 10 129:130:131:132:136 0.0666666666666667 0.752634187514088 0 GBM PTEN PTEN Nutlin3 0.711946796087612 0.000506711697355944 10 129:130:131:132:136 0.0666666666666667 0.895167134863111 0 GBM PTEN PTEN Paclitaxel 0.69605734905209 -0.0334028071418961 10 129:130:131:132:136 0.0666666666666667 0.892078030448865 0 GBM PTEN PTEN Panobinostat 0.656925778023571 0.00534783758299096 10 129:130:131:132:136 0.0666666666666667 0.834160500928178 0 GBM PTEN PTEN PD0325901 0.114417156377708 0.203842499140027 10 129:130:131:132:136 0.0666666666666667 0.338581381117707 0 GBM PTEN PTEN PD0332991 0.31182308546176 -0.0250377498741293 10 129:130:131:132:136 0.0666666666666667 0.56517934239944 0 GBM PTEN PTEN PF2341066 0.365795443414459 0.038478469274606 10 129:130:131:132:136 0.0666666666666667 0.588703668570395 0 GBM PTEN PTEN PHA665752 0.20090717885004 0.034962685764815 10 129:130:131:132:136 0.0666666666666667 0.422196245409504 0 GBM PTEN PTEN PLX4720 0.793155023647347 -0.0254627096063602 10 129:130:131:132:136 0.0666666666666667 0.912757765308455 0 GBM PTEN PTEN RAF265 0.277336174787562 0.044704860335278 10 129:130:131:132:136 0.0666666666666667 0.550873223893103 0 GBM PTEN PTEN Sorafenib 0.425247626851538 0.0145383037384517 10 129:130:131:132:136 0.0666666666666667 0.726991153689387 0 GBM PTEN PTEN TAE684 0.826334489398399 -0.00208963782424854 10 129:130:131:132:136 0.0666666666666667 0.943937105852541 0 GBM PTEN PTEN TKI258 0.744097534596152 0.0113524144655288 10 129:130:131:132:136 0.0666666666666667 0.922172158260188 0 GBM PTEN PTEN Topotecan 0.859827026692079 -0.0358971992958685 10 129:130:131:132:136 0.0666666666666667 0.940917023721381 0 GBM PTEN PTEN ZD6474 0.483286736593619 -0.0353695772693488 10 129:130:131:132:136 0.0666666666666667 0.770072272594228 0 GBM TP53 TP53 17-AAG 0.43621198070654 -0.0545616455739175 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.706823826958002 0 GBM TP53 TP53 AEW541 0.884581556723646 0.0123981583345976 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.929451635687889 0 GBM TP53 TP53 AZD0530 0.425914996846878 -0.0223956319600231 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.71811249468369 0 GBM TP53 TP53 AZD6244 0.478806583478187 -0.081615362695062 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.730810048466706 0 GBM TP53 TP53 Erlotinib 0.0886850331853656 -0.0409501530517559 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.25718659623756 0 GBM TP53 TP53 Irinotecan 0.721607587154524 0.0973560816318675 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.87194250114505 0 GBM TP53 TP53 L685458 0.23668836713982 -0.0113936022791687 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.474945983684696 0 GBM TP53 TP53 Lapatinib 0.188418542034227 -0.0307733763521293 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.413949827196408 0 GBM TP53 TP53 LBW242 0.056815847904233 -0.0569540213364795 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 1 0 GBM TP53 TP53 Nilotinib 0.0627814932496056 -0.0748662386468512 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.337159871155289 0 GBM TP53 TP53 Nutlin3 0.00396062076964332 -0.0488128923108759 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.0607502083038393 1 GBM TP53 TP53 Paclitaxel 0.884581556723646 0.00146478348230428 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.957196460633796 0 GBM TP53 TP53 Panobinostat 0.0382763403468527 -0.0632604840722104 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.19734998332249 1 GBM TP53 TP53 PD0325901 0.305389463072354 -0.143029490045268 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.560524963866979 0 GBM TP53 TP53 PD0332991 0.213172390484769 -0.0178216325366163 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.454558773827816 0 GBM TP53 TP53 PF2341066 0.386170081886611 -0.0227100719814809 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.58941749340588 0 GBM TP53 TP53 PHA665752 0.185479899271085 -0.0342122069823912 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.407493718095566 0 GBM TP53 TP53 PLX4720 0.0177396220127572 -0.131329302570282 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.151308540697047 1 GBM TP53 TP53 RAF265 0.168556610341152 -0.0573469339207888 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.414249296601136 0 GBM TP53 TP53 Sorafenib 0.0920310807436957 -0.037569206165426 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.332007366961092 0 GBM TP53 TP53 TAE684 0.968419901365204 0.0027865675687313 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.984846233442031 0 GBM TP53 TP53 TKI258 0.233221011613128 -0.0994438087980234 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.58305252903282 0 GBM TP53 TP53 Topotecan 0.0762688548334433 -0.112390050421442 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.283563691047417 0 GBM TP53 TP53 ZD6474 0.715030103332726 0.0284028427562468 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.910370895332992 0 HNSC CDKN2A CDKN2A 17-AAG 0.123956620932198 -0.0695141344224828 12 58 0.0240480961923848 0.343479841576651 0 HNSC CDKN2A CDKN2A AEW541 0.73633144570633 0.0105468644485085 12 58 0.0240480961923848 0.843121071823001 0 HNSC CDKN2A CDKN2A AZD0530 0.272306096380228 0.0837030541458754 12 58 0.0240480961923848 0.570250045569471 0 HNSC CDKN2A CDKN2A AZD6244 0.369457231834075 -0.0835054965339872 12 58 0.0240480961923848 0.627350862443665 0 HNSC CDKN2A CDKN2A Erlotinib 0.00487558214680525 -0.0686181247854551 12 58 0.0240480961923848 0.0607346511562043 1 HNSC CDKN2A CDKN2A Irinotecan 0.153227366349562 -0.159451669141859 12 58 0.0240480961923848 0.465634304540565 0 HNSC CDKN2A CDKN2A L685458 0.0685662246760311 -0.0532613307102099 12 58 0.0240480961923848 0.292414781706603 0 HNSC CDKN2A CDKN2A Lapatinib 0.0232448167292092 -0.0749062511789815 12 58 0.0240480961923848 0.116224083646046 1 HNSC CDKN2A CDKN2A LBW242 0.4310838764709 0.0185324161581182 12 58 0.0240480961923848 1 0 HNSC CDKN2A CDKN2A Nilotinib 0.160560339065163 -0.0530745338673294 12 58 0.0240480961923848 0.447716330085551 0 HNSC CDKN2A CDKN2A Nutlin3 0.86384082772773 -0.00131802075966636 12 58 0.0240480961923848 0.917341274328711 0 HNSC CDKN2A CDKN2A Paclitaxel 0.824659354202346 -0.0391719543038995 12 58 0.0240480961923848 0.919010695591438 0 HNSC CDKN2A CDKN2A Panobinostat 0.929182968257335 -0.0253299179146378 12 58 0.0240480961923848 0.969291585592184 0 HNSC CDKN2A CDKN2A PD0325901 0.19948387753139 -0.131593299925894 12 58 0.0240480961923848 0.448151505729182 0 HNSC CDKN2A CDKN2A PD0332991 0.453383385884121 -0.0433791648815159 12 58 0.0240480961923848 0.699367988863804 0 HNSC CDKN2A CDKN2A PF2341066 0.528943061999786 -0.012766422096677 12 58 0.0240480961923848 0.693981044721598 0 HNSC CDKN2A CDKN2A PHA665752 0.0917802935339187 -0.0344050465058866 12 58 0.0240480961923848 0.260943971812122 0 HNSC CDKN2A CDKN2A PLX4720 0.65316395885453 -0.0200778855302173 12 58 0.0240480961923848 0.877019401596361 0 HNSC CDKN2A CDKN2A RAF265 0.266876389298615 -0.0365015598875338 12 58 0.0240480961923848 0.537459395115266 0 HNSC CDKN2A CDKN2A Sorafenib 0.0450679215960716 -0.0566732131643248 12 58 0.0240480961923848 0.221896308143565 0 HNSC CDKN2A CDKN2A TAE684 0.204797007823247 -0.0574756855777772 12 58 0.0240480961923848 0.458469343101435 0 HNSC CDKN2A CDKN2A TKI258 0.480981967045086 -0.0816280897572101 12 58 0.0240480961923848 0.792527104790198 0 HNSC CDKN2A CDKN2A Topotecan 0.119137500912025 -0.18254503999256 12 58 0.0240480961923848 0.392612218914628 0 HNSC CDKN2A CDKN2A ZD6474 0.328271581071373 0.0584075798885022 12 58 0.0240480961923848 0.715965674999802 0 HNSC CDKN2A CDKN2A 17-AAG 0.258250148400938 -0.030278678078973 33 80:83:84:87:88:90 0.0661322645290581 0.5760964848944 0 HNSC CDKN2A CDKN2A AEW541 0.368426663367545 -0.0174046381188121 33 80:83:84:87:88:90 0.0661322645290581 0.660796770817279 0 HNSC CDKN2A CDKN2A AZD0530 0.0177878304831185 0.112596761095895 33 80:83:84:87:88:90 0.0661322645290581 0.0955272377797105 2 HNSC CDKN2A CDKN2A AZD6244 0.204998857241213 -0.062197104762 33 80:83:84:87:88:90 0.0661322645290581 0.471822766666284 0 HNSC CDKN2A CDKN2A Erlotinib 0.923771990643521 0.0140556654423725 33 80:83:84:87:88:90 0.0661322645290581 0.949978288250429 0 HNSC CDKN2A CDKN2A Irinotecan 0.04624395883187 0.142390450303711 33 80:83:84:87:88:90 0.0661322645290581 0.274719342741761 0 HNSC CDKN2A CDKN2A L685458 0.648148075810034 -0.00177328678503502 33 80:83:84:87:88:90 0.0661322645290581 0.789760260440798 0 HNSC CDKN2A CDKN2A Lapatinib 0.243073893576951 -0.024918615928055 33 80:83:84:87:88:90 0.0661322645290581 0.463759402219183 0 HNSC CDKN2A CDKN2A LBW242 0.0545427239879196 0.0278816852564394 33 80:83:84:87:88:90 0.0661322645290581 1 0 HNSC CDKN2A CDKN2A Nilotinib 0.0679488788619982 0.0345127036311998 33 80:83:84:87:88:90 0.0661322645290581 0.339744394309991 0 HNSC CDKN2A CDKN2A Nutlin3 0.244264416034777 0.00997015752000652 33 80:83:84:87:88:90 0.0661322645290581 0.49192139340337 0 HNSC CDKN2A CDKN2A Paclitaxel 0.731607228998572 -0.0135806954611386 33 80:83:84:87:88:90 0.0661322645290581 0.892078030448865 0 HNSC CDKN2A CDKN2A Panobinostat 0.54712776378043 -0.0445237771873765 33 80:83:84:87:88:90 0.0661322645290581 0.770228405321965 0 HNSC CDKN2A CDKN2A PD0325901 0.0579594843273765 -0.116709235492272 33 80:83:84:87:88:90 0.0661322645290581 0.221161190196568 0 HNSC CDKN2A CDKN2A PD0332991 0.83902302009264 -0.0189757826023316 33 80:83:84:87:88:90 0.0661322645290581 0.928689602392617 0 HNSC CDKN2A CDKN2A PF2341066 0.271496165836172 0.0169460514214588 33 80:83:84:87:88:90 0.0661322645290581 0.517986105871644 0 HNSC CDKN2A CDKN2A PHA665752 0.750512666898932 -0.00557935811595145 33 80:83:84:87:88:90 0.0661322645290581 0.877092920919321 0 HNSC CDKN2A CDKN2A PLX4720 0.00468670615315181 0.0980215715505429 33 80:83:84:87:88:90 0.0661322645290581 0.0522747994005394 2 HNSC CDKN2A CDKN2A RAF265 0.955391188078121 -0.00310770995012311 33 80:83:84:87:88:90 0.0661322645290581 0.988055037433057 0 HNSC CDKN2A CDKN2A Sorafenib 0.246657729287301 0.01510426741142 33 80:83:84:87:88:90 0.0661322645290581 0.582277123494778 0 HNSC CDKN2A CDKN2A TAE684 0.424102121176192 -0.0277587353213249 33 80:83:84:87:88:90 0.0661322645290581 0.64629317885846 0 HNSC CDKN2A CDKN2A TKI258 0.949528986906974 -0.0282293676023939 33 80:83:84:87:88:90 0.0661322645290581 0.971503724878681 0 HNSC CDKN2A CDKN2A Topotecan 0.49738093409935 -0.0548054242769211 33 80:83:84:87:88:90 0.0661322645290581 0.775486402628019 0 HNSC CDKN2A CDKN2A ZD6474 0.668383643044733 -0.00882655630050055 33 80:83:84:87:88:90 0.0661322645290581 0.881051165831693 0 HNSC CDKN2A CDKN2A 17-AAG 0.53435357668176 -0.0551598860353844 19 108:110:114:118:120 0.0380761523046092 0.756002304022029 0 HNSC CDKN2A CDKN2A AEW541 0.127793873323613 0.0317665839846935 19 108:110:114:118:120 0.0380761523046092 0.373852057889815 0 HNSC CDKN2A CDKN2A AZD0530 0.466677708679275 0.0581029892997309 19 108:110:114:118:120 0.0380761523046092 0.727615782349407 0 HNSC CDKN2A CDKN2A AZD6244 0.651464200097225 0.0389462384070516 19 108:110:114:118:120 0.0380761523046092 0.821411382731284 0 HNSC CDKN2A CDKN2A Erlotinib 0.194293781949859 0.0407818504452953 19 108:110:114:118:120 0.0380761523046092 0.440196849730149 0 HNSC CDKN2A CDKN2A Irinotecan 0.575327405234569 -0.0202594118469053 19 108:110:114:118:120 0.0380761523046092 0.802139170759736 0 HNSC CDKN2A CDKN2A L685458 0.668609154140048 0.00272587440730104 19 108:110:114:118:120 0.0380761523046092 0.794658420904155 0 HNSC CDKN2A CDKN2A Lapatinib 0.522739965306935 0.0202096475966222 19 108:110:114:118:120 0.0380761523046092 0.716406762711615 0 HNSC CDKN2A CDKN2A LBW242 0.420919361266711 0.015899106610634 19 108:110:114:118:120 0.0380761523046092 1 0 HNSC CDKN2A CDKN2A Nilotinib 0.299458206713817 0.0251770873666681 19 108:110:114:118:120 0.0380761523046092 0.62929623150005 0 HNSC CDKN2A CDKN2A Nutlin3 0.416379909987508 0.012532974531006 19 108:110:114:118:120 0.0380761523046092 0.67329174137326 0 HNSC CDKN2A CDKN2A Paclitaxel 0.446400439408261 0.0277668070781152 19 108:110:114:118:120 0.0380761523046092 0.748298203965188 0 HNSC CDKN2A CDKN2A Panobinostat 0.837453331216678 0.00733309951323413 19 108:110:114:118:120 0.0380761523046092 0.921561008340168 0 HNSC CDKN2A CDKN2A PD0325901 0.843622838262498 0.0281015340576578 19 108:110:114:118:120 0.0380761523046092 0.926706905667138 0 HNSC CDKN2A CDKN2A PD0332991 0.306868460126483 0.0175700939709104 19 108:110:114:118:120 0.0380761523046092 0.563239578713165 0 HNSC CDKN2A CDKN2A PF2341066 0.267598412328055 0.0154184196226675 19 108:110:114:118:120 0.0380761523046092 0.517986105871644 0 HNSC CDKN2A CDKN2A PHA665752 0.309678356579916 0.0105725341533696 19 108:110:114:118:120 0.0380761523046092 0.54583632016244 0 HNSC CDKN2A CDKN2A PLX4720 0.599780758147831 0.0254682983884613 19 108:110:114:118:120 0.0380761523046092 0.852629509131721 0 HNSC CDKN2A CDKN2A RAF265 0.831293802897559 -0.00826847280923926 19 108:110:114:118:120 0.0380761523046092 0.949114971812174 0 HNSC CDKN2A CDKN2A Sorafenib 0.984261823257477 -0.00393184347291498 19 108:110:114:118:120 0.0380761523046092 0.984261823257477 0 HNSC CDKN2A CDKN2A TAE684 0.690284943663269 0.00733891448657187 19 108:110:114:118:120 0.0380761523046092 0.859245198290398 0 HNSC CDKN2A CDKN2A TKI258 0.879272574394109 0.000706882228030281 19 108:110:114:118:120 0.0380761523046092 0.959342395190069 0 HNSC CDKN2A CDKN2A Topotecan 0.848256295446318 -0.00238470778054722 19 108:110:114:118:120 0.0380761523046092 0.940917023721381 0 HNSC CDKN2A CDKN2A ZD6474 0.0818858533409807 0.071254588425161 19 108:110:114:118:120 0.0380761523046092 0.410193048864343 0 HNSC HRAS HRAS 17-AAG 0.0274972367443925 0.0758258834699461 25 12:13 0.0501002004008016 0.147246531215636 2 HNSC HRAS HRAS AEW541 0.559332665572426 -0.0098773836454904 25 12:13 0.0501002004008016 0.752244949119026 0 HNSC HRAS HRAS AZD0530 0.138626659069023 0.067473785076823 25 12:13 0.0501002004008016 0.402017311300167 0 HNSC HRAS HRAS AZD6244 0.036222623471232 0.11647673363648 25 12:13 0.0501002004008016 0.159590117997514 2 HNSC HRAS HRAS Erlotinib 0.00854399719553809 -0.0393135376059919 25 12:13 0.0501002004008016 0.0728752701972366 1 HNSC HRAS HRAS Irinotecan 0.000176028724339069 0.332053686638767 25 12:13 0.0501002004008016 0.00850805500972167 2 HNSC HRAS HRAS L685458 0.55641565607394 0.00732275128370619 25 12:13 0.0501002004008016 0.747039538247419 0 HNSC HRAS HRAS Lapatinib 0.276876921945776 -0.0296146948712264 25 12:13 0.0501002004008016 0.510375068112605 0 HNSC HRAS HRAS LBW242 0.0754788387044261 -0.0269676569638477 25 12:13 0.0501002004008016 1 0 HNSC HRAS HRAS Nilotinib 0.124916344142153 0.0421674530785595 25 12:13 0.0501002004008016 0.411656134104822 0 HNSC HRAS HRAS Nutlin3 0.00195399900747659 0.0410620447164297 25 12:13 0.0501002004008016 0.0566659712168211 2 HNSC HRAS HRAS Paclitaxel 0.0227159369041313 0.139963269112006 25 12:13 0.0501002004008016 0.156848135766621 2 HNSC HRAS HRAS Panobinostat 0.627362619696041 0.0292171673678947 25 12:13 0.0501002004008016 0.805850920143751 0 HNSC HRAS HRAS PD0325901 0.0462466658796718 0.110075936094211 25 12:13 0.0501002004008016 0.191593330072926 2 HNSC HRAS HRAS PD0332991 0.0616646036334468 0.0430845594487272 25 12:13 0.0501002004008016 0.229265834021789 0 HNSC HRAS HRAS PF2341066 5.88490776676095e-05 0.064549275955108 25 12:13 0.0501002004008016 0.00426655813090169 2 HNSC HRAS HRAS PHA665752 0.135568115927352 0.018245473089514 25 12:13 0.0501002004008016 0.334110707610379 0 HNSC HRAS HRAS PLX4720 3.03595375627369e-05 0.161261869702121 25 12:13 0.0501002004008016 0.00349235196641606 2 HNSC HRAS HRAS RAF265 0.0190405030226182 0.0636794288250597 25 12:13 0.0501002004008016 0.0869142697142903 2 HNSC HRAS HRAS Sorafenib 0.0517284687537226 0.041874851394078 25 12:13 0.0501002004008016 0.228949479597925 0 HNSC HRAS HRAS TAE684 0.783937296992069 0.00696028076074229 25 12:13 0.0501002004008016 0.924153724096342 0 HNSC HRAS HRAS TKI258 0.0105886877518349 0.147004276253518 25 12:13 0.0501002004008016 0.076767986200803 2 HNSC HRAS HRAS Topotecan 0.0449940181874372 0.163025052182729 25 12:13 0.0501002004008016 0.197700989005406 2 HNSC HRAS HRAS ZD6474 0.388088562323356 -0.0287137292672257 25 12:13 0.0501002004008016 0.739978986852158 0 HNSC NFE2L2 NFE2L2 17-AAG 0.198121720294108 -0.0515287945351233 13 24:28:29:30:32:34 0.0260521042084168 0.463349184558801 0 HNSC NFE2L2 NFE2L2 AEW541 0.159493632033999 -0.0396297657268083 13 24:28:29:30:32:34 0.0260521042084168 0.391975875337794 0 HNSC NFE2L2 NFE2L2 AZD0530 0.00366100065457706 0.159404784325661 13 24:28:29:30:32:34 0.0260521042084168 0.0370435174342952 2 HNSC NFE2L2 NFE2L2 AZD6244 0.694256791015776 0.041152983954946 13 24:28:29:30:32:34 0.0260521042084168 0.839296016389673 0 HNSC NFE2L2 NFE2L2 Erlotinib 0.151804849009567 0.0475750997691404 13 24:28:29:30:32:34 0.0260521042084168 0.366861718439787 0 HNSC NFE2L2 NFE2L2 Irinotecan 0.0780220418470262 -0.194681476353406 13 24:28:29:30:32:34 0.0260521042084168 0.37710653559396 0 HNSC NFE2L2 NFE2L2 L685458 0.120413392494687 -0.0425035069145099 13 24:28:29:30:32:34 0.0260521042084168 0.387998709149547 0 HNSC NFE2L2 NFE2L2 Lapatinib 0.628031086647315 -0.0191361749156072 13 24:28:29:30:32:34 0.0260521042084168 0.813075960391613 0 HNSC NFE2L2 NFE2L2 LBW242 0.00844426005866577 -0.0600152800094551 13 24:28:29:30:32:34 0.0260521042084168 1 0 HNSC NFE2L2 NFE2L2 Nilotinib 0.135673616679255 -0.0472011147289548 13 24:28:29:30:32:34 0.0260521042084168 0.418689328721262 0 HNSC NFE2L2 NFE2L2 Nutlin3 0.719931539118219 -0.00859560400463721 13 24:28:29:30:32:34 0.0260521042084168 0.895167134863111 0 HNSC NFE2L2 NFE2L2 Paclitaxel 0.0287533256233344 0.184693578552292 13 24:28:29:30:32:34 0.0260521042084168 0.173718008974312 2 HNSC NFE2L2 NFE2L2 Panobinostat 0.00870025697425151 -0.18884702204863 13 24:28:29:30:32:34 0.0260521042084168 0.0700854034036927 1 HNSC NFE2L2 NFE2L2 PD0325901 0.729070970326572 0.0548546250018282 13 24:28:29:30:32:34 0.0260521042084168 0.868135580610847 0 HNSC NFE2L2 NFE2L2 PD0332991 0.180991818077685 -0.0601296736486393 13 24:28:29:30:32:34 0.0260521042084168 0.423287316472005 0 HNSC NFE2L2 NFE2L2 PF2341066 0.111923459925598 -0.0320550799337316 13 24:28:29:30:32:34 0.0260521042084168 0.334693632312871 0 HNSC NFE2L2 NFE2L2 PHA665752 0.770659339541353 -0.0019488761512122 13 24:28:29:30:32:34 0.0260521042084168 0.879886647507844 0 HNSC NFE2L2 NFE2L2 PLX4720 0.384040992373649 -0.0436736843857226 13 24:28:29:30:32:34 0.0260521042084168 0.769266275380849 0 HNSC NFE2L2 NFE2L2 RAF265 0.860513832191079 -0.0169853520492365 13 24:28:29:30:32:34 0.0260521042084168 0.952477142501576 0 HNSC NFE2L2 NFE2L2 Sorafenib 0.248973666597767 -0.0335986760827853 13 24:28:29:30:32:34 0.0260521042084168 0.582277123494778 0 HNSC NFE2L2 NFE2L2 TAE684 0.247309651619808 -0.052294105374064 13 24:28:29:30:32:34 0.0260521042084168 0.518188266916398 0 HNSC NFE2L2 NFE2L2 TKI258 0.516307914994781 -0.0682861665799233 13 24:28:29:30:32:34 0.0260521042084168 0.831829418602703 0 HNSC NFE2L2 NFE2L2 Topotecan 0.338150011022036 -0.134517295777934 13 24:28:29:30:32:34 0.0260521042084168 0.672501135222698 0 HNSC NFE2L2 NFE2L2 ZD6474 0.405478203510902 0.0389987351007679 13 24:28:29:30:32:34 0.0260521042084168 0.739978986852158 0 HNSC NOTCH1 NOTCH1 17-AAG 0.893049157295022 0.0203410171089939 10 449:454:455:456:461:465:468 0.0200400801603206 0.945198013195461 0 HNSC NOTCH1 NOTCH1 AEW541 0.903583813081344 0.00790822917182499 10 449:454:455:456:461:465:468 0.0200400801603206 0.935854663548535 0 HNSC NOTCH1 NOTCH1 AZD0530 0.663352927749607 -0.0164510460484848 10 449:454:455:456:461:465:468 0.0200400801603206 0.882441968107275 0 HNSC NOTCH1 NOTCH1 AZD6244 0.294813124777245 -0.0892897108845654 10 449:454:455:456:461:465:468 0.0200400801603206 0.569972041236007 0 HNSC NOTCH1 NOTCH1 Erlotinib 0.303486686720529 -0.0727811771379669 10 449:454:455:456:461:465:468 0.0200400801603206 0.550069619680959 0 HNSC NOTCH1 NOTCH1 Irinotecan 0.760491697156598 0.0432950602080164 10 449:454:455:456:461:465:468 0.0200400801603206 0.896514602339079 0 HNSC NOTCH1 NOTCH1 L685458 0.498051104969183 0.0157122720000342 10 449:454:455:456:461:465:468 0.0200400801603206 0.712950676140981 0 HNSC NOTCH1 NOTCH1 Lapatinib 0.523718047223663 -0.0458056078299744 10 449:454:455:456:461:465:468 0.0200400801603206 0.716406762711615 0 HNSC NOTCH1 NOTCH1 LBW242 0.986193254444265 -0.00226032073989524 10 449:454:455:456:461:465:468 0.0200400801603206 1 0 HNSC NOTCH1 NOTCH1 Nilotinib 0.392033984144252 0.0432156631309807 10 449:454:455:456:461:465:468 0.0200400801603206 0.682464106351632 0 HNSC NOTCH1 NOTCH1 Nutlin3 0.316168826803707 0.0298917917540605 10 449:454:455:456:461:465:468 0.0200400801603206 0.580309871981488 0 HNSC NOTCH1 NOTCH1 Paclitaxel 0.728266631624493 0.0169289499582135 10 449:454:455:456:461:465:468 0.0200400801603206 0.892078030448865 0 HNSC NOTCH1 NOTCH1 Panobinostat 0.276791151951203 0.0935052097723581 10 449:454:455:456:461:465:468 0.0200400801603206 0.508034392821828 0 HNSC NOTCH1 NOTCH1 PD0325901 0.182699525458221 -0.139084016590391 10 449:454:455:456:461:465:468 0.0200400801603206 0.448010695353218 0 HNSC NOTCH1 NOTCH1 PD0332991 0.380360054761312 0.0455574736842055 10 449:454:455:456:461:465:468 0.0200400801603206 0.633933424602187 0 HNSC NOTCH1 NOTCH1 PF2341066 0.3604512909675 0.0242229618146395 10 449:454:455:456:461:465:468 0.0200400801603206 0.588703668570395 0 HNSC NOTCH1 NOTCH1 PHA665752 0.542962545010002 0.010938174871214 10 449:454:455:456:461:465:468 0.0200400801603206 0.722289624095874 0 HNSC NOTCH1 NOTCH1 PLX4720 0.153196189986342 0.059497018632885 10 449:454:455:456:461:465:468 0.0200400801603206 0.459613915651279 0 HNSC NOTCH1 NOTCH1 RAF265 0.323942739258919 -0.0392662070180083 10 449:454:455:456:461:465:468 0.0200400801603206 0.606352849891732 0 HNSC NOTCH1 NOTCH1 Sorafenib 0.230382827396194 0.0351000645049361 10 449:454:455:456:461:465:468 0.0200400801603206 0.556758499540802 0 HNSC NOTCH1 NOTCH1 TAE684 0.95859629527181 0.00258993879319558 10 449:454:455:456:461:465:468 0.0200400801603206 0.984846233442031 0 HNSC NOTCH1 NOTCH1 TKI258 0.303486686720529 0.0912403847293066 10 449:454:455:456:461:465:468 0.0200400801603206 0.666751054158738 0 HNSC NOTCH1 NOTCH1 Topotecan 0.886737288352496 0.0331003548275519 10 449:454:455:456:461:465:468 0.0200400801603206 0.952421531934162 0 HNSC NOTCH1 NOTCH1 ZD6474 0.101841032821492 -0.0726124322762747 10 449:454:455:456:461:465:468 0.0200400801603206 0.410193048864343 0 HNSC PIK3CA PIK3CA 17-AAG 0.360968756909284 0.0309546123298503 47 542:545:546 0.094188376753507 0.664341939262211 0 HNSC PIK3CA PIK3CA AEW541 0.00298256330024727 -0.0432209726221411 47 542:545:546 0.094188376753507 0.0332670521950657 1 HNSC PIK3CA PIK3CA AZD0530 0.892586590575895 -0.0233486733593391 47 542:545:546 0.094188376753507 0.958704115803739 0 HNSC PIK3CA PIK3CA AZD6244 0.730817710269302 0.0107786079378984 47 542:545:546 0.094188376753507 0.854585225718135 0 HNSC PIK3CA PIK3CA Erlotinib 0.0112045811936321 0.038790109016418 47 542:545:546 0.094188376753507 0.0791708260175595 2 HNSC PIK3CA PIK3CA Irinotecan 0.0828683643027099 0.132028881116173 47 542:545:546 0.094188376753507 0.379164567227334 0 HNSC PIK3CA PIK3CA L685458 0.157442336934087 0.0258845000168444 47 542:545:546 0.094188376753507 0.449648285948942 0 HNSC PIK3CA PIK3CA Lapatinib 0.00426345673782436 0.0581655654762525 47 542:545:546 0.094188376753507 0.0412134151323021 2 HNSC PIK3CA PIK3CA LBW242 0.107438026048938 -0.0156111268774686 47 542:545:546 0.094188376753507 1 0 HNSC PIK3CA PIK3CA Nilotinib 0.421211660994662 0.0165964775866233 47 542:545:546 0.094188376753507 0.682464106351632 0 HNSC PIK3CA PIK3CA Nutlin3 0.886091703018475 0.00152588464246084 47 542:545:546 0.094188376753507 0.917737835269135 0 HNSC PIK3CA PIK3CA Paclitaxel 0.0441605619380593 0.1163884876082 47 542:545:546 0.094188376753507 0.188331808265253 2 HNSC PIK3CA PIK3CA Panobinostat 0.746769039293121 0.0199548279447246 47 542:545:546 0.094188376753507 0.875816151937502 0 HNSC PIK3CA PIK3CA PD0325901 0.72552597286454 -0.0157546002792397 47 542:545:546 0.094188376753507 0.868135580610847 0 HNSC PIK3CA PIK3CA PD0332991 0.771796954124649 0.0172882009192259 47 542:545:546 0.094188376753507 0.874867122585577 0 HNSC PIK3CA PIK3CA PF2341066 0.949442954426202 -0.00224185065817406 47 542:545:546 0.094188376753507 0.962721876865729 0 HNSC PIK3CA PIK3CA PHA665752 0.0304617223268539 0.0267593508503352 47 542:545:546 0.094188376753507 0.138029679293557 2 HNSC PIK3CA PIK3CA PLX4720 0.843620865173422 0.005718394724749 47 542:545:546 0.094188376753507 0.940352289112414 0 HNSC PIK3CA PIK3CA RAF265 0.550848541263993 -0.0143888045540272 47 542:545:546 0.094188376753507 0.79873038483279 0 HNSC PIK3CA PIK3CA Sorafenib 0.213695280524847 0.0204145002104004 47 542:545:546 0.094188376753507 0.534238201312117 0 HNSC PIK3CA PIK3CA TAE684 0.390708221649289 0.0206676882154029 47 542:545:546 0.094188376753507 0.64629317885846 0 HNSC PIK3CA PIK3CA TKI258 0.268180571427729 0.0621629087267026 47 542:545:546 0.094188376753507 0.627196497693882 0 HNSC PIK3CA PIK3CA Topotecan 0.138385749622263 0.103907084638728 47 542:545:546 0.094188376753507 0.413001291751911 0 HNSC PIK3CA PIK3CA ZD6474 0.737893295797924 0.000682693170767523 47 542:545:546 0.094188376753507 0.910370895332992 0 HNSC TP53 TP53 17-AAG 0.991165444771066 -0.00457783377098053 10 101:103:104:105:110 0.0200400801603206 0.994159764319742 0 HNSC TP53 TP53 AEW541 0.523131559157534 0.0147486168326845 10 101:103:104:105:110 0.0200400801603206 0.722419772169928 0 HNSC TP53 TP53 AZD0530 0.0758446069257366 0.179143278257882 10 101:103:104:105:110 0.0200400801603206 0.274936700105795 0 HNSC TP53 TP53 AZD6244 0.306601447852454 -0.106684286764861 10 101:103:104:105:110 0.0200400801603206 0.577366362839037 0 HNSC TP53 TP53 Erlotinib 0.949969327763792 -0.0389138173040378 10 101:103:104:105:110 0.0200400801603206 0.963255612068181 0 HNSC TP53 TP53 Irinotecan 0.095993427249771 -0.263740481080296 10 101:103:104:105:110 0.0200400801603206 0.390791012941619 0 HNSC TP53 TP53 L685458 0.0325954743912203 -0.0781274624629584 10 101:103:104:105:110 0.0200400801603206 0.175049769878776 1 HNSC TP53 TP53 Lapatinib 0.00583161383985842 -0.143495334318719 10 101:103:104:105:110 0.0200400801603206 0.04974023569291 1 HNSC TP53 TP53 LBW242 0.903057658326039 -0.0039865662468217 10 101:103:104:105:110 0.0200400801603206 1 0 HNSC TP53 TP53 Nilotinib 0.393882360780335 -0.0479915030219275 10 101:103:104:105:110 0.0200400801603206 0.682464106351632 0 HNSC TP53 TP53 Nutlin3 0.299669298406354 -0.0331489634612646 10 101:103:104:105:110 0.0200400801603206 0.571737477222649 0 HNSC TP53 TP53 Paclitaxel 0.00168397514089337 -0.358938354333985 10 101:103:104:105:110 0.0200400801603206 0.0241690496574986 1 HNSC TP53 TP53 Panobinostat 0.0770707716566261 -0.175936533067616 10 101:103:104:105:110 0.0200400801603206 0.286545176672071 0 HNSC TP53 TP53 PD0325901 0.955848877097384 -0.0481231024660986 10 101:103:104:105:110 0.0200400801603206 0.982965157298728 0 HNSC TP53 TP53 PD0332991 0.0613054266445749 -0.0980903293127858 10 101:103:104:105:110 0.0200400801603206 0.229265834021789 0 HNSC TP53 TP53 PF2341066 0.121986999396165 -0.0412436581195211 10 101:103:104:105:110 0.0200400801603206 0.334693632312871 0 HNSC TP53 TP53 PHA665752 0.0198613047816051 -0.0644544710421417 10 101:103:104:105:110 0.0200400801603206 0.0993065239080255 1 HNSC TP53 TP53 PLX4720 0.155317805978708 -0.0872651324204353 10 101:103:104:105:110 0.0200400801603206 0.459613915651279 0 HNSC TP53 TP53 RAF265 0.89721404158887 0.00280595277641571 10 101:103:104:105:110 0.0200400801603206 0.9673168432365 0 HNSC TP53 TP53 Sorafenib 0.0677004652984373 -0.0599149074540436 10 101:103:104:105:110 0.0200400801603206 0.258950503504941 0 HNSC TP53 TP53 TAE684 0.296242731513318 -0.0518366755950992 10 101:103:104:105:110 0.0200400801603206 0.58047562255988 0 HNSC TP53 TP53 TKI258 0.0397987938384773 -0.260130708073464 10 101:103:104:105:110 0.0200400801603206 0.198993969192386 1 HNSC TP53 TP53 Topotecan 0.144866620674396 -0.191432952436188 10 101:103:104:105:110 0.0200400801603206 0.420113199955748 0 HNSC TP53 TP53 ZD6474 0.532783861982084 0.0407903247709764 10 101:103:104:105:110 0.0200400801603206 0.803883136441038 0 HNSC TP53 TP53 17-AAG 0.505227054186736 -0.0221498685264767 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.743131537045869 0 HNSC TP53 TP53 AEW541 0.256470987918716 -0.0389454305375423 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.568886802508775 0 HNSC TP53 TP53 AZD0530 0.000614490402912619 0.216189398312863 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.014850184737055 2 HNSC TP53 TP53 AZD6244 0.606320970816337 -0.0405173622450758 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.799002078426664 0 HNSC TP53 TP53 Erlotinib 0.211559045525627 -0.0201735290698484 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.454518038257004 0 HNSC TP53 TP53 Irinotecan 0.0315694734089785 -0.238299005629455 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.240924928647467 0 HNSC TP53 TP53 L685458 0.000303223918160064 -0.0980185941865498 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.00732791135553488 1 HNSC TP53 TP53 Lapatinib 1.14328950424908e-05 -0.156011024087403 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.000552589927053722 1 HNSC TP53 TP53 LBW242 0.958485867065268 0.00285416338249411 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 1 0 HNSC TP53 TP53 Nilotinib 0.038289773890446 -0.0688882200218808 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.259813085953551 0 HNSC TP53 TP53 Nutlin3 0.00494027742350776 -0.0587647164251964 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0607502083038393 1 HNSC TP53 TP53 Paclitaxel 0.0368560314678533 -0.174451279857689 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.180378723619157 1 HNSC TP53 TP53 Panobinostat 0.000580098436378463 -0.247092206662733 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0120163247535539 1 HNSC TP53 TP53 PD0325901 0.348775298376938 0.0664846674331041 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.588051375170419 0 HNSC TP53 TP53 PD0332991 0.000506697975411541 -0.150888885885061 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.00865497417950243 1 HNSC TP53 TP53 PF2341066 0.00793692923532289 -0.052616675944911 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0767236492747879 1 HNSC TP53 TP53 PHA665752 0.000377589756207499 -0.0651741443699163 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.00912508577501456 1 HNSC TP53 TP53 PLX4720 0.235296480192253 -0.0581107478610775 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.550290155288334 0 HNSC TP53 TP53 RAF265 0.979235903530455 0.00461592037572722 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.988055037433057 0 HNSC TP53 TP53 Sorafenib 0.0226104083451293 -0.0601274851476072 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.13660455041849 1 HNSC TP53 TP53 TAE684 0.00426655396293196 -0.107088476369364 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0441893089017953 1 HNSC TP53 TP53 TKI258 0.00367723755407271 -0.247464165321885 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0333249653337839 1 HNSC TP53 TP53 Topotecan 0.00240748328740173 -0.320648291485217 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0290904230561042 1 HNSC TP53 TP53 ZD6474 0.381844409459471 0.0222585800221 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.739978986852158 0 HNSC TP53 TP53 17-AAG 0.671592983247818 -0.0175371166224432 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.822905843052979 0 HNSC TP53 TP53 AEW541 0.585984709608469 -0.0190743472670517 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.752244949119026 0 HNSC TP53 TP53 AZD0530 0.00121090368030882 0.179146022882825 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0175660329374408 2 HNSC TP53 TP53 AZD6244 0.871748619642229 0.00223836488221596 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.936322591467579 0 HNSC TP53 TP53 Erlotinib 0.0772679445887204 -0.0246550817913374 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.228650040109479 0 HNSC TP53 TP53 Irinotecan 0.00817238349331709 -0.199450951715384 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.118499560653098 1 HNSC TP53 TP53 L685458 0.000209701061770326 -0.0695301217587736 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00732791135553488 1 HNSC TP53 TP53 Lapatinib 6.26100630416088e-05 -0.0914246784260913 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00226961478525832 1 HNSC TP53 TP53 LBW242 