cancer symbol gene Drug ps.twosided fcs nMut clust.name nMut.prop adjp color BLCA ERBB2 ERBB2 Erlotinib 0.0181415236792116 -0.0794799532569297 22 310 0.054320987654321 0.0974267012402104 1 BLCA ERBB2 ERBB2 PHA665752 0.019815138712525 0.0389270850231042 22 310 0.054320987654321 0.0993065239080255 2 BLCA FGFR3 FGFR3 17-AAG 9.42138169837156e-06 0.177459082803221 34 248:249 0.0839506172839506 0.000341525086565969 2 BLCA FGFR3 FGFR3 AZD0530 0.00383208801044433 0.118923485591995 34 248:249 0.0839506172839506 0.0370435174342952 2 BLCA FGFR3 FGFR3 Erlotinib 4.67338134538775e-08 0.186006953390571 34 248:249 0.0839506172839506 6.77640295081224e-06 2 BLCA FGFR3 FGFR3 Lapatinib 0.00283164552250051 0.130205860543035 34 248:249 0.0839506172839506 0.0342157167302145 2 BLCA FGFR3 FGFR3 Nutlin3 0.0319780965559904 -0.0369124709957054 34 248:249 0.0839506172839506 0.15456080002062 1 BLCA FGFR3 FGFR3 Panobinostat 4.01108018788984e-07 -0.222762204477495 34 248:249 0.0839506172839506 5.81606627244027e-05 1 BLCA FGFR3 FGFR3 PD0325901 0.0192590591197621 0.175121541190338 34 248:249 0.0839506172839506 0.109286101344252 2 BLCA FGFR3 FGFR3 PD0332991 0.0287087546340097 -0.0551305988733011 34 248:249 0.0839506172839506 0.138758980731047 1 BLCA FGFR3 FGFR3 Sorafenib 0.0101939850144982 -0.0477082386147699 34 248:249 0.0839506172839506 0.0821182126167911 1 BLCA FGFR3 FGFR3 TAE684 0.00211001169553569 -0.085750018545542 34 248:249 0.0839506172839506 0.0339946328725194 1 BLCA FGFR3 FGFR3 TKI258 0.00658252234020241 -0.126438523389116 34 248:249 0.0839506172839506 0.0530258744071861 1 BLCA FGFR3 FGFR3 Topotecan 0.00334148564856438 -0.200321488338603 34 248:249 0.0839506172839506 0.0372704168493719 1 BLCA FGFR3 FGFR3 17-AAG 0.000438800985923679 0.249727871886279 10 373:375 0.0246913580246914 0.00908944899413335 2 BLCA FGFR3 FGFR3 AZD0530 0.0108668681439728 0.179729718626951 10 373:375 0.0246913580246914 0.0750331371845741 2 BLCA FGFR3 FGFR3 AZD6244 0.0395962359189076 0.20255066407358 10 373:375 0.0246913580246914 0.16538682214573 2 BLCA FGFR3 FGFR3 Erlotinib 0.0040262791296177 0.192066998784826 10 373:375 0.0246913580246914 0.0583810473794567 2 BLCA FGFR3 FGFR3 L685458 0.0146721881374702 -0.0729057680618541 10 373:375 0.0246913580246914 0.101307965711104 1 BLCA FGFR3 FGFR3 Lapatinib 0.000127011872383703 0.276220077