0.45334154780296 -0.0073146847356822 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 1 0 HNSC TP53 TP53 Nilotinib 0.0131788393174572 -0.0536278451349924 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.136495121502235 1 HNSC TP53 TP53 Nutlin3 0.0547749830840094 -0.027427666349917 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.196107212464119 1 HNSC TP53 TP53 Paclitaxel 0.00774545852619616 -0.164011607697448 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0748727657532295 1 HNSC TP53 TP53 Panobinostat 0.0114982533529005 -0.134447366596722 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0877498282195038 1 HNSC TP53 TP53 PD0325901 0.198102696152198 0.0702819091309062 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.448151505729182 0 HNSC TP53 TP53 PD0332991 0.00458302811318126 -0.0836469748030502 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.039090533906546 1 HNSC TP53 TP53 PF2341066 0.0142166612305181 -0.0307298224360744 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0907580284145761 1 HNSC TP53 TP53 PHA665752 6.42271658644477e-05 -0.0476327017532366 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00310431301678164 1 HNSC TP53 TP53 PLX4720 0.43715076308444 -0.0256854074424459 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.782553835151158 0 HNSC 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PF2341066 0.0123057680563406 0.0651746362213518 15 107:112:115:116:117:118:120:121 0.040983606557377 0.0883764757820365 2 KIRC VHL VHL PHA665752 0.665595701141336 0.0134048658133143 15 107:112:115:116:117:118:120:121 0.040983606557377 0.862130279044413 0 KIRC VHL VHL PLX4720 0.609224116089335 0.0216070255818721 15 107:112:115:116:117:118:120:121 0.040983606557377 0.855934496427476 0 KIRC VHL VHL RAF265 0.249401893420998 0.056483120203068 15 107:112:115:116:117:118:120:121 0.040983606557377 0.530713589453383 0 KIRC VHL VHL Sorafenib 0.22841291079385 0.0285101548705774 15 107:112:115:116:117:118:120:121 0.040983606557377 0.556758499540802 0 KIRC VHL VHL TAE684 0.987747066904885 0.0267122854848421 15 107:112:115:116:117:118:120:121 0.040983606557377 0.987747066904885 0 KIRC VHL VHL TKI258 0.630895691452136 0.0342380907247493 15 107:112:115:116:117:118:120:121 0.040983606557377 0.888524196411969 0 KIRC VHL VHL Topotecan 0.251209929139488 0.092208321409279 15 107:112:115:116:117:118:120:121 0.040983606557377 0.587507092342351 0 KIRC VHL VHL ZD6474 0.931814182628087 0.0102127223909365 15 107:112:115:116:117:118:120:121 0.040983606557377 0.96509326057909 0 KIRC VHL VHL 17-AAG 0.424904124336862 0.0502489642360149 12 128:130:131:135:136 0.0327868852459016 0.706823826958002 0 KIRC VHL VHL AEW541 0.637035229117902 0.020168509336854 12 128:130:131:135:136 0.0327868852459016 0.794167116706957 0 KIRC VHL VHL AZD0530 0.822129264062228 0.0302447803564778 12 128:130:131:135:136 0.0327868852459016 0.934998064477449 0 KIRC VHL VHL AZD6244 0.346589182194307 0.0805452736928347 12 128:130:131:135:136 0.0327868852459016 0.620437424915735 0 KIRC VHL VHL Erlotinib 0.845265895553445 0.00577796811179876 12 128:130:131:135:136 0.0327868852459016 0.912366747423057 0 KIRC VHL VHL Irinotecan 0.605634114807605 -0.12240401721107 12 128:130:131:135:136 0.0327868852459016 0.828461760821724 0 KIRC VHL VHL L685458 0.799146300192519 -0.0103352999112958 12 128:130:131:135:136 0.0327868852459016 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PF2341066 0.334079289214993 0.042796356938121 12 128:130:131:135:136 0.0327868852459016 0.576684487335405 0 KIRC VHL VHL PHA665752 0.938955543580839 0.00338356272100926 12 128:130:131:135:136 0.0327868852459016 0.981403557938373 0 KIRC VHL VHL PLX4720 0.950753782832359 -0.0046744140791195 12 128:130:131:135:136 0.0327868852459016 0.978697382843298 0 KIRC VHL VHL RAF265 0.317061069484705 0.0457399111974781 12 128:130:131:135:136 0.0327868852459016 0.604919145727398 0 KIRC VHL VHL Sorafenib 0.907565986826197 -0.00841476993583201 12 128:130:131:135:136 0.0327868852459016 0.972333716193179 0 KIRC VHL VHL TAE684 0.402329229257917 0.0615007735272564 12 128:130:131:135:136 0.0327868852459016 0.64629317885846 0 KIRC VHL VHL TKI258 0.70912482946448 0.0370689608602541 12 128:130:131:135:136 0.0327868852459016 0.921239375376304 0 KIRC VHL VHL Topotecan 0.205040994193758 -0.0936337760650554 12 128:130:131:135:136 0.0327868852459016 0.530909717108838 0 KIRC VHL VHL ZD6474 0.868536763707171 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151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.802139170759736 0 KIRC VHL VHL L685458 0.480131706930234 0.0189913667571503 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.712950676140981 0 KIRC VHL VHL Lapatinib 0.380189244613095 -0.0246310334135558 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.61037286593332 0 KIRC VHL VHL LBW242 0.406094147494732 0.026723475628901 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 1 0 KIRC VHL VHL Nilotinib 0.951527036277361 0.0105298061138489 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.98401675142912 0 KIRC VHL VHL Nutlin3 0.345674240391901 0.0223756858855321 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.61879956613365 0 KIRC VHL VHL Paclitaxel 0.375132820339599 0.0941371801762658 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.686425949904921 0 KIRC VHL VHL Panobinostat 0.978860219200401 0.0103954901605201 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.995218754111337 0 KIRC VHL VHL PD0325901 0.573645710883475 0.0647759638566126 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.792177410267656 0 KIRC VHL VHL PD0332991 0.267760277370657 0.0339876228700066 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.512221588580807 0 KIRC VHL VHL PF2341066 0.110117174322998 0.0447478602518604 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.334693632312871 0 KIRC VHL VHL PHA665752 0.297054932814423 0.016292665747858 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.538412065726142 0 KIRC VHL VHL PLX4720 0.511687490924195 -0.00345182092894203 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.806463980260959 0 KIRC VHL VHL RAF265 0.499728651334563 0.0348986727915417 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.745662374723171 0 KIRC VHL VHL Sorafenib 0.413176150987312 0.0185654771346377 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.721813757748919 0 KIRC VHL VHL TAE684 0.693321987586045 0.0238490905937485 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.859245198290398 0 KIRC VHL VHL TKI258 0.556780935565115 0.0536301744944117 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.863421346550092 0 KIRC VHL VHL Topotecan 0.274548313058247 0.0914454098929678 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.603174324143118 0 KIRC VHL VHL ZD6474 0.254532550988045 -0.0421206523863213 28 151:153:156:158:159:160:161:162:164:165:168:169:173:175:177:178 0.0765027322404372 0.605036391692894 0 LAML FLT3 FLT3 17-AAG 0.482764939823958 0.0319613155059821 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.729176211192437 0 LAML FLT3 FLT3 AEW541 8.20411888098272e-05 -0.107163668061107 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00396532412580831 1 LAML FLT3 FLT3 AZD0530 0.229805114798749 0.04218121491417 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.515942709081624 0 LAML FLT3 FLT3 AZD6244 0.00197306198531411 0.296493509402906 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.0357617484838182 2 LAML FLT3 FLT3 Erlotinib 0.029589639566379 0.0194610345566208 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.128843068169096 2 LAML FLT3 FLT3 Irinotecan 0.120991248166977 0.0806223683829206 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.410975591222968 0 LAML FLT3 FLT3 L685458 0.622717042340876 0.00471114928568417 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.778685976507075 0 LAML FLT3 FLT3 Lapatinib 0.0467013197836907 0.0203144413290366 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.183018685638788 2 LAML FLT3 FLT3 LBW242 0.0148220283680745 -0.0429981373780223 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 1 0 LAML FLT3 FLT3 Nilotinib 0.00758793798886671 0.00836346582480108 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.100022818944152 2 LAML FLT3 FLT3 Nutlin3 0.415766769014721 -0.00148853331460885 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.67329174137326 0 LAML FLT3 FLT3 Paclitaxel 0.00273256695381326 0.0985820817942686 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.0330185173585769 2 LAML FLT3 FLT3 Panobinostat 0.000249075078807217 0.120655316068331 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00722317728540929 2 LAML FLT3 FLT3 PD0325901 0.00313327110137612 0.315047630817949 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.0567905387124422 2 LAML FLT3 FLT3 PD0332991 0.497426345243683 -0.00106657241584918 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.70712568686602 0 LAML FLT3 FLT3 PF2341066 0.00572471103549567 0.0631928146847398 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.063852546165144 2 LAML FLT3 FLT3 PHA665752 0.0451784095498292 0.0200735042068811 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.17584271195418 2 LAML FLT3 FLT3 PLX4720 0.192418152543809 0.0259663461658066 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.516678372571339 0 LAML FLT3 FLT3 RAF265 0.000109549717670959 0.13433751925509 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00317694181245781 2 LAML FLT3 FLT3 Sorafenib 0.000142887862832136 0.061585688004139 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00517968502766493 2 LAML FLT3 FLT3 TAE684 0.0532317032765599 0.0722516949593 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.241206155471912 0 LAML FLT3 FLT3 TKI258 0.000473490679895259 0.114919146061011 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00686561485848126 2 LAML FLT3 FLT3 Topotecan 0.248407670811389 -0.0205858262466743 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.587507092342351 0 LAML FLT3 FLT3 ZD6474 0.220884816630083 -0.014497267883806 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.546830087594659 0 LIHC CTNNB1 CTNNB1 17-AAG 0.615616123053015 0.0172214479826809 69 32:33:34:35:37:41:42:45 0.192737430167598 0.816774250615736 0 LIHC CTNNB1 CTNNB1 AEW541 0.387363624272198 -0.00634811982681005 69 32:33:34:35:37:41:42:45 0.192737430167598 0.660796770817279 0 LIHC CTNNB1 CTNNB1 AZD0530 0.011917475221755 -0.0611605812867266 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0751319090067163 1 LIHC CTNNB1 CTNNB1 AZD6244 0.00237822382604426 -0.125777569370878 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0383158283084909 1 LIHC CTNNB1 CTNNB1 Erlotinib 0.000201805850773456 -0.0484163411184463 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0076262395382254 1 LIHC CTNNB1 CTNNB1 Irinotecan 0.14202264154717 -0.0854422073908789 69 32:33:34:35:37:41:42:45 0.192737430167598 0.447680065746514 0 LIHC CTNNB1 CTNNB1 L685458 0.441947271133382 -0.00712670891719724 69 32:33:34:35:37:41:42:45 0.192737430167598 0.704201695761982 0 LIHC CTNNB1 CTNNB1 Lapatinib 0.0243250709473212 -0.0517512472882493 69 32:33:34:35:37:41:42:45 0.192737430167598 0.117571176245386 1 LIHC CTNNB1 CTNNB1 LBW242 1.8819593736406e-08 -0.0868991794212568 69 32:33:34:35:37:41:42:45 0.192737430167598 1 0 LIHC CTNNB1 CTNNB1 Nilotinib 0.277344716889979 0.0141882902559378 69 32:33:34:35:37:41:42:45 0.192737430167598 0.607339296144791 0 LIHC CTNNB1 CTNNB1 Nutlin3 0.0317113646196932 -0.0210902200233014 69 32:33:34:35:37:41:42:45 0.192737430167598 0.15456080002062 1 LIHC CTNNB1 CTNNB1 Paclitaxel 0.820570996509084 -0.0217864492866928 69 32:33:34:35:37:41:42:45 0.192737430167598 0.919010695591438 0 LIHC CTNNB1 CTNNB1 Panobinostat 0.247467068520326 0.0541759484303803 69 32:33:34:35:37:41:42:45 0.192737430167598 0.495156982023114 0 LIHC CTNNB1 CTNNB1 PD0325901 0.000696573462710588 -0.152376880276108 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0252507880232588 1 LIHC CTNNB1 CTNNB1 PD0332991 0.464785077173871 -0.0050741486259559 69 32:33:34:35:37:41:42:45 0.192737430167598 0.702019126981368 0 LIHC CTNNB1 CTNNB1 PF2341066 0.0119650254943576 -0.0311599626318665 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0883764757820365 1 LIHC CTNNB1 CTNNB1 PHA665752 0.0591856621651102 -0.0112811091534837 69 32:33:34:35:37:41:42:45 0.192737430167598 0.211182188608486 0 LIHC CTNNB1 CTNNB1 PLX4720 0.00013233335660759 0.0771969249303307 69 32:33:34:35:37:41:42:45 0.192737430167598 0.00383766734162011 2 LIHC CTNNB1 CTNNB1 RAF265 0.0562257148211773 -0.0466237598625258 69 32:33:34:35:37:41:42:45 0.192737430167598 0.194112586882636 1 LIHC CTNNB1 CTNNB1 Sorafenib 0.924476059389131 0.000741920428504517 69 32:33:34:35:37:41:42:45 0.192737430167598 0.972333716193179 0 LIHC CTNNB1 CTNNB1 TAE684 0.0354579649392006 -0.0425629506329979 69 32:33:34:35:37:41:42:45 0.192737430167598 0.20706063802039 0 LIHC CTNNB1 CTNNB1 TKI258 0.0697111637616052 0.0739510723080976 69 32:33:34:35:37:41:42:45 0.192737430167598 0.257337606466146 0 LIHC CTNNB1 CTNNB1 Topotecan 0.050674865775295 -0.0863415250353468 69 32:33:34:35:37:41:42:45 0.192737430167598 0.204107098261605 0 LIHC CTNNB1 CTNNB1 ZD6474 0.000273164646105775 0.0887268868486122 69 32:33:34:35:37:41:42:45 0.192737430167598 0.00622799922840304 2 LIHC TP53 TP53 17-AAG 0.405973577544922 0.0543206662288029 10 191:192:193:194:195:197 0.0279329608938547 0.703231692747136 0 LIHC TP53 TP53 AEW541 0.925667090685874 -0.00378526504689969 10 191:192:193:194:195:197 0.0279329608938547 0.949694837438315 0 LIHC TP53 TP53 AZD0530 0.81304569992515 -0.0287728948569036 10 191:192:193:194:195:197 0.0279329608938547 0.934998064477449 0 LIHC TP53 TP53 AZD6244 0.112725647969992 -0.161443256055971 10 191:192:193:194:195:197 0.0279329608938547 0.326904379112977 0 LIHC TP53 TP53 Erlotinib 0.746477715140836 -0.0319171004558081 10 191:192:193:194:195:197 0.0279329608938547 0.852277706263159 0 LIHC TP53 TP53 Irinotecan 0.345258996415573 0.174684785822004 10 191:192:193:194:195:197 0.0279329608938547 0.637913040533528 0 LIHC TP53 TP53 L685458 0.550727001822494 -0.0138839021877666 10 191:192:193:194:195:197 0.0279329608938547 0.746312292189361 0 LIHC TP53 TP53 Lapatinib 0.499815070197282 0.0271943763699913 10 191:192:193:194:195:197 0.0279329608938547 0.710521423319666 0 LIHC TP53 TP53 LBW242 0.640866018858646 -0.0205893280028193 10 191:192:193:194:195:197 0.0279329608938547 1 0 LIHC TP53 TP53 Nilotinib 0.963657784158173 0.00877801253614774 10 191:192:193:194:195:197 0.0279329608938547 0.98401675142912 0 LIHC TP53 TP53 Nutlin3 0.109803160030659 -0.0314931323218243 10 191:192:193:194:195:197 0.0279329608938547 0.289481058262646 0 LIHC TP53 TP53 Paclitaxel 0.448912170647867 0.134458261180608 10 191:192:193:194:195:197 0.0279329608938547 0.748298203965188 0 LIHC TP53 TP53 Panobinostat 0.343045667889937 -0.0566927486633872 10 191:192:193:194:195:197 0.0279329608938547 0.571742779816562 0 LIHC TP53 TP53 PD0325901 0.0909884642935589 -0.190184710478451 10 191:192:193:194:195:197 0.0279329608938547 0.298146273182703 0 LIHC TP53 TP53 PD0332991 0.187833324761165 -0.03885230154566 10 191:192:193:194:195:197 0.0279329608938547 0.427689232195893 0 LIHC TP53 TP53 PF2341066 0.401088423002686 0.0164609831374759 10 191:192:193:194:195:197 0.0279329608938547 0.599565168406077 0 LIHC TP53 TP53 PHA665752 0.710621943659683 0.0119752121438021 10 191:192:193:194:195:197 0.0279329608938547 0.877092920919321 0 LIHC TP53 TP53 PLX4720 0.228515866766211 -0.0623177467686136 10 191:192:193:194:195:197 0.0279329608938547 0.543193453788534 0 LIHC TP53 TP53 RAF265 0.901573681341415 0.022194619246812 10 191:192:193:194:195:197 0.0279329608938547 0.9673168432365 0 LIHC TP53 TP53 Sorafenib 0.707392485272803 0.0137005828082172 10 191:192:193:194:195:197 0.0279329608938547 0.882361413084552 0 LIHC TP53 TP53 TAE684 0.809680562864777 -0.00307831696413263 10 191:192:193:194:195:197 0.0279329608938547 0.939229452923141 0 LIHC TP53 TP53 TKI258 0.428392596644119 -0.0826556489927317 10 191:192:193:194:195:197 0.0279329608938547 0.766875635967867 0 LIHC TP53 TP53 Topotecan 0.505345969418525 -0.0530420407656909 10 191:192:193:194:195:197 0.0279329608938547 0.779523037932831 0 LIHC TP53 TP53 ZD6474 0.413367571965688 0.0405491696443852 10 191:192:193:194:195:197 0.0279329608938547 0.739978986852158 0 LIHC TP53 TP53 17-AAG 0.149401667081981 0.075025159441056 17 245:246:248:249 0.0474860335195531 0.373504167704952 0 LIHC TP53 TP53 AEW541 0.710574354962145 0.0125666222342462 17 245:246:248:249 0.0474860335195531 0.843121071823001 0 LIHC TP53 TP53 AZD0530 0.971184042675607 -0.00295199193417739 17 245:246:248:249 0.0474860335195531 0.998735363035199 0 LIHC TP53 TP53 AZD6244 0.356118658733162 0.101135643429428 17 245:246:248:249 0.0474860335195531 0.622135006220584 0 LIHC TP53 TP53 Erlotinib 0.490428996303633 -0.021115735443451 17 245:246:248:249 0.0474860335195531 0.704248870091984 0 LIHC TP53 TP53 Irinotecan 0.0251139994543264 0.259137624875476 17 245:246:248:249 0.0474860335195531 0.2377385824247 0 LIHC TP53 TP53 L685458 0.183520157160216 -0.011663149929605 17 245:246:248:249 0.0474860335195531 0.45880039290054 0 LIHC TP53 TP53 Lapatinib 0.147556654098729 0.05746325572676 17 245:246:248:249 0.0474860335195531 0.356595247405262 0 LIHC TP53 TP53 LBW242 0.645694880681846 0.028154193238767 17 245:246:248:249 0.0474860335195531 1 0 LIHC TP53 TP53 Nilotinib 0.795302727382033 0.000121439503626086 17 245:246:248:249 0.0474860335195531 0.922551163763158 0 LIHC TP53 TP53 Nutlin3 0.0137798222575819 -0.0384015857698913 17 245:246:248:249 0.0474860335195531 0.0999037113674688 1 LIHC TP53 TP53 Paclitaxel 0.492497012507155 0.131573222460353 17 245:246:248:249 0.0474860335195531 0.802382773185814 0 LIHC TP53 TP53 Panobinostat 0.669443612030842 -0.018529288094034 17 245:246:248:249 0.0474860335195531 0.836804515038553 0 LIHC TP53 TP53 PD0325901 0.636293904462736 0.0489319696175634 17 245:246:248:249 0.0474860335195531 0.825166897472712 0 LIHC TP53 TP53 PD0332991 0.103348483359032 -0.03291632564627 17 245:246:248:249 0.0474860335195531 0.297179094417211 0 LIHC TP53 TP53 PF2341066 0.356118658733162 0.0347498737080426 17 245:246:248:249 0.0474860335195531 0.588703668570395 0 LIHC TP53 TP53 PHA665752 0.496647032140694 0.0195940906741126 17 245:246:248:249 0.0474860335195531 0.696907272160628 0 LIHC TP53 TP53 PLX4720 5.59217599856638e-05 -0.161386101111345 17 245:246:248:249 0.0474860335195531 0.00349235196641606 1 LIHC TP53 TP53 RAF265 0.122721594297889 0.0792182334153788 17 245:246:248:249 0.0474860335195531 0.340713612390311 0 LIHC TP53 TP53 Sorafenib 0.818188472816484 0.011615697963502 17 245:246:248:249 0.0474860335195531 0.917914256371406 0 LIHC TP53 TP53 TAE684 0.00177016331898598 0.160441780325568 17 245:246:248:249 0.0474860335195531 0.0320842101566209 2 LIHC TP53 TP53 TKI258 0.163804612620963 -0.120349064252822 17 245:246:248:249 0.0474860335195531 0.448199814441618 0 LIHC TP53 TP53 Topotecan 0.438334335354488 -0.00470187244605214 17 245:246:248:249 0.0474860335195531 0.745156389465223 0 LIHC TP53 TP53 ZD6474 0.411655312948251 -0.0359084707902539 17 245:246:248:249 0.0474860335195531 0.739978986852158 0 LIHC TP53 TP53 17-AAG 0.966950114342578 -0.00372583956891726 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.984846233442031 0 LIHC TP53 TP53 AEW541 0.00733246919714817 0.0933150915222767 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.0603418050494983 2 LIHC TP53 TP53 AZD0530 0.682966596403284 -0.0288117571768047 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.88419782570068 0 LIHC TP53 TP53 AZD6244 0.694589806667316 0.0273813844170346 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.839296016389673 0 LIHC TP53 TP53 Erlotinib 0.0370240919355186 -0.0640302904618674 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.145094414341897 1 LIHC TP53 TP53 Irinotecan 0.15832712229904 0.313476653952116 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.46851903537471 0 LIHC TP53 TP53 L685458 0.153722764152659 0.0588551868875423 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.449648285948942 0 LIHC TP53 TP53 Lapatinib 0.651394999035574 0.00613515587257107 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.835860839470427 0 LIHC TP53 TP53 LBW242 0.712159329022863 0.0113396065257697 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 1 0 LIHC TP53 TP53 Nilotinib 0.134254420935911 0.0839828399128983 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.418689328721262 0 LIHC TP53 TP53 Nutlin3 0.747752142871149 0.00666792740494893 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.89606661749022 0 LIHC TP53 TP53 Paclitaxel 0.0313515834442159 0.301192545054864 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.180378723619157 2 LIHC TP53 TP53 Panobinostat 0.27177650269448 0.0920071324263061 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.508034392821828 0 LIHC TP53 TP53 PD0325901 0.882360409171585 -0.0161465465647597 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.938433143098641 0 LIHC TP53 TP53 PD0332991 0.851316954262029 0.00686945836776853 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.935158775515108 0 LIHC TP53 TP53 PF2341066 0.159494366102531 0.0331912516312668 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.373386709934991 0 LIHC TP53 TP53 PHA665752 0.0238755849528238 0.0553151843884544 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.115398660605315 2 LIHC TP53 TP53 PLX4720 0.973242692500512 0.0135090259641409 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.978697382843298 0 LIHC TP53 TP53 RAF265 0.0191810802128089 0.133507713285211 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.0869142697142903 2 LIHC TP53 TP53 Sorafenib 0.10869692826509 0.0630371081012499 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.350245657743068 0 LIHC TP53 TP53 TAE684 0.049169817573501 0.155829900016948 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.230411724809262 0 LIHC TP53 TP53 TKI258 0.466582965484515 0.0934948512191036 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.792527104790198 0 LIHC TP53 TP53 Topotecan 0.445126717096277 0.0958370027616398 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.745156389465223 0 LIHC TP53 TP53 ZD6474 0.369328947303535 -0.0521991631936636 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.733598593959076 0 LUAD BRAF BRAF 17-AAG 0.817128341807779 0.020126708278585 14 464:466:469 0.0275049115913556 0.918477593504868 0 LUAD BRAF BRAF AEW541 0.751166744800451 -0.0141030289533851 14 464:466:469 0.0275049115913556 0.843121071823001 0 LUAD BRAF BRAF AZD0530 0.143585425748057 -0.118348976344156 14 464:466:469 0.0275049115913556 0.40823307320526 0 LUAD BRAF BRAF AZD6244 0.958758252746358 -0.0544804769522902 14 464:466:469 0.0275049115913556 0.990629855225245 0 LUAD BRAF BRAF Erlotinib 0.554992052588641 0.0266087197715589 14 464:466:469 0.0275049115913556 0.766417596431933 0 LUAD BRAF BRAF Irinotecan 0.378288732351382 -0.136897256101011 14 464:466:469 0.0275049115913556 0.683762297256219 0 LUAD BRAF BRAF L685458 0.209925717240506 -0.0406111031572751 14 464:466:469 0.0275049115913556 0.464414853606848 0 LUAD BRAF BRAF Lapatinib 0.128722450689097 0.0605995788778095 14 464:466:469 0.0275049115913556 0.324316390107145 0 LUAD BRAF BRAF LBW242 0.017789708149856 -0.0797823515106659 14 464:466:469 0.0275049115913556 1 0 LUAD BRAF BRAF Nilotinib 0.100166239223489 -0.0609403002700077 14 464:466:469 0.0275049115913556 0.382213281247524 0 LUAD BRAF BRAF Nutlin3 0.107633142574188 -0.0486044959587523 14 464:466:469 0.0275049115913556 0.289481058262646 0 LUAD BRAF BRAF Paclitaxel 0.338487485810936 -0.158101387479894 14 464:466:469 0.0275049115913556 0.657917533572212 0 LUAD BRAF BRAF Panobinostat 0.468487406018276 -0.0507739554273208 14 464:466:469 0.0275049115913556 0.722666743326064 0 LUAD BRAF BRAF PD0325901 0.968090298009236 -0.037628829749951 14 464:466:469 0.0275049115913556 0.988542909939009 0 LUAD BRAF BRAF PD0332991 0.698496060238266 -0.0202794168159028 14 464:466:469 0.0275049115913556 0.830179743725808 0 LUAD BRAF BRAF PF2341066 0.0118587218094087 -0.0621073705661289 14 464:466:469 0.0275049115913556 0.0883764757820365 1 LUAD BRAF BRAF PHA665752 0.392171685607713 -0.014110441627372 14 464:466:469 0.0275049115913556 0.597216943251763 0 LUAD BRAF BRAF PLX4720 0.0245137729805003 -0.144797883964923 14 464:466:469 0.0275049115913556 0.172410275043407 1 LUAD BRAF BRAF RAF265 0.439092160006736 -0.0265339774644044 14 464:466:469 0.0275049115913556 0.70742625778863 0 LUAD BRAF BRAF Sorafenib 0.296939342308598 -0.026104575041796 14 464:466:469 0.0275049115913556 0.624002965720967 0 LUAD BRAF BRAF TAE684 0.94632453246952 0.00745062468972524 14 464:466:469 0.0275049115913556 0.984846233442031 0 LUAD BRAF BRAF TKI258 0.0727644266559446 -0.142182411931028 14 464:466:469 0.0275049115913556 0.257337606466146 0 LUAD BRAF BRAF Topotecan 0.157999280580659 -0.195241998966574 14 464:466:469 0.0275049115913556 0.432262182720671 0 LUAD BRAF BRAF ZD6474 0.985209480180015 0.011277340880103 14 464:466:469 0.0275049115913556 0.985922145811339 0 LUAD BRAF BRAF 17-AAG 0.277224401949381 0.065164757639907 16 594:596:600:604 0.031434184675835 0.591140268862651 0 LUAD BRAF BRAF AEW541 0.69734386409624 0.00730641858358649 16 594:596:600:604 0.031434184675835 0.842623835782957 0 LUAD BRAF BRAF AZD0530 0.0288894657453676 0.171997272243098 16 594:596:600:604 0.031434184675835 0.130905391658697 2 LUAD BRAF BRAF AZD6244 0.0410615558430778 0.228146533947085 16 594:596:600:604 0.031434184675835 0.16538682214573 2 LUAD BRAF BRAF Erlotinib 0.599216641290274 0.0233056746441036 16 594:596:600:604 0.031434184675835 0.781959988906675 0 LUAD BRAF BRAF Irinotecan 0.665286129662605 0.0383392119581134 16 594:596:600:604 0.031434184675835 0.83883903305285 0 LUAD BRAF BRAF L685458 0.944089366204441 -0.00141930468590179 16 594:596:600:604 0.031434184675835 0.964034916194676 0 LUAD BRAF BRAF Lapatinib 0.899256856310015 0.0103467214646975 16 594:596:600:604 0.031434184675835 0.958766501212884 0 LUAD BRAF BRAF LBW242 0.482541270579381 -0.0136625379768618 16 594:596:600:604 0.031434184675835 1 0 LUAD BRAF BRAF Nilotinib 0.173313102460439 0.0629106851996346 16 594:596:600:604 0.031434184675835 0.465377775125253 0 LUAD BRAF BRAF Nutlin3 0.504381928587124 0.0170559970895975 16 594:596:600:604 0.031434184675835 0.743373854209307 0 LUAD BRAF BRAF Paclitaxel 0.129400612667792 -0.177751658821112 16 594:596:600:604 0.031434184675835 0.390897684100622 0 LUAD BRAF BRAF Panobinostat 0.272420636216204 -0.0715271469087195 16 594:596:600:604 0.031434184675835 0.508034392821828 0 LUAD BRAF BRAF PD0325901 0.0266943440775024 0.268581290178102 16 594:596:600:604 0.031434184675835 0.137852407807249 2 LUAD BRAF BRAF PD0332991 0.95714489002463 -0.0024944967749958 16 594:596:600:604 0.031434184675835 0.984297936550151 0 LUAD BRAF BRAF PF2341066 0.623484986068269 0.00887895555837104 16 594:596:600:604 0.031434184675835 0.766146804914398 0 LUAD BRAF BRAF PHA665752 0.399517541347731 0.0179134712944555 16 594:596:600:604 0.031434184675835 0.597216943251763 0 LUAD BRAF BRAF PLX4720 0.201948273967638 0.112293860847289 16 594:596:600:604 0.031434184675835 0.525535397237866 0 LUAD BRAF BRAF RAF265 0.569189612365675 0.0328741941621165 16 594:596:600:604 0.031434184675835 0.805608273766497 0 LUAD BRAF BRAF Sorafenib 0.574143911550477 0.0211131373872959 16 594:596:600:604 0.031434184675835 0.831376335950175 0 LUAD BRAF BRAF TAE684 0.586618193887732 0.0169283556959423 16 594:596:600:604 0.031434184675835 0.794949888913282 0 LUAD BRAF BRAF TKI258 0.892052040830629 0.0323531279350728 16 594:596:600:604 0.031434184675835 0.959342395190069 0 LUAD BRAF BRAF Topotecan 0.272420636216204 0.0956978542932356 16 594:596:600:604 0.031434184675835 0.603174324143118 0 LUAD BRAF BRAF ZD6474 0.343060659247241 0.0460488951658979 16 594:596:600:604 0.031434184675835 0.720924573780434 0 LUAD CTNNB1 CTNNB1 17-AAG 0.0133827755010716 0.171669953453247 11 33:34:37:41:45 0.0216110019646365 0.0970251223827691 2 LUAD CTNNB1 CTNNB1 AEW541 0.724280639016845 -0.00117796179942953 11 33:34:37:41:45 0.0216110019646365 0.843121071823001 0 LUAD CTNNB1 CTNNB1 AZD0530 0.291874191681764 0.0938047041761731 11 33:34:37:41:45 0.0216110019646365 0.579750106765148 0 LUAD CTNNB1 CTNNB1 AZD6244 0.101115787031605 0.19992177757513 11 33:34:37:41:45 0.0216110019646365 0.31242646304435 0 LUAD CTNNB1 CTNNB1 Erlotinib 0.645411297210354 0.0151041947470416 11 33:34:37:41:45 0.0216110019646365 0.806764121512942 0 LUAD CTNNB1 CTNNB1 Irinotecan 0.185643110062473 0.148339394494524 11 33:34:37:41:45 0.0216110019646365 0.498486128871455 0 LUAD CTNNB1 CTNNB1 L685458 0.0241709899379066 0.0578987377398591 11 33:34:37:41:45 0.0216110019646365 0.146033064208186 2 LUAD CTNNB1 CTNNB1 Lapatinib 0.0279818862657847 0.102636718121674 11 33:34:37:41:45 0.0216110019646365 0.122950712379963 2 LUAD CTNNB1 CTNNB1 LBW242 0.0742974100454811 -0.0780391804598199 11 33:34:37:41:45 0.0216110019646365 1 0 LUAD CTNNB1 CTNNB1 Nilotinib 0.0395374904334859 0.0858195692454247 11 33:34:37:41:45 0.0216110019646365 0.259813085953551 0 LUAD CTNNB1 CTNNB1 Nutlin3 0.768927898853558 -0.00993209024800046 11 33:34:37:41:45 0.0216110019646365 0.898414789240926 0 LUAD CTNNB1 CTNNB1 Paclitaxel 0.26662033795827 -0.194976962124841 11 33:34:37:41:45 0.0216110019646365 0.588872462745123 0 LUAD CTNNB1 CTNNB1 Panobinostat 0.000529617831785219 0.25679752260404 11 33:34:37:41:45 0.0216110019646365 0.0120163247535539 2 LUAD CTNNB1 CTNNB1 PD0325901 0.0677153822374786 0.306253409892346 11 33:34:37:41:45 0.0216110019646365 0.251762318575241 0 LUAD CTNNB1 CTNNB1 PD0332991 0.0437550241498646 0.0787375261846724 11 33:34:37:41:45 0.0216110019646365 0.181270814335153 2 LUAD CTNNB1 CTNNB1 PF2341066 0.139028803320682 -0.0440911166301258 11 33:34:37:41:45 0.0216110019646365 0.347572008301705 0 LUAD CTNNB1 CTNNB1 PHA665752 0.039335999737855 0.0529077681459706 11 33:34:37:41:45 0.0216110019646365 0.162963427485399 2 LUAD CTNNB1 CTNNB1 PLX4720 0.102880934995939 0.0840450354192087 11 33:34:37:41:45 0.0216110019646365 0.369577395380993 0 LUAD CTNNB1 CTNNB1 RAF265 0.756085721607225 -0.00942739083094413 11 33:34:37:41:45 0.0216110019646365 0.917183515889574 0 LUAD CTNNB1 CTNNB1 Sorafenib 0.00347812862575289 0.0863480717782941 11 33:34:37:41:45 0.0216110019646365 0.0420273875611808 2 LUAD CTNNB1 CTNNB1 TAE684 0.182168451657351 0.0689553633597393 11 33:34:37:41:45 0.0216110019646365 0.431350700714002 0 LUAD CTNNB1 CTNNB1 TKI258 0.179423637205136 0.0898873875848016 11 33:34:37:41:45 0.0216110019646365 0.473025952631722 0 LUAD CTNNB1 CTNNB1 Topotecan 0.351401133265731 -0.107282956068308 11 33:34:37:41:45 0.0216110019646365 0.672501135222698 0 LUAD CTNNB1 CTNNB1 ZD6474 0.00389948993807929 0.150158501780799 11 33:34:37:41:45 0.0216110019646365 0.0403875743586784 2 LUAD EGFR EGFR 17-AAG 0.00949403410940053 -0.128231115114196 24 746:747:751:754:759 0.0471512770137525 0.0801348619087406 1 LUAD EGFR EGFR AEW541 0.80137652466157 -0.0146946088775701 24 746:747:751:754:759 0.0471512770137525 0.880299970272179 0 LUAD EGFR EGFR AZD0530 0.20674671821798 0.0821441065787469 24 746:747:751:754:759 0.0471512770137525 0.491447117075526 0 LUAD EGFR EGFR AZD6244 0.0270726408722367 0.111360355120387 24 746:747:751:754:759 0.0471512770137525 0.138184273413645 2 LUAD EGFR EGFR Erlotinib 0.214215183458177 0.0294051946893575 24 746:747:751:754:759 0.0471512770137525 0.454518038257004 0 LUAD EGFR EGFR Irinotecan 0.0931623932082307 0.15056275537024 24 746:747:751:754:759 0.0471512770137525 0.390791012941619 0 LUAD EGFR EGFR L685458 0.908961781477073 0.00785567629475059 24 746:747:751:754:759 0.0471512770137525 0.941424702244111 0 LUAD EGFR EGFR Lapatinib 0.124293941346112 -0.0392448702246335 24 746:747:751:754:759 0.0471512770137525 0.324316390107145 0 LUAD EGFR EGFR LBW242 0.637784202394486 -0.0173005733490703 24 746:747:751:754:759 0.0471512770137525 1 0 LUAD EGFR EGFR Nilotinib 0.46571873566184 -0.00448799348732443 24 746:747:751:754:759 0.0471512770137525 0.699371112859351 0 LUAD EGFR EGFR Nutlin3 0.912713490723267 0.00273695633206106 24 746:747:751:754:759 0.0471512770137525 0.938606072020381 0 LUAD EGFR EGFR Paclitaxel 0.602178673643939 -0.0513769142164042 24 746:747:751:754:759 0.0471512770137525 0.868066926299283 0 LUAD EGFR EGFR Panobinostat 0.780721667421477 0.023769664921284 24 746:747:751:754:759 0.0471512770137525 0.884411263875892 0 LUAD EGFR EGFR PD0325901 0.0169083651262639 0.175407496018081 24 746:747:751:754:759 0.0471512770137525 0.103595167522569 2 LUAD EGFR EGFR PD0332991 0.350859455894789 -0.0290073835793714 24 746:747:751:754:759 0.0471512770137525 0.612947242225836 0 LUAD EGFR EGFR PF2341066 0.124293941346112 -0.0323637770254088 24 746:747:751:754:759 0.0471512770137525 0.334693632312871 0 LUAD EGFR EGFR PHA665752 0.518363464496755 -0.0176169524418761 24 746:747:751:754:759 0.0471512770137525 0.709082097660655 0 LUAD EGFR EGFR PLX4720 0.632162603948028 0.0399947605263302 24 746:747:751:754:759 0.0471512770137525 0.872986453071086 0 LUAD EGFR EGFR RAF265 0.257780434863785 0.0578527877016972 24 746:747:751:754:759 0.0471512770137525 0.530713589453383 0 LUAD EGFR EGFR Sorafenib 0.730378720821658 0.0167610101767301 24 746:747:751:754:759 0.0471512770137525 0.882361413084552 0 LUAD EGFR EGFR TAE684 0.160166667462418 -0.0507089604045421 24 746:747:751:754:759 0.0471512770137525 0.400416668656045 0 LUAD EGFR EGFR TKI258 0.5011491053617 0.0499776735932609 24 746:747:751:754:759 0.0471512770137525 0.816478879521871 0 LUAD EGFR EGFR Topotecan 0.467649872009209 0.0999349041065174 24 746:747:751:754:759 0.0471512770137525 0.745156389465223 0 LUAD EGFR EGFR ZD6474 0.716195272653814 0.0200429220466927 24 746:747:751:754:759 0.0471512770137525 0.910370895332992 0 LUAD EGFR EGFR 17-AAG 0.0815015667821873 -0.0779465081336035 25 858:861:866 0.0491159135559921 0.273753844028507 0 LUAD EGFR EGFR AEW541 0.461997289007343 -0.0296640592577732 25 858:861:866 0.0491159135559921 0.697808405271508 0 LUAD EGFR EGFR AZD0530 0.0155987976614554 0.129007007684298 25 858:861:866 0.0491159135559921 0.0904730264364413 2 LUAD EGFR EGFR AZD6244 0.0115294912730808 0.153791271745531 25 858:861:866 0.0491159135559921 0.111451748973114 2 LUAD EGFR EGFR Erlotinib 0.375995570708753 0.0268159578371827 25 858:861:866 0.0491159135559921 0.592556893008983 0 LUAD EGFR EGFR Irinotecan 0.874278027061394 -0.0102544830079929 25 858:861:866 0.0491159135559921 0.94604711883509 0 LUAD EGFR EGFR L685458 0.214848060654966 -0.0275250547658127 25 858:861:866 0.0491159135559921 0.464969683507016 0 LUAD EGFR EGFR Lapatinib 0.258813641231447 -0.0359421702246936 25 858:861:866 0.0491159135559921 0.487376337383894 0 LUAD EGFR EGFR LBW242 0.06082086073659 0.044750353283503 25 858:861:866 0.0491159135559921 1 0 LUAD EGFR EGFR Nilotinib 0.215419330177616 -0.0391640681302301 25 858:861:866 0.0491159135559921 0.512062342225481 0 LUAD EGFR EGFR Nutlin3 0.882799622493849 -0.00511453352188973 25 858:861:866 0.0491159135559921 0.917737835269135 0 LUAD EGFR EGFR Paclitaxel 0.661652793374693 -0.0489881823458598 25 858:861:866 0.0491159135559921 0.880180321461748 0 LUAD EGFR EGFR Panobinostat 0.14870812653192 -0.0701457953729001 25 858:861:866 0.0491159135559921 0.379102999248063 0 LUAD EGFR EGFR PD0325901 0.00399969929700829 0.208572522154698 25 858:861:866 0.0491159135559921 0.0644395997851336 2 LUAD EGFR EGFR PD0332991 0.0106489182965628 -0.0716835575085139 25 858:861:866 0.0491159135559921 0.0772046576500803 1 LUAD EGFR EGFR PF2341066 0.0568938579646052 -0.0307445426450903 25 858:861:866 0.0491159135559921 0.22261777110587 0 LUAD EGFR EGFR PHA665752 0.0184519083169315 -0.0355175474873688 25 858:861:866 0.0491159135559921 0.0990935817020395 1 LUAD EGFR EGFR PLX4720 0.701272202554806 0.0151086074319291 25 858:861:866 0.0491159135559921 0.883928936310306 0 LUAD EGFR EGFR RAF265 0.593798003986797 -0.0139775436843801 25 858:861:866 0.0491159135559921 0.807595878912942 0 LUAD EGFR EGFR Sorafenib 0.267373326573184 -0.024214463283777 25 858:861:866 0.0491159135559921 0.600934477746716 0 LUAD EGFR EGFR TAE684 0.00366114633795959 -0.0995716705374781 25 858:861:866 0.0491159135559921 0.0409067065450795 1 LUAD EGFR EGFR TKI258 0.790020299269032 -0.026437776462322 25 858:861:866 0.0491159135559921 0.954607861616747 0 LUAD EGFR EGFR Topotecan 0.791209316676453 -0.00519607442394054 25 858:861:866 0.0491159135559921 0.940371728836768 0 LUAD EGFR EGFR ZD6474 0.612086170913471 0.0199272375105966 25 858:861:866 0.0491159135559921 0.84149733845491 0 LUAD KRAS KRAS 17-AAG 0.0284338129243987 0.0464405240816625 122 12:13 0.239685658153242 0.147246531215636 2 LUAD KRAS KRAS AEW541 0.104371027221675 -0.0228707504420343 122 12:13 0.239685658153242 0.343949976071429 0 LUAD KRAS KRAS AZD0530 0.304522034661001 0.0370362473619079 122 12:13 0.239685658153242 0.590011003560525 0 LUAD KRAS KRAS AZD6244 0.71902032212492 0.0486619175440737 122 12:13 0.239685658153242 0.854573333673061 0 LUAD KRAS KRAS Erlotinib 0.579513225591913 -0.000768395247076725 122 12:13 0.239685658153242 0.781959988906675 0 LUAD KRAS KRAS Irinotecan 0.0193324606026108 -0.107873122458371 122 12:13 0.239685658153242 0.230405841195158 0 LUAD KRAS KRAS L685458 0.506440825120835 -0.013670735340421 122 12:13 0.239685658153242 0.712950676140981 0 LUAD KRAS KRAS Lapatinib 0.00816475974429287 0.0478548814777902 122 12:13 0.239685658153242 0.0623100085748666 2 LUAD KRAS KRAS LBW242 0.508363098168051 0.0114656960389987 122 12:13 0.239685658153242 1 0 LUAD KRAS KRAS Nilotinib 0.423598410838944 -0.0182266775444134 122 12:13 0.239685658153242 0.682464106351632 0 LUAD KRAS KRAS Nutlin3 0.145820254447567 -0.0169005144031129 122 12:13 0.239685658153242 0.347847631476817 0 LUAD KRAS KRAS Paclitaxel 9.60220370876262e-05 -0.190375766348159 122 12:13 0.239685658153242 0.00464106512590193 1 LUAD KRAS KRAS Panobinostat 0.202793609399719 -0.0410967646995273 122 12:13 0.239685658153242 0.459454271296238 0 LUAD KRAS KRAS PD0325901 0.599176914532859 0.0665445180531865 122 12:13 0.239685658153242 0.811968715955744 0 LUAD KRAS KRAS PD0332991 0.364943175759824 0.00617878501347535 122 12:13 0.239685658153242 0.617418888054418 0 LUAD KRAS KRAS PF2341066 0.999102022086916 -0.00224059925183395 122 12:13 0.239685658153242 0.999102022086916 0 LUAD KRAS KRAS PHA665752 0.0829951047048657 -0.0195007809437213 122 12:13 0.239685658153242 0.260943971812122 0 LUAD KRAS KRAS PLX4720 0.460107732012639 0.00715706456860055 122 12:13 0.239685658153242 0.791842381808024 0 LUAD KRAS KRAS RAF265 0.00617733819532606 -0.0607647599865282 122 12:13 0.239685658153242 0.0408094473117676 1 LUAD KRAS KRAS Sorafenib 0.106469196249396 -0.0213984212476105 122 12:13 0.239685658153242 0.350245657743068 0 LUAD KRAS KRAS TAE684 0.383086895609618 0.0146303524676199 122 12:13 0.239685658153242 0.64629317885846 0 LUAD KRAS KRAS TKI258 0.00139395888853414 -0.107270425795115 122 12:13 0.239685658153242 0.0168436699031209 1 LUAD KRAS KRAS Topotecan 0.000201916473656128 -0.194116843391165 122 12:13 0.239685658153242 0.00418255552573408 1 LUAD KRAS KRAS ZD6474 0.114507232713495 -0.036228656633569 122 12:13 0.239685658153242 0.436935493248862 0 LUAD STK11 STK11 17-AAG 0.460198735689223 0.0399405037851794 11 56:60:62:65:69:70 0.0216110019646365 0.729176211192437 0 LUAD STK11 STK11 AEW541 0.128914502720626 -0.051878774917821 11 56:60:62:65:69:70 0.0216110019646365 0.373852057889815 0 LUAD STK11 STK11 AZD0530 0.80676794090526 -0.0578582750366969 11 56:60:62:65:69:70 0.0216110019646365 0.934998064477449 0 LUAD STK11 STK11 AZD6244 0.727403690390453 -0.0233925129948265 11 56:60:62:65:69:70 0.0216110019646365 0.854585225718135 0 LUAD STK11 STK11 Erlotinib 0.890042147092274 -0.0158242996369381 11 56:60:62:65:69:70 0.0216110019646365 0.934968612058213 0 LUAD STK11 STK11 Irinotecan 0.0569612262708508 -0.249565100551843 11 56:60:62:65:69:70 0.0216110019646365 0.317668377279745 0 LUAD STK11 STK11 L685458 0.620527015354976 -0.018352875178593 11 56:60:62:65:69:70 0.0216110019646365 0.778685976507075 0 LUAD STK11 STK11 Lapatinib 0.0012927589829877 0.146656977877692 11 56:60:62:65:69:70 0.0216110019646365 0.0187450052533217 2 LUAD STK11 STK11 LBW242 0.153121421116438 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127:130:132:135:136:141:144:146 0.0275049115913556 0.522111221291938 0 LUAD TP53 TP53 ZD6474 0.158928947030936 0.0740963941779307 14 127:130:132:135:136:141:144:146 0.0275049115913556 0.522950688624405 0 LUAD TP53 TP53 17-AAG 0.814855700992704 0.0110977163184134 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.918477593504868 0 LUAD TP53 TP53 AEW541 0.00749070683373083 -0.0698885378518814 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.0603418050494983 1 LUAD TP53 TP53 AZD0530 0.873417727039597 -0.0134823449969212 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.95407367119588 0 LUAD TP53 TP53 AZD6244 0.0143842598568067 -0.17230068258184 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.115873204402054 1 LUAD TP53 TP53 Erlotinib 0.270287636332546 -0.0316066548499958 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.523136465079901 0 LUAD TP53 TP53 Irinotecan 0.302151917716611 0.076976038348417 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.626643853759755 0 LUAD TP53 TP53 L685458 0.00241756902608651 -0.0609505483103054 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.0350547508782544 1 LUAD TP53 TP53 Lapatinib 0.109924174366212 -0.0476315183505116 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.318780105662015 0 LUAD TP53 TP53 LBW242 0.339656888933379 -0.0147074191078682 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 1 0 LUAD TP53 TP53 Nilotinib 0.298161672585636 -0.0373223469042296 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.62929623150005 0 LUAD TP53 TP53 Nutlin3 0.015350699208732 -0.0414379113619069 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.105992923107911 1 LUAD TP53 TP53 Paclitaxel 0.0119433039148415 0.201296824547288 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.108236191728251 2 LUAD TP53 TP53 Panobinostat 0.0699267666098019 -0.080607827198099 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.286545176672071 0 LUAD TP53 TP53 PD0325901 0.235700430579939 -0.142112374633275 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.481360034282974 0 LUAD TP53 TP53 PD0332991 8.06912141453523e-05 -0.0910111478408516 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.00292505651276902 1 LUAD TP53 TP53 PF2341066 0.98720343523323 0.00648895460059784 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.994059014644572 0 LUAD TP53 TP53 PHA665752 0.112806697236259 -0.0150746255131297 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.308622096212407 0 LUAD TP53 TP53 PLX4720 0.000204398278439155 -0.145560542495409 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.00493962506227958 1 LUAD TP53 TP53 RAF265 7.51238684079618e-05 0.125865332367053 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.00272324022978862 2 LUAD TP53 TP53 Sorafenib 0.54150165595022 0.0111313879549794 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.809461238276102 0 LUAD TP53 TP53 TAE684 0.937783898107057 -0.0168996771326084 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.984846233442031 0 LUAD TP53 TP53 TKI258 0.843192230974336 -0.0246355091619244 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.959342395190069 0 LUAD TP53 TP53 Topotecan 0.369663572359881 0.0831299091278064 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.685598064003738 0 LUAD TP53 TP53 ZD6474 0.194629621921153 0.0382459274353688 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.546043030477178 0 LUAD TP53 TP53 17-AAG 0.507379463224421 -0.024078580939205 17 191:192:193:194:195:196:198 0.0333988212180747 0.743131537045869 0 LUAD TP53 TP53 AEW541 0.121106779171042 -0.0539356510347776 17 191:192:193:194:195:196:198 0.0333988212180747 0.373852057889815 0 LUAD TP53 TP53 AZD0530 0.612332953436822 0.0443253472375293 17 191:192:193:194:195:196:198 0.0333988212180747 0.829796992975133 0 LUAD TP53 TP53 AZD6244 0.537628785770181 -0.0155498503389258 17 191:192:193:194:195:196:198 0.0333988212180747 0.764276215065453 0 LUAD TP53 TP53 Erlotinib 0.264918347948637 -0.0455396604064818 17 191:192:193:194:195:196:198 0.0333988212180747 0.523136465079901 0 LUAD TP53 TP53 Irinotecan 0.0411577100432321 0.206601868245759 17 191:192:193:194:195:196:198 0.0333988212180747 0.274719342741761 0 LUAD TP53 TP53 L685458 0.467802467210062 -0.0259837373368292 17 191:192:193:194:195:196:198 0.0333988212180747 0.712950676140981 0 LUAD TP53 TP53 Lapatinib 0.1967187432046 -0.0449409032856947 17 191:192:193:194:195:196:198 0.0333988212180747 0.423328452453569 0 LUAD TP53 TP53 LBW242 0.571013975605711 -0.0216275308330149 17 191:192:193:194:195:196:198 0.0333988212180747 1 0 LUAD TP53 TP53 Nilotinib 0.111083316005829 0.0397850293998292 17 191:192:193:194:195:196:198 0.0333988212180747 0.392855629776712 0 LUAD TP53 TP53 Nutlin3 0.227092109273356 -0.0334595778586871 17 191:192:193:194:195:196:198 0.0333988212180747 0.477222548472995 0 LUAD TP53 TP53 Paclitaxel 0.998674345136377 0.00840040576313417 17 191:192:193:194:195:196:198 0.0333988212180747 1 0 LUAD TP53 TP53 Panobinostat 0.593805481551503 0.0185928618077753 17 191:192:193:194:195:196:198 0.0333988212180747 0.797238840971925 0 LUAD TP53 TP53 PD0325901 0.758561297429194 0.0640371895338732 17 191:192:193:194:195:196:198 0.0333988212180747 0.869726746344263 0 LUAD TP53 TP53 PD0332991 0.188773178348532 -0.0516903018665734 17 191:192:193:194:195:196:198 0.0333988212180747 0.427689232195893 0 LUAD TP53 TP53 PF2341066 0.252313631097513 0.0261592796440261 17 191:192:193:194:195:196:198 0.0333988212180747 0.508131618182491 0 LUAD TP53 TP53 PHA665752 0.948335592583339 -0.00132781364359535 17 191:192:193:194:195:196:198 0.0333988212180747 0.981403557938373 0 LUAD TP53 TP53 PLX4720 0.528894559715538 -0.0499506134188205 17 191:192:193:194:195:196:198 0.0333988212180747 0.816096385865643 0 LUAD TP53 TP53 RAF265 0.00596460544752229 0.105016165556263 17 191:192:193:194:195:196:198 0.0333988212180747 0.0408094473117676 2 LUAD TP53 TP53 Sorafenib 0.0124017631291791 0.0484283602600403 17 191:192:193:194:195:196:198 0.0333988212180747 0.0856312216062366 2 LUAD TP53 TP53 TAE684 0.308451485599114 0.0505017443128621 17 191:192:193:194:195:196:198 0.0333988212180747 0.596339538824954 0 LUAD TP53 TP53 TKI258 0.359947057834738 -0.115955730218938 17 191:192:193:194:195:196:198 0.0333988212180747 0.724893380361625 0 LUAD TP53 TP53 Topotecan 0.0616025617882751 0.192671852116091 17 191:192:193:194:195:196:198 0.0333988212180747 0.241415444845943 0 LUAD TP53 TP53 ZD6474 0.885068341037568 0.0200639156918363 17 191:192:193:194:195:196:198 0.0333988212180747 0.963890952546201 0 LUAD TP53 TP53 17-AAG 0.534620962180966 0.0411175447657248 12 205:209:213:214:216:220 0.0235756385068762 0.756002304022029 0 LUAD TP53 TP53 AEW541 0.328877843973674 -0.0413838709581531 12 205:209:213:214:216:220 0.0235756385068762 0.656586643346452 0 LUAD TP53 TP53 AZD0530 0.585689063400586 0.0162263323627174 12 205:209:213:214:216:220 0.0235756385068762 0.808808706600809 0 LUAD TP53 TP53 AZD6244 0.466131167377328 -0.113726677073075 12 205:209:213:214:216:220 0.0235756385068762 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232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.959342395190069 0 LUAD TP53 TP53 Topotecan 0.0103052366410076 0.229885212428361 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.0713415000667662 2 LUAD TP53 TP53 ZD6474 0.758397944288933 0.01400773888441 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.916397516015794 0 LUAD TP53 TP53 17-AAG 0.950644946082377 0.0042332989673346 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.984596551299605 0 LUAD TP53 TP53 AEW541 0.377635353344512 -0.0184186034762224 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.660796770817279 0 LUAD TP53 TP53 AZD0530 0.0255550696803716 -0.0974336729561374 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.119531777537222 1 LUAD TP53 TP53 AZD6244 0.00176492690083959 -0.21027027411542 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.0357617484838182 1 LUAD TP53 TP53 Erlotinib 0.0382505239048699 -0.0541600908041938 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.145955946479109 1 LUAD TP53 TP53 Irinotecan 0.62766717701052 0.0449275816431447 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.831248558064582 0 LUAD TP53 TP53 L685458 0.00830543558473497 -0.0460216622102111 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.0602144079893285 1 LUAD TP53 TP53 Lapatinib 0.0621504142050423 -0.0490638827025565 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.219487729635549 0 LUAD TP53 TP53 LBW242 0.114374470201328 -0.0268884941598677 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 1 0 LUAD TP53 TP53 Nilotinib 0.186165933508596 -0.0387352078603598 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.482036792120472 0 LUAD TP53 TP53 Nutlin3 0.0180743443865151 -0.0370539700118179 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.113946953741073 1 LUAD TP53 TP53 Paclitaxel 0.0213763263001066 0.163705092269696 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.154978365675773 2 LUAD TP53 TP53 Panobinostat 0.370682704853401 -0.0376351466851723 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.610784002315263 0 LUAD TP53 TP53 PD0325901 0.0275704815614497 -0.190213073429103 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.137852407807249 1 LUAD TP53 TP53 PD0332991 0.000164350280640791 -0.0785330335067945 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.00397179844881912 1 LUAD TP53 TP53 PF2341066 0.775288106545114 0.00679427026116197 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.851642238250315 0 LUAD TP53 TP53 PHA665752 0.396908225346925 -0.0126819859781312 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.597216943251763 0 LUAD TP53 TP53 PLX4720 7.42235205161291e-05 -0.1489042640176 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.00349235196641606 1 LUAD TP53 TP53 RAF265 0.0159401384129872 0.0723776207328466 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.079780384256353 2 LUAD TP53 TP53 Sorafenib 0.813760374228227 -0.0123794510555575 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.917914256371406 0 LUAD TP53 TP53 TAE684 0.12998420898743 0.0370761160357505 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.37180812605012 0 LUAD TP53 TP53 TKI258 0.596557846317123 -0.0483640747376839 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.876858719196181 0 LUAD TP53 TP53 Topotecan 0.574956164279005 0.0495896075526123 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.799087021720268 0 LUAD TP53 TP53 ZD6474 0.595276983225387 0.00517374377904312 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.838351456165102 0 LUAD TP53 TP53 17-AAG 0.0830701319810643 -0.0905779618566975 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.273753844028507 0 LUAD TP53 TP53 AEW541 0.0563274790846131 -0.0598071580540412 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.247274382314841 0 LUAD TP53 TP53 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331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.939770585322949 0 LUAD TP53 TP53 PHA665752 0.0472956259738828 -0.0403514065184793 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.17584271195418 1 LUAD TP53 TP53 PLX4720 0.0303681318386893 -0.13634030480849 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.172410275043407 1 LUAD TP53 TP53 RAF265 0.0100110210258329 0.125199080421669 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.0604832520310738 2 LUAD TP53 TP53 Sorafenib 0.164921917783763 0.021611376243146 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.451201473181993 0 LUAD TP53 TP53 TAE684 0.381474467566646 0.0450318967148997 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.64629317885846 0 LUAD TP53 TP53 TKI258 0.427329097176853 0.050283791307232 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.766875635967867 0 LUAD TP53 TP53 Topotecan 0.152885563873235 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U2AF1 PHA665752 0.338000859289574 0.0214847386641066 12 34 0.0235756385068762 0.559245474248325 0 LUAD U2AF1 U2AF1 PLX4720 0.406403189578775 0.0330438551316775 12 34 0.0235756385068762 0.769266275380849 0 LUAD U2AF1 U2AF1 RAF265 0.948221341107576 0.00943211899224439 12 34 0.0235756385068762 0.988055037433057 0 LUAD U2AF1 U2AF1 Sorafenib 0.728829795616603 0.00457937796618818 12 34 0.0235756385068762 0.882361413084552 0 LUAD U2AF1 U2AF1 TAE684 0.151091849133165 0.0755742947896598 12 34 0.0235756385068762 0.384356458321209 0 LUAD U2AF1 U2AF1 TKI258 0.951403647812226 -0.022149002398212 12 34 0.0235756385068762 0.971503724878681 0 LUAD U2AF1 U2AF1 Topotecan 0.268731982109029 0.123644994628443 12 34 0.0235756385068762 0.603174324143118 0 LUAD U2AF1 U2AF1 ZD6474 0.524504462392683 -0.0451082832671057 12 34 0.0235756385068762 0.803883136441038 0 LUSC CDKN2A CDKN2A 17-AAG 0.0641889943100376 -0.0550691012202389 17 80:81:83:84:85:88 0.0356394129979036 0.251551464187985 0 LUSC CDKN2A CDKN2A AEW541 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0.466835267865283 -0.0271172694210107 17 80:81:83:84:85:88 0.0356394129979036 0.699371112859351 0 LUSC CDKN2A CDKN2A Nutlin3 0.415802710470575 -0.0168953415958552 17 80:81:83:84:85:88 0.0356394129979036 0.67329174137326 0 LUSC CDKN2A CDKN2A Paclitaxel 0.147302184249668 0.174789892604699 17 80:81:83:84:85:88 0.0356394129979036 0.400181164632015 0 LUSC CDKN2A CDKN2A Panobinostat 0.16902663936324 -0.112149118838753 17 80:81:83:84:85:88 0.0356394129979036 0.40848104512783 0 LUSC CDKN2A CDKN2A PD0325901 0.262212406055131 0.132663189598655 17 80:81:83:84:85:88 0.0356394129979036 0.50694398503992 0 LUSC CDKN2A CDKN2A PD0332991 0.72442905827326 -0.0140057212032362 17 80:81:83:84:85:88 0.0356394129979036 0.854001735362786 0 LUSC CDKN2A CDKN2A PF2341066 0.192370278796329 -0.0245136640671375 17 80:81:83:84:85:88 0.0356394129979036 0.416323737693548 0 LUSC CDKN2A CDKN2A PHA665752 0.335371107142784 -0.019005168053271 17 80:81:83:84:85:88 0.0356394129979036 0.559245474248325 0 LUSC CDKN2A CDKN2A PLX4720 0.380342793979307 -0.0197112784431683 17 80:81:83:84:85:88 0.0356394129979036 0.769266275380849 0 LUSC CDKN2A CDKN2A RAF265 0.40995486002111 0.0222397136786918 17 80:81:83:84:85:88 0.0356394129979036 0.703927107918497 0 LUSC CDKN2A CDKN2A Sorafenib 0.489726688866629 -0.0215981859670282 17 80:81:83:84:85:88 0.0356394129979036 0.797869324557991 0 LUSC CDKN2A CDKN2A TAE684 0.283726830549257 -0.049178850356687 17 80:81:83:84:85:88 0.0356394129979036 0.576370642063286 0 LUSC CDKN2A CDKN2A TKI258 0.876209586355418 0.0247932634968528 17 80:81:83:84:85:88 0.0356394129979036 0.959342395190069 0 LUSC CDKN2A CDKN2A Topotecan 0.561873722955455 -0.0472680889452226 17 80:81:83:84:85:88 0.0356394129979036 0.799087021720268 0 LUSC CDKN2A CDKN2A ZD6474 0.00166532671356763 0.137642482589488 17 80:81:83:84:85:88 0.0356394129979036 0.0241472373467306 2 LUSC CDKN2A CDKN2A 17-AAG 0.417089141905198 -0.0790811505084723 15 108:109:110:114:118:120 0.0314465408805031 0.703231692747136 0 LUSC CDKN2A CDKN2A AEW541 0.51170535560149 0.0147507178604357 15 108:109:110:114:118:120 0.0314465408805031 0.722419772169928 0 LUSC CDKN2A CDKN2A AZD0530 0.835391543071695 0.0306051949071544 15 108:109:110:114:118:120 0.0314465408805031 0.939005998026324 0 LUSC CDKN2A CDKN2A AZD6244 0.279911882869362 0.0870636075383435 15 108:109:110:114:118:120 0.0314465408805031 0.556849407821519 0 LUSC CDKN2A CDKN2A Erlotinib 0.179274839469225 0.0880204456533167 15 108:109:110:114:118:120 0.0314465408805031 0.41261669401647 0 LUSC CDKN2A CDKN2A Irinotecan 0.122534780240087 0.135297653714184 15 108:109:110:114:118:120 0.0314465408805031 0.410975591222968 0 LUSC CDKN2A CDKN2A L685458 0.613374728550245 -0.0124345287380513 15 108:109:110:114:118:120 0.0314465408805031 0.778685976507075 0 LUSC CDKN2A CDKN2A Lapatinib 0.784537874149776 0.0235683644026434 15 108:109:110:114:118:120 0.0314465408805031 0.878114235868334 0 LUSC CDKN2A CDKN2A LBW242 0.0141225755634631 -0.0763702720204795 15 108:109:110:114:118:120 0.0314465408805031 1 0 LUSC CDKN2A CDKN2A Nilotinib 0.666545042991211 -0.025296170305331 15 108:109:110:114:118:120 0.0314465408805031 0.847965386361886 0 LUSC CDKN2A CDKN2A Nutlin3 0.930281016291646 0.0030623036655234 15 108:109:110:114:118:120 0.0314465408805031 0.943291939596424 0 LUSC CDKN2A CDKN2A Paclitaxel 0.000147682572445451 0.43887996163211 15 108:109:110:114:118:120 0.0314465408805031 0.0053534932511476 2 LUSC CDKN2A CDKN2A Panobinostat 0.850793359957273 -0.0347072888066533 15 108:109:110:114:118:120 0.0314465408805031 0.926437464508441 0 LUSC CDKN2A CDKN2A PD0325901 0.261830268520649 0.12350901956789 15 108:109:110:114:118:120 0.0314465408805031 0.50694398503992 0 LUSC CDKN2A CDKN2A PD0332991 0.596581926819872 0.0203386950442532 15 108:109:110:114:118:120 0.0314465408805031 0.779318733233166 0 LUSC CDKN2A CDKN2A PF2341066 0.0942740113096314 -0.0445401424749694 15 108:109:110:114:118:120 0.0314465408805031 0.317900735811548 0 LUSC CDKN2A CDKN2A PHA665752 0.7811775488996 -0.00941544556585272 15 108:109:110:114:118:120 0.0314465408805031 0.880532300090862 0 LUSC CDKN2A CDKN2A PLX4720 0.866252313228393 -0.0254794922143219 15 108:109:110:114:118:120 0.0314465408805031 0.951565041046341 0 LUSC CDKN2A CDKN2A RAF265 0.403412764093584 0.0413771717368498 15 108:109:110:114:118:120 0.0314465408805031 0.703927107918497 0 LUSC CDKN2A CDKN2A Sorafenib 0.409595702719019 -0.0170354165770704 15 108:109:110:114:118:120 0.0314465408805031 0.721813757748919 0 LUSC CDKN2A CDKN2A TAE684 0.335846664207699 -0.043272026830695 15 108:109:110:114:118:120 0.0314465408805031 0.632438523508005 0 LUSC CDKN2A CDKN2A TKI258 0.867973250310494 -0.00588046669637499 15 108:109:110:114:118:120 0.0314465408805031 0.959342395190069 0 LUSC CDKN2A CDKN2A Topotecan 0.443944877937113 0.0798130368785395 15 108:109:110:114:118:120 0.0314465408805031 0.745156389465223 0 LUSC CDKN2A CDKN2A ZD6474 0.00713756467816742 0.135233588490392 15 108:109:110:114:118:120 0.0314465408805031 0.0689964585556184 2 LUSC NFE2L2 NFE2L2 17-AAG 0.0155901759589255 -0.0832128582779057 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.107646453049724 1 LUSC NFE2L2 NFE2L2 AEW541 0.0482372220071309 -0.0425195285844091 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.225625715839806 0 LUSC NFE2L2 NFE2L2 AZD0530 0.00681222293723566 0.116615272212067 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.0548762403277317 2 LUSC NFE2L2 NFE2L2 AZD6244 0.189564082032211 0.0476286651648099 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.462213035177092 0 LUSC NFE2L2 NFE2L2 Erlotinib 0.249093694894593 0.0675967190106532 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.5016470244405 0 LUSC NFE2L2 NFE2L2 Irinotecan 0.0276794118188356 -0.117738421375007 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.2377385824247 0 LUSC NFE2L2 NFE2L2 L685458 0.0617297424895023 -0.0407053661560032 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.273864246259975 0 LUSC NFE2L2 NFE2L2 Lapatinib 0.441775315687183 0.00555862840354027 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.674288639733069 0 LUSC NFE2L2 NFE2L2 LBW242 2.49783401193167e-07 -0.0933978329577081 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 1 0 LUSC NFE2L2 NFE2L2 Nilotinib 0.0339304205342545 -0.0547574096763679 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.258942683024574 0 LUSC NFE2L2 NFE2L2 Nutlin3 0.773717215810866 0.000957819916847402 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.898414789240926 0 LUSC NFE2L2 NFE2L2 Paclitaxel 0.00023281874095499 0.252326289500296 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.00675174348769471 2 LUSC NFE2L2 NFE2L2 Panobinostat 2.66801392169978e-06 -0.256960086028431 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.000193431009323234 1 LUSC NFE2L2 NFE2L2 PD0325901 0.111403162080383 0.090295871871116 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.338581381117707 0 LUSC NFE2L2 NFE2L2 PD0332991 0.229231888159565 -0.0415099164491421 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.481719185262854 0 LUSC NFE2L2 NFE2L2 PF2341066 0.00151062936065648 -0.043235241275394 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.0312916081850271 1 LUSC NFE2L2 NFE2L2 PHA665752 0.311582459645035 -0.0159302482161938 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.54583632016244 0 LUSC NFE2L2 NFE2L2 PLX4720 0.745290214584335 -0.0162975665739393 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.893116372848996 0 LUSC NFE2L2 NFE2L2 RAF265 0.849945434050618 0.0106967805906124 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.950250786733846 0 LUSC NFE2L2 NFE2L2 Sorafenib 0.0946079634932967 -0.0272610038128938 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.332007366961092 0 LUSC NFE2L2 NFE2L2 TAE684 0.0167462032770386 -0.0657503798077386 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.12140997375853 1 LUSC NFE2L2 NFE2L2 TKI258 0.55604688051479 -0.0384538323118524 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.863421346550092 0 LUSC NFE2L2 NFE2L2 Topotecan 0.139565953764439 -0.0764374931980498 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.413001291751911 0 LUSC NFE2L2 NFE2L2 ZD6474 0.0120144276804966 0.0736718672297616 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.102476000804236 2 LUSC NFE2L2 NFE2L2 17-AAG 0.08515437501464 -0.0659420785182947 17 77:79:80:81 0.0356394129979036 0.274386319491618 0 LUSC NFE2L2 NFE2L2 AEW541 0.936595598301235 0.00570180024758205 17 77:79:80:81 0.0356394129979036 0.949694837438315 0 LUSC NFE2L2 NFE2L2 AZD0530 0.67137347294618 -0.00961106430566505 17 77:79:80:81 0.0356394129979036 0.883665821328236 0 LUSC NFE2L2 NFE2L2 AZD6244 0.421597145292082 0.0709159903546304 17 77:79:80:81 0.0356394129979036 0.679057671028548 0 LUSC NFE2L2 NFE2L2 Erlotinib 0.902595088349368 0.0534306851534707 17 77:79:80:81 0.0356394129979036 0.934968612058213 0 LUSC NFE2L2 NFE2L2 Irinotecan 0.65803966393819 -0.0472187852461148 17 77:79:80:81 0.0356394129979036 0.83883903305285 0 LUSC NFE2L2 NFE2L2 L685458 0.310704161566136 0.0283204984684512 17 77:79:80:81 0.0356394129979036 0.555901535098092 0 LUSC NFE2L2 NFE2L2 Lapatinib 0.750334891974094 0.0221717910970671 17 77:79:80:81 0.0356394129979036 0.8569095338034 0 LUSC NFE2L2 NFE2L2 LBW242 0.00144225887509036 -0.0848978628327555 17 77:79:80:81 0.0356394129979036 1 0 LUSC NFE2L2 NFE2L2 Nilotinib 0.784604351046307 -0.00225879396226247 17 77:79:80:81 0.0356394129979036 0.922551163763158 0 LUSC NFE2L2 NFE2L2 Nutlin3 0.0332147605782322 0.0475533915215324 17 77:79:80:81 0.0356394129979036 0.155359363994957 2 LUSC NFE2L2 NFE2L2 Paclitaxel 0.000620101725647972 0.389307137052748 17 77:79:80:81 0.0356394129979036 0.00999052780210622 2 LUSC NFE2L2 NFE2L2 Panobinostat 0.0866439702905405 -0.138392321980964 17 77:79:80:81 0.0356394129979036 0.292935191977058 0 LUSC NFE2L2 NFE2L2 PD0325901 0.537895622430897 0.080424288199324 17 77:79:80:81 0.0356394129979036 0.757231701480389 0 LUSC NFE2L2 NFE2L2 PD0332991 0.142494274857646 0.049847959042899 17 77:79:80:81 0.0356394129979036 0.356235687144115 0 LUSC NFE2L2 NFE2L2 PF2341066 0.369462302344179 -0.0215921400983151 17 77:79:80:81 0.0356394129979036 0.588703668570395 0 LUSC NFE2L2 NFE2L2 PHA665752 0.346010887299086 0.0228959299752949 17 77:79:80:81 0.0356394129979036 0.559245474248325 0 LUSC NFE2L2 NFE2L2 PLX4720 0.67137347294618 0.010720111391061 17 77:79:80:81 0.0356394129979036 0.877019401596361 0 LUSC NFE2L2 NFE2L2 RAF265 0.745698049607371 -0.00246836145458751 17 77:79:80:81 0.0356394129979036 0.916323874517532 0 LUSC NFE2L2 NFE2L2 Sorafenib 0.636058185272124 0.000703601022801648 17 77:79:80:81 0.0356394129979036 0.831376335950175 0 LUSC NFE2L2 NFE2L2 TAE684 0.480345841300647 0.0296639130408018 17 77:79:80:81 0.0356394129979036 0.685188787439197 0 LUSC NFE2L2 NFE2L2 TKI258 0.355487620546038 0.0624913248433212 17 77:79:80:81 0.0356394129979036 0.724893380361625 0 LUSC NFE2L2 NFE2L2 Topotecan 0.846352604242756 0.0268601565255908 17 77:79:80:81 0.0356394129979036 0.940917023721381 0 LUSC NFE2L2 NFE2L2 ZD6474 0.00224674445145522 0.126867711125066 17 77:79:80:81 0.0356394129979036 0.0296161768600915 2 LUSC PIK3CA PIK3CA 17-AAG 0.347915206770668 0.055396848895291 30 538:542:545 0.0628930817610063 0.655164999762946 0 LUSC PIK3CA PIK3CA AEW541 0.0377143006614052 -0.0510666422752308 30 538:542:545 0.0628930817610063 0.188571503307026 1 LUSC PIK3CA PIK3CA AZD0530 0.991203071868584 0.00740011395720774 30 538:542:545 0.0628930817610063 1 0 LUSC PIK3CA PIK3CA AZD6244 0.0527674152738615 -0.112279500056307 30 538:542:545 0.0628930817610063 0.201315842889406 0 LUSC PIK3CA PIK3CA Erlotinib 0.0459750463704332 0.0920667394004691 30 538:542:545 0.0628930817610063 0.16665954309282 2 LUSC PIK3CA PIK3CA Irinotecan 0.62082663705874 -0.0220438935241072 30 538:542:545 0.0628930817610063 0.831248558064582 0 LUSC PIK3CA PIK3CA L685458 0.147405829593516 -0.0307244573430237 30 538:542:545 0.0628930817610063 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PHA665752 0.0466061218597478 -0.0506601490085109 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.17584271195418 1 LUSC TP53 TP53 PLX4720 0.00187115757279942 -0.172502176981851 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.0301464275617684 1 LUSC TP53 TP53 RAF265 0.0649491790537028 0.0454143798660185 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.214037067336066 0 LUSC TP53 TP53 Sorafenib 0.357216219886809 -0.0293991746636479 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.681530945836675 0 LUSC TP53 TP53 TAE684 0.544038716068542 -0.0142727416300483 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.758515517595563 0 LUSC TP53 TP53 TKI258 0.0546085593217314 -0.126566694940144 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.239946700050032 0 LUSC TP53 TP53 Topotecan 0.584160167602403 -0.0636970772586083 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.799087021720268 0 LUSC TP53 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0.129979035639413 0.446644822676478 0 PAAD CDKN2A CDKN2A 17-AAG 0.081665069043522 0.16580839808661 11 80:83:88 0.0647058823529412 0.273753844028507 0 PAAD CDKN2A CDKN2A AEW541 0.344141964788485 0.0279705949549145 11 80:83:88 0.0647058823529412 0.656586643346452 0 PAAD CDKN2A CDKN2A AZD0530 0.450487946319564 0.0804965337145498 11 80:83:88 0.0647058823529412 0.727615782349407 0 PAAD CDKN2A CDKN2A AZD6244 0.240301305883443 0.205452899074646 11 80:83:88 0.0647058823529412 0.510941392332687 0 PAAD CDKN2A CDKN2A Erlotinib 0.340400128419562 0.0703888279005049 11 80:83:88 0.0647058823529412 0.56712243933804 0 PAAD CDKN2A CDKN2A Irinotecan 0.0190379500142937 0.184004737571773 11 80:83:88 0.0647058823529412 0.230405841195158 0 PAAD CDKN2A CDKN2A L685458 0.874234333019408 -0.0112307438563017 11 80:83:88 0.0647058823529412 0.940915480959262 0 PAAD CDKN2A CDKN2A Lapatinib 0.00051819918815707 0.188095500705802 11 80:83:88 0.0647058823529412 0.0107341260403965 2 PAAD CDKN2A CDKN2A LBW242 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0.194117647058824 0.660796770817279 0 PAAD KRAS KRAS AZD0530 0.00167602028624132 0.203068114103115 33 12:13 0.194117647058824 0.0220929946822719 2 PAAD KRAS KRAS AZD6244 9.01360888403367e-05 0.502765939241859 33 12:13 0.194117647058824 0.00653486644092441 2 PAAD KRAS KRAS Erlotinib 9.01360888403367e-05 0.16507839687548 33 12:13 0.194117647058824 0.00653486644092441 2 PAAD KRAS KRAS Irinotecan 0.826026033100894 -0.0733788066186563 33 12:13 0.194117647058824 0.935732615622106 0 PAAD KRAS KRAS L685458 4.37603180558869e-05 -0.106922410668201 33 12:13 0.194117647058824 0.0031726230590518 1 PAAD KRAS KRAS Lapatinib 5.77957746840609e-07 0.255591516872624 33 12:13 0.194117647058824 4.19019366459442e-05 2 PAAD KRAS KRAS LBW242 0.0516971435977838 -0.0510664537745413 33 12:13 0.194117647058824 1 0 PAAD KRAS KRAS Nilotinib 0.000103110453498004 -0.136245304008377 33 12:13 0.194117647058824 0.00747550787860529 1 PAAD KRAS KRAS Nutlin3 0.00473025088347172 -0.0596457464502254 33 12:13 0.194117647058824 0.0607502083038393 1 PAAD KRAS KRAS Paclitaxel 0.781943956746775 -0.0686736398017462 33 12:13 0.194117647058824 0.904119771478386 0 PAAD KRAS KRAS Panobinostat 0.00834916411935346 -0.172067395138589 33 12:13 0.194117647058824 0.0700854034036927 1 PAAD KRAS KRAS PD0325901 2.22181442422776e-05 0.702642861858155 33 12:13 0.194117647058824 0.00322163091513025 2 PAAD KRAS KRAS PD0332991 0.366193271535724 -0.0440768674396081 33 12:13 0.194117647058824 0.617418888054418 0 PAAD KRAS KRAS PF2341066 0.00197812218637191 0.0770455364417525 33 12:13 0.194117647058824 0.0318697463359919 2 PAAD KRAS KRAS PHA665752 0.254407303881682 0.0301503144149644 33 12:13 0.194117647058824 0.498500798146539 0 PAAD KRAS KRAS PLX4720 0.00654753543996244 -0.157385762245163 33 12:13 0.194117647058824 0.0678137599138967 1 PAAD KRAS KRAS RAF265 0.25781575370008 0.069322700308459 33 12:13 0.194117647058824 0.530713589453383 0 PAAD KRAS KRAS Sorafenib 7.10619126707641e-05 -0.0844757680081179 33 12:13 0.194117647058824 0.00343465911242026 1 PAAD KRAS KRAS TAE684 0.149607688270486 0.11185413475183 33 12:13 0.194117647058824 0.384356458321209 0 PAAD KRAS KRAS TKI258 2.47655703589333e-05 -0.275926286239765 33 12:13 0.194117647058824 0.000897751925511332 1 PAAD KRAS KRAS Topotecan 0.0843751262864863 -0.214838778452115 33 12:13 0.194117647058824 0.301978538484004 0 PAAD KRAS KRAS ZD6474 0.00097717560658605 0.190423234614089 33 12:13 0.194117647058824 0.0177113078693722 2 PAAD TP53 TP53 17-AAG 0.0616384545902678 0.174376103696287 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.248265997655245 0 PAAD TP53 TP53 AEW541 0.405295016949288 -0.0206018184407619 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.666033009907976 0 PAAD TP53 TP53 AZD0530 0.384166327379901 0.0344215467558375 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.686878953488684 0 PAAD TP53 TP53 AZD6244 0.571463623312982 0.0543369650481189 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.785588984525203 0 PAAD TP53 TP53 Erlotinib 0.288934043529147 0.0629822915042719 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.537120978355466 0 PAAD TP53 TP53 Irinotecan 0.0473654039209932 0.234800082075896 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.274719342741761 0 PAAD TP53 TP53 L685458 0.449580352216786 -0.0219971725321101 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.708577729037326 0 PAAD TP53 TP53 Lapatinib 0.166409657461288 0.120711223057084 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.377021880185731 0 PAAD TP53 TP53 LBW242 0.958281820123959 0.00819275370070405 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 1 0 PAAD TP53 TP53 Nilotinib 0.80837153006854 -0.0062665611007936 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.930268824285225 0 PAAD TP53 TP53 Nutlin3 0.728480840785152 -0.00402942937403161 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.895167134863111 0 PAAD TP53 TP53 Paclitaxel 0.0422983770384028 0.280683844319555 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.188331808265253 2 PAAD TP53 TP53 Panobinostat 0.610869993227861 -0.0217744962474944 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.797983324486845 0 PAAD TP53 TP53 PD0325901 0.779039529701738 0.154102516002851 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.88250571724025 0 PAAD TP53 TP53 PD0332991 0.461065752160968 0.0290491767734805 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.702019126981368 0 PAAD TP53 TP53 PF2341066 0.0517780328497112 0.059062615439988 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.208550410089115 0 PAAD TP53 TP53 PHA665752 0.539577741093814 0.0376317787580585 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.722289624095874 0 PAAD TP53 TP53 PLX4720 0.943133855998311 -0.00158152108421505 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.978697382843298 0 PAAD TP53 TP53 RAF265 0.124536699701286 0.117167329582419 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.340713612390311 0 PAAD TP53 TP53 Sorafenib 0.604219067312269 0.00434826366229735 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.831376335950175 0 PAAD TP53 TP53 TAE684 0.0238937371928549 0.127321521205361 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.15748144968018 2 PAAD TP53 TP53 TKI258 0.591015772636163 -0.00926919937471782 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.876858719196181 0 PAAD TP53 TP53 Topotecan 0.571463623312982 0.124621216966623 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.799087021720268 0 PAAD TP53 TP53 ZD6474 0.104888003313078 0.11702123986755 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.411047580551252 0 PAAD TP53 TP53 17-AAG 0.537022326305303 -0.0450777729273915 11 272:273:275:278:282:283:286 0.0647058823529412 0.756002304022029 0 PAAD TP53 TP53 AEW541 0.472870539358538 0.017463716932459 11 272:273:275:278:282:283:286 0.0647058823529412 0.706868332030804 0 PAAD TP53 TP53 AZD0530 0.0020245285765822 0.234328761826387 11 272:273:275:278:282:283:286 0.0647058823529412 0.022581280277263 2 PAAD TP53 TP53 AZD6244 0.537022326305303 0.0189464348831465 11 272:273:275:278:282:283:286 0.0647058823529412 0.764276215065453 0 PAAD TP53 TP53 Erlotinib 0.0208125036900701 0.143881420901652 11 272:273:275:278:282:283:286 0.0647058823529412 0.10600526169423 2 PAAD TP53 TP53 Irinotecan 0.931356747773338 -0.0429922484800944 11 272:273:275:278:282:283:286 0.0647058823529412 0.964619488765243 0 PAAD TP53 TP53 L685458 0.00310242037898149 -0.106354534164831 11 272:273:275:278:282:283:286 0.0647058823529412 0.0374875795793597 1 PAAD TP53 TP53 Lapatinib 0.128066562406453 0.138280588365592 11 272:273:275:278:282:283:286 0.0647058823529412 0.324316390107145 0 PAAD TP53 TP53 LBW242 0.256731712513618 0.0453259224881195 11 272:273:275:278:282:283:286 0.0647058823529412 1 0 PAAD TP53 TP53 Nilotinib 0.147061587035551 -0.064965397540372 11 272:273:275:278:282:283:286 0.0647058823529412 0.431335026863153 0 PAAD TP53 TP53 Nutlin3 0.0600156251608136 -0.0600659562667263 11 272:273:275:278:282:283:286 0.0647058823529412 0.202378270891116 0 PAAD TP53 TP53 Paclitaxel 1 -0.0583725216019371 11 272:273:275:278:282:283:286 0.0647058823529412 1 0 PAAD TP53 TP53 Panobinostat 0.00447538327583761 -0.26279445516278 11 272:273:275:278:282:283:286 0.0647058823529412 0.0502886202180841 1 PAAD TP53 TP53 PD0325901 0.730431316100161 0.159267844284773 11 272:273:275:278:282:283:286 0.0647058823529412 0.868135580610847 0 PAAD TP53 TP53 PD0332991 0.0312834075074718 -0.109949917506645 11 272:273:275:278:282:283:286 0.0647058823529412 0.146325615760755 1 PAAD TP53 TP53 PF2341066 0.615335940669804 0.0314581675668256 11 272:273:275:278:282:283:286 0.0647058823529412 0.762595823907022 0 PAAD TP53 TP53 PHA665752 0.159451106754682 -0.042156958881856 11 272:273:275:278:282:283:286 0.0647058823529412 0.379023122613588 0 PAAD TP53 TP53 PLX4720 0.0526105224580007 -0.157925196417566 11 272:273:275:278:282:283:286 0.0647058823529412 0.264983950547292 0 PAAD TP53 TP53 RAF265 0.851948981209655 0.0188814773372094 11 272:273:275:278:282:283:286 0.0647058823529412 0.950250786733846 0 PAAD TP53 TP53 Sorafenib 0.0216180694797919 -0.0717932797133742 11 272:273:275:278:282:283:286 0.0647058823529412 0.13660455041849 1 PAAD TP53 TP53 TAE684 0.42142337058001 0.0864497166095981 11 272:273:275:278:282:283:286 0.0647058823529412 0.64629317885846 0 PAAD TP53 TP53 TKI258 0.328950392216216 -0.124037815696174 11 272:273:275:278:282:283:286 0.0647058823529412 0.71190756524405 0 PAAD TP53 TP53 Topotecan 0.35819762373598 -0.156267338603505 11 272:273:275:278:282:283:286 0.0647058823529412 0.674527992749573 0 PAAD TP53 TP53 ZD6474 0.0373728626476663 0.170702963552382 11 272:273:275:278:282:283:286 0.0647058823529412 0.216762603356465 0 PRAD FOXA1 FOXA1 17-AAG 0.80973415132836 0.00319019303166845 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.918477593504868 0 PRAD FOXA1 FOXA1 AEW541 0.099492944919483 -0.0246456186705202 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.342762037145397 0 PRAD FOXA1 FOXA1 AZD0530 0.0155178778082316 -0.0894493721992234 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.0904730264364413 1 PRAD FOXA1 FOXA1 AZD6244 0.105088337425328 -0.0874329897168579 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.317454352639012 0 PRAD FOXA1 FOXA1 Erlotinib 0.72404013538296 4.60629212744035e-05 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.852277706263159 0 PRAD FOXA1 FOXA1 Irinotecan 0.120171416096486 0.104184040157456 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.410975591222968 0 PRAD FOXA1 FOXA1 L685458 0.625408461796958 0.000520885823084349 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.778685976507075 0 PRAD FOXA1 FOXA1 Lapatinib 0.459641782576459 0.0289251621786466 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.69425060909986 0 PRAD FOXA1 FOXA1 LBW242 0.515704394351793 -0.0323601094963626 15 247:249:250:251:252:253:254:255 0.0303643724696356 1 0 PRAD FOXA1 FOXA1 Nilotinib 0.0883033637692201 0.0375607955284299 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.376587874898145 0 PRAD FOXA1 FOXA1 Nutlin3 0.031122635160933 -0.035280287543743 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.15456080002062 1 PRAD FOXA1 FOXA1 Paclitaxel 0.0926510043779847 -0.146609114039125 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.29205207901756 0 PRAD FOXA1 FOXA1 Panobinostat 0.214972445297785 0.067863092143873 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.472287948002709 0 PRAD FOXA1 FOXA1 PD0325901 0.140450526240776 -0.0913830243385136 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.391640890479087 0 PRAD FOXA1 FOXA1 PD0332991 0.47479828577367 -0.0192089411672812 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.70712568686602 0 PRAD FOXA1 FOXA1 PF2341066 0.11481985932005 0.0380248327759745 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.334693632312871 0 PRAD FOXA1 FOXA1 PHA665752 0.346608556248523 -0.0067234446370274 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.559245474248325 0 PRAD FOXA1 FOXA1 PLX4720 0.143030402591532 -0.0382020095217684 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.441264007995152 0 PRAD FOXA1 FOXA1 RAF265 0.0817573818017155 0.0937684749228856 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.252230220452101 0 PRAD FOXA1 FOXA1 Sorafenib 0.059142283221378 0.0317767368475398 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.245018030488566 0 PRAD FOXA1 FOXA1 TAE684 0.638950639193102 0.00904071307104004 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.827212881098212 0 PRAD FOXA1 FOXA1 TKI258 0.0178520690587662 0.104649856326142 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.103542000540844 2 PRAD FOXA1 FOXA1 Topotecan 0.0427570013591951 -0.102831926048042 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.193742662408853 1 PRAD FOXA1 FOXA1 ZD6474 0.445894947664983 -0.0268925007954696 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.750921728318306 0 PRAD SPOP SPOP 17-AAG 0.022073446281697 0.0777981826242042 25 131:133 0.0506072874493927 0.139158683080264 2 PRAD SPOP SPOP AEW541 0.85308198938236 0.0013033209151142 25 131:133 0.0506072874493927 0.906068571639172 0 PRAD SPOP SPOP AZD0530 0.541273625344018 0.0268346850146673 25 131:133 0.0506072874493927 0.771368198236586 0 PRAD SPOP SPOP AZD6244 0.111869514245419 -0.0576483737353138 25 131:133 0.0506072874493927 0.326904379112977 0 PRAD SPOP SPOP Erlotinib 0.274195664455672 0.0286621125748866 25 131:133 0.0506072874493927 0.523136465079901 0 PRAD SPOP SPOP Irinotecan 0.414029711047527 0.038259434621349 25 131:133 0.0506072874493927 0.690049518412545 0 PRAD SPOP SPOP L685458 0.405301122070467 -0.0110299025367837 25 131:133 0.0506072874493927 0.660322052811435 0 PRAD SPOP SPOP Lapatinib 0.973641294594676 0.00381135078962913 25 131:133 0.0506072874493927 0.994211181100197 0 PRAD SPOP SPOP LBW242 0.0144507955514897 -0.0479473888005237 25 131:133 0.0506072874493927 1 0 PRAD SPOP SPOP Nilotinib 0.0745072160065839 0.0254419912194779 25 131:133 0.0506072874493927 0.357183338552474 0 PRAD SPOP SPOP Nutlin3 0.00135039164772212 -0.0446349583699381 25 131:133 0.0506072874493927 0.0566659712168211 1 PRAD SPOP SPOP Paclitaxel 0.0512401316537309 -0.156047489096331 25 131:133 0.0506072874493927 0.200805921345702 0 PRAD SPOP SPOP Panobinostat 0.561812357985402 0.0142355751754204 25 131:133 0.0506072874493927 0.781969313462144 0 PRAD SPOP SPOP PD0325901 0.438145577594377 -0.0153788599338216 25 131:133 0.0506072874493927 0.683833290652702 0 PRAD SPOP SPOP PD0332991 0.146631851913611 -0.0244443683053627 25 131:133 0.0506072874493927 0.360366415719891 0 PRAD SPOP SPOP PF2341066 0.197527365466248 0.0162306552384658 25 131:133 0.0506072874493927 0.421198058714793 0 PRAD SPOP SPOP PHA665752 0.183477907872426 0.00698842806618233 25 131:133 0.0506072874493927 0.407493718095566 0 PRAD SPOP SPOP PLX4720 0.217462922994979 0.0194267267789092 25 131:133 0.0506072874493927 0.525535397237866 0 PRAD SPOP SPOP RAF265 0.202925805959518 0.021868229287261 25 131:133 0.0506072874493927 0.459753779127033 0 PRAD SPOP SPOP Sorafenib 0.983447360850636 -0.00407909683921709 25 131:133 0.0506072874493927 0.984261823257477 0 PRAD SPOP SPOP TAE684 0.481994871164125 0.0147207263705899 25 131:133 0.0506072874493927 0.685188787439197 0 PRAD SPOP SPOP TKI258 0.69911779348322 -0.024753912509595 25 131:133 0.0506072874493927 0.921239375376304 0 PRAD SPOP SPOP Topotecan 0.461178388131142 -0.0519482469885832 25 131:133 0.0506072874493927 0.745156389465223 0 PRAD SPOP SPOP ZD6474 0.145353310497624 0.0453482498061978 25 131:133 0.0506072874493927 0.501815000527511 0 PRAD TP53 TP53 17-AAG 0.777629216214473 -0.00926477095018496 11 245:248:249 0.0222672064777328 0.916717368708119 0 PRAD TP53 TP53 AEW541 0.073426327219338 -0.0418349925146937 11 245:248:249 0.0222672064777328 0.287751822886595 0 PRAD TP53 TP53 AZD0530 0.362275441339278 -0.0512451178820482 11 245:248:249 0.0222672064777328 0.673460756335837 0 PRAD TP53 TP53 AZD6244 0.236883244026127 0.0750893239970146 11 245:248:249 0.0222672064777328 0.510941392332687 0 PRAD TP53 TP53 Erlotinib 0.0370167327091144 -0.0677236099077412 11 245:248:249 0.0222672064777328 0.145094414341897 1 PRAD TP53 TP53 Irinotecan 0.908747714875282 -0.0132290054306758 11 245:248:249 0.0222672064777328 0.947974234941841 0 PRAD TP53 TP53 L685458 0.734513140582713 -0.00108669339645634 11 245:248:249 0.0222672064777328 0.842196576055683 0 PRAD TP53 TP53 Lapatinib 0.0617398718297084 -0.052743464993507 11 245:248:249 0.0222672064777328 0.219487729635549 0 PRAD TP53 TP53 LBW242 0.978318143270191 -0.006344421471423 11 245:248:249 0.0222672064777328 1 0 PRAD TP53 TP53 Nilotinib 0.910621232439323 -0.00399306858285353 11 245:248:249 0.0222672064777328 0.98401675142912 0 PRAD TP53 TP53 Nutlin3 0.860244383594153 0.000612654419915204 11 245:248:249 0.0222672064777328 0.917341274328711 0 PRAD TP53 TP53 Paclitaxel 0.153121421116438 -0.143365637706744 11 245:248:249 0.0222672064777328 0.400181164632015 0 PRAD TP53 TP53 Panobinostat 0.759572256721723 0.0297117099666933 11 245:248:249 0.0222672064777328 0.875816151937502 0 PRAD TP53 TP53 PD0325901 0.109352428439481 0.110069020146111 11 245:248:249 0.0222672064777328 0.338581381117707 0 PRAD TP53 TP53 PD0332991 0.764976096928148 -0.0029316434523059 11 245:248:249 0.0222672064777328 0.874867122585577 0 PRAD TP53 TP53 PF2341066 0.910621232439323 -0.00431610076723304 11 245:248:249 0.0222672064777328 0.939770585322949 0 PRAD TP53 TP53 PHA665752 0.959476801704223 0.00138990328935296 11 245:248:249 0.0222672064777328 0.981403557938373 0 PRAD TP53 TP53 PLX4720 0.723857701025822 0.0106504231319424 11 245:248:249 0.0222672064777328 0.893116372848996 0 PRAD TP53 TP53 RAF265 0.306728280158831 0.0495075205626544 11 245:248:249 0.0222672064777328 0.601021630040953 0 PRAD TP53 TP53 Sorafenib 0.673140040927968 0.0124249507130793 11 245:248:249 0.0222672064777328 0.863763769332348 0 PRAD TP53 TP53 TAE684 0.738076461365386 0.00121229347451668 11 245:248:249 0.0222672064777328 0.893469679228757 0 PRAD TP53 TP53 TKI258 0.334348068321001 -0.00170771745877696 11 245:248:249 0.0222672064777328 0.712785848346515 0 PRAD TP53 TP53 Topotecan 0.539700000947656 0.03327614361557 11 245:248:249 0.0222672064777328 0.799087021720268 0 PRAD TP53 TP53 ZD6474 0.362275441339278 -0.0387851449733376 11 245:248:249 0.0222672064777328 0.733598593959076 0 READ KRAS KRAS 17-AAG 0.479996693776908 -0.034449772220944 27 11:12:13 0.3 0.729176211192437 0 READ KRAS KRAS AEW541 0.0589592660419989 -0.029220516523724 27 11:12:13 0.3 0.247274382314841 0 READ KRAS KRAS AZD0530 0.699708320918757 0.0117183241749053 27 11:12:13 0.3 0.889979881870349 0 READ KRAS KRAS AZD6244 0.285982793599515 -0.0422532096656409 27 11:12:13 0.3 0.560371690161212 0 READ KRAS KRAS Erlotinib 0.605885558146925 -0.00156929520732663 27 11:12:13 0.3 0.781959988906675 0 READ KRAS KRAS Irinotecan 0.0278727993187579 -0.138821778816332 27 11:12:13 0.3 0.2377385824247 0 READ KRAS KRAS L685458 0.00307158102818551 -0.0372509286556365 27 11:12:13 0.3 0.0374875795793597 1 READ KRAS KRAS Lapatinib 0.0139109616454 -0.0484867177870933 27 11:12:13 0.3 0.0918748547435794 1 READ KRAS KRAS LBW242 0.0340969206195324 -0.0370421216743166 27 11:12:13 0.3 1 0 READ KRAS KRAS Nilotinib 0.0117466337118675 -0.0552580653334402 27 11:12:13 0.3 0.136495121502235 1 READ KRAS KRAS Nutlin3 0.0445668815633019 -0.0279398519797105 27 11:12:13 0.3 0.174653995315643 1 READ KRAS KRAS Paclitaxel 0.147706372467897 -0.119773467354477 27 11:12:13 0.3 0.400181164632015 0 READ KRAS KRAS Panobinostat 0.0027848682204236 -0.129465537795472 27 11:12:13 0.3 0.0448673213290469 1 READ KRAS KRAS PD0325901 0.737156327640123 -0.0214732268903757 27 11:12:13 0.3 0.869005426892828 0 READ KRAS KRAS PD0332991 0.0139109616454 -0.0476938416124622 27 11:12:13 0.3 0.0916858835719545 1 READ KRAS KRAS PF2341066 0.00186606385662613 -0.0385491096799149 27 11:12:13 0.3 0.0318697463359919 1 READ KRAS KRAS PHA665752 0.0117466337118675 -0.0286127009895401 27 11:12:13 0.3 0.0774209949191267 1 READ KRAS KRAS PLX4720 0.707143149048245 -0.0152062902610913 27 11:12:13 0.3 0.883928936310306 0 READ KRAS KRAS RAF265 0.670262012172328 0.00955413724328835 27 11:12:13 0.3 0.860070723583961 0 READ KRAS KRAS Sorafenib 0.268272337134523 -0.0162164344573427 27 11:12:13 0.3 0.600934477746716 0 READ KRAS KRAS TAE684 0.00960329446537725 -0.0864166911073139 27 11:12:13 0.3 0.0773598720822056 1 READ KRAS KRAS TKI258 0.0645412099738172 -0.0879079996816596 27 11:12:13 0.3 0.257337606466146 0 READ KRAS KRAS Topotecan 0.000834210392549538 -0.161576736233193 27 11:12:13 0.3 0.0120960506919683 1 READ KRAS KRAS ZD6474 0.684925318656532 -0.0101978761503767 27 11:12:13 0.3 0.894722263109884 0 READ TP53 TP53 17-AAG 0.437101705670827 0.0844456371027444 12 245:248:250 0.133333333333333 0.706823826958002 0 READ TP53 TP53 AEW541 0.574292636963252 0.00420429057206118 12 245:248:250 0.133333333333333 0.752244949119026 0 READ TP53 TP53 AZD0530 0.0397950118262408 -0.0966340267553933 12 245:248:250 0.133333333333333 0.171288814221152 1 READ TP53 TP53 AZD6244 0.574292636963252 -0.0406496941142804 12 245:248:250 0.133333333333333 0.785588984525203 0 READ TP53 TP53 Erlotinib 0.768886794992597 -0.0276984523037209 12 245:248:250 0.133333333333333 0.864252599022687 0 READ TP53 TP53 Irinotecan 0.0596757879353114 0.218677464676324 12 245:248:250 0.133333333333333 0.32043340907208 0 READ TP53 TP53 L685458 0.247091129357922 0.0163230448597789 12 245:248:250 0.133333333333333 0.474945983684696 0 READ TP53 TP53 Lapatinib 0.347492644655116 0.0105674966630322 12 245:248:250 0.133333333333333 0.585888761337114 0 READ TP53 TP53 LBW242 0.186070034421091 0.0322887454093053 12 245:248:250 0.133333333333333 1 0 READ TP53 TP53 Nilotinib 0.376020229602138 0.0373619350620532 12 245:248:250 0.133333333333333 0.682464106351632 0 READ TP53 TP53 Nutlin3 0.437101705670827 0.0125198639980206 12 245:248:250 0.133333333333333 0.695505604276078 0 READ TP53 TP53 Paclitaxel 0.893790742841759 0.018026056233249 12 245:248:250 0.133333333333333 0.958957954905148 0 READ TP53 TP53 Panobinostat 0.40590427475338 0.089236432900706 12 245:248:250 0.133333333333333 0.653956887102668 0 READ TP53 TP53 PD0325901 0.40590427475338 -0.0831712531625941 12 245:248:250 0.133333333333333 0.646770547683957 0 READ TP53 TP53 PD0332991 0.503319039286195 0.0263403403652718 12 245:248:250 0.133333333333333 0.707676674129253 0 READ TP53 TP53 PF2341066 0.376020229602138 0.0347108979912225 12 245:248:250 0.133333333333333 0.58941749340588 0 READ TP53 TP53 PHA665752 0.205086629617522 0.0249479687548866 12 245:248:250 0.133333333333333 0.424822304207724 0 READ TP53 TP53 PLX4720 0.978697382843298 -0.0286095620540971 12 245:248:250 0.133333333333333 0.978697382843298 0 READ TP53 TP53 RAF265 0.688522200642271 0.0263441329699736 12 245:248:250 0.133333333333333 0.875751921869555 0 READ TP53 TP53 Sorafenib 0.294537238236256 0.0199705213968274 12 245:248:250 0.133333333333333 0.624002965720967 0 READ TP53 TP53 TAE684 0.936161759898467 0.0240962207545672 12 245:248:250 0.133333333333333 0.984846233442031 0 READ TP53 TP53 TKI258 0.978697382843297 0.0185986542008019 12 245:248:250 0.133333333333333 0.985493892446375 0 READ TP53 TP53 Topotecan 0.437101705670827 0.096827370804768 12 245:248:250 0.133333333333333 0.745156389465223 0 READ TP53 TP53 ZD6474 0.768886794992597 -0.00452155948707045 12 245:248:250 0.133333333333333 0.921393266726666 0 READ TP53 TP53 17-AAG 0.316208626852724 0.106707463529828 15 272:273:275:278:282:287 0.166666666666667 0.643594390748735 0 READ TP53 TP53 AEW541 0.273709743241309 0.00828880108394947 15 272:273:275:278:282:287 0.166666666666667 0.575187141594055 0 READ TP53 TP53 AZD0530 0.413045508058296 -0.0371880161030291 15 272:273:275:278:282:287 0.166666666666667 0.70460704315827 0 READ TP53 TP53 AZD6244 0.495646351599373 0.0586901423042807 15 272:273:275:278:282:287 0.166666666666667 0.740914649298032 0 READ TP53 TP53 Erlotinib 0.273709743241309 -0.0519458229410322 15 272:273:275:278:282:287 0.166666666666667 0.523136465079901 0 READ TP53 TP53 Irinotecan 0.184606229982458 0.15055815160821 15 272:273:275:278:282:287 0.166666666666667 0.498486128871455 0 READ TP53 TP53 L685458 0.387376636390636 0.00471254288644474 15 272:273:275:278:282:287 0.166666666666667 0.640829114918742 0 READ TP53 TP53 Lapatinib 0.495646351599373 -0.0374370057760565 15 272:273:275:278:282:287 0.166666666666667 0.710521423319666 0 READ TP53 TP53 LBW242 0.362672238994759 0.0252940750160653 15 272:273:275:278:282:287 0.166666666666667 1 0 READ TP53 TP53 Nilotinib 0.856156001683663 0.00920542849702355 15 272:273:275:278:282:287 0.166666666666667 0.962345893365358 0 READ TP53 TP53 Nutlin3 0.155541507220737 0.0184094295740356 15 272:273:275:278:282:287 0.166666666666667 0.354735681299389 0 READ TP53 TP53 Paclitaxel 0.785648904870873 0.0645959166572894 15 272:273:275:278:282:287 0.166666666666667 0.904119771478386 0 READ TP53 TP53 Panobinostat 0.856156001683663 0.00884628473611127 15 272:273:275:278:282:287 0.166666666666667 0.926437464508441 0 READ TP53 TP53 PD0325901 0.524956038861006 0.0173455453096656 15 272:273:275:278:282:287 0.166666666666667 0.753982608416788 0 READ TP53 TP53 PD0332991 0.683161815450818 0.0121928376927642 15 272:273:275:278:282:287 0.166666666666667 0.825487193669738 0 READ TP53 TP53 PF2341066 0.00518057718892286 0.0655992233135968 15 272:273:275:278:282:287 0.166666666666667 0.0625986410328179 2 READ TP53 TP53 PHA665752 0.316208626852724 0.016280654600436 15 272:273:275:278:282:287 0.166666666666667 0.54583632016244 0 READ TP53 TP53 PLX4720 0.586037076920776 -0.0112212709812507 15 272:273:275:278:282:287 0.166666666666667 0.852629509131721 0 READ TP53 TP53 RAF265 0.785648904870873 -0.00934377483013638 15 272:273:275:278:282:287 0.166666666666667 0.933763042674398 0 READ TP53 TP53 Sorafenib 0.891867456364697 0.00564799432436325 15 272:273:275:278:282:287 0.166666666666667 0.972333716193179 0 READ TP53 TP53 TAE684 0.439662455371164 0.0696319129435288 15 272:273:275:278:282:287 0.166666666666667 0.650520979885906 0 READ TP53 TP53 TKI258 0.586037076920776 0.0349096415589587 15 272:273:275:278:282:287 0.166666666666667 0.876858719196181 0 READ TP53 TP53 Topotecan 0.338947005194145 0.0723157615542442 15 272:273:275:278:282:287 0.166666666666667 0.672501135222698 0 READ TP53 TP53 ZD6474 0.217360002734885 -0.0546277393257371 15 272:273:275:278:282:287 0.166666666666667 0.546830087594659 0 SARC TP53 TP53 17-AAG 0.790813791399171 0.0302168028602718 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.917343998023038 0 SARC TP53 TP53 AEW541 0.696218564902086 0.00993908586309455 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.842623835782957 0 SARC TP53 TP53 AZD0530 0.525544909741469 -0.0402935357826523 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.769737494065788 0 SARC TP53 TP53 AZD6244 0.395653799845859 -0.143808850519009 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.651929556564199 0 SARC TP53 TP53 Erlotinib 0.855737087238178 -0.00781756856331328 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.912366747423057 0 SARC TP53 TP53 Irinotecan 0.683044372964433 0.0504334489528153 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.852231054153143 0 SARC TP53 TP53 L685458 0.494918098190216 0.0287751112457784 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.712950676140981 0 SARC TP53 TP53 Lapatinib 0.0139396331335086 0.0899964580015643 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.0918748547435794 2 SARC TP53 TP53 LBW242 0.216139589326219 0.0356695052944169 14 234:237:238:241:242:244:248:252 0.0598290598290598 1 0 SARC TP53 TP53 Nilotinib 0.827765801388101 0.0240642700992858 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.937703446884958 0 SARC TP53 TP53 Nutlin3 0.517798339828552 0.028823806904145 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.743373854209307 0 SARC TP53 TP53 Paclitaxel 0.992866092410638 0.00385878063212175 14 234:237:238:241:242:244:248:252 0.0598290598290598 1 0 SARC TP53 TP53 Panobinostat 0.32976617999588 0.0571119262785942 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.556001117434914 0 SARC TP53 TP53 PD0325901 0.211745511030624 -0.299197730861171 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.45825521043941 0 SARC TP53 TP53 PD0332991 0.969093721354963 0.0163018211857699 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.989567532369504 0 SARC TP53 TP53 PF2341066 0.656986960723128 0.0162610283384282 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.793859244207113 0 SARC TP53 TP53 PHA665752 0.969093721354963 0.00748029436631592 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.982647479695592 0 SARC TP53 TP53 PLX4720 0.687425294548288 -0.0184291915418817 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.882094404508865 0 SARC TP53 TP53 RAF265 0.510111266876212 -0.0276957344136555 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.747132663606573 0 SARC TP53 TP53 Sorafenib 0.436639916747252 0.032998573202457 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.736195208469204 0 SARC TP53 TP53 TAE684 0.405676200960372 -0.0590125368471766 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.64629317885846 0 SARC TP53 TP53 TKI258 0.158622157076751 0.15155049000892 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.448199814441618 0 SARC TP53 TP53 Topotecan 0.553116878937813 -0.0725488192901951 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.799087021720268 0 SARC TP53 TP53 ZD6474 0.220598938644948 -0.0700834237069237 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.546830087594659 0 SARC TP53 TP53 17-AAG 0.816473036107326 0.0151170317502043 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.918477593504868 0 SARC TP53 TP53 AEW541 0.154262269121106 -0.0660538612718792 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.391975875337794 0 SARC TP53 TP53 AZD0530 0.00983764376603282 -0.200711956358433 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.071322917303738 1 SARC TP53 TP53 AZD6244 0.0771602033750974 -0.246587369623282 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.248627321986425 0 SARC TP53 TP53 Erlotinib 0.536773384597805 -0.0118035811974253 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.760192809262725 0 SARC TP53 TP53 Irinotecan 0.455523518669907 -0.072575111824392 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.720003332158644 0 SARC TP53 TP53 L685458 0.481811481542544 -0.0264000795139367 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.712950676140981 0 SARC TP53 TP53 Lapatinib 0.0324567160169822 0.110308094671014 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.134463537784641 2 SARC TP53 TP53 LBW242 0.455523518669907 -0.0203566092508084 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 1 0 SARC TP53 TP53 Nilotinib 0.434247833414473 -0.0546505984870196 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.687369552132832 0 SARC TP53 TP53 Nutlin3 0.866729341951955 0.00962302448136709 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.917341274328711 0 SARC TP53 TP53 Paclitaxel 0.536773384597805 -0.0779322010457522 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.845618335540587 0 SARC TP53 TP53 Panobinostat 0.681358858643253 0.0568333303543724 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.844419098318561 0 SARC TP53 TP53 PD0325901 0.0759726543911303 -0.36309950205637 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.268683777724729 0 SARC TP53 TP53 PD0332991 0.614652834962558 -0.00960673642370991 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.781795272540096 0 SARC TP53 TP53 PF2341066 0.508903637112247 -0.0302104576792697 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.683250253530332 0 SARC TP53 TP53 PHA665752 0.78337011525325 -0.00643002770293011 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.880532300090862 0 SARC TP53 TP53 PLX4720 0.204964473787367 -0.149896201310196 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.525535397237866 0 SARC TP53 TP53 RAF265 0.0150355082148484 -0.132759088780258 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.079780384256353 1 SARC TP53 TP53 Sorafenib 0.541491870132607 -0.0331587544899464 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.809461238276102 0 SARC TP53 TP53 TAE684 0.150173561457888 -0.0996464231084588 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.384356458321209 0 SARC TP53 TP53 TKI258 0.833152158231215 -0.0675150920095828 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.959342395190069 0 SARC TP53 TP53 Topotecan 0.302128497373484 -0.10465397329784 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.653860180882913 0 SARC TP53 TP53 ZD6474 0.245878540253056 0.0790241658825431 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.594206472278219 0 SKCM BRAF BRAF 17-AAG 0.27647639087645 0.075109731843622 13 466:467:469 0.0359116022099447 0.591140268862651 0 SKCM BRAF BRAF AEW541 0.234580070093852 -0.0535319318212581 13 466:467:469 0.0359116022099447 0.531470471306383 0 SKCM BRAF BRAF AZD0530 0.731308213895212 -0.0208127897621074 13 466:467:469 0.0359116022099447 0.90632214542569 0 SKCM BRAF BRAF AZD6244 0.475730688958864 0.022653937945619 13 466:467:469 0.0359116022099447 0.730810048466706 0 SKCM BRAF BRAF Erlotinib 0.723375190342575 -0.0252295377552691 13 466:467:469 0.0359116022099447 0.852277706263159 0 SKCM BRAF BRAF Irinotecan 0.615757839422641 0.0703865199628684 13 466:467:469 0.0359116022099447 0.831248558064582 0 SKCM BRAF BRAF L685458 0.894927757662779 0.00430343229745511 13 466:467:469 0.0359116022099447 0.940915480959262 0 SKCM BRAF BRAF Lapatinib 0.869913288347812 -0.00136953793603733 13 466:467:469 0.0359116022099447 0.941324080674871 0 SKCM BRAF BRAF LBW242 0.799822187615448 0.00982120973685774 13 466:467:469 0.0359116022099447 1 0 SKCM BRAF BRAF Nilotinib 0.86575614229638 -0.023154760994673 13 466:467:469 0.0359116022099447 0.965651081792116 0 SKCM BRAF BRAF Nutlin3 0.779484005013861 0.0105227264309229 13 466:467:469 0.0359116022099447 0.898414789240926 0 SKCM BRAF BRAF Paclitaxel 0.60465351418088 -0.0548195431288452 13 466:467:469 0.0359116022099447 0.868066926299283 0 SKCM BRAF BRAF Panobinostat 0.820297045935903 0.0128240889226481 13 466:467:469 0.0359116022099447 0.914946705082353 0 SKCM BRAF BRAF PD0325901 0.861602707222934 -0.00390916612642078 13 466:467:469 0.0359116022099447 0.932331287666608 0 SKCM BRAF BRAF PD0332991 0.932638435178621 -0.00207341533353989 13 466:467:469 0.0359116022099447 0.965946950720715 0 SKCM BRAF BRAF PF2341066 0.469218196289052 0.0353626584427705 13 466:467:469 0.0359116022099447 0.659603683825225 0 SKCM BRAF BRAF PHA665752 0.116645812469147 0.0459433099656456 13 466:467:469 0.0359116022099447 0.313215607556043 0 SKCM BRAF BRAF PLX4720 0.779484005013861 0.0163213723214746 13 466:467:469 0.0359116022099447 0.904201445816079 0 SKCM BRAF BRAF RAF265 0.485591674225729 -0.0205294989675928 13 466:467:469 0.0359116022099447 0.745662374723171 0 SKCM BRAF BRAF Sorafenib 0.352483353633966 0.0171347927102508 13 466:467:469 0.0359116022099447 0.681467817025668 0 SKCM BRAF BRAF TAE684 0.143371100441949 0.0621513519915298 13 466:467:469 0.0359116022099447 0.384356458321209 0 SKCM BRAF BRAF TKI258 0.395024764271098 -0.0804029693191783 13 466:467:469 0.0359116022099447 0.753665668675121 0 SKCM BRAF BRAF Topotecan 0.352483353633966 0.181702937097622 13 466:467:469 0.0359116022099447 0.672501135222698 0 SKCM BRAF BRAF ZD6474 0.502269523219203 0.0440047605191789 13 466:467:469 0.0359116022099447 0.791620444204179 0 SKCM BRAF BRAF 17-AAG 0.000799974418703676 0.0975689613048956 159 594:597:600 0.439226519337017 0.0128884767457814 2 SKCM BRAF BRAF AEW541 0.460126868973398 -0.0140206916279978 159 594:597:600 0.439226519337017 0.697808405271508 0 SKCM BRAF BRAF AZD0530 0.041345575846485 -0.0532944209681823 159 594:597:600 0.439226519337017 0.171288814221152 1 SKCM BRAF BRAF AZD6244 0.31312925834549 0.0311965342156704 159 594:597:600 0.439226519337017 0.582099262308924 0 SKCM BRAF BRAF Erlotinib 0.545343302044859 -0.015123304381836 159 594:597:600 0.439226519337017 0.760334411504851 0 SKCM BRAF BRAF Irinotecan 0.896185600940341 -0.0283360213806461 159 594:597:600 0.439226519337017 0.947844676277817 0 SKCM BRAF BRAF L685458 0.633689277433344 0.00895048882020666 159 594:597:600 0.439226519337017 0.778685976507075 0 SKCM BRAF BRAF Lapatinib 0.809912006714039 -0.0086889920391946 159 594:597:600 0.439226519337017 0.8964674883476 0 SKCM BRAF BRAF LBW242 0.0858302798522275 0.0271373994191788 159 594:597:600 0.439226519337017 1 0 SKCM BRAF BRAF Nilotinib 0.649938083566531 0.00734565237640217 159 594:597:600 0.439226519337017 0.847965386361886 0 SKCM BRAF BRAF Nutlin3 0.0176685694894182 0.0270206309886514 159 594:597:600 0.439226519337017 0.113946953741073 2 SKCM BRAF BRAF Paclitaxel 0.117933373078782 0.0481677423483875 159 594:597:600 0.439226519337017 0.363837002051561 0 SKCM BRAF BRAF Panobinostat 0.0868704362414724 0.0550325871852069 159 594:597:600 0.439226519337017 0.292935191977058 0 SKCM BRAF BRAF PD0325901 0.705557901920372 0.013093185475566 159 594:597:600 0.439226519337017 0.863235058240048 0 SKCM BRAF BRAF PD0332991 0.507574993858223 0.0121399215624828 159 594:597:600 0.439226519337017 0.707676674129253 0 SKCM BRAF BRAF PF2341066 0.468438220330451 0.00805169378076576 159 594:597:600 0.439226519337017 0.659603683825225 0 SKCM BRAF BRAF PHA665752 0.000562153538039225 0.0372704856346386 159 594:597:600 0.439226519337017 0.0116446090022411 2 SKCM BRAF BRAF PLX4720 0.0909161732624268 0.0508081166413579 159 594:597:600 0.439226519337017 0.362320363410075 0 SKCM BRAF BRAF RAF265 0.56512047164883 0.0217336273591724 159 594:597:600 0.439226519337017 0.805608273766497 0 SKCM BRAF BRAF Sorafenib 0.327492280303959 0.0133843264994442 159 594:597:600 0.439226519337017 0.641707846541541 0 SKCM BRAF BRAF TAE684 0.135692334310169 0.0235431354568609 159 594:597:600 0.439226519337017 0.378372855287971 0 SKCM BRAF BRAF TKI258 0.401758614002691 0.0356878368295628 159 594:597:600 0.439226519337017 0.756558428966106 0 SKCM BRAF BRAF Topotecan 0.0003815935979778 0.180580721778337 159 594:597:600 0.439226519337017 0.00691638396334762 2 SKCM BRAF BRAF ZD6474 0.0175603285284132 -0.0576285371425644 159 594:597:600 0.439226519337017 0.125907308974925 1 SKCM CDKN2A CDKN2A 17-AAG 0.628597896438011 -0.0679076861014241 11 80:81:83:88 0.0303867403314917 0.819443075531059 0 SKCM CDKN2A CDKN2A AEW541 0.677029146038274 0.0122708789214998 11 80:81:83:88 0.0303867403314917 0.831942594708049 0 SKCM CDKN2A CDKN2A AZD0530 0.650210388124802 -0.0167384136430638 11 80:81:83:88 0.0303867403314917 0.872967650723114 0 SKCM CDKN2A CDKN2A AZD6244 0.994639793512714 0.012016347441679 11 80:81:83:88 0.0303867403314917 1 0 SKCM CDKN2A CDKN2A Erlotinib 0.112100068020986 0.0438239624390915 11 80:81:83:88 0.0303867403314917 0.295536542964418 0 SKCM CDKN2A CDKN2A Irinotecan 0.525521091443047 -0.0820774774134452 11 80:81:83:88 0.0303867403314917 0.771125751713089 0 SKCM CDKN2A CDKN2A L685458 0.505993418174385 -0.0310948590657746 11 80:81:83:88 0.0303867403314917 0.712950676140981 0 SKCM CDKN2A CDKN2A Lapatinib 0.516794778782688 -0.0388310409782625 11 80:81:83:88 0.0303867403314917 0.716406762711615 0 SKCM CDKN2A CDKN2A LBW242 0.927735748707247 0.0017879592207386 11 80:81:83:88 0.0303867403314917 1 0 SKCM CDKN2A CDKN2A Nilotinib 0.664785422824476 -0.0303458730302086 11 80:81:83:88 0.0303867403314917 0.847965386361886 0 SKCM CDKN2A CDKN2A Nutlin3 0.63576794818852 -0.0170553321961309 11 80:81:83:88 0.0303867403314917 0.834680100207675 0 SKCM CDKN2A CDKN2A Paclitaxel 0.731883053653544 -0.0545720002387773 11 80:81:83:88 0.0303867403314917 0.892078030448865 0 SKCM CDKN2A CDKN2A Panobinostat 0.505993418174385 -0.0580136204935373 11 80:81:83:88 0.0303867403314917 0.755880715994261 0 SKCM CDKN2A CDKN2A PD0325901 0.61436293559666 0.0754917609875703 11 80:81:83:88 0.0303867403314917 0.817271795059777 0 SKCM CDKN2A CDKN2A PD0332991 0.527714386754217 -0.0355675654193781 11 80:81:83:88 0.0303867403314917 0.715126972704313 0 SKCM CDKN2A CDKN2A PF2341066 0.130644192524872 -0.0477432089642992 11 80:81:83:88 0.0303867403314917 0.334693632312871 0 SKCM CDKN2A CDKN2A PHA665752 0.593281473786993 -0.017197633089137 11 80:81:83:88 0.0303867403314917 0.782052851810127 0 SKCM CDKN2A CDKN2A PLX4720 0.975882563044616 -0.0133646064213004 11 80:81:83:88 0.0303867403314917 0.978697382843298 0 SKCM CDKN2A CDKN2A RAF265 0.981240864761105 0.00191938768963174 11 80:81:83:88 0.0303867403314917 0.988055037433057 0 SKCM CDKN2A CDKN2A Sorafenib 0.62146270841489 -0.0207000865844872 11 80:81:83:88 0.0303867403314917 0.831376335950175 0 SKCM CDKN2A CDKN2A TAE684 0.148630506117627 -0.0822866125670128 11 80:81:83:88 0.0303867403314917 0.384356458321209 0 SKCM CDKN2A CDKN2A TKI258 0.602610147739121 0.0598417821929951 11 80:81:83:88 0.0303867403314917 0.876858719196181 0 SKCM CDKN2A CDKN2A Topotecan 0.222718864788518 -0.200608756000379 11 80:81:83:88 0.0303867403314917 0.556797161971295 0 SKCM CDKN2A CDKN2A ZD6474 0.362664895632373 0.0481866927804038 11 80:81:83:88 0.0303867403314917 0.733598593959076 0 SKCM CDKN2A CDKN2A 17-AAG 0.843771756405236 0.00834924237200463 14 110:114 0.0386740331491713 0.918827868253112 0 SKCM CDKN2A CDKN2A AEW541 0.0832463520642297 -0.0635370400685179 14 110:114 0.0386740331491713 0.30950566793111 0 SKCM CDKN2A CDKN2A AZD0530 0.932691403518939 -0.00362553480188954 14 110:114 0.0386740331491713 0.980001837030769 0 SKCM CDKN2A CDKN2A AZD6244 0.84609147112764 0.0247639534748214 14 110:114 0.0386740331491713 0.936322591467579 0 SKCM CDKN2A CDKN2A Erlotinib 0.899773235667934 -0.0102861148768896 14 110:114 0.0386740331491713 0.934968612058213 0 SKCM CDKN2A CDKN2A Irinotecan 0.410869122432598 -0.0987217237903457 14 110:114 0.0386740331491713 0.690049518412545 0 SKCM CDKN2A CDKN2A L685458 0.632222019610543 -0.0165406634000881 14 110:114 0.0386740331491713 0.778685976507075 0 SKCM CDKN2A CDKN2A Lapatinib 0.38118894388281 -0.028831655137858 14 110:114 0.0386740331491713 0.61037286593332 0 SKCM CDKN2A CDKN2A LBW242 0.961001072246386 0.0209126662846439 14 110:114 0.0386740331491713 1 0 SKCM CDKN2A CDKN2A Nilotinib 0.878698651523347 -0.00905062957023017 14 110:114 0.0386740331491713 0.969341017501976 0 SKCM CDKN2A CDKN2A Nutlin3 0.949197339614195 -0.00152559781339434 14 110:114 0.0386740331491713 0.95578898780596 0 SKCM CDKN2A CDKN2A Paclitaxel 0.328833600710894 0.101151722168997 14 110:114 0.0386740331491713 0.657917533572212 0 SKCM CDKN2A CDKN2A Panobinostat 0.871692092771413 -0.00991161130067564 14 110:114 0.0386740331491713 0.936261877421147 0 SKCM CDKN2A CDKN2A PD0325901 0.613367113714433 0.0785687847907517 14 110:114 0.0386740331491713 0.817271795059777 0 SKCM CDKN2A CDKN2A PD0332991 0.278741324574587 -0.049682475144068 14 110:114 0.0386740331491713 0.524902494328768 0 SKCM CDKN2A CDKN2A PF2341066 0.384420222030264 -0.0221103815584368 14 110:114 0.0386740331491713 0.58941749340588 0 SKCM CDKN2A CDKN2A PHA665752 0.871692092771413 -0.00518074637718569 14 110:114 0.0386740331491713 0.957540556453446 0 SKCM CDKN2A CDKN2A PLX4720 0.666333105112604 -0.0395030301107266 14 110:114 0.0386740331491713 0.877019401596361 0 SKCM CDKN2A CDKN2A RAF265 0.503964915330143 0.0178007870637762 14 110:114 0.0386740331491713 0.745662374723171 0 SKCM CDKN2A CDKN2A Sorafenib 0.822957609160571 -0.0142761497763744 14 110:114 0.0386740331491713 0.917914256371406 0 SKCM CDKN2A CDKN2A TAE684 0.0446691953829298 -0.110364610034293 14 110:114 0.0386740331491713 0.223345976914649 0 SKCM CDKN2A CDKN2A TKI258 0.906814584898725 0.000884493618353188 14 110:114 0.0386740331491713 0.959342395190069 0 SKCM CDKN2A CDKN2A Topotecan 0.765833274042616 0.0170046947221212 14 110:114 0.0386740331491713 0.93315819106033 0 SKCM CDKN2A CDKN2A ZD6474 0.402489985078655 -0.032162553343566 14 110:114 0.0386740331491713 0.739978986852158 0 SKCM IDH1 IDH1 17-AAG 0.0798402178389139 -0.141994601742974 13 132 0.0359116022099447 0.273753844028507 0 SKCM IDH1 IDH1 AEW541 0.584415393129611 0.0159261374143398 13 132 0.0359116022099447 0.752244949119026 0 SKCM IDH1 IDH1 AZD0530 0.755381107385123 -0.0108370713959647 13 132 0.0359116022099447 0.91275217142369 0 SKCM IDH1 IDH1 AZD6244 0.630884531130897 -0.017762833226582 13 132 0.0359116022099447 0.803053398126123 0 SKCM IDH1 IDH1 Erlotinib 0.609389508596236 -0.0155999119148311 13 132 0.0359116022099447 0.781959988906675 0 SKCM IDH1 IDH1 Irinotecan 0.326230615580894 0.119607792763913 13 132 0.0359116022099447 0.630712523456395 0 SKCM IDH1 IDH1 L685458 0.851714631555318 -0.0226982262077206 13 132 0.0359116022099447 0.935595617996372 0 SKCM IDH1 IDH1 Lapatinib 0.983429028992505 -0.0117861043913573 13 132 0.0359116022099447 0.997183281146246 0 SKCM IDH1 IDH1 LBW242 0.64076069362385 -0.0265336275777396 13 132 0.0359116022099447 1 0 SKCM IDH1 IDH1 Nilotinib 0.595882777289532 0.0149142627259393 13 132 0.0359116022099447 0.815453138326596 0 SKCM IDH1 IDH1 Nutlin3 0.78928262366775 -0.0131690126804912 13 132 0.0359116022099447 0.901149452219085 0 SKCM IDH1 IDH1 Paclitaxel 0.0478497228117909 -0.224985121073974 13 132 0.0359116022099447 0.198234565934562 1 SKCM IDH1 IDH1 Panobinostat 0.689030510345009 -0.0375064340356346 13 132 0.0359116022099447 0.846690033898528 0 SKCM IDH1 IDH1 PD0325901 0.47749437945173 -0.0302534639183167 13 132 0.0359116022099447 0.728807210742114 0 SKCM IDH1 IDH1 PD0332991 0.985638234804487 -0.0173554213439665 13 132 0.0359116022099447 0.9909205500128 0 SKCM IDH1 IDH1 PF2341066 0.362964129159171 -0.0176194446903257 13 132 0.0359116022099447 0.588703668570395 0 SKCM IDH1 IDH1 PHA665752 0.347117880567926 -0.029003369617295 13 132 0.0359116022099447 0.559245474248325 0 SKCM IDH1 IDH1 PLX4720 0.652696462380588 0.013249949103612 13 132 0.0359116022099447 0.877019401596361 0 SKCM IDH1 IDH1 RAF265 0.906307444518908 0.00413957027425438 13 132 0.0359116022099447 0.9673168432365 0 SKCM IDH1 IDH1 Sorafenib 0.61521948450513 0.0120812389463933 13 132 0.0359116022099447 0.831376335950175 0 SKCM IDH1 IDH1 TAE684 0.738600906054729 -0.0118214799792205 13 132 0.0359116022099447 0.893469679228757 0 SKCM IDH1 IDH1 TKI258 0.974593645757176 -0.00666355983453859 13 132 0.0359116022099447 0.985493892446375 0 SKCM IDH1 IDH1 Topotecan 0.347117880567926 -0.161974441267457 13 132 0.0359116022099447 0.672501135222698 0 SKCM IDH1 IDH1 ZD6474 0.222503277021275 0.075942939049864 13 132 0.0359116022099447 0.546830087594659 0 SKCM KLHDC7A KLHDC7A 17-AAG 0.142659055288011 0.107522584128268 11 635 0.0303867403314917 0.362904614329151 0 SKCM KLHDC7A KLHDC7A AEW541 0.747480511550634 -0.0244112687504179 11 635 0.0303867403314917 0.843121071823001 0 SKCM KLHDC7A KLHDC7A AZD0530 0.154198027411565 -0.0979452466585059 11 635 0.0303867403314917 0.429975268743787 0 SKCM KLHDC7A KLHDC7A AZD6244 0.842530127656075 0.0153720945388132 11 635 0.0303867403314917 0.936322591467579 0 SKCM KLHDC7A KLHDC7A Erlotinib 0.731964012577298 -0.0118188335180903 11 635 0.0303867403314917 0.852277706263159 0 SKCM KLHDC7A KLHDC7A Irinotecan 0.459402837863002 0.138993507178558 11 635 0.0303867403314917 0.720003332158644 0 SKCM KLHDC7A KLHDC7A L685458 0.653652767345846 0.0174043485679706 11 635 0.0303867403314917 0.789830427209564 0 SKCM KLHDC7A KLHDC7A Lapatinib 0.731964012577298 -0.0221223220153307 11 635 0.0303867403314917 0.8569095338034 0 SKCM KLHDC7A KLHDC7A LBW242 0.912723024691275 -0.00041284295331212 11 635 0.0303867403314917 1 0 SKCM KLHDC7A KLHDC7A Nilotinib 0.794624090038517 0.0415554145824358 11 635 0.0303867403314917 0.922551163763158 0 SKCM KLHDC7A KLHDC7A Nutlin3 0.2775808549854 0.0262817469102038 11 635 0.0303867403314917 0.53665631963844 0 SKCM KLHDC7A KLHDC7A Paclitaxel 0.378717765464784 0.0280520506279345 11 635 0.0303867403314917 0.686425949904921 0 SKCM KLHDC7A KLHDC7A Panobinostat 0.942659233095611 -0.0123374464402985 11 635 0.0303867403314917 0.976325634277597 0 SKCM KLHDC7A KLHDC7A PD0325901 0.51298168145898 0.0763241618742665 11 635 0.0303867403314917 0.751336806177294 0 SKCM KLHDC7A KLHDC7A PD0332991 0.489013607529501 0.0299954412066853 11 635 0.0303867403314917 0.70712568686602 0 SKCM KLHDC7A KLHDC7A PF2341066 0.0932847951204158 0.0385748408130516 11 635 0.0303867403314917 0.317900735811548 0 SKCM KLHDC7A KLHDC7A PHA665752 0.355076116060715 0.0238060398883245 11 635 0.0303867403314917 0.565780624492348 0 SKCM KLHDC7A KLHDC7A PLX4720 0.465662178657775 0.0757802113965853 11 635 0.0303867403314917 0.791842381808024 0 SKCM KLHDC7A KLHDC7A RAF265 0.0880601561971877 0.0864279037888358 11 635 0.0303867403314917 0.260586176501882 0 SKCM KLHDC7A KLHDC7A Sorafenib 0.193068998830508 0.0565466540694926 11 635 0.0303867403314917 0.505356822286908 0 SKCM KLHDC7A KLHDC7A TAE684 0.918158025063203 0.00766353791998231 11 635 0.0303867403314917 0.984846233442031 0 SKCM KLHDC7A KLHDC7A TKI258 0.459402837863002 0.0941779773197968 11 635 0.0303867403314917 0.792527104790198 0 SKCM KLHDC7A KLHDC7A Topotecan 0.671042610060439 0.0543221305982904 11 635 0.0303867403314917 0.861072375741271 0 SKCM KLHDC7A KLHDC7A ZD6474 0.209986808022196 -0.0780280105296433 11 635 0.0303867403314917 0.546830087594659 0 SKCM MAGEC1 MAGEC1 17-AAG 0.284231141154729 0.0967031223341714 11 683:687:688:691:695 0.0303867403314917 0.59729732561501 0 SKCM MAGEC1 MAGEC1 AEW541 0.384327497094415 -0.0383358351717608 11 683:687:688:691:695 0.0303867403314917 0.660796770817279 0 SKCM MAGEC1 MAGEC1 AZD0530 0.275293125447331 0.101492863777592 11 683:687:688:691:695 0.0303867403314917 0.570250045569471 0 SKCM MAGEC1 MAGEC1 AZD6244 0.943939506706947 0.00536166335230992 11 683:687:688:691:695 0.0303867403314917 0.990629855225245 0 SKCM MAGEC1 MAGEC1 Erlotinib 0.329845640510054 -0.058537059291933 11 683:687:688:691:695 0.0303867403314917 0.56712243933804 0 SKCM MAGEC1 MAGEC1 Irinotecan 0.231919690162466 0.171027313750524 11 683:687:688:691:695 0.0303867403314917 0.551284509402583 0 SKCM MAGEC1 MAGEC1 L685458 0.181527358800874 0.0430467672826235 11 683:687:688:691:695 0.0303867403314917 0.45880039290054 0 SKCM MAGEC1 MAGEC1 Lapatinib 0.75243339179214 0.00551830033676959 11 683:687:688:691:695 0.0303867403314917 0.8569095338034 0 SKCM MAGEC1 MAGEC1 LBW242 0.858085337368999 0.0183558111585171 11 683:687:688:691:695 0.0303867403314917 1 0 SKCM MAGEC1 MAGEC1 Nilotinib 0.280632640287593 0.0309786059127019 11 683:687:688:691:695 0.0303867403314917 0.607339296144791 0 SKCM MAGEC1 MAGEC1 Nutlin3 0.146335900138523 0.0399720018903519 11 683:687:688:691:695 0.0303867403314917 0.347847631476817 0 SKCM MAGEC1 MAGEC1 Paclitaxel 0.0434696571983662 0.285948348857 11 683:687:688:691:695 0.0303867403314917 0.188331808265253 2 SKCM MAGEC1 MAGEC1 Panobinostat 0.749384832332446 0.0124386467821758 11 683:687:688:691:695 0.0303867403314917 0.875816151937502 0 SKCM MAGEC1 MAGEC1 PD0325901 0.483188155806002 -0.129384804473706 11 683:687:688:691:695 0.0303867403314917 0.729815443665316 0 SKCM MAGEC1 MAGEC1 PD0332991 0.346049885076768 0.0365107350898483 11 683:687:688:691:695 0.0303867403314917 0.612947242225836 0 SKCM MAGEC1 MAGEC1 PF2341066 0.0127993516649846 0.0887723896311021 11 683:687:688:691:695 0.0303867403314917 0.0883764757820365 2 SKCM MAGEC1 MAGEC1 PHA665752 0.00895232177887161 0.0820642348880151 11 683:687:688:691:695 0.0303867403314917 0.0645246258731337 2 SKCM MAGEC1 MAGEC1 PLX4720 0.701169260316684 -0.0451006626332935 11 683:687:688:691:695 0.0303867403314917 0.883928936310306 0 SKCM MAGEC1 MAGEC1 RAF265 0.045166983894683 -0.117297210345193 11 683:687:688:691:695 0.0303867403314917 0.163730316618226 1 SKCM MAGEC1 MAGEC1 Sorafenib 0.273528796767471 0.0316371500941992 11 683:687:688:691:695 0.0303867403314917 0.600934477746716 0 SKCM MAGEC1 MAGEC1 TAE684 0.0078589512843277 0.140406737634366 11 683:687:688:691:695 0.0303867403314917 0.0670322315427951 2 SKCM MAGEC1 MAGEC1 TKI258 0.163824759761419 0.141600168603621 11 683:687:688:691:695 0.0303867403314917 0.448199814441618 0 SKCM MAGEC1 MAGEC1 Topotecan 0.0250797215772481 0.361235146352493 11 683:687:688:691:695 0.0303867403314917 0.12539860788624 2 SKCM MAGEC1 MAGEC1 ZD6474 0.460910578071236 -0.0263626965182469 11 683:687:688:691:695 0.0303867403314917 0.750921728318306 0 SKCM RAC1 RAC1 17-AAG 0.0246470424783627 0.117843204072056 19 29:34 0.0524861878453039 0.142952846374504 2 SKCM RAC1 RAC1 AEW541 0.581787120271909 -0.0273854668441934 19 29:34 0.0524861878453039 0.752244949119026 0 SKCM RAC1 RAC1 AZD0530 0.850116932675386 0.0120876233455683 19 29:34 0.0524861878453039 0.948207347984084 0 SKCM RAC1 RAC1 AZD6244 0.355431323464331 0.075457403658157 19 29:34 0.0524861878453039 0.622135006220584 0 SKCM RAC1 RAC1 Erlotinib 0.159799349606028 -0.0343402812639618 19 29:34 0.0524861878453039 0.379850912997935 0 SKCM RAC1 RAC1 Irinotecan 0.107716314590591 0.190395378972019 19 29:34 0.0524861878453039 0.41023116820951 0 SKCM RAC1 RAC1 L685458 0.225447894638786 0.0313962958778058 19 29:34 0.0524861878453039 0.474945983684696 0 SKCM RAC1 RAC1 Lapatinib 0.668187033998007 -0.000472225155917494 19 29:34 0.0524861878453039 0.842496695040965 0 SKCM RAC1 RAC1 LBW242 0.33425104390092 0.0338385995131196 19 29:34 0.0524861878453039 1 0 SKCM RAC1 RAC1 Nilotinib 0.458057099320477 0.0297345814690329 19 29:34 0.0524861878453039 0.699371112859351 0 SKCM RAC1 RAC1 Nutlin3 0.140244324182925 0.0327983354424849 19 29:34 0.0524861878453039 0.344668254347867 0 SKCM RAC1 RAC1 Paclitaxel 0.0395977163989604 0.169480123948329 19 29:34 0.0524861878453039 0.185215125091912 2 SKCM RAC1 RAC1 Panobinostat 0.298650929826461 0.0696315968010328 19 29:34 0.0524861878453039 0.527961669173014 0 SKCM RAC1 RAC1 PD0325901 0.462256429631798 0.108689696314912 19 29:34 0.0524861878453039 0.713055130815008 0 SKCM RAC1 RAC1 PD0332991 0.242652338941883 0.0425192289804981 19 29:34 0.0524861878453039 0.502636987808186 0 SKCM RAC1 RAC1 PF2341066 0.0217168080534799 0.0469242580397755 19 29:34 0.0524861878453039 0.112462041705521 2 SKCM RAC1 RAC1 PHA665752 0.0860057426986238 0.0368855367253151 19 29:34 0.0524861878453039 0.260943971812122 0 SKCM RAC1 RAC1 PLX4720 0.465067876017883 0.031210734939449 19 29:34 0.0524861878453039 0.791842381808024 0 SKCM RAC1 RAC1 RAF265 0.974262284155516 0.0151340786450469 19 29:34 0.0524861878453039 0.988055037433057 0 SKCM RAC1 RAC1 Sorafenib 0.320592662455758 0.0256636318670272 19 29:34 0.0524861878453039 0.636793644603903 0 SKCM RAC1 RAC1 TAE684 0.116562584938376 0.0531047349809914 19 29:34 0.0524861878453039 0.352116142001344 0 SKCM RAC1 RAC1 TKI258 0.191330555589287 0.0993407430579734 19 29:34 0.0524861878453039 0.49540947429369 0 SKCM RAC1 RAC1 Topotecan 0.136564062249644 0.193696669569047 19 29:34 0.0524861878453039 0.413001291751911 0 SKCM RAC1 RAC1 ZD6474 0.459454492986105 0.0420786788934888 19 29:34 0.0524861878453039 0.750921728318306 0 SKCM SLC27A5 SLC27A5 17-AAG 0.1255478041625 0.132014228683094 10 550:554 0.0276243093922652 0.343479841576651 0 SKCM SLC27A5 SLC27A5 AEW541 0.978244883571611 -0.0147475094715934 10 550:554 0.0276243093922652 0.984983456779033 0 SKCM SLC27A5 SLC27A5 AZD0530 0.184649358504506 0.10280561856389 10 550:554 0.0276243093922652 0.469722052336024 0 SKCM SLC27A5 SLC27A5 AZD6244 0.027636854682729 0.261064401795499 10 550:554 0.0276243093922652 0.138184273413645 2 SKCM SLC27A5 SLC27A5 Erlotinib 0.715763660636462 -0.0252355981476746 10 550:554 0.0276243093922652 0.852277706263159 0 SKCM SLC27A5 SLC27A5 Irinotecan 0.235853111286912 -0.173806060548201 10 550:554 0.0276243093922652 0.551591953816165 0 SKCM SLC27A5 SLC27A5 L685458 0.209117675101451 -0.0641786041983397 10 550:554 0.0276243093922652 0.464414853606848 0 SKCM SLC27A5 SLC27A5 Lapatinib 0.412395527079697 -0.0305533298271757 10 550:554 0.0276243093922652 0.646177427933877 0 SKCM SLC27A5 SLC27A5 LBW242 0.369889060949475 -0.0372479376795022 10 550:554 0.0276243093922652 1 0 SKCM SLC27A5 SLC27A5 Nilotinib 0.250091994776083 -0.0604477821982898 10 550:554 0.0276243093922652 0.566782215231189 0 SKCM SLC27A5 SLC27A5 Nutlin3 0.417905218783403 -0.0327626239903235 10 550:554 0.0276243093922652 0.67329174137326 0 SKCM SLC27A5 SLC27A5 Paclitaxel 0.640651902528775 -0.0868361547124117 10 550:554 0.0276243093922652 0.877715146851436 0 SKCM SLC27A5 SLC27A5 Panobinostat 0.142176500052993 -0.160197403554029 10 550:554 0.0276243093922652 0.374828954685163 0 SKCM SLC27A5 SLC27A5 PD0325901 0.00786147680147922 0.426042442199486 10 550:554 0.0276243093922652 0.0759942757476325 2 SKCM SLC27A5 SLC27A5 PD0332991 0.201089947858744 -0.0792132886563245 10 550:554 0.0276243093922652 0.441788521810877 0 SKCM SLC27A5 SLC27A5 PF2341066 0.929698287836431 0.00152829364885965 10 550:554 0.0276243093922652 0.949339800959736 0 SKCM SLC27A5 SLC27A5 PHA665752 0.0616570225841573 -0.0594158444039085 10 550:554 0.0276243093922652 0.212863530350067 0 SKCM SLC27A5 SLC27A5 PLX4720 0.960340333830902 -0.0158009835496968 10 550:554 0.0276243093922652 0.978697382843298 0 SKCM SLC27A5 SLC27A5 RAF265 0.0726590439818257 0.0984889273742662 10 550:554 0.0276243093922652 0.22903394298619 0 SKCM SLC27A5 SLC27A5 Sorafenib 0.950117557062075 -0.00481577469326133 10 550:554 0.0276243093922652 0.977901744972689 0 SKCM SLC27A5 SLC27A5 TAE684 0.0752519520653396 -0.0862523832963096 10 550:554 0.0276243093922652 0.272788326236856 0 SKCM SLC27A5 SLC27A5 TKI258 0.38025191944416 -0.087998874986883 10 550:554 0.0276243093922652 0.74110540961577 0 SKCM SLC27A5 SLC27A5 Topotecan 0.558218620434963 -0.148726539449194 10 550:554 0.0276243093922652 0.799087021720268 0 SKCM SLC27A5 SLC27A5 ZD6474 0.985922145811339 0.015417087662247 10 550:554 0.0276243093922652 0.985922145811339 0 SKCM TPTE TPTE 17-AAG 0.132869473793659 0.101242718847894 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.349529088491264 0 SKCM TPTE TPTE AEW541 0.456764131486865 -0.0248015160803904 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.697808405271508 0 SKCM TPTE TPTE AZD0530 0.824465955746427 0.000392974215645214 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.934998064477449 0 SKCM TPTE TPTE AZD6244 0.373846406410766 0.0404065130255897 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.627350862443665 0 SKCM TPTE TPTE Erlotinib 0.339261391710388 -0.0251552032612292 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.56712243933804 0 SKCM TPTE TPTE Irinotecan 0.461795240625889 0.148552305620496 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.720003332158644 0 SKCM TPTE TPTE L685458 0.661828181691795 -0.0241461479565774 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.793099887151325 0 SKCM TPTE TPTE Lapatinib 0.701353496477002 0.0162066059155768 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.8569095338034 0 SKCM TPTE TPTE LBW242 0.738573157357498 -0.0134852847677285 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 1 0 SKCM TPTE TPTE Nilotinib 0.632045840439935 -0.027211474721844 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.841313416915054 0 SKCM TPTE TPTE Nutlin3 0.568637890909806 -0.0205443093508917 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.796542408695479 0 SKCM TPTE TPTE Paclitaxel 0.365001972910615 0.117198886246439 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.686425949904921 0 SKCM TPTE TPTE Panobinostat 0.582779493489193 -0.0510354544173595 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.789747911737691 0 SKCM TPTE TPTE PD0325901 0.200895502568254 0.0757479765062579 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.448151505729182 0 SKCM TPTE TPTE PD0332991 0.484813911429567 -0.0468717947878208 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.70712568686602 0 SKCM TPTE TPTE PF2341066 0.770069002964068 0.00390058359740253 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.851642238250315 0 SKCM TPTE TPTE PHA665752 0.998346033805656 -0.00947342281156638 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.998346033805656 0 SKCM TPTE TPTE PLX4720 0.902658659246072 -0.0263125898566907 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.975642553280488 0 SKCM TPTE TPTE RAF265 0.18806755204089 0.0531298185343165 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.447045820425066 0 SKCM TPTE TPTE Sorafenib 0.978501026223734 -0.00572717464412187 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.984261823257477 0 SKCM TPTE TPTE TAE684 0.876450367425946 -0.0135577585972644 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.976897576553956 0 SKCM TPTE TPTE TKI258 0.726093320968651 0.0391313527567601 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.921239375376304 0 SKCM TPTE TPTE Topotecan 0.948762278014733 8.93941664377174e-05 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.989716045411052 0 SKCM TPTE TPTE ZD6474 0.856881069866223 0.0196123984050847 11 371:373:375:379:383:384:388:392:394:396 0.0303867403314917 0.963890952546201 0 STAD CTNNB1 CTNNB1 17-AAG 0.479318547187143 0.0786011073174868 10 32:34:37:41 0.0242718446601942 0.729176211192437 0 STAD CTNNB1 CTNNB1 AEW541 0.0199373083595147 -0.0952468729903129 10 32:34:37:41 0.0242718446601942 0.125691726614332 1 STAD CTNNB1 CTNNB1 AZD0530 0.238025695769002 -0.0420781462602728 10 32:34:37:41 0.0242718446601942 0.515942709081624 0 STAD CTNNB1 CTNNB1 AZD6244 0.701025700766521 0.0234473772215149 10 32:34:37:41 0.0242718446601942 0.840072120753269 0 STAD CTNNB1 CTNNB1 Erlotinib 0.063597843578629 -0.115480262817126 10 32:34:37:41 0.0242718446601942 0.201151618689558 0 STAD CTNNB1 CTNNB1 Irinotecan 0.296057454944734 0.178187993234313 10 32:34:37:41 0.0242718446601942 0.626643853759755 0 STAD CTNNB1 CTNNB1 L685458 0.387087461843149 -0.0388321035490945 10 32:34:37:41 0.0242718446601942 0.640829114918742 0 STAD CTNNB1 CTNNB1 Lapatinib 0.73254246504344 -0.0593242021142824 10 32:34:37:41 0.0242718446601942 0.8569095338034 0 STAD CTNNB1 CTNNB1 LBW242 0.000474409481682537 -0.0993493535881648 10 32:34:37:41 0.0242718446601942 1 0 STAD CTNNB1 CTNNB1 Nilotinib 0.940583042862053 -0.00458415265183254 10 32:34:37:41 0.0242718446601942 0.98401675142912 0 STAD CTNNB1 CTNNB1 Nutlin3 0.011965332408263 -0.0836683611017581 10 32:34:37:41 0.0242718446601942 0.091314378905165 1 STAD CTNNB1 CTNNB1 Paclitaxel 0.55003815848619 -0.0930660430736303 10 32:34:37:41 0.0242718446601942 0.845618335540587 0 STAD CTNNB1 CTNNB1 Panobinostat 0.741026294188655 -0.0451380008825115 10 32:34:37:41 0.0242718446601942 0.875816151937502 0 STAD CTNNB1 CTNNB1 PD0325901 0.548162622732977 0.0998753276020357 10 32:34:37:41 0.0242718446601942 0.764265195156554 0 STAD CTNNB1 CTNNB1 PD0332991 0.83621689847884 -0.0223025849179723 10 32:34:37:41 0.0242718446601942 0.928689602392617 0 STAD CTNNB1 CTNNB1 PF2341066 0.188527888736218 -0.0495065027261161 10 32:34:37:41 0.0242718446601942 0.414190058587146 0 STAD CTNNB1 CTNNB1 PHA665752 0.665921318986029 -0.0301920696563075 10 32:34:37:41 0.0242718446601942 0.862130279044413 0 STAD CTNNB1 CTNNB1 PLX4720 0.678232560223803 0.0271796396199547 10 32:34:37:41 0.0242718446601942 0.878068939575459 0 STAD CTNNB1 CTNNB1 RAF265 0.108569393856095 0.0881583262228878 10 32:34:37:41 0.0242718446601942 0.308677688414388 0 STAD CTNNB1 CTNNB1 Sorafenib 0.0961676511197646 0.0572785235658897 10 32:34:37:41 0.0242718446601942 0.332007366961092 0 STAD CTNNB1 CTNNB1 TAE684 0.404297096741383 -0.0546845692285354 10 32:34:37:41 0.0242718446601942 0.64629317885846 0 STAD CTNNB1 CTNNB1 TKI258 0.474091893661462 -0.120538992918803 10 32:34:37:41 0.0242718446601942 0.792527104790198 0 STAD CTNNB1 CTNNB1 Topotecan 0.781739490349982 -0.116579667190852 10 32:34:37:41 0.0242718446601942 0.93679525703097 0 STAD CTNNB1 CTNNB1 ZD6474 0.100751345612518 -0.100073207849286 10 32:34:37:41 0.0242718446601942 0.410193048864343 0 STAD DHX16 DHX16 17-AAG 0.0344362555124434 0.210729342550142 10 1033 0.0242718446601942 0.171110547504076 2 STAD DHX16 DHX16 AEW541 0.416214094281834 -0.0421372646022737 10 1033 0.0242718446601942 0.66971069948411 0 STAD DHX16 DHX16 AZD0530 0.0011402776657158 -0.172787728267138 10 1033 0.0242718446601942 0.0175660329374408 1 STAD DHX16 DHX16 AZD6244 0.690998178350689 0.0977145303689886 10 1033 0.0242718446601942 0.839296016389673 0 STAD DHX16 DHX16 Erlotinib 0.311323020160242 0.0395664985996824 10 1033 0.0242718446601942 0.557306641027594 0 STAD DHX16 DHX16 Irinotecan 0.0297730291841609 0.353495321018837 10 1033 0.0242718446601942 0.239838290650185 0 STAD DHX16 DHX16 L685458 0.0861546947449657 0.0431860809914212 10 1033 0.0242718446601942 0.347011964945001 0 STAD DHX16 DHX16 Lapatinib 0.0317005326087269 0.0892709581714339 10 1033 0.0242718446601942 0.134463537784641 2 STAD DHX16 DHX16 LBW242 0.484280065327686 0.014699905053547 10 1033 0.0242718446601942 1 0 STAD DHX16 DHX16 Nilotinib 0.0984674571806707 0.0588901923173583 10 1033 0.0242718446601942 0.382213281247524 0 STAD DHX16 DHX16 Nutlin3 0.499990381649893 0.0180899251074389 10 1033 0.0242718446601942 0.743373854209307 0 STAD DHX16 DHX16 Paclitaxel 0.601564049781528 -0.0578025791431918 10 1033 0.0242718446601942 0.868066926299283 0 STAD DHX16 DHX16 Panobinostat 0.199172113123021 0.112831815333005 10 1033 0.0242718446601942 0.458412006394255 0 STAD DHX16 DHX16 PD0325901 0.530387765920775 0.168202419989246 10 1033 0.0242718446601942 0.753982608416788 0 STAD DHX16 DHX16 PD0332991 0.0235428769888655 0.109679133126078 10 1033 0.0242718446601942 0.126433969014278 2 STAD DHX16 DHX16 PF2341066 0.000856855263140616 0.109245303494932 10 1033 0.0242718446601942 0.0296449688710562 2 STAD DHX16 DHX16 PHA665752 0.0358781450700409 0.0668307267868378 10 1033 0.0242718446601942 0.153009736328116 2 STAD DHX16 DHX16 PLX4720 0.184100662381075 -0.112604339308809 10 1033 0.0242718446601942 0.513357616254921 0 STAD DHX16 DHX16 RAF265 0.0064973629313525 0.120899989664968 10 1033 0.0242718446601942 0.0409616358715701 2 STAD DHX16 DHX16 Sorafenib 0.0113922138759696 0.0693971241158061 10 1033 0.0242718446601942 0.0856312216062366 2 STAD DHX16 DHX16 TAE684 0.130773892610732 0.0840329541133029 10 1033 0.0242718446601942 0.37180812605012 0 STAD DHX16 DHX16 TKI258 0.0681412288028623 0.207564714131859 10 1033 0.0242718446601942 0.257337606466146 0 STAD DHX16 DHX16 Topotecan 0.0113922138759696 0.335547506423123 10 1033 0.0242718446601942 0.074913703501537 2 STAD DHX16 DHX16 ZD6474 0.882187163860565 0.0172532373768255 10 1033 0.0242718446601942 0.963890952546201 0 STAD KRAS KRAS 17-AAG 0.0206729749106395 0.155455309831469 19 12:13 0.0461165048543689 0.136253698274669 2 STAD KRAS KRAS AEW541 0.000773198617802238 -0.0890370332223342 19 12:13 0.0461165048543689 0.0160162570830464 1 STAD KRAS KRAS AZD0530 0.408288492959879 -0.0208861809112586 19 12:13 0.0461165048543689 0.70460704315827 0 STAD KRAS KRAS AZD6244 0.24666136181578 0.138273575277385 19 12:13 0.0461165048543689 0.510941392332687 0 STAD KRAS KRAS Erlotinib 0.336662795438546 0.0281604640091647 19 12:13 0.0461165048543689 0.56712243933804 0 STAD KRAS KRAS Irinotecan 0.700899850482509 0.000996886650114437 19 12:13 0.0461165048543689 0.854037632940872 0 STAD KRAS KRAS L685458 0.178329665096472 -0.0466720580354458 19 12:13 0.0461165048543689 0.45880039290054 0 STAD KRAS KRAS Lapatinib 0.217709889076589 -0.0276092933448053 19 12:13 0.0461165048543689 0.426593701568992 0 STAD KRAS KRAS LBW242 0.0223086911498764 -0.0580471001144477 19 12:13 0.0461165048543689 1 0 STAD KRAS KRAS Nilotinib 0.646772956204356 -0.0214348278574117 19 12:13 0.0461165048543689 0.847965386361886 0 STAD KRAS KRAS Nutlin3 0.00544657039965456 -0.0687926681896762 19 12:13 0.0461165048543689 0.0607502083038393 1 STAD KRAS KRAS Paclitaxel 0.018313674211587 -0.259218929506583 19 12:13 0.0461165048543689 0.139762250562111 1 STAD KRAS KRAS Panobinostat 0.0914494168055076 -0.113496968196042 19 12:13 0.0461165048543689 0.301367396290877 0 STAD KRAS KRAS PD0325901 0.0120881169235474 0.298896489927351 19 12:13 0.0461165048543689 0.0922514186270723 2 STAD KRAS KRAS PD0332991 0.44174974045925 -0.0397317861979775 19 12:13 0.0461165048543689 0.695401643212966 0 STAD KRAS KRAS PF2341066 0.0987938824807823 0.0411495281538544 19 12:13 0.0461165048543689 0.321714414152914 0 STAD KRAS KRAS PHA665752 0.900838038824148 -0.00160838660995732 19 12:13 0.0461165048543689 0.967566782440752 0 STAD KRAS KRAS PLX4720 0.0529967901094584 -0.108592400467043 19 12:13 0.0461165048543689 0.264983950547292 0 STAD KRAS KRAS RAF265 0.000903518907413797 0.119803078044849 19 12:13 0.0461165048543689 0.0145566935083334 2 STAD KRAS KRAS Sorafenib 0.684183464054743 0.0107449443391631 19 12:13 0.0461165048543689 0.870233353402962 0 STAD KRAS KRAS TAE684 0.739423182810006 0.00120496578733675 19 12:13 0.0461165048543689 0.893469679228757 0 STAD KRAS KRAS TKI258 0.445425695070264 -0.0771288800844248 19 12:13 0.0461165048543689 0.779744457815764 0 STAD KRAS KRAS Topotecan 0.462808865049017 0.0215515038456049 19 12:13 0.0461165048543689 0.745156389465223 0 STAD KRAS KRAS ZD6474 0.0153033298179807 -0.116894580651568 19 12:13 0.0461165048543689 0.116895651224692 1 STAD PGM5 PGM5 17-AAG 9.32266071929086e-07 0.313004768817122 22 98 0.0533980582524272 6.75892902148587e-05 2 STAD PGM5 PGM5 AEW541 0.153841480512001 -0.0359590824320006 22 98 0.0533980582524272 0.391975875337794 0 STAD PGM5 PGM5 AZD0530 0.00121145054740971 -0.129093347064096 22 98 0.0533980582524272 0.0175660329374408 1 STAD PGM5 PGM5 AZD6244 0.0198456113927478 0.207435194607844 22 98 0.0533980582524272 0.136900600982901 2 STAD PGM5 PGM5 Erlotinib 0.0276955384654405 0.0708424440778513 22 98 0.0533980582524272 0.127962769411911 2 STAD PGM5 PGM5 Irinotecan 0.00148313937095887 0.31905560932794 22 98 0.0533980582524272 0.0238950231987818 2 STAD PGM5 PGM5 L685458 0.111535702732968 0.0258643187907408 22 98 0.0533980582524272 0.381741104703408 0 STAD PGM5 PGM5 Lapatinib 0.0171392620136905 0.0816809037769815 22 98 0.0533980582524272 0.10507624518148 2 STAD PGM5 PGM5 LBW242 0.0287753284320201 0.0440020086728339 22 98 0.0533980582524272 1 0 STAD PGM5 PGM5 Nilotinib 0.0219229273473496 0.0678460404165128 22 98 0.0533980582524272 0.189607480242724 2 STAD PGM5 PGM5 Nutlin3 0.57131317589193 0.00691278831110798 22 98 0.0533980582524272 0.796542408695479 0 STAD PGM5 PGM5 Paclitaxel 0.984270268280689 -0.00497029101053403 22 98 0.0533980582524272 1 0 STAD PGM5 PGM5 Panobinostat 0.118014205466061 0.0982293323486791 22 98 0.0533980582524272 0.330600267099532 0 STAD PGM5 PGM5 PD0325901 0.00903029550164655 0.299992077167607 22 98 0.0533980582524272 0.076894019973766 2 STAD PGM5 PGM5 PD0332991 0.0147622747439894 0.0769276401391528 22 98 0.0533980582524272 0.0920795152853798 2 STAD PGM5 PGM5 PF2341066 1.57641359227232e-07 0.12069093247058 22 98 0.0533980582524272 2.28579970879486e-05 2 STAD PGM5 PGM5 PHA665752 0.000779151606086323 0.0652087823940338 22 98 0.0533980582524272 0.0126790040380323 2 STAD PGM5 PGM5 PLX4720 0.022140711116216 -0.12069348282234 22 98 0.0533980582524272 0.16896858483428 1 STAD PGM5 PGM5 RAF265 0.00146404376477098 0.103211737402164 22 98 0.0533980582524272 0.0163297189147532 2 STAD PGM5 PGM5 Sorafenib 0.00679625074612884 0.0565477759454786 22 98 0.0533980582524272 0.0615910223867926 2 STAD PGM5 PGM5 TAE684 0.0809330849638893 0.0672040806622602 22 98 0.0533980582524272 0.286226763896682 0 STAD PGM5 PGM5 TKI258 0.00353454450669879 0.203412084861627 22 98 0.0533980582524272 0.0333249653337839 2 STAD PGM5 PGM5 Topotecan 5.88731138888061e-05 0.370255457883917 22 98 0.0533980582524272 0.00213415037846922 2 STAD PGM5 PGM5 ZD6474 0.741753830948646 -0.018651364616749 22 98 0.0533980582524272 0.910370895332992 0 STAD PIK3CA PIK3CA 17-AAG 0.00780894841259422 0.172958623856722 20 542:545:546:547 0.0485436893203883 0.0707685949891351 2 STAD PIK3CA PIK3CA AEW541 0.381150046149456 -0.0193857033117781 20 542:545:546:547 0.0485436893203883 0.660796770817279 0 STAD PIK3CA PIK3CA AZD0530 0.197014944422733 -0.0599205418129554 20 542:545:546:547 0.0485436893203883 0.484189270191463 0 STAD PIK3CA PIK3CA AZD6244 0.587428222380075 0.115112403617327 20 542:545:546:547 0.0485436893203883 0.788676780047323 0 STAD PIK3CA PIK3CA Erlotinib 0.344184652839638 0.0266535788390104 20 542:545:546:547 0.0485436893203883 0.56712243933804 0 STAD PIK3CA PIK3CA Irinotecan 0.000439465810077692 0.357534840785948 20 542:545:546:547 0.0485436893203883 0.0113067162661185 2 STAD PIK3CA PIK3CA L685458 0.0254215465325538 0.0467035001055752 20 542:545:546:547 0.0485436893203883 0.147444969888812 2 STAD PIK3CA PIK3CA Lapatinib 0.0210393115444663 0.0749901310708152 20 542:545:546:547 0.0485436893203883 0.114830203793484 2 STAD PIK3CA PIK3CA LBW242 0.6210671521972 0.0108398670058336 20 542:545:546:547 0.0485436893203883 1 0 STAD PIK3CA PIK3CA Nilotinib 0.0766951407841804 0.0589150397989432 20 542:545:546:547 0.0485436893203883 0.357183338552474 0 STAD PIK3CA PIK3CA Nutlin3 0.608737803636138 0.0122902411584043 20 542:545:546:547 0.0485436893203883 0.816230497417743 0 STAD PIK3CA PIK3CA Paclitaxel 0.372862339387769 0.0695398104431 20 542:545:546:547 0.0485436893203883 0.686425949904921 0 STAD PIK3CA PIK3CA Panobinostat 0.0670150028857312 0.112870125070108 20 542:545:546:547 0.0485436893203883 0.285799277012677 0 STAD PIK3CA PIK3CA PD0325901 0.810295659141643 0.0913284397013769 20 542:545:546:547 0.0485436893203883 0.896892141798002 0 STAD PIK3CA PIK3CA PD0332991 0.00215519946581985 0.111686059259233 20 542:545:546:547 0.0485436893203883 0.0260419935453232 2 STAD PIK3CA PIK3CA PF2341066 0.00136623398886875 0.0868381938946543 20 542:545:546:547 0.0485436893203883 0.0312916081850271 2 STAD PIK3CA PIK3CA PHA665752 0.000786972664429593 0.0719756843308218 20 542:545:546:547 0.0485436893203883 0.0126790040380323 2 STAD PIK3CA PIK3CA PLX4720 0.211865836707186 0.052350799132754 20 542:545:546:547 0.0485436893203883 0.525535397237866 0 STAD PIK3CA PIK3CA RAF265 0.0265958682813944 0.0966627983280051 20 542:545:546:547 0.0485436893203883 0.110182882880063 2 STAD PIK3CA PIK3CA Sorafenib 0.00236995432215844 0.0729662293988784 20 542:545:546:547 0.0485436893203883 0.0343643376712974 2 STAD PIK3CA PIK3CA TAE684 0.286197836059011 0.0499150298018662 20 542:545:546:547 0.0485436893203883 0.576370642063286 0 STAD PIK3CA PIK3CA TKI258 0.00198758121566961 0.236275165995181 20 542:545:546:547 0.0485436893203883 0.0221691750978533 2 STAD PIK3CA PIK3CA Topotecan 0.00054828583826615 0.30412189482313 20 542:545:546:547 0.0485436893203883 0.00883349406095464 2 STAD PIK3CA PIK3CA ZD6474 0.929253867841747 -0.0040687413559739 20 542:545:546:547 0.0485436893203883 0.96509326057909 0 STAD SMAD4 SMAD4 17-AAG 0.566380044149483 0.0577729797273014 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.782143870492143 0 STAD SMAD4 SMAD4 AEW541 0.739917078631585 0.0139775073469992 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.843121071823001 0 STAD SMAD4 SMAD4 AZD0530 0.881824370176622 0.00674527236553657 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.954212937877688 0 STAD SMAD4 SMAD4 AZD6244 0.246424901866817 0.167550532586714 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.510941392332687 0 STAD SMAD4 SMAD4 Erlotinib 0.780772445660825 -0.0123712873053494 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.870861574006305 0 STAD SMAD4 SMAD4 Irinotecan 0.858944723023892 0.0535880557673183 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.936443495026048 0 STAD SMAD4 SMAD4 L685458 0.301186659884991 0.0162948791251323 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.545900821041546 0 STAD SMAD4 SMAD4 Lapatinib 0.703097227060672 -0.00109589195612037 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.8569095338034 0 STAD SMAD4 SMAD4 LBW242 0.806626072482162 0.00872700833339179 16 351:352:355:356:361:362:363:368 0.0388349514563107 1 0 STAD SMAD4 SMAD4 Nilotinib 0.342648489729329 0.0300458401916153 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.662453746810036 0 STAD SMAD4 SMAD4 Nutlin3 0.517528072907289 0.0169363328489226 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.743373854209307 0 STAD SMAD4 SMAD4 Paclitaxel 0.920759409480313 -0.000253720988289352 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.96746459691772 0 STAD SMAD4 SMAD4 Panobinostat 0.149026696256135 0.115192447473623 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.379102999248063 0 STAD SMAD4 SMAD4 PD0325901 0.383915403900751 0.173506664544905 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.626312936062762 0 STAD SMAD4 SMAD4 PD0332991 0.521877372982912 0.0267290300691418 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.715126972704313 0 STAD SMAD4 SMAD4 PF2341066 0.26800799737643 0.0390409027018692 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.517986105871644 0 STAD SMAD4 SMAD4 PHA665752 0.364686190624779 0.0278195598242452 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.56859674882358 0 STAD SMAD4 SMAD4 PLX4720 0.416457056355128 0.0324739039887865 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.772258841804041 0 STAD SMAD4 SMAD4 RAF265 0.765373830500955 0.0221063500917427 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.917183515889574 0 STAD SMAD4 SMAD4 Sorafenib 0.815292652110466 0.0112526931575505 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.917914256371406 0 STAD SMAD4 SMAD4 TAE684 0.126531233903226 0.0737141240660519 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.37180812605012 0 STAD SMAD4 SMAD4 TKI258 0.990190310906998 -0.0177195738071021 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.990190310906998 0 STAD SMAD4 SMAD4 Topotecan 0.578547669043452 0.0621889417711166 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.799087021720268 0 STAD SMAD4 SMAD4 ZD6474 0.21266932709785 -0.0554274619945123 16 351:352:355:356:361:362:363:368 0.0388349514563107 0.546830087594659 0 STAD TP53 TP53 17-AAG 0.128463282744688 0.129331001858325 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.344947703666292 0 STAD TP53 TP53 AEW541 0.148604238232409 -0.0391339966535629 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.391975875337794 0 STAD TP53 TP53 AZD0530 0.504485381982859 0.0418243699648906 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.76198312903661 0 STAD TP53 TP53 AZD6244 0.806407371990335 0.0757932916010957 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.934814796224334 0 STAD TP53 TP53 Erlotinib 0.58102326947536 0.0298952100658522 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.781959988906675 0 STAD TP53 TP53 Irinotecan 0.979336297967502 -0.0202727682429233 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.993033309127887 0 STAD TP53 TP53 L685458 0.113205982774114 -0.0534466884838705 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.381741104703408 0 STAD TP53 TP53 Lapatinib 0.597511803473762 -0.00720436194099672 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.787629195488141 0 STAD TP53 TP53 LBW242 0.0167178720268187 -0.057324388782431 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 1 0 STAD TP53 TP53 Nilotinib 0.104419821097698 -0.0643590385157657 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.387190505036129 0 STAD TP53 TP53 Nutlin3 0.035208609484713 -0.0650738219153336 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.156137205198638 1 STAD TP53 TP53 Paclitaxel 0.554025806043833 -0.131681037233118 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.845618335540587 0 STAD TP53 TP53 Panobinostat 0.282869502646083 -0.10028320692887 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.510182678700501 0 STAD TP53 TP53 PD0325901 0.147487347129777 0.228524919873978 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.403503119505994 0 STAD TP53 TP53 PD0332991 0.247037225789686 -0.068637199162376 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.504512644218373 0 STAD TP53 TP53 PF2341066 0.496882359127142 0.0228830279047426 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.673345253022763 0 STAD TP53 TP53 PHA665752 0.685878776983175 -0.00300334207708541 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.8723896724786 0 STAD TP53 TP53 PLX4720 0.00409140769954179 -0.184916197262047 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.04943784303613 1 STAD TP53 TP53 RAF265 0.13562146026513 0.0617134391987888 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.361825117567096 0 STAD TP53 TP53 Sorafenib 0.925393467825232 -0.00473379753245079 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.972333716193179 0 STAD TP53 TP53 TAE684 0.91906494200474 0.00931076193311475 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.984846233442031 0 STAD TP53 TP53 TKI258 0.0641802417925798 -0.183550716493347 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.257337606466146 0 STAD TP53 TP53 Topotecan 0.133545528586669 -0.149228811265414 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.413001291751911 0 STAD TP53 TP53 ZD6474 0.979336297967502 0.00996196675376027 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.985922145811339 0 STAD TP53 TP53 17-AAG 0.654894243008755 -0.0165906763787897 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.819443075531059 0 STAD TP53 TP53 AEW541 0.156855284851719 -0.0427142144889567 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.391975875337794 0 STAD TP53 TP53 AZD0530 0.690373161891517 -0.0192597178338285 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.885877066143982 0 STAD TP53 TP53 AZD6244 0.0547724877942176 -0.131195479879389 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.201315842889406 0 STAD TP53 TP53 Erlotinib 0.439886404904416 0.0539706527635441 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.664411757407712 0 STAD TP53 TP53 Irinotecan 0.396887933408899 -0.103569702595524 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.690049518412545 0 STAD TP53 TP53 L685458 0.198856994149714 -0.0387279904396627 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.464414853606848 0 STAD TP53 TP53 Lapatinib 0.516368718508111 0.0253452537706829 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.716406762711615 0 STAD TP53 TP53 LBW242 0.950789000617635 0.00643568036979181 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 1 0 STAD TP53 TP53 Nilotinib 0.418061636390095 -0.0364462010290426 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.682464106351632 0 STAD TP53 TP53 Nutlin3 0.0638321964802054 -0.0629915405310177 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.205681521991773 0 STAD TP53 TP53 Paclitaxel 0.71255576320817 0.0345267368544153 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.892078030448865 0 STAD TP53 TP53 Panobinostat 0.18485333096074 -0.0907786337318512 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.432318274021086 0 STAD TP53 TP53 PD0325901 0.328022374985871 -0.0745491870003887 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.566229099677992 0 STAD TP53 TP53 PD0332991 0.040574798750961 -0.0920014911456732 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.17303958290851 1 STAD TP53 TP53 PF2341066 0.0611994230289085 -0.0584119208297278 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.227536316389532 0 STAD TP53 TP53 PHA665752 0.294098987786616 -0.0296345718007448 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.538412065726142 0 STAD TP53 TP53 PLX4720 0.119266113137709 -0.109395291949534 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.411752057261138 0 STAD TP53 TP53 RAF265 0.326176015803828 -0.034635076475944 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.606352849891732 0 STAD TP53 TP53 Sorafenib 0.407392771120805 -0.0208042431416505 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.721813757748919 0 STAD TP53 TP53 TAE684 0.0627680725585832 -0.0659608071309143 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.256043938355137 0 STAD TP53 TP53 TKI258 0.0420638869382159 -0.18639409962581 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.2014691608934 0 STAD TP53 TP53 Topotecan 0.037046375691139 -0.242956737625363 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.17328143468436 1 STAD TP53 TP53 ZD6474 0.543314119801529 0.00524854385592266 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.803883136441038 0 STAD TP53 TP53 17-AAG 0.107699341032616 -0.122014668400645 12 191:192:193:195:196:198 0.029126213592233 0.318702131627129 0 STAD TP53 TP53 AEW541 0.499369996075165 0.0270652910375555 12 191:192:193:195:196:198 0.029126213592233 0.722419772169928 0 STAD TP53 TP53 AZD0530 0.998147918705402 -0.0422958021380893 12 191:192:193:195:196:198 0.029126213592233 1 0 STAD TP53 TP53 AZD6244 0.191260566280176 -0.145235502044152 12 191:192:193:195:196:198 0.029126213592233 0.462213035177092 0 STAD TP53 TP53 Erlotinib 0.677774250774486 -0.0262701006930917 12 191:192:193:195:196:198 0.029126213592233 0.832858189511021 0 STAD TP53 TP53 Irinotecan 0.902086657423026 -0.00325134846466346 12 191:192:193:195:196:198 0.029126213592233 0.947844676277817 0 STAD TP53 TP53 L685458 0.0623277250108909 -0.0682084095677613 12 191:192:193:195:196:198 0.029126213592233 0.273864246259975 0 STAD TP53 TP53 Lapatinib 0.160214276612042 -0.0715667085254867 12 191:192:193:195:196:198 0.029126213592233 0.372560336449659 0 STAD TP53 TP53 LBW242 0.557019590025432 0.00325468846650501 12 191:192:193:195:196:198 0.029126213592233 1 0 STAD TP53 TP53 Nilotinib 0.0222295165588269 -0.097498514810031 12 191:192:193:195:196:198 0.029126213592233 0.189607480242724 1 STAD TP53 TP53 Nutlin3 0.00754570082069384 -0.0970541803287064 12 191:192:193:195:196:198 0.029126213592233 0.0729417746000404 1 STAD TP53 TP53 Paclitaxel 0.266191984886996 -0.159621064854518 12 191:192:193:195:196:198 0.029126213592233 0.588872462745123 0 STAD TP53 TP53 Panobinostat 0.10369665115548 -0.134523100923667 12 191:192:193:195:196:198 0.029126213592233 0.308351251300938 0 STAD TP53 TP53 PD0325901 0.754001368916322 -0.00349328063980403 12 191:192:193:195:196:198 0.029126213592233 0.869726746344263 0 STAD TP53 TP53 PD0332991 0.00260688674583643 -0.148871370119118 12 191:192:193:195:196:198 0.029126213592233 0.0269998984390202 1 STAD TP53 TP53 PF2341066 0.705161391653808 -0.011826051222521 12 191:192:193:195:196:198 0.029126213592233 0.811495252300017 0 STAD TP53 TP53 PHA665752 0.0164919443222264 -0.0685912839447214 12 191:192:193:195:196:198 0.029126213592233 0.0919743048739549 1 STAD TP53 TP53 PLX4720 0.000851080656866218 -0.251123824120328 12 191:192:193:195:196:198 0.029126213592233 0.0176295278922288 1 STAD TP53 TP53 RAF265 0.373983951815691 0.0179199074374432 12 191:192:193:195:196:198 0.029126213592233 0.67784591266594 0 STAD TP53 TP53 Sorafenib 0.950026478036275 -0.00484551504566855 12 191:192:193:195:196:198 0.029126213592233 0.977901744972689 0 STAD TP53 TP53 TAE684 0.0988605609412548 -0.0628574510785573 12 191:192:193:195:196:198 0.029126213592233 0.319828070469847 0 STAD TP53 TP53 TKI258 0.0194136970978367 -0.238858769177344 12 191:192:193:195:196:198 0.029126213592233 0.104392576358009 1 STAD TP53 TP53 Topotecan 0.0643092721758437 -0.216000622722032 12 191:192:193:195:196:198 0.029126213592233 0.245390643828877 0 STAD TP53 TP53 ZD6474 0.0906106600645039 0.0652843630996922 12 191:192:193:195:196:198 0.029126213592233 0.410193048864343 0 STAD TP53 TP53 17-AAG 0.111559168297975 -0.109076268093858 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.323521588064128 0 STAD TP53 TP53 AEW541 0.372950411929422 -0.0259367344879906 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.660796770817279 0 STAD TP53 TP53 AZD0530 0.341930495978484 -0.100221338437697 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.65236739364316 0 STAD TP53 TP53 AZD6244 0.0219352259005954 -0.212129518961516 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.136900600982901 1 STAD TP53 TP53 Erlotinib 0.138391434301533 -0.0625179376162196 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.340114541927496 0 STAD TP53 TP53 Irinotecan 0.173865705917294 -0.111687543853257 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.494324065843287 0 STAD TP53 TP53 L685458 0.0219352259005954 -0.0400573015176003 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.138287293721145 1 STAD TP53 TP53 Lapatinib 0.659364354820725 -0.0312816153719606 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.838665188149168 0 STAD TP53 TP53 LBW242 0.0707731589010851 -0.0334574905063179 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 1 0 STAD TP53 TP53 Nilotinib 0.0412117308753908 -0.068115293870967 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.259813085953551 0 STAD TP53 TP53 Nutlin3 0.0115385604664037 -0.0602890996938522 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.091314378905165 1 STAD TP53 TP53 Paclitaxel 0.337187950529837 -0.0466552712606934 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.657917533572212 0 STAD TP53 TP53 Panobinostat 0.21922650182648 -0.0631568580484547 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.474445414400591 0 STAD TP53 TP53 PD0325901 0.156729214940231 -0.200131417079545 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.41199437047666 0 STAD TP53 TP53 PD0332991 0.0178053133750834 -0.07479745935413 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.103270817575484 1 STAD TP53 TP53 PF2341066 0.166084163212063 -0.0203893332950235 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.37628443227733 0 STAD TP53 TP53 PHA665752 0.166084163212063 -0.0231371540672021 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.388422639770147 0 STAD TP53 TP53 PLX4720 0.0300396830921418 -0.0960056883921933 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.172410275043407 1 STAD TP53 TP53 RAF265 0.650335868266265 0.0189792522355134 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.841952686594718 0 STAD TP53 TP53 Sorafenib 0.75457113946541 -0.0103250830420812 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.882361413084552 0 STAD TP53 TP53 TAE684 0.40213438870967 -0.038239736828529 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.64629317885846 0 STAD TP53 TP53 TKI258 0.0173587062054843 -0.190564171922628 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.103542000540844 1 STAD TP53 TP53 Topotecan 0.00386976444629204 -0.230232377178081 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.0399522094084361 1 STAD TP53 TP53 ZD6474 0.912872392924046 -0.00963017085899298 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.96509326057909 0 STAD TP53 TP53 17-AAG 0.470719067210007 0.0872636372361497 17 265:267:270:271:272:273 0.0412621359223301 0.729176211192437 0 STAD TP53 TP53 AEW541 0.760576090370621 0.0142793777034926 17 265:267:270:271:272:273 0.0412621359223301 0.843121071823001 0 STAD TP53 TP53 AZD0530 0.275005641205831 -0.057509819316381 17 265:267:270:271:272:273 0.0412621359223301 0.570250045569471 0 STAD TP53 TP53 AZD6244 0.130521138631646 -0.0876281486618939 17 265:267:270:271:272:273 0.0412621359223301 0.344101183665249 0 STAD TP53 TP53 Erlotinib 0.0316740847215045 -0.0885324938636405 17 265:267:270:271:272:273 0.0412621359223301 0.131221208131947 1 STAD TP53 TP53 Irinotecan 0.473095055984989 0.0925545940730976 17 265:267:270:271:272:273 0.0412621359223301 0.726016907836284 0 STAD TP53 TP53 L685458 0.2113888299176 -0.0444035547078211 17 265:267:270:271:272:273 0.0412621359223301 0.464414853606848 0 STAD TP53 TP53 Lapatinib 0.205805122548092 -0.021029496617273 17 265:267:270:271:272:273 0.0412621359223301 0.423328452453569 0 STAD TP53 TP53 LBW242 0.219968455119687 -0.0232011585374082 17 265:267:270:271:272:273 0.0412621359223301 1 0 STAD TP53 TP53 Nilotinib 0.632435603060282 -0.00629583127762867 17 265:267:270:271:272:273 0.0412621359223301 0.841313416915054 0 STAD TP53 TP53 Nutlin3 0.0355346742865866 -0.0616156320525045 17 265:267:270:271:272:273 0.0412621359223301 0.156137205198638 1 STAD TP53 TP53 Paclitaxel 0.50951488857426 -0.112370007945955 17 265:267:270:271:272:273 0.0412621359223301 0.82088509825853 0 STAD TP53 TP53 Panobinostat 0.92624161001388 -0.00206301610658066 17 265:267:270:271:272:273 0.0412621359223301 0.969291585592184 0 STAD TP53 TP53 PD0325901 0.66013351797817 0.0174667544151772 17 265:267:270:271:272:273 0.0412621359223301 0.825166897472712 0 STAD TP53 TP53 PD0332991 0.13855545619325 -0.0682052274129146 17 265:267:270:271:272:273 0.0412621359223301 0.356235687144115 0 STAD TP53 TP53 PF2341066 0.473095055984989 0.0180610220521996 17 265:267:270:271:272:273 0.0412621359223301 0.659603683825225 0 STAD TP53 TP53 PHA665752 0.426847548785058 -0.0116193519309559 17 265:267:270:271:272:273 0.0412621359223301 0.625180753271045 0 STAD TP53 TP53 PLX4720 0.00240000413201061 -0.187574792535255 17 265:267:270:271:272:273 0.0412621359223301 0.0348000599141539 1 STAD TP53 TP53 RAF265 0.396104185334471 0.0417098546281334 17 265:267:270:271:272:273 0.0412621359223301 0.700428132603638 0 STAD TP53 TP53 Sorafenib 0.534586106716667 0.025494854684163 17 265:267:270:271:272:273 0.0412621359223301 0.809461238276102 0 STAD TP53 TP53 TAE684 0.0416862516079586 0.0891597011490464 17 265:267:270:271:272:273 0.0412621359223301 0.223345976914649 0 STAD TP53 TP53 TKI258 0.148043620995047 -0.114205375965732 17 265:267:270:271:272:273 0.0412621359223301 0.436798374270213 0 STAD TP53 TP53 Topotecan 0.711160490959299 0.0756507454130797 17 265:267:270:271:272:273 0.0412621359223301 0.881352745205969 0 STAD TP53 TP53 ZD6474 0.456602345665145 -0.0379645471280325 17 265:267:270:271:272:273 0.0412621359223301 0.750921728318306 0 STAD TP53 TP53 17-AAG 0.438718237422208 0.0856799379158475 13 282:285:286 0.0315533980582524 0.706823826958002 0 STAD TP53 TP53 AEW541 0.209480066224023 0.0421325653160785 13 282:285:286 0.0315533980582524 0.48991305810457 0 STAD TP53 TP53 AZD0530 0.559896812677796 0.0397960371861679 13 282:285:286 0.0315533980582524 0.780625363829619 0 STAD TP53 TP53 AZD6244 0.219336490972946 0.0595218557308184 13 282:285:286 0.0315533980582524 0.490952207665806 0 STAD TP53 TP53 Erlotinib 0.841273034273238 0.0011795464887927 13 282:285:286 0.0315533980582524 0.912366747423057 0 STAD TP53 TP53 Irinotecan 0.310259372233309 -0.147868835457762 13 282:285:286 0.0315533980582524 0.626643853759755 0 STAD TP53 TP53 L685458 0.133675233825568 -0.0509903968236504 13 282:285:286 0.0315533980582524 0.421367584884943 0 STAD TP53 TP53 Lapatinib 0.050736697777241 -0.0718741682663022 13 282:285:286 0.0315533980582524 0.193600557307893 1 STAD TP53 TP53 LBW242 0.178947339616507 -0.0391686521458656 13 282:285:286 0.0315533980582524 1 0 STAD TP53 TP53 Nilotinib 0.0562367278321064 -0.0740013176348445 13 282:285:286 0.0315533980582524 0.313627905217516 0 STAD TP53 TP53 Nutlin3 0.053979876564771 -0.0758554375317972 13 282:285:286 0.0315533980582524 0.196107212464119 1 STAD TP53 TP53 Paclitaxel 0.204673907153973 -0.13852165062504 13 282:285:286 0.0315533980582524 0.486519943234854 0 STAD TP53 TP53 Panobinostat 0.0597688920396804 -0.15489689420157 13 282:285:286 0.0315533980582524 0.262620889265262 0 STAD TP53 TP53 PD0325901 0.0750535851657695 0.142560116078133 13 282:285:286 0.0315533980582524 0.268683777724729 0 STAD TP53 TP53 PD0332991 0.11827150181867 -0.0857759813919949 13 282:285:286 0.0315533980582524 0.319707579225012 0 STAD TP53 TP53 PF2341066 0.718489937694927 -0.00112292237682143 13 282:285:286 0.0315533980582524 0.820323157210743 0 STAD TP53 TP53 PHA665752 0.340907768523693 -0.0287942300309202 13 282:285:286 0.0315533980582524 0.559245474248325 0 STAD TP53 TP53 PLX4720 0.0298732553476715 -0.159778463077678 13 282:285:286 0.0315533980582524 0.172410275043407 1 STAD TP53 TP53 RAF265 0.240038627483284 -0.0512192546821313 13 282:285:286 0.0315533980582524 0.527357590682972 0 STAD TP53 TP53 Sorafenib 0.405288204745744 -0.0274370440592152 13 282:285:286 0.0315533980582524 0.721813757748919 0 STAD TP53 TP53 TAE684 0.837794233750039 -0.0112778466392627 13 282:285:286 0.0315533980582524 0.943937105852541 0 STAD TP53 TP53 TKI258 0.0174785882029375 -0.231819264116647 13 282:285:286 0.0315533980582524 0.103542000540844 1 STAD TP53 TP53 Topotecan 0.0176905486359436 -0.308875856490685 13 282:285:286 0.0315533980582524 0.100526081063372 1 STAD TP53 TP53 ZD6474 0.659514301720266 -0.00279505798273094 13 282:285:286 0.0315533980582524 0.877335538985675 0 THYM GTF2I GTF2I 17-AAG 0.346604742694014 0.00288185305115851 56 424 0.474576271186441 0.655164999762946 0 THYM GTF2I GTF2I AEW541 0.00732436824140214 -0.0463796394441442 56 424 0.474576271186441 0.0603418050494983 1 THYM GTF2I GTF2I AZD0530 0.0167319331575065 0.089400546438853 56 424 0.474576271186441 0.0933127041476324 2 THYM GTF2I GTF2I AZD6244 1.08036861955891e-05 0.224233291811236 56 424 0.474576271186441 0.00156653449836042 2 THYM GTF2I GTF2I Erlotinib 0.366524861865323 0.0378577614637079 56 424 0.474576271186441 0.584023131543646 0 THYM GTF2I GTF2I Irinotecan 3.10245475022097e-05 -0.633118538147692 56 424 0.474576271186441 0.00449855938782041 1 THYM GTF2I GTF2I L685458 0.00421269766984375 -0.0829306125468123 56 424 0.474576271186441 0.0469877817021034 1 THYM GTF2I GTF2I Lapatinib 0.00686032013094414 -0.0966893401925488 56 424 0.474576271186441 0.0552636899437167 1 THYM GTF2I GTF2I LBW242 2.85538937561098e-11 -0.152884340827281 56 424 0.474576271186441 1 0 THYM GTF2I GTF2I Nilotinib 0.118004909898934 -0.075105044768728 56 424 0.474576271186441 0.407234498782906 0 THYM GTF2I GTF2I Nutlin3 0.343816347436906 -0.0311318001015408 56 424 0.474576271186441 0.61879956613365 0 THYM GTF2I GTF2I Paclitaxel 0.0368882740782078 -0.221122348421817 56 424 0.474576271186441 0.180378723619157 1 THYM GTF2I GTF2I Panobinostat 0.720806273038938 -0.0715437961320271 56 424 0.474576271186441 0.870974246588717 0 THYM GTF2I GTF2I PD0325901 0.000135294768936371 0.277667945759327 56 424 0.474576271186441 0.0098088707478869 2 THYM GTF2I GTF2I PD0332991 0.660498865798368 -0.0334516071580226 56 424 0.474576271186441 0.811629962209859 0 THYM GTF2I GTF2I PF2341066 0.436858391689674 -0.0518441247091556 56 424 0.474576271186441 0.646372110153089 0 THYM GTF2I GTF2I PHA665752 0.360761849208631 -0.0236200704671997 56 424 0.474576271186441 0.568592044948386 0 THYM GTF2I GTF2I PLX4720 0.496949356858829 -0.0208157805114126 56 424 0.474576271186441 0.791842381808024 0 THYM GTF2I GTF2I RAF265 0.259866654146139 0.0783330800702446 56 424 0.474576271186441 0.530713589453383 0 THYM GTF2I GTF2I Sorafenib 0.0696487561151221 -0.0844868238456479 56 424 0.474576271186441 0.258950503504941 0 THYM GTF2I GTF2I TAE684 0.00366749782817954 0.123692492365413 56 424 0.474576271186441 0.0409067065450795 2 THYM GTF2I GTF2I TKI258 0.262181397758587 0.0115994916003812 56 424 0.474576271186441 0.627196497693882 0 THYM GTF2I GTF2I Topotecan 0.863539369602067 -0.113013967217176 56 424 0.474576271186441 0.940917023721381 0 THYM GTF2I GTF2I ZD6474 1.25566286162985e-05 0.0696795684554201 56 424 0.474576271186441 0.000910355574681641 2 UCEC BCOR BCOR 17-AAG 0.00239094445781453 0.439879032407691 11 1459 0.0654761904761905 0.031516995125737 2 UCEC BCOR BCOR AEW541 0.428703820454415 -0.0362312063873046 11 1459 0.0654761904761905 0.675674499629241 0 UCEC BCOR BCOR AZD0530 0.0897091783214948 0.138645494381626 11 1459 0.0654761904761905 0.310166270468772 0 UCEC BCOR BCOR AZD6244 0.0290487935097078 0.237849981948945 11 1459 0.0654761904761905 0.140402501963588 2 UCEC BCOR BCOR Erlotinib 0.240301305883443 0.0218808346894996 11 1459 0.0654761904761905 0.49075618807182 0 UCEC BCOR BCOR Irinotecan 0.382993857234733 0.163016548563817 11 1459 0.0654761904761905 0.683762297256219 0 UCEC BCOR BCOR L685458 0.737648035579805 -0.00498230981063591 11 1459 0.0654761904761905 0.842196576055683 0 UCEC BCOR BCOR Lapatinib 0.119457098527047 0.0898464761502593 11 1459 0.0654761904761905 0.324316390107145 0 UCEC BCOR BCOR LBW242 0.0897091783214948 -0.0562000682322322 11 1459 0.0654761904761905 1 0 UCEC BCOR BCOR Nilotinib 0.240301305883443 -0.0400356998657075 11 1459 0.0654761904761905 0.561994989566117 0 UCEC BCOR BCOR Nutlin3 0.243262047179831 -0.0231751235366169 11 1459 0.0654761904761905 0.49192139340337 0 UCEC BCOR BCOR Paclitaxel 0.932529597916606 -0.0173725280382593 11 1459 0.0654761904761905 0.972591103603163 0 UCEC BCOR BCOR Panobinostat 0.110965999474754 -0.134993661526337 11 1459 0.0654761904761905 0.321801398476787 0 UCEC BCOR BCOR PD0325901 0.0925281537463561 0.295059525474153 11 1459 0.0654761904761905 0.298146273182703 0 UCEC BCOR BCOR PD0332991 0.897488643299856 0.0207215456094215 11 1459 0.0654761904761905 0.96396928354429 0 UCEC BCOR BCOR PF2341066 0.897488643299856 0.00664446287842813 11 1459 0.0654761904761905 0.939770585322949 0 UCEC BCOR BCOR PHA665752 0.495882811940306 0.0253918651916532 11 1459 0.0654761904761905 0.696907272160628 0 UCEC BCOR BCOR PLX4720 0.428703820454415 -0.0430598001345964 11 1459 0.0654761904761905 0.777025674573627 0 UCEC BCOR BCOR RAF265 0.50055284619601 -0.0323268875677563 11 1459 0.0654761904761905 0.745662374723171 0 UCEC BCOR BCOR Sorafenib 0.748782127877759 0.00177941986740782 11 1459 0.0654761904761905 0.882361413084552 0 UCEC BCOR BCOR TAE684 0.18390229476167 -0.0757173418681965 11 1459 0.0654761904761905 0.431350700714002 0 UCEC BCOR BCOR TKI258 0.726568721231742 0.0992271251811545 11 1459 0.0654761904761905 0.921239375376304 0 UCEC BCOR BCOR Topotecan 0.583371508589532 -0.0325387190248758 11 1459 0.0654761904761905 0.799087021720268 0 UCEC BCOR BCOR ZD6474 0.862646502967276 -0.0104237464460832 11 1459 0.0654761904761905 0.963890952546201 0 UCEC CTNNB1 CTNNB1 17-AAG 0.00367685443323914 0.25359761054022 22 32:33:34:37:41:45 0.130952380952381 0.0409092743958475 2 UCEC CTNNB1 CTNNB1 AEW541 0.0156260097075939 -0.0668924959563681 22 32:33:34:37:41:45 0.130952380952381 0.107893876552434 1 UCEC CTNNB1 CTNNB1 AZD0530 0.117255253526939 0.0782757561533025 22 32:33:34:37:41:45 0.130952380952381 0.354208578362628 0 UCEC CTNNB1 CTNNB1 AZD6244 0.000264192577310182 0.2919335630756 22 32:33:34:37:41:45 0.130952380952381 0.0127693079033255 2 UCEC CTNNB1 CTNNB1 Erlotinib 0.661106053458725 0.0137278114841656 22 32:33:34:37:41:45 0.130952380952381 0.819319467961668 0 UCEC CTNNB1 CTNNB1 Irinotecan 0.316153933605227 -0.115197325586286 22 32:33:34:37:41:45 0.130952380952381 0.627976991407643 0 UCEC CTNNB1 CTNNB1 L685458 0.729271554105161 0.00227765798444113 22 32:33:34:37:41:45 0.130952380952381 0.842196576055683 0 UCEC CTNNB1 CTNNB1 Lapatinib 0.595641570499085 -0.0470242176701579 22 32:33:34:37:41:45 0.130952380952381 0.787629195488141 0 UCEC CTNNB1 CTNNB1 LBW242 0.90409323807896 -0.00514813543041037 22 32:33:34:37:41:45 0.130952380952381 1 0 UCEC CTNNB1 CTNNB1 Nilotinib 0.308785012223014 0.0297982850719791 22 32:33:34:37:41:45 0.130952380952381 0.639626096747672 0 UCEC CTNNB1 CTNNB1 Nutlin3 0.638962007745186 0.0168268753558298 22 32:33:34:37:41:45 0.130952380952381 0.834680100207675 0 UCEC CTNNB1 CTNNB1 Paclitaxel 0.464996418274015 0.108424793407738 22 32:33:34:37:41:45 0.130952380952381 0.766187280110593 0 UCEC CTNNB1 CTNNB1 Panobinostat 0.628007958456854 -0.041649708189059 22 32:33:34:37:41:45 0.130952380952381 0.805850920143751 0 UCEC CTNNB1 CTNNB1 PD0325901 0.00246432684707707 0.326537834112266 22 32:33:34:37:41:45 0.130952380952381 0.0510467704037393 2 UCEC CTNNB1 CTNNB1 PD0332991 0.033138183935836 0.0593737176622038 22 32:33:34:37:41:45 0.130952380952381 0.150157395959257 2 UCEC CTNNB1 CTNNB1 PF2341066 0.393271104103919 -0.0268671081809615 22 32:33:34:37:41:45 0.130952380952381 0.594003230156961 0 UCEC CTNNB1 CTNNB1 PHA665752 0.748621129147884 -0.00901194066498034 22 32:33:34:37:41:45 0.130952380952381 0.877092920919321 0 UCEC CTNNB1 CTNNB1 PLX4720 0.00146510738918465 0.149909500962084 22 32:33:34:37:41:45 0.130952380952381 0.0265550714289718 2 UCEC CTNNB1 CTNNB1 RAF265 0.0169970506642133 -0.109884714377267 22 32:33:34:37:41:45 0.130952380952381 0.0821524115436976 1 UCEC CTNNB1 CTNNB1 Sorafenib 0.202613382575456 -0.0410541401918844 22 32:33:34:37:41:45 0.130952380952381 0.515420008305985 0 UCEC CTNNB1 CTNNB1 TAE684 0.0492604377178422 0.0849061195188066 22 32:33:34:37:41:45 0.130952380952381 0.230411724809262 0 UCEC CTNNB1 CTNNB1 TKI258 0.736991500301043 0.01989005805183 22 32:33:34:37:41:45 0.130952380952381 0.921239375376304 0 UCEC CTNNB1 CTNNB1 Topotecan 0.706278643098513 -0.0403904032456217 22 32:33:34:37:41:45 0.130952380952381 0.881352745205969 0 UCEC CTNNB1 CTNNB1 ZD6474 0.0510631623579751 -0.0851501803367549 22 32:33:34:37:41:45 0.130952380952381 0.284775328534861 0 UCEC PIK3CA PIK3CA 17-AAG 0.0354021822422226 -0.283820653567821 11 539:542:545:546 0.0654761904761905 0.171110547504076 1 UCEC PIK3CA PIK3CA AEW541 0.0966319963671666 -0.0714955004666361 11 539:542:545:546 0.0654761904761905 0.341747304225345 0 UCEC PIK3CA PIK3CA AZD0530 0.922650842281671 -0.0246943751214836 11 539:542:545:546 0.0654761904761905 0.976528263728776 0 UCEC PIK3CA PIK3CA AZD6244 0.026256297815394 -0.299685766867365 11 539:542:545:546 0.0654761904761905 0.138184273413645 1 UCEC PIK3CA PIK3CA Erlotinib 0.424674489234608 -0.0354568812668422 11 539:542:545:546 0.0654761904761905 0.655082988712959 0 UCEC PIK3CA PIK3CA Irinotecan 0.110338038346006 -0.218404788906436 11 539:542:545:546 0.0654761904761905 0.41023116820951 0 UCEC PIK3CA PIK3CA L685458 0.496715992459379 -0.0172528981487623 11 539:542:545:546 0.0654761904761905 0.712950676140981 0 UCEC PIK3CA PIK3CA Lapatinib 0.0988167361997379 -0.0867967734356765 11 539:542:545:546 0.0654761904761905 0.298508890603375 0 UCEC PIK3CA PIK3CA LBW242 0.336973171710316 -0.0381228637970444 11 539:542:545:546 0.0654761904761905 1 0 UCEC PIK3CA PIK3CA Nilotinib 0.418442590188174 -0.0351624957820588 11 539:542:545:546 0.0654761904761905 0.682464106351632 0 UCEC PIK3CA PIK3CA Nutlin3 0.400072817248191 0.0146453957955058 11 539:542:545:546 0.0654761904761905 0.67329174137326 0 UCEC PIK3CA PIK3CA Paclitaxel 0.552940805053458 0.0408368031579549 11 539:542:545:546 0.0654761904761905 0.845618335540587 0 UCEC PIK3CA PIK3CA Panobinostat 0.275879154537718 -0.0754467297022998 11 539:542:545:546 0.0654761904761905 0.508034392821828 0 UCEC PIK3CA PIK3CA PD0325901 0.00875261159876096 -0.481075653077725 11 539:542:545:546 0.0654761904761905 0.076894019973766 1 UCEC PIK3CA PIK3CA PD0332991 0.524442391667546 -0.0445836963822582 11 539:542:545:546 0.0654761904761905 0.715126972704313 0 UCEC PIK3CA PIK3CA PF2341066 0.666080176433916 -0.021898906979521 11 539:542:545:546 0.0654761904761905 0.798195252751387 0 UCEC PIK3CA PIK3CA PHA665752 0.503573551135419 -0.015612715310718 11 539:542:545:546 0.0654761904761905 0.696907272160628 0 UCEC PIK3CA PIK3CA PLX4720 0.729923604941089 -0.0241028824260756 11 539:542:545:546 0.0654761904761905 0.893116372848996 0 UCEC PIK3CA PIK3CA RAF265 0.418442590188174 -0.0548854332644404 11 539:542:545:546 0.0654761904761905 0.703927107918497 0 UCEC PIK3CA PIK3CA Sorafenib 0.589598856235972 -0.0244717481073428 11 539:542:545:546 0.0654761904761905 0.831376335950175 0 UCEC PIK3CA PIK3CA TAE684 0.496715992459379 -0.0308031810020208 11 539:542:545:546 0.0654761904761905 0.699260377734077 0 UCEC PIK3CA PIK3CA TKI258 0.905535351406467 -0.0349173268887211 11 539:542:545:546 0.0654761904761905 0.959342395190069 0 UCEC PIK3CA PIK3CA Topotecan 0.862955178497625 -0.0255227741837203 11 539:542:545:546 0.0654761904761905 0.940917023721381 0 UCEC PIK3CA PIK3CA ZD6474 0.364818739714675 0.0443440444001619 11 539:542:545:546 0.0654761904761905 0.733598593959076 0 UCEC POLE POLE 17-AAG 0.000954453853871131 0.40406533660502 10 286 0.0595238095238095 0.0138395808811314 2 UCEC POLE POLE AEW541 0.0915355918556663 -0.0672035807321478 10 286 0.0595238095238095 0.33181652047679 0 UCEC POLE POLE AZD0530 0.503047076320473 0.0392804870392778 10 286 0.0595238095238095 0.76198312903661 0 UCEC POLE POLE AZD6244 0.0236035518936037 0.247895715301899 10 286 0.0595238095238095 0.136900600982901 2 UCEC POLE POLE Erlotinib 0.137459298269875 -0.0669349897032759 10 286 0.0595238095238095 0.340114541927496 0 UCEC POLE POLE Irinotecan 0.546935426627768 0.0420393358819902 10 286 0.0595238095238095 0.777506243735553 0 UCEC POLE POLE L685458 0.118725306741238 0.0296050664871237 10 286 0.0595238095238095 0.387998709149547 0 UCEC POLE POLE Lapatinib 0.465656228094885 0.0434720221816949 10 286 0.0595238095238095 0.696084052306787 0 UCEC POLE POLE LBW242 0.878086250095693 -0.000918017404683003 10 286 0.0595238095238095 1 0 UCEC POLE POLE Nilotinib 0.395720897143139 0.0260340838790559 10 286 0.0595238095238095 0.682464106351632 0 UCEC POLE POLE Nutlin3 0.925479377915942 -0.0147568001347429 10 286 0.0595238095238095 0.943291939596424 0 UCEC POLE POLE Paclitaxel 0.151874942367082 0.112899846633927 10 286 0.0595238095238095 0.400181164632015 0 UCEC POLE POLE Panobinostat 0.661575569701658 -0.0349932866754239 10 286 0.0595238095238095 0.834160500928178 0 UCEC POLE POLE PD0325901 0.169727969277248 0.23831754935396 10 286 0.0595238095238095 0.43066281766744 0 UCEC POLE POLE PD0332991 0.0989554298436735 0.0502270712005572 10 286 0.0595238095238095 0.297179094417211 0 UCEC POLE POLE PF2341066 0.310626633436768 0.0363178254033283 10 286 0.0595238095238095 0.556060022818906 0 UCEC POLE POLE PHA665752 0.0164753925827985 0.0649917594661596 10 286 0.0595238095238095 0.0919743048739549 2 UCEC POLE POLE PLX4720 0.279584815690401 0.0434358196566462 10 286 0.0595238095238095 0.60507161604639 0 UCEC POLE POLE RAF265 0.43424757857448 0.0333550419771997 10 286 0.0595238095238095 0.70742625778863 0 UCEC POLE POLE Sorafenib 0.158394457013268 0.0315452954571491 10 286 0.0595238095238095 0.441676851286997 0 UCEC POLE POLE TAE684 0.412582520011398 0.0815512560464848 10 286 0.0595238095238095 0.64629317885846 0 UCEC POLE POLE TKI258 0.0201585664691328 0.232046123638994 10 286 0.0595238095238095 0.104392576358009 2 UCEC POLE POLE Topotecan 0.235618147211171 0.160899982166111 10 286 0.0595238095238095 0.579061548230844 0 UCEC POLE POLE ZD6474 0.567032194797731 -0.0363832452233632 10 286 0.0595238095238095 0.82219668245671 0 UCEC PPP2R1A PPP2R1A 17-AAG 0.00323760041031572 -0.276340372669978 21 177:179:183 0.125 0.0391210049579816 1 UCEC PPP2R1A PPP2R1A AEW541 0.984983456779033 -0.00794194002297044 21 177:179:183 0.125 0.984983456779033 0 UCEC PPP2R1A PPP2R1A AZD0530 0.040739437607379 -0.129925966894309 21 177:179:183 0.125 0.171288814221152 1 UCEC PPP2R1A PPP2R1A AZD6244 0.0221279964123183 -0.223989571962598 21 177:179:183 0.125 0.136900600982901 1 UCEC PPP2R1A PPP2R1A Erlotinib 0.600059601017538 -0.00941095225861621 21 177:179:183 0.125 0.781959988906675 0 UCEC PPP2R1A PPP2R1A Irinotecan 0.124709834578004 -0.0959284201111599 21 177:179:183 0.125 0.410975591222968 0 UCEC PPP2R1A PPP2R1A L685458 0.773575667019646 0.0053204733241583 21 177:179:183 0.125 0.86952303657247 0 UCEC PPP2R1A PPP2R1A Lapatinib 0.183204487134166 -0.0505144955283818 21 177:179:183 0.125 0.408686932837755 0 UCEC PPP2R1A PPP2R1A LBW242 0.630307487383717 -0.0129358940427433 21 177:179:183 0.125 1 0 UCEC PPP2R1A PPP2R1A Nilotinib 0.882434581450075 0.00599644224061957 21 177:179:183 0.125 0.969341017501976 0 UCEC PPP2R1A PPP2R1A Nutlin3 0.878192257007086 0.00560985162233696 21 177:179:183 0.125 0.917737835269135 0 UCEC PPP2R1A PPP2R1A Paclitaxel 0.899436426669656 -0.0270724399101159 21 177:179:183 0.125 0.958957954905148 0 UCEC PPP2R1A PPP2R1A Panobinostat 0.122090928696728 0.0942152279665187 21 177:179:183 0.125 0.330600267099532 0 UCEC PPP2R1A PPP2R1A PD0325901 0.188570335587569 -0.198276520630774 21 177:179:183 0.125 0.448151505729182 0 UCEC PPP2R1A PPP2R1A PD0332991 0.362031394159929 -0.026179506805823 21 177:179:183 0.125 0.617418888054418 0 UCEC PPP2R1A PPP2R1A PF2341066 0.486179857397051 0.0230381370983822 21 177:179:183 0.125 0.66505735209974 0 UCEC PPP2R1A PPP2R1A PHA665752 0.449918396786917 0.0201163572979237 21 177:179:183 0.125 0.65238167534103 0 UCEC PPP2R1A PPP2R1A PLX4720 0.388080930298275 -0.0350592520212046 21 177:179:183 0.125 0.769266275380849 0 UCEC PPP2R1A PPP2R1A RAF265 0.00604632423681395 0.118542932041205 21 177:179:183 0.125 0.0408094473117676 2 UCEC PPP2R1A PPP2R1A Sorafenib 0.588888410372237 0.0144947622092235 21 177:179:183 0.125 0.831376335950175 0 UCEC PPP2R1A PPP2R1A TAE684 0.798386818274035 0.0277683416348244 21 177:179:183 0.125 0.933597489110767 0 UCEC PPP2R1A PPP2R1A TKI258 0.424538756133173 -0.0617185257807908 21 177:179:183 0.125 0.766875635967867 0 UCEC PPP2R1A PPP2R1A Topotecan 0.806704027339485 0.00663578363257011 21 177:179:183 0.125 0.940917023721381 0 UCEC PPP2R1A PPP2R1A ZD6474 0.0982071389988178 0.0885282740513214 21 177:179:183 0.125 0.410193048864343 0 UCEC PTEN PTEN 17-AAG 7.53746050353353e-08 0.462820813357658 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 1.09293177301236e-05 2 UCEC PTEN PTEN AEW541 0.00127807845248283 -0.0860206669193653 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0205912639566678 1 UCEC PTEN PTEN AZD0530 0.167473570638161 0.0614125520552988 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.441521231682424 0 UCEC PTEN PTEN AZD6244 0.128249368360555 0.124477763856722 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.344101183665249 0 UCEC PTEN PTEN Erlotinib 0.974282349241311 -0.00354512428373743 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.98104819888882 0 UCEC PTEN PTEN Irinotecan 0.196202785810686 0.0968311760017484 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.508025070402669 0 UCEC PTEN PTEN L685458 0.29815212397094 0.0184245260845248 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.545900821041546 0 UCEC PTEN PTEN Lapatinib 0.0635757561702969 0.0591970030094906 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.219487729635549 0 UCEC PTEN PTEN LBW242 0.0204386424670933 0.0415131746436317 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 1 0 UCEC PTEN PTEN Nilotinib 0.18430550893434 0.0332735596810941 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.482036792120472 0 UCEC PTEN PTEN Nutlin3 0.780691472030046 0.00703597340946405 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.898414789240926 0 UCEC PTEN PTEN Paclitaxel 0.0771910764946314 0.136676256546658 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.254461241349235 0 UCEC PTEN PTEN Panobinostat 0.571646532599912 -0.0432912763842657 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.781969313462144 0 UCEC PTEN PTEN PD0325901 0.670870316104802 0.047301616056737 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.8314204772239 0 UCEC PTEN PTEN PD0332991 0.00531802388204163 0.0765457131917094 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0428396368275576 2 UCEC PTEN PTEN PF2341066 0.158635816850778 -0.0315878531241848 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.373386709934991 0 UCEC PTEN PTEN PHA665752 0.132721128739808 0.0253557626333522 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.334110707610379 0 UCEC PTEN PTEN PLX4720 0.158635816850778 0.0454903574036906 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.460043868867256 0 UCEC PTEN PTEN RAF265 0.00335005042063392 -0.104984586150053 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0285739594701128 1 UCEC PTEN PTEN Sorafenib 0.950925145111373 -0.00170988482870016 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.977901744972689 0 UCEC PTEN PTEN TAE684 0.0434598418475815 -0.0751217113188243 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.223345976914649 0 UCEC PTEN PTEN TKI258 0.00261380559455601 0.217128545116679 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0270715579436158 2 UCEC PTEN PTEN Topotecan 0.997661630122024 0.0438088671680745 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 1 0 UCEC PTEN PTEN ZD6474 0.0627434987410108 -0.0714598204603536 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.336955826572095 0 UCEC TP53 TP53 17-AAG 0.000280198124385057 -0.378086645192997 18 236:237:238:241:245:246:248:249 0.107142857142857 0.00677145467263888 1 UCEC TP53 TP53 AEW541 0.587229804126864 0.0150341234598123 18 236:237:238:241:245:246:248:249 0.107142857142857 0.752244949119026 0 UCEC TP53 TP53 AZD0530 0.305178105289927 -0.0452217909845141 18 236:237:238:241:245:246:248:249 0.107142857142857 0.590011003560525 0 UCEC TP53 TP53 AZD6244 0.000399891454044171 -0.31235099324468 18 236:237:238:241:245:246:248:249 0.107142857142857 0.0144960652091012 1 UCEC TP53 TP53 Erlotinib 0.115745013847159 -0.0844860519489086 18 236:237:238:241:245:246:248:249 0.107142857142857 0.299696910854251 0 UCEC TP53 TP53 Irinotecan 0.427542995959563 -0.0618989941526602 18 236:237:238:241:245:246:248:249 0.107142857142857 0.704474254706098 0 UCEC TP53 TP53 L685458 0.784278845549531 -0.00633952249871772 18 236:237:238:241:245:246:248:249 0.107142857142857 0.874772558497554 0 UCEC TP53 TP53 Lapatinib 0.0177434017821692 -0.133874354017023 18 236:237:238:241:245:246:248:249 0.107142857142857 0.10507624518148 1 UCEC TP53 TP53 LBW242 0.632722959245871 -0.0126075036244793 18 236:237:238:241:245:246:248:249 0.107142857142857 1 0 UCEC TP53 TP53 Nilotinib 0.741834711751695 0.0268818891615454 18 236:237:238:241:245:246:248:249 0.107142857142857 0.896383610033298 0 UCEC TP53 TP53 Nutlin3 0.827374678754428 -0.00201480379914465 18 236:237:238:241:245:246:248:249 0.107142857142857 0.917341274328711 0 UCEC TP53 TP53 Paclitaxel 0.798577793373971 0.0231759445181217 18 236:237:238:241:245:246:248:249 0.107142857142857 0.911762047552959 0 UCEC TP53 TP53 Panobinostat 0.981491598882215 0.00339671310737799 18 236:237:238:241:245:246:248:249 0.107142857142857 0.995218754111337 0 UCEC TP53 TP53 PD0325901 0.0324404823076069 -0.285577927427175 18 236:237:238:241:245:246:248:249 0.107142857142857 0.156795664486767 1 UCEC TP53 TP53 PD0332991 0.0152407473575801 -0.0819426460999836 18 236:237:238:241:245:246:248:249 0.107142857142857 0.0920795152853798 1 UCEC TP53 TP53 PF2341066 0.129213806827791 0.0513951434255139 18 236:237:238:241:245:246:248:249 0.107142857142857 0.334693632312871 0 UCEC TP53 TP53 PHA665752 0.900306495525008 -0.00426230294891627 18 236:237:238:241:245:246:248:249 0.107142857142857 0.967566782440752 0 UCEC TP53 TP53 PLX4720 0.878309257288917 -0.00496615221418639 18 236:237:238:241:245:246:248:249 0.107142857142857 0.957555205314985 0 UCEC TP53 TP53 RAF265 0.0137501385022047 0.142231633758781 18 236:237:238:241:245:246:248:249 0.107142857142857 0.0766834647238339 2 UCEC TP53 TP53 Sorafenib 0.14134206794893 0.0415470801300899 18 236:237:238:241:245:246:248:249 0.107142857142857 0.409891997051897 0 UCEC TP53 TP53 TAE684 0.606541799101249 -0.0280086938410702 18 236:237:238:241:245:246:248:249 0.107142857142857 0.799532371542555 0 UCEC TP53 TP53 TKI258 0.477774213604759 0.0379959063358271 18 236:237:238:241:245:246:248:249 0.107142857142857 0.792527104790198 0 UCEC TP53 TP53 Topotecan 0.593635473746088 0.066536427035949 18 236:237:238:241:245:246:248:249 0.107142857142857 0.804356346925081 0 UCEC TP53 TP53 ZD6474 0.0939416614317064 0.0740097250655272 18 236:237:238:241:245:246:248:249 0.107142857142857 0.410193048864343 0 UCEC TP53 TP53 17-AAG 0.000603735282054691 -0.41996542354116 13 273:276:278:281:282:286 0.0773809523809524 0.0109427019872413 1 UCEC TP53 TP53 AEW541 0.0596869198690996 0.0651851198239528 13 273:276:278:281:282:286 0.0773809523809524 0.247274382314841 0 UCEC TP53 TP53 AZD0530 0.164557246121217 -0.0973554372638725 13 273:276:278:281:282:286 0.0773809523809524 0.441521231682424 0 UCEC TP53 TP53 AZD6244 0.0197293168052434 -0.256839527284728 13 273:276:278:281:282:286 0.0773809523809524 0.136900600982901 1 UCEC TP53 TP53 Erlotinib 0.621876464575667 -0.021445922074304 13 273:276:278:281:282:286 0.0773809523809524 0.78410510750845 0 UCEC TP53 TP53 Irinotecan 0.230389986106754 -0.170001910115354 13 273:276:278:281:282:286 0.0773809523809524 0.551284509402583 0 UCEC TP53 TP53 L685458 0.20529534057725 -0.0363980473088877 13 273:276:278:281:282:286 0.0773809523809524 0.464414853606848 0 UCEC TP53 TP53 Lapatinib 0.286944816580545 -0.049078310064028 13 273:276:278:281:282:286 0.0773809523809524 0.513666646965173 0 UCEC TP53 TP53 LBW242 0.234775913522897 -0.034637099378689 13 273:276:278:281:282:286 0.0773809523809524 1 0 UCEC TP53 TP53 Nilotinib 0.136017452102886 -0.0618853779004617 13 273:276:278:281:282:286 0.0773809523809524 0.418689328721262 0 UCEC TP53 TP53 Nutlin3 0.537570626567813 -0.0203569757347084 13 273:276:278:281:282:286 0.0773809523809524 0.764193537767969 0 UCEC TP53 TP53 Paclitaxel 0.694827445366289 -0.0508391450830947 13 273:276:278:281:282:286 0.0773809523809524 0.892078030448865 0 UCEC TP53 TP53 Panobinostat 0.567555640230592 -0.0347972521497564 13 273:276:278:281:282:286 0.0773809523809524 0.781969313462144 0 UCEC TP53 TP53 PD0325901 0.243724394218503 -0.161398036587634 13 273:276:278:281:282:286 0.0773809523809524 0.490833849467819 0 UCEC TP53 TP53 PD0332991 0.0124337089116178 -0.0883956113451286 13 273:276:278:281:282:286 0.0773809523809524 0.0858517996278372 1 UCEC TP53 TP53 PF2341066 0.281901894682938 0.031624731057694 13 273:276:278:281:282:286 0.0773809523809524 0.524048393961872 0 UCEC TP53 TP53 PHA665752 0.76216350369541 -0.00712876403124663 13 273:276:278:281:282:286 0.0773809523809524 0.877092920919321 0 UCEC TP53 TP53 PLX4720 0.0660235799597979 -0.102183644479762 13 273:276:278:281:282:286 0.0773809523809524 0.31911396980569 0 UCEC TP53 TP53 RAF265 0.0159560768512706 0.148178909873357 13 273:276:278:281:282:286 0.0773809523809524 0.079780384256353 2 UCEC TP53 TP53 Sorafenib 0.637801554443348 0.00494761749853145 13 273:276:278:281:282:286 0.0773809523809524 0.831376335950175 0 UCEC TP53 TP53 TAE684 0.419641979168954 -0.0433372343770781 13 273:276:278:281:282:286 0.0773809523809524 0.64629317885846 0 UCEC TP53 TP53 TKI258 0.919645468492549 -0.0364026031419964 13 273:276:278:281:282:286 0.0773809523809524 0.959342395190069 0 UCEC TP53 TP53 Topotecan 0.582842624182948 -0.0931343509025568 13 273:276:278:281:282:286 0.0773809523809524 0.799087021720268 0 UCEC TP53 TP53 ZD6474 0.213429433209026 0.0654307806882195 13 273:276:278:281:282:286 0.0773809523809524 0.546830087594659 0 UCS TP53 TP53 17-AAG 0.97126214746352 -0.0545274108941625 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.984846233442031 0 UCS TP53 TP53 AEW541 0.745341614906832 -0.0134847775785174 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.843121071823001 0 UCS TP53 TP53 AZD0530 0.538203215548753 0.0258631805728067 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.771368198236586 0 UCS TP53 TP53 AZD6244 0.913845879520937 -0.061388743198009 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.967209142558656 0 UCS TP53 TP53 Erlotinib 0.745341614906832 -0.0117977359909769 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.852277706263159 0 UCS TP53 TP53 Irinotecan 0.289934321970935 -0.218077124785796 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.626643853759755 0 UCS TP53 TP53 L685458 0.97126214746352 0.00733907482908686 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.978007023487572 0 UCS TP53 TP53 Lapatinib 1 -0.0251193192237524 18 238:239:241:242:243:244:245:248:249 0.315789473684211 1 0 UCS TP53 TP53 LBW242 0.490950696900354 -0.0357770762553069 18 238:239:241:242:243:244:245:248:249 0.315789473684211 1 0 UCS TP53 TP53 Nilotinib 1 -0.00203869774178678 18 238:239:241:242:243:244:245:248:249 0.315789473684211 1 0 UCS TP53 TP53 Nutlin3 0.745341614906832 0.0143985731297854 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.89606661749022 0 UCS TP53 TP53 Paclitaxel 0.325180540283515 0.233400583065813 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.657917533572212 0 UCS TP53 TP53 Panobinostat 0.446016226336592 0.135647512500146 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.70296035672615 0 UCS TP53 TP53 PD0325901 1 -0.0177087794570444 18 238:239:241:242:243:244:245:248:249 0.315789473684211 1 0 UCS TP53 TP53 PD0332991 0.446016226336592 -0.0159564436967887 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.695401643212966 0 UCS TP53 TP53 PF2341066 0.913845879520937 -0.0368983005800932 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.939770585322949 0 UCS TP53 TP53 PHA665752 0.129632381348628 0.0372239841113199 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.334110707610379 0 UCS TP53 TP53 PLX4720 0.0943267259056733 0.119750042836126 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.362320363410075 0 UCS TP53 TP53 RAF265 0.913845879520937 0.00306466883528689 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.9673168432365 0 UCS TP53 TP53 Sorafenib 0.638473654491961 -0.0291013278710994 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.831376335950175 0 UCS TP53 TP53 TAE684 0.97126214746352 0.00159084238837748 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.984846233442031 0 UCS TP53 TP53 TKI258 0.691134952004517 -0.0660138311172613 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.921239375376304 0 UCS TP53 TP53 Topotecan 0.325180540283515 0.153129977169446 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.664101103395911 0 UCS TP53 TP53 ZD6474 0.638473654491961 0.035470606387052 18 238:239:241:242:243:244:245:248:249 0.315789473684211 0.865221307489106 0 UVM GNA11 GNA11 17-AAG 0.829471612143239 -0.0172932440243923 34 209 0.425 0.918827868253112 0 UVM GNA11 GNA11 AEW541 0.492218689737841 0.0179888112198427 34 209 0.425 0.722419772169928 0 UVM GNA11 GNA11 AZD0530 0.0212760702539023 -0.0633696029035158 34 209 0.425 0.106380351269511 1 UVM GNA11 GNA11 AZD6244 0.0351149903428001 -0.134783475126102 34 209 0.425 0.159590117997514 1 UVM GNA11 GNA11 Erlotinib 0.380053731378175 0.0109010011252444 34 209 0.425 0.592556893008983 0 UVM GNA11 GNA11 Irinotecan 0.041843831320499 0.143103908954318 34 209 0.425 0.274719342741761 0 UVM GNA11 GNA11 L685458 0.544214971041876 0.0039742471097417 34 209 0.425 0.744445007557283 0 UVM GNA11 GNA11 Lapatinib 0.619846088381883 0.01585125352577 34 209 0.425 0.80970885419255 0 UVM GNA11 GNA11 LBW242 0.308305688170139 0.0281142937289417 34 209 0.425 1 0 UVM GNA11 GNA11 Nilotinib 0.821668969669111 0.000201882034068346 34 209 0.425 0.937703446884958 0 UVM GNA11 GNA11 Nutlin3 0.108305828044104 0.0264324692111969 34 209 0.425 0.289481058262646 0 UVM GNA11 GNA11 Paclitaxel 0.448978922379113 -0.0479789942901663 34 209 0.425 0.748298203965188 0 UVM GNA11 GNA11 Panobinostat 0.237916760246169 0.053269003214341 34 209 0.425 0.495156982023114 0 UVM GNA11 GNA11 PD0325901 0.0388385182049369 -0.213451358412144 34 209 0.425 0.170654095142905 1 UVM GNA11 GNA11 PD0332991 0.612786371988679 0.00737464200130866 34 209 0.425 0.781795272540096 0 UVM GNA11 GNA11 PF2341066 0.308305688170139 0.00454386290406739 34 209 0.425 0.556060022818906 0 UVM GNA11 GNA11 PHA665752 0.530967297675383 0.00238744173372296 34 209 0.425 0.719535123018042 0 UVM GNA11 GNA11 PLX4720 0.166812381621249 -0.0331441558076253 34 209 0.425 0.474270496766296 0 UVM GNA11 GNA11 RAF265 0.829471612143239 -0.00139003156956186 34 209 0.425 0.949114971812174 0 UVM GNA11 GNA11 Sorafenib 0.280463575927763 0.016010449238547 34 209 0.425 0.606973410589935 0 UVM GNA11 GNA11 TAE684 0.0735658130041662 0.0401339546981996 34 209 0.425 0.272788326236856 0 UVM GNA11 GNA11 TKI258 0.916234633590161 0.00688427211313924 34 209 0.425 0.959342395190069 0 UVM GNA11 GNA11 Topotecan 0.544214971041876 0.0293189790615083 34 209 0.425 0.799087021720268 0 UVM GNA11 GNA11 ZD6474 0.43702787095894 -0.016879608175937 34 209 0.425 0.745518132812309 0 UVM SF3B1 SF3B1 17-AAG 0.498615499784382 0.039248692231094 14 625 0.175 0.743131537045869 0 UVM SF3B1 SF3B1 AEW541 0.587353068490934 -0.0203779100133106 14 625 0.175 0.752244949119026 0 UVM SF3B1 SF3B1 AZD0530 0.0979597831188797 0.0721335175935347 14 625 0.175 0.327843022903418 0 UVM SF3B1 SF3B1 AZD6244 0.000618095480779416 0.245373616216449 14 625 0.175 0.0179247689426031 2 UVM SF3B1 SF3B1 Erlotinib 0.433119338709776 0.0196247163124934 14 625 0.175 0.661076885399132 0 UVM SF3B1 SF3B1 Irinotecan 0.000153504185869458 -0.295786649774999 14 625 0.175 0.00850805500972167 1 UVM SF3B1 SF3B1 L685458 0.00693437726036336 -0.0441414098928526 14 625 0.175 0.0529202475132993 1 UVM SF3B1 SF3B1 Lapatinib 0.36575174962189 0.0210771428389063 14 625 0.175 0.602659132899705 0 UVM SF3B1 SF3B1 LBW242 0.0780657010716617 -0.0476357700475438 14 625 0.175 1 0 UVM SF3B1 SF3B1 Nilotinib 0.210262473364109 -0.0412865355913344 14 625 0.175 0.50813431062993 0 UVM SF3B1 SF3B1 Nutlin3 0.00846387384999571 -0.0482736978778588 14 625 0.175 0.0767038567655861 1 UVM SF3B1 SF3B1 Paclitaxel 0.195996451406609 -0.115461258994561 14 625 0.175 0.473658090899305 0 UVM SF3B1 SF3B1 Panobinostat 0.00459731585814538 -0.151328295609001 14 625 0.175 0.0502886202180841 1 UVM SF3B1 SF3B1 PD0325901 0.000649277164828218 0.391024656874763 14 625 0.175 0.0252507880232588 2 UVM SF3B1 SF3B1 PD0332991 0.10070887669779 -0.0362037956156757 14 625 0.175 0.297179094417211 0 UVM SF3B1 SF3B1 PF2341066 0.00274655262818052 -0.0561270713150195 14 625 0.175 0.0398250131086175 1 UVM SF3B1 SF3B1 PHA665752 0.138704168293737 -0.0275354884875461 14 625 0.175 0.335201740043198 0 UVM SF3B1 SF3B1 PLX4720 0.973277059162849 3.79518068915896e-05 14 625 0.175 0.978697382843298 0 UVM SF3B1 SF3B1 RAF265 0.0200828631957629 -0.0782874023927154 14 625 0.175 0.0882428837389582 1 UVM SF3B1 SF3B1 Sorafenib 0.0078191432789209 -0.0450833587180495 14 625 0.175 0.0666926926731488 1 UVM SF3B1 SF3B1 TAE684 0.00589479033865476 -0.110191057293675 14 625 0.175 0.0548554285934821 1 UVM SF3B1 SF3B1 TKI258 0.225265259441028 -0.0780678708786187 14 625 0.175 0.573043203841212 0 UVM SF3B1 SF3B1 Topotecan 0.0348234239253194 -0.158002462842299 14 625 0.175 0.168313215639044 1 UVM SF3B1 SF3B1 ZD6474 0.814604964520728 0.0211972080945725 14 625 0.175 0.937442221075441 0 LGG-coc1 IDH1 IDH1 17-AAG 0.163721609955139 0.0147506886163877 126 132 0.9 0.389174318745822 0 LGG-coc1 IDH1 IDH1 AEW541 1.79402115143587e-06 0.202414129275491 126 132 0.9 0.000260133066958201 2 LGG-coc1 IDH1 IDH1 AZD0530 0.000391262061622737 0.156101704734671 126 132 0.9 0.0113465997870594 2 LGG-coc1 IDH1 IDH1 AZD6244 0.0401182982231024 -0.152274787693642 126 132 0.9 0.16538682214573 1 LGG-coc1 IDH1 IDH1 Erlotinib 0.00821908784095086 -0.0459897840026483 126 132 0.9 0.0728752701972366 1 LGG-coc1 IDH1 IDH1 Irinotecan 0.664199851585707 0.0829680053192203 126 132 0.9 0.83883903305285 0 LGG-coc1 IDH1 IDH1 L685458 0.00495973166350337 0.0471914483016407 126 132 0.9 0.048195038708365 2 LGG-coc1 IDH1 IDH1 Lapatinib 0.0651612464477451 0.0240151349907426 126 132 0.9 0.219729784533094 0 LGG-coc1 IDH1 IDH1 LBW242 4.34513894937591e-07 -0.0997662912001895 126 132 0.9 1 0 LGG-coc1 IDH1 IDH1 Nilotinib 0.00152005600494859 0.114350979094783 126 132 0.9 0.0518747850017199 2 LGG-coc1 IDH1 IDH1 Nutlin3 0.0593184112433232 0.0169807838296284 126 132 0.9 0.202378270891116 0 LGG-coc1 IDH1 IDH1 Paclitaxel 0.00425972227544756 0.193568748751233 126 132 0.9 0.044118552138564 2 LGG-coc1 IDH1 IDH1 Panobinostat 0.609681974427885 -0.0202648146767519 126 132 0.9 0.797983324486845 0 LGG-coc1 IDH1 IDH1 PD0325901 0.0149100656056909 -0.203400240923914 126 132 0.9 0.102950452991675 1 LGG-coc1 IDH1 IDH1 PD0332991 1.63281714183666e-05 0.101867236741531 126 132 0.9 0.00118379242783158 2 LGG-coc1 IDH1 IDH1 PF2341066 0.0187127340241949 0.0393806091346067 126 132 0.9 0.105489683472048 2 LGG-coc1 IDH1 IDH1 PHA665752 0.00312160100578082 0.0377754580444167 126 132 0.9 0.0323308675598728 2 LGG-coc1 IDH1 IDH1 PLX4720 0.129092438370727 0.0587006689529508 126 132 0.9 0.415964523639009 0 LGG-coc1 IDH1 IDH1 RAF265 0.00138091416233166 0.12666222457815 126 132 0.9 0.0163297189147532 2 LGG-coc1 IDH1 IDH1 Sorafenib 0.00125360353446562 0.0525050602042493 126 132 0.9 0.0291120249237609 2 LGG-coc1 IDH1 IDH1 TAE684 9.20764189213247e-06 0.209310555073392 126 132 0.9 0.000496757081313102 2 LGG-coc1 IDH1 IDH1 TKI258 0.000535068447006326 0.2324188492743 126 132 0.9 0.00705317498326521 2 LGG-coc1 IDH1 IDH1 Topotecan 0.0180253662596392 0.159746343131007 126 132 0.9 0.100526081063372 2 LGG-coc1 IDH1 IDH1 ZD6474 3.89502354453323e-07 0.244282709779615 126 132 0.9 5.64778413957318e-05 2 LGG-coc1 TP53 TP53 17-AAG 0.134990544520764 0.0335756084180985 10 173:176:179 0.0714285714285714 0.349529088491264 0 LGG-coc1 TP53 TP53 AEW541 0.00501756958884432 0.16290592290829 10 173:176:179 0.0714285714285714 0.0519676850273162 2 LGG-coc1 TP53 TP53 AZD0530 0.0198003100681792 0.153383282859667 10 173:176:179 0.0714285714285714 0.102537319995928 2 LGG-coc1 TP53 TP53 AZD6244 0.0604465395958194 -0.178892952621275 10 173:176:179 0.0714285714285714 0.208684481937948 0 LGG-coc1 TP53 TP53 Erlotinib 0.200535230014299 -0.0273607940357364 10 173:176:179 0.0714285714285714 0.447347820801129 0 LGG-coc1 TP53 TP53 Irinotecan 0.310172853126144 0.0702035712107154 10 173:176:179 0.0714285714285714 0.626643853759755 0 LGG-coc1 TP53 TP53 L685458 0.200535230014299 0.0598222420047079 10 173:176:179 0.0714285714285714 0.464414853606848 0 LGG-coc1 TP53 TP53 Lapatinib 0.0230572496557151 0.0380971063792211 10 173:176:179 0.0714285714285714 0.116224083646046 2 LGG-coc1 TP53 TP53 LBW242 0.219925881091583 -0.0317852471486831 10 173:176:179 0.0714285714285714 1 0 LGG-coc1 TP53 TP53 Nilotinib 0.00276595123815477 0.193679918514709 10 173:176:179 0.0714285714285714 0.0668438215887403 2 LGG-coc1 TP53 TP53 Nutlin3 0.00180694255266876 0.0499882377928874 10 173:176:179 0.0714285714285714 0.0566659712168211 2 LGG-coc1 TP53 TP53 Paclitaxel 0.0772158249611473 0.141362636730847 10 173:176:179 0.0714285714285714 0.254461241349235 0 LGG-coc1 TP53 TP53 Panobinostat 0.0974141217511792 0.0576657986442273 10 173:176:179 0.0714285714285714 0.308351251300938 0 LGG-coc1 TP53 TP53 PD0325901 0.0144242888623021 -0.245998590390403 10 173:176:179 0.0714285714285714 0.102950452991675 1 LGG-coc1 TP53 TP53 PD0332991 0.00115103633746789 0.10291534036627 10 173:176:179 0.0714285714285714 0.0151727517211676 2 LGG-coc1 TP53 TP53 PF2341066 0.0467071493589195 0.0425155491562749 10 173:176:179 0.0714285714285714 0.205228383546767 0 LGG-coc1 TP53 TP53 PHA665752 0.00501756958884432 0.0614385284013289 10 173:176:179 0.0714285714285714 0.0424151983645355 2 LGG-coc1 TP53 TP53 PLX4720 0.0309149458698523 0.168581503755144 10 173:176:179 0.0714285714285714 0.172410275043407 2 LGG-coc1 TP53 TP53 RAF265 0.00144773788602029 0.17871347254782 10 173:176:179 0.0714285714285714 0.0163297189147532 2 LGG-coc1 TP53 TP53 Sorafenib 0.00339248851834664 0.0879574551399026 10 173:176:179 0.0714285714285714 0.0420273875611808 2 LGG-coc1 TP53 TP53 TAE684 0.00605301281031527 0.157351321540688 10 173:176:179 0.0714285714285714 0.0548554285934821 2 LGG-coc1 TP53 TP53 TKI258 0.000137808079657588 0.361588726253407 10 173:176:179 0.0714285714285714 0.00285459593576432 2 LGG-coc1 TP53 TP53 Topotecan 0.0103322172510489 0.291004051921587 10 173:176:179 0.0714285714285714 0.0713415000667662 2 LGG-coc1 TP53 TP53 ZD6474 0.00276595123815477 0.182623295488811 10 173:176:179 0.0714285714285714 0.0334219107943701 2 LGG-coc1 TP53 TP53 17-AAG 0.0796671548589707 0.0862762833712898 11 190:193:194:195:196 0.0785714285714286 0.273753844028507 0 LGG-coc1 TP53 TP53 AEW541 0.000300662031716009 0.205900146005564 11 190:193:194:195:196 0.0785714285714286 0.00902431152580788 2 LGG-coc1 TP53 TP53 AZD0530 0.000102777327168228 0.229227142605667 11 190:193:194:195:196 0.0785714285714286 0.00372567810984827 2 LGG-coc1 TP53 TP53 AZD6244 0.0228500076124252 -0.184427109176434 11 190:193:194:195:196 0.0785714285714286 0.136900600982901 1 LGG-coc1 TP53 TP53 Erlotinib 0.0171467863485632 -0.0676137342034054 11 190:193:194:195:196 0.0785714285714286 0.0972525230793827 1 LGG-coc1 TP53 TP53 Irinotecan 0.194506398463862 0.210188261594197 11 190:193:194:195:196 0.0785714285714286 0.508025070402669 0 LGG-coc1 TP53 TP53 L685458 0.000300662031716009 0.0673290572112956 11 190:193:194:195:196 0.0785714285714286 0.00732791135553488 2 LGG-coc1 TP53 TP53 Lapatinib 0.0564744538899876 0.0411087002342063 11 190:193:194:195:196 0.0785714285714286 0.209969123437133 0 LGG-coc1 TP53 TP53 LBW242 0.00269844173465118 -0.0833861195967837 11 190:193:194:195:196 0.0785714285714286 1 0 LGG-coc1 TP53 TP53 Nilotinib 0.000777732908571514 0.157285593497389 11 190:193:194:195:196 0.0785714285714286 0.0375904239142898 2 LGG-coc1 TP53 TP53 Nutlin3 0.0300510166710194 0.037003295605465 11 190:193:194:195:196 0.0785714285714286 0.15456080002062 2 LGG-coc1 TP53 TP53 Paclitaxel 0.000619731942924836 0.340685608456182 11 190:193:194:195:196 0.0785714285714286 0.00999052780210622 2 LGG-coc1 TP53 TP53 Panobinostat 0.0988654993770083 0.0835700949047649 11 190:193:194:195:196 0.0785714285714286 0.308351251300938 0 LGG-coc1 TP53 TP53 PD0325901 0.0171467863485632 -0.22150056734732 11 190:193:194:195:196 0.0785714285714286 0.103595167522569 1 LGG-coc1 TP53 TP53 PD0332991 0.000385491676378741 0.117452160951233 11 190:193:194:195:196 0.0785714285714286 0.00798518472498821 2 LGG-coc1 TP53 TP53 PF2341066 0.000970708845254544 0.0728576432038998 11 190:193:194:195:196 0.0785714285714286 0.0296449688710562 2 LGG-coc1 TP53 TP53 PHA665752 0.000300662031716009 0.0657406578718305 11 190:193:194:195:196 0.0785714285714286 0.00871919891976426 2 LGG-coc1 TP53 TP53 PLX4720 0.0796671548589707 0.108924215861042 11 190:193:194:195:196 0.0785714285714286 0.331576984443117 0 LGG-coc1 TP53 TP53 RAF265 0.000178863229071871 0.221777478502566 11 190:193:194:195:196 0.0785714285714286 0.00432252803590355 2 LGG-coc1 TP53 TP53 Sorafenib 2.99128041758275e-05 0.101507024164317 11 190:193:194:195:196 0.0785714285714286 0.00216867830274749 2 LGG-coc1 TP53 TP53 TAE684 1.02777327168228e-05 0.276744391246428 11 190:193:194:195:196 0.0785714285714286 0.000496757081313102 2 LGG-coc1 TP53 TP53 TKI258 1.02777327168228e-05 0.356528469961016 11 190:193:194:195:196 0.0785714285714286 0.000496757081313102 2 LGG-coc1 TP53 TP53 Topotecan 4.60196987320423e-06 0.426890248472619 11 190:193:194:195:196 0.0785714285714286 0.000333642815807307 2 LGG-coc1 TP53 TP53 ZD6474 0.000300662031716009 0.242607524676584 11 190:193:194:195:196 0.0785714285714286 0.00622799922840304 2 LGG-coc1 TP53 TP53 17-AAG 0.329135889080375 0.0327097475029907 13 205:208:213:214:216:220 0.0928571428571429 0.643594390748735 0 LGG-coc1 TP53 TP53 AEW541 0.00124914691408534 0.179145486497445 13 205:208:213:214:216:220 0.0928571428571429 0.0205912639566678 2 LGG-coc1 TP53 TP53 AZD0530 0.011563405972084 0.135188989394241 13 205:208:213:214:216:220 0.0928571428571429 0.0751319090067163 2 LGG-coc1 TP53 TP53 AZD6244 0.0555354049350085 -0.175616986095426 13 205:208:213:214:216:220 0.0928571428571429 0.201315842889406 0 LGG-coc1 TP53 TP53 Erlotinib 0.13181968650055 -0.0431522994583546 13 205:208:213:214:216:220 0.0928571428571429 0.335330781448768 0 LGG-coc1 TP53 TP53 Irinotecan 0.845997493660659 0.0822244943737207 13 205:208:213:214:216:220 0.0928571428571429 0.936443495026048 0 LGG-coc1 TP53 TP53 L685458 0.0283306378654989 0.038262702675488 13 205:208:213:214:216:220 0.0928571428571429 0.157997788096052 2 LGG-coc1 TP53 TP53 Lapatinib 0.307870036675603 0.0188839667145855 13 205:208:213:214:216:220 0.0928571428571429 0.531442325213838 0 LGG-coc1 TP53 TP53 LBW242 0.0172435380422718 -0.0613997319431343 13 205:208:213:214:216:220 0.0928571428571429 1 0 LGG-coc1 TP53 TP53 Nilotinib 0.00178878568971448 0.135911279026342 13 205:208:213:214:216:220 0.0928571428571429 0.0518747850017199 2 LGG-coc1 TP53 TP53 Nutlin3 0.183978481052854 0.0212116089063662 13 205:208:213:214:216:220 0.0928571428571429 0.398162384368117 0 LGG-coc1 TP53 TP53 Paclitaxel 0.268038500283987 0.136354653911391 13 205:208:213:214:216:220 0.0928571428571429 0.588872462745123 0 LGG-coc1 TP53 TP53 Panobinostat 1 0.0275648726491795 13 205:208:213:214:216:220 0.0928571428571429 1 0 LGG-coc1 TP53 TP53 PD0325901 0.0195961285169003 -0.21971816395906 13 205:208:213:214:216:220 0.0928571428571429 0.109286101344252 1 LGG-coc1 TP53 TP53 PD0332991 0.00103778274507152 0.089928535817881 13 205:208:213:214:216:220 0.0928571428571429 0.015047849803537 2 LGG-coc1 TP53 TP53 PF2341066 0.183978481052854 0.0509135220457311 13 205:208:213:214:216:220 0.0928571428571429 0.410413534656367 0 LGG-coc1 TP53 TP53 PHA665752 0.00481705188980034 0.0395053283301218 13 205:208:213:214:216:220 0.0928571428571429 0.0424151983645355 2 LGG-coc1 TP53 TP53 PLX4720 0.249468425156433 0.0772545840801466 13 205:208:213:214:216:220 0.0928571428571429 0.565201900745044 0 LGG-coc1 TP53 TP53 RAF265 0.00103778274507152 0.158960758241054 13 205:208:213:214:216:220 0.0928571428571429 0.015047849803537 2 LGG-coc1 TP53 TP53 Sorafenib 0.000580013693580749 0.0663531257954518 13 205:208:213:214:216:220 0.0928571428571429 0.0168203971138417 2 LGG-coc1 TP53 TP53 TAE684 0.00103778274507152 0.195862684731134 13 205:208:213:214:216:220 0.0928571428571429 0.0214969282907672 2 LGG-coc1 TP53 TP53 TKI258 0.000311152104914666 0.297670864544223 13 205:208:213:214:216:220 0.0928571428571429 0.00501300613473629 2 LGG-coc1 TP53 TP53 Topotecan 0.0499237923423663 0.248629296429622 13 205:208:213:214:216:220 0.0928571428571429 0.204107098261605 0 LGG-coc1 TP53 TP53 ZD6474 0.000250236079070888 0.234753822670711 13 205:208:213:214:216:220 0.0928571428571429 0.00622799922840304 2 LGG-coc1 TP53 TP53 17-AAG 0.271134621443897 0.009737824752452 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.591140268862651 0 LGG-coc1 TP53 TP53 AEW541 0.00160577828506074 0.13930417251085 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0213221054035784 2 LGG-coc1 TP53 TP53 AZD0530 0.00113011631731449 0.154978913969376 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0175660329374408 2 LGG-coc1 TP53 TP53 AZD6244 0.101269267331617 -0.139958018665776 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.31242646304435 0 LGG-coc1 TP53 TP53 Erlotinib 0.0174383834487169 -0.0484094246162099 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0972525230793827 1 LGG-coc1 TP53 TP53 Irinotecan 0.114476264530489 0.184081537210616 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.410975591222968 0 LGG-coc1 TP53 TP53 L685458 0.00578195412970176 0.0434012655386462 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0495179843388488 2 LGG-coc1 TP53 TP53 Lapatinib 0.12896499215984 0.0154021512499888 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.324316390107145 0 LGG-coc1 TP53 TP53 LBW242 0.0112310026608246 -0.0582195287644974 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 1 0 LGG-coc1 TP53 TP53 Nilotinib 0.00473139635709554 0.103596549904566 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0980074959684076 2 LGG-coc1 TP53 TP53 Nutlin3 0.211669055232812 0.0141785984504089 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.451353132481731 0 LGG-coc1 TP53 TP53 Paclitaxel 0.0160044719979473 0.188163502180127 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.129576144669057 2 LGG-coc1 TP53 TP53 Panobinostat 0.491756204505672 0.0272093005683258 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.750575259508657 0 LGG-coc1 TP53 TP53 PD0325901 0.0558359202214245 -0.171329703697822 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.218816444110988 0 LGG-coc1 TP53 TP53 PD0332991 0.000537205293900151 0.0764913085275216 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00865497417950243 2 LGG-coc1 TP53 TP53 PF2341066 0.0450343229104153 0.0328405572352726 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.204061775687819 0 LGG-coc1 TP53 TP53 PHA665752 0.00934494581610902 0.0234694152473274 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0645246258731337 2 LGG-coc1 TP53 TP53 PLX4720 0.420747920707029 0.0549924937296737 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.772258841804041 0 LGG-coc1 TP53 TP53 RAF265 0.00201494476268604 0.12221435252558 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0208690707563911 2 LGG-coc1 TP53 TP53 Sorafenib 0.0122913456065516 0.0475805968404255 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0856312216062366 2 LGG-coc1 TP53 TP53 TAE684 0.000117166771400825 0.183531891196013 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00345416954180369 2 LGG-coc1 TP53 TP53 TKI258 6.3533436355664e-05 0.252022308199971 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00184246965431426 2 LGG-coc1 TP53 TP53 Topotecan 0.000117166771400825 0.235452930545089 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00316725464315788 2 LGG-coc1 TP53 TP53 ZD6474 1.99404006239228e-05 0.225377391871795 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.000963786030156269 2 LGG-coc1 TP53 TP53 17-AAG 0.316656028033356 0.0153688860072583 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.643594390748735 0 LGG-coc1 TP53 TP53 AEW541 2.91197627436345e-05 0.172137455354529 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0021111827989135 2 LGG-coc1 TP53 TP53 AZD0530 1.86876087483311e-06 0.212589619298178 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000270970326850801 2 LGG-coc1 TP53 TP53 AZD6244 0.00646316947813552 -0.134096172923942 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0726893163536467 1 LGG-coc1 TP53 TP53 Erlotinib 0.489726734913014 -0.0093426498360995 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.704248870091984 0 LGG-coc1 TP53 TP53 Irinotecan 0.0723756123232753 0.214670692854424 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.361878061616376 0 LGG-coc1 TP53 TP53 L685458 6.85351666349916e-05 0.0726343816204345 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00331253305402459 2 LGG-coc1 TP53 TP53 Lapatinib 0.114250283828317 0.0228126736065547 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.324316390107145 0 LGG-coc1 TP53 TP53 LBW242 0.0555498085847603 -0.0420114460890558 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 1 0 LGG-coc1 TP53 TP53 Nilotinib 4.90058315695754e-05 0.171622220344852 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00710584557758843 2 LGG-coc1 TP53 TP53 Nutlin3 0.00417226274590342 0.0381375203832441 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0607502083038393 2 LGG-coc1 TP53 TP53 Paclitaxel 0.00183351411194817 0.230538131356093 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0241690496574986 2 LGG-coc1 TP53 TP53 Panobinostat 0.0039438032733166 0.0993104885951865 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0502886202180841 2 LGG-coc1 TP53 TP53 PD0325901 0.00207146237159461 -0.188767640468643 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0500603406468697 1 LGG-coc1 TP53 TP53 PD0332991 1.40534108070927e-05 0.101038374809828 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00118379242783158 2 LGG-coc1 TP53 TP53 PF2341066 0.00646316947813552 0.0578764851364081 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.066939969594975 2 LGG-coc1 TP53 TP53 PHA665752 0.000152579506451223 0.0542501295598578 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00553100710885683 2 LGG-coc1 TP53 TP53 PLX4720 0.00372649925230416 0.1592032891696 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0491220355985548 2 LGG-coc1 TP53 TP53 RAF265 3.18063058380346e-05 0.162286357408412 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00230595717325751 2 LGG-coc1 TP53 TP53 Sorafenib 1.40534108070927e-05 0.087293296010385 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00203774456702844 2 LGG-coc1 TP53 TP53 TAE684 1.07320078160439e-06 0.209097089347316 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000155614113332637 2 LGG-coc1 TP53 TP53 TKI258 2.26694019667314e-07 0.350187953386379 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 3.28706328517605e-05 2 LGG-coc1 TP53 TP53 Topotecan 1.27926692675832e-05 0.290065305729859 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000618312347933188 2 LGG-coc1 TP53 TP53 ZD6474 2.66438278486468e-05 0.194124924748738 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000965838759513446 2 LGG-coc2 IDH1 IDH1 17-AAG 0.722875176735981 0.00723631287732074 10 132 0.181818181818182 0.87347417188931 0 LGG-coc2 IDH1 IDH1 AEW541 0.0471547617027868 0.0560931290696529 10 132 0.181818181818182 0.225625715839806 0 LGG-coc2 IDH1 IDH1 AZD0530 0.940075136248778 0.0317094878462871 10 132 0.181818181818182 0.980653919108437 0 LGG-coc2 IDH1 IDH1 AZD6244 0.457407917791847 0.0467598385972596 10 132 0.181818181818182 0.720914653041498 0 LGG-coc2 IDH1 IDH1 Erlotinib 0.104704330616335 -0.0532727992578941 10 132 0.181818181818182 0.289741722186202 0 LGG-coc2 IDH1 IDH1 Irinotecan 0.000973066604942381 0.35767908770092 10 132 0.181818181818182 0.0176368322145807 2 LGG-coc2 IDH1 IDH1 L685458 0.0497616993045549 0.0744016775707732 10 132 0.181818181818182 0.232756335456789 0 LGG-coc2 IDH1 IDH1 Lapatinib 0.88895909475161 0.0109286715143038 10 132 0.181818181818182 0.954807916585063 0 LGG-coc2 IDH1 IDH1 LBW242 0.739057849003731 -0.0240166061257112 10 132 0.181818181818182 1 0 LGG-coc2 IDH1 IDH1 Nilotinib 0.148736216159708 0.0965519552869516 10 132 0.181818181818182 0.431335026863153 0 LGG-coc2 IDH1 IDH1 Nutlin3 0.370753293684645 0.0400070608035974 10 132 0.181818181818182 0.647701537159922 0 LGG-coc2 IDH1 IDH1 Paclitaxel 0.821528875632601 -0.0330941062497843 10 132 0.181818181818182 0.919010695591438 0 LGG-coc2 IDH1 IDH1 Panobinostat 0.213116450279804 0.110895005150208 10 132 0.181818181818182 0.472287948002709 0 LGG-coc2 IDH1 IDH1 PD0325901 0.35923692658516 0.0700961615216881 10 132 0.181818181818182 0.598728210975267 0 LGG-coc2 IDH1 IDH1 PD0332991 0.00257193537021378 0.091941652139906 10 132 0.181818181818182 0.0269998984390202 2 LGG-coc2 IDH1 IDH1 PF2341066 0.0788429591430882 0.0604395054498815 10 132 0.181818181818182 0.278834855506044 0 LGG-coc2 IDH1 IDH1 PHA665752 0.940075136248778 0.0254207567562149 10 132 0.181818181818182 0.981403557938373 0 LGG-coc2 IDH1 IDH1 PLX4720 0.974298773972484 0.052794028548403 10 132 0.181818181818182 0.978697382843298 0 LGG-coc2 IDH1 IDH1 RAF265 0.347940841246563 0.0593090886214807 10 132 0.181818181818182 0.638625594693059 0 LGG-coc2 IDH1 IDH1 Sorafenib 0.155080223476835 0.0722391905781617 10 132 0.181818181818182 0.440914360865511 0 LGG-coc2 IDH1 IDH1 TAE684 0.000119109294544955 0.208342149318249 10 132 0.181818181818182 0.00345416954180369 2 LGG-coc2 IDH1 IDH1 TKI258 0.0999930438839411 0.172203442770141 10 132 0.181818181818182 0.315195464416771 0 LGG-coc2 IDH1 IDH1 Topotecan 0.315383622552448 0.0940031834375907 10 132 0.181818181818182 0.662762685073985 0 LGG-coc2 IDH1 IDH1 ZD6474 0.0910622371940406 0.136963582804342 10 132 0.181818181818182 0.410193048864343 0 LGG-coc3 IDH1 IDH1 17-AAG 0.412264883602999 -0.037724430183161 83 132 0.912087912087912 0.703231692747136 0 LGG-coc3 IDH1 IDH1 AEW541 0.420301197607269 0.0199273808665879 83 132 0.912087912087912 0.66971069948411 0 LGG-coc3 IDH1 IDH1 AZD0530 0.230786045899912 0.0496287899242718 83 132 0.912087912087912 0.515942709081624 0 LGG-coc3 IDH1 IDH1 AZD6244 0.523661672597607 0.0526219787309294 83 132 0.912087912087912 0.764276215065453 0 LGG-coc3 IDH1 IDH1 Erlotinib 0.171774531655113 0.0347082864367466 83 132 0.912087912087912 0.40173075951599 0 LGG-coc3 IDH1 IDH1 Irinotecan 0.994408617783507 0.0212643265069965 83 132 0.912087912087912 0.994408617783507 0 LGG-coc3 IDH1 IDH1 L685458 0.0809942484973637 0.024616505615447 83 132 0.912087912087912 0.33554760091765 0 LGG-coc3 IDH1 IDH1 Lapatinib 0.358606373665264 0.0203414517740593 83 132 0.912087912087912 0.597677289442107 0 LGG-coc3 IDH1 IDH1 LBW242 0.679268796307903 0.00693143984639377 83 132 0.912087912087912 1 0 LGG-coc3 IDH1 IDH1 Nilotinib 0.381042555353493 0.0495023937256106 83 132 0.912087912087912 0.682464106351632 0 LGG-coc3 IDH1 IDH1 Nutlin3 0.139234117212264 0.0177778955395558 83 132 0.912087912087912 0.344668254347867 0 LGG-coc3 IDH1 IDH1 Paclitaxel 0.628712872297685 0.0316257656114853 83 132 0.912087912087912 0.877715146851436 0 LGG-coc3 IDH1 IDH1 Panobinostat 0.883002472020585 0.00876096649543801 83 132 0.912087912087912 0.941436459139594 0 LGG-coc3 IDH1 IDH1 PD0325901 0.860926103869026 0.00816254963330196 83 132 0.912087912087912 0.932331287666608 0 LGG-coc3 IDH1 IDH1 PD0332991 0.289973307169429 0.0186613085514833 83 132 0.912087912087912 0.539052942814964 0 LGG-coc3 IDH1 IDH1 PF2341066 0.579840685745021 -0.00911214714424757 83 132 0.912087912087912 0.731103473330679 0 LGG-coc3 IDH1 IDH1 PHA665752 0.927411857675441 0.00780234525011264 83 132 0.912087912087912 0.981403557938373 0 LGG-coc3 IDH1 IDH1 PLX4720 0.0695201789291326 0.0838176971517695 83 132 0.912087912087912 0.325175030474975 0 LGG-coc3 IDH1 IDH1 RAF265 0.479076056499894 0.0143334556133873 83 132 0.912087912087912 0.745662374723171 0 LGG-coc3 IDH1 IDH1 Sorafenib 0.412264883602999 0.0192326796573824 83 132 0.912087912087912 0.721813757748919 0 LGG-coc3 IDH1 IDH1 TAE684 0.436647102080097 -0.0214721439781478 83 132 0.912087912087912 0.650520979885906 0 LGG-coc3 IDH1 IDH1 TKI258 0.731310368692518 0.0615629006532843 83 132 0.912087912087912 0.921239375376304 0 LGG-coc3 IDH1 IDH1 Topotecan 1 0.0137749670814995 83 132 0.912087912087912 1 0 LGG-coc3 IDH1 IDH1 ZD6474 0.608951601808636 0.00299238684144409 83 132 0.912087912087912 0.84149733845491 0 BRCA-Basal TP53 TP53 17-AAG 0.0429637442021343 -0.220059202543676 10 193:194:195:196:198:199 0.153846153846154 0.188780088160893 1 BRCA-Basal TP53 TP53 AEW541 0.151736808083557 0.0821079521170884 10 193:194:195:196:198:199 0.153846153846154 0.391975875337794 0 BRCA-Basal TP53 TP53 AZD0530 0.80940473355334 0.0343272092006098 10 193:194:195:196:198:199 0.153846153846154 0.934998064477449 0 BRCA-Basal TP53 TP53 AZD6244 0.426167228024813 0.144933990750406 10 193:194:195:196:198:199 0.153846153846154 0.679057671028548 0 BRCA-Basal TP53 TP53 Erlotinib 0.0610009185860579 0.102176272893267 10 193:194:195:196:198:199 0.153846153846154 0.201151618689558 0 BRCA-Basal TP53 TP53 Irinotecan 0.386679368103517 0.232250013228953 10 193:194:195:196:198:199 0.153846153846154 0.683762297256219 0 BRCA-Basal TP53 TP53 L685458 0.314371902607197 0.044631547587926 10 193:194:195:196:198:199 0.153846153846154 0.555901535098092 0 BRCA-Basal TP53 TP53 Lapatinib 0.756444278116105 -0.0171349093900757 10 193:194:195:196:198:199 0.153846153846154 0.8569095338034 0 BRCA-Basal TP53 TP53 LBW242 0.426167228024813 0.0325471511988766 10 193:194:195:196:198:199 0.153846153846154 1 0 BRCA-Basal TP53 TP53 Nilotinib 0.467855158257635 0.0364218158706975 10 193:194:195:196:198:199 0.153846153846154 0.699371112859351 0 BRCA-Basal TP53 TP53 Nutlin3 0.386679368103517 0.0179514146350362 10 193:194:195:196:198:199 0.153846153846154 0.667482242559643 0 BRCA-Basal TP53 TP53 Paclitaxel 0.972538813096089 0.00999722706520334 10 193:194:195:196:198:199 0.153846153846154 1 0 BRCA-Basal TP53 TP53 Panobinostat 0.223023622404427 0.0916183864837778 10 193:194:195:196:198:199 0.153846153846154 0.475565077185911 0 BRCA-Basal TP53 TP53 PD0325901 0.314371902607197 0.287451092162938 10 193:194:195:196:198:199 0.153846153846154 0.565530852379404 0 BRCA-Basal TP53 TP53 PD0332991 0.756444278116105 -0.0398943841308536 10 193:194:195:196:198:199 0.153846153846154 0.874867122585577 0 BRCA-Basal TP53 TP53 PF2341066 0.756444278116105 -0.000210026235256011 10 193:194:195:196:198:199 0.153846153846154 0.843726310206425 0 BRCA-Basal TP53 TP53 PHA665752 0.314371902607197 0.0460687666051633 10 193:194:195:196:198:199 0.153846153846154 0.54583632016244 0 BRCA-Basal TP53 TP53 PLX4720 0.467855158257635 0.0428569656120584 10 193:194:195:196:198:199 0.153846153846154 0.791842381808024 0 BRCA-Basal TP53 TP53 RAF265 0.0610009185860579 0.169159807375146 10 193:194:195:196:198:199 0.153846153846154 0.205700771976242 0 BRCA-Basal TP53 TP53 Sorafenib 0.426167228024813 0.0364156020282284 10 193:194:195:196:198:199 0.153846153846154 0.726991153689387 0 BRCA-Basal TP53 TP53 TAE684 0.0357001100035156 0.30019954497096 10 193:194:195:196:198:199 0.153846153846154 0.20706063802039 0 BRCA-Basal TP53 TP53 TKI258 0.60473015116978 0.0712744436629527 10 193:194:195:196:198:199 0.153846153846154 0.876858719196181 0 BRCA-Basal TP53 TP53 Topotecan 0.60473015116978 0.110823046570108 10 193:194:195:196:198:199 0.153846153846154 0.804457540546955 0 BRCA-Basal TP53 TP53 ZD6474 0.91769015298427 0.0144808494165736 10 193:194:195:196:198:199 0.153846153846154 0.96509326057909 0 BRCA-LumA PIK3CA PIK3CA 17-AAG 0.0794019374661377 0.0624565891131881 28 539:542:545:546 0.193103448275862 0.273753844028507 0 BRCA-LumA PIK3CA PIK3CA AEW541 0.270621656840991 -0.0364977406655531 28 539:542:545:546 0.193103448275862 0.575187141594055 0 BRCA-LumA PIK3CA PIK3CA AZD0530 0.20664433980043 0.0584585836697309 28 539:542:545:546 0.193103448275862 0.491447117075526 0 BRCA-LumA PIK3CA PIK3CA AZD6244 0.631366119906055 0.0406764053792625 28 539:542:545:546 0.193103448275862 0.803053398126123 0 BRCA-LumA PIK3CA PIK3CA Erlotinib 0.791123236742848 0.00220241474959137 28 539:542:545:546 0.193103448275862 0.875670758226817 0 BRCA-LumA PIK3CA PIK3CA Irinotecan 0.335322615971152 -0.124599770023329 28 539:542:545:546 0.193103448275862 0.631451679426195 0 BRCA-LumA PIK3CA PIK3CA L685458 0.48240830427717 -0.00482916994383964 28 539:542:545:546 0.193103448275862 0.712950676140981 0 BRCA-LumA PIK3CA PIK3CA Lapatinib 0.417991506758222 -0.0232266493909516 28 539:542:545:546 0.193103448275862 0.646177427933877 0 BRCA-LumA PIK3CA PIK3CA LBW242 0.143619203984881 0.0146018929686311 28 539:542:545:546 0.193103448275862 1 0 BRCA-LumA PIK3CA PIK3CA Nilotinib 0.703941339759385 -0.00738407199796576 28 539:542:545:546 0.193103448275862 0.857743649286645 0 BRCA-LumA PIK3CA PIK3CA Nutlin3 0.109459073997832 0.010560776406963 28 539:542:545:546 0.193103448275862 0.289481058262646 0 BRCA-LumA PIK3CA PIK3CA Paclitaxel 0.170586150075267 0.0900286278922175 28 539:542:545:546 0.193103448275862 0.433947223875679 0 BRCA-LumA PIK3CA PIK3CA Panobinostat 0.526510015968416 -0.0390989543444284 28 539:542:545:546 0.193103448275862 0.755880715994261 0 BRCA-LumA PIK3CA PIK3CA PD0325901 0.893129474121465 0.0380501350900249 28 539:542:545:546 0.193103448275862 0.938433143098641 0 BRCA-LumA PIK3CA PIK3CA PD0332991 0.609692511251378 -0.0263688345467405 28 539:542:545:546 0.193103448275862 0.781795272540096 0 BRCA-LumA PIK3CA PIK3CA PF2341066 0.141528647281917 0.00817608386121482 28 539:542:545:546 0.193103448275862 0.34782464162505 0 BRCA-LumA PIK3CA PIK3CA PHA665752 0.755866318254994 -0.00255924628379939 28 539:542:545:546 0.193103448275862 0.877092920919321 0 BRCA-LumA PIK3CA PIK3CA PLX4720 0.670059199206537 -0.00100199653135125 28 539:542:545:546 0.193103448275862 0.877019401596361 0 BRCA-LumA PIK3CA PIK3CA RAF265 0.501757587941738 0.0224431855845213 28 539:542:545:546 0.193103448275862 0.745662374723171 0 BRCA-LumA PIK3CA PIK3CA Sorafenib 0.129472953645139 0.00816493453723549 28 539:542:545:546 0.193103448275862 0.399437835713727 0 BRCA-LumA PIK3CA PIK3CA TAE684 0.209417180814228 -0.0373825506600661 28 539:542:545:546 0.193103448275862 0.460083200273683 0 BRCA-LumA PIK3CA PIK3CA TKI258 0.339187748523514 0.0371296085183035 28 539:542:545:546 0.193103448275862 0.712785848346515 0 BRCA-LumA PIK3CA PIK3CA Topotecan 0.185416193331042 -0.119725243478894 28 539:542:545:546 0.193103448275862 0.497876815425946 0 BRCA-LumA PIK3CA PIK3CA ZD6474 0.187977877445879 -0.0630352309523314 28 539:542:545:546 0.193103448275862 0.546043030477178 0 THCA-Braf-like BRAF BRAF 17-AAG 4.90153988158706e-06 -0.15484778301649 224 600 0.842105263157895 0.000236907760943375 1 THCA-Braf-like BRAF BRAF AEW541 0.00161753903061629 -0.0383645995677155 224 600 0.842105263157895 0.0213221054035784 1 THCA-Braf-like BRAF BRAF AZD0530 0.231810333551904 0.0712324025929725 224 600 0.842105263157895 0.515942709081624 0 THCA-Braf-like BRAF BRAF AZD6244 0.0363205096132273 -0.065720591972211 224 600 0.842105263157895 0.159590117997514 1 THCA-Braf-like BRAF BRAF Erlotinib 0.539999030028005 -0.0315532160260145 224 600 0.842105263157895 0.760192809262725 0 THCA-Braf-like BRAF BRAF Irinotecan 0.0454748665200465 -0.193759236714389 224 600 0.842105263157895 0.274719342741761 0 THCA-Braf-like BRAF BRAF L685458 0.0017447210453629 -0.0569527041358083 224 600 0.842105263157895 0.0316230689472026 1 THCA-Braf-like BRAF BRAF Lapatinib 0.0055417066530154 -0.0483068963506268 224 600 0.842105263157895 0.04974023569291 1 THCA-Braf-like BRAF BRAF LBW242 0.803100264062141 0.00183076688179939 224 600 0.842105263157895 1 0 THCA-Braf-like BRAF BRAF Nilotinib 0.0663240841961476 -0.0308064749611996 224 600 0.842105263157895 0.339744394309991 0 THCA-Braf-like BRAF BRAF Nutlin3 0.00182537942685676 -0.0440743949176559 224 600 0.842105263157895 0.0566659712168211 1 THCA-Braf-like BRAF BRAF Paclitaxel 6.00382792445341e-05 -0.257843093736585 224 600 0.842105263157895 0.00435277524522872 1 THCA-Braf-like BRAF BRAF Panobinostat 0.302212541664553 -0.097051146533409 224 600 0.842105263157895 0.527961669173014 0 THCA-Braf-like BRAF BRAF PD0325901 0.219089275953734 -0.0348466092105413 224 600 0.842105263157895 0.460405000192629 0 THCA-Braf-like BRAF BRAF PD0332991 0.00397527447821632 -0.0757308216410975 224 600 0.842105263157895 0.0360259249588354 1 THCA-Braf-like BRAF BRAF PF2341066 0.10075792759382 -0.0230598776820785 224 600 0.842105263157895 0.321714414152914 0 THCA-Braf-like BRAF BRAF PHA665752 0.371167815460936 -0.0245126565183157 224 600 0.842105263157895 0.572546098317401 0 THCA-Braf-like BRAF BRAF PLX4720 9.63407439011328e-05 -0.0904205606562192 224 600 0.842105263157895 0.00349235196641606 1 THCA-Braf-like BRAF BRAF RAF265 0.0957991193526159 0.0238638496415369 224 600 0.842105263157895 0.277817446122586 0 THCA-Braf-like BRAF BRAF Sorafenib 0.780897938350197 -0.0088140090284099 224 600 0.842105263157895 0.905841608486229 0 THCA-Braf-like BRAF BRAF TAE684 0.0724415475013707 0.0444611248094606 224 600 0.842105263157895 0.272788326236856 0 THCA-Braf-like BRAF BRAF TKI258 0.0724415475013707 -0.0600803877329066 224 600 0.842105263157895 0.257337606466146 0 THCA-Braf-like BRAF BRAF Topotecan 0.0502153422436072 -0.131704222078893 224 600 0.842105263157895 0.204107098261605 0 THCA-Braf-like BRAF BRAF ZD6474 0.162295041297229 -0.020539202603677 224 600 0.842105263157895 0.522950688624405 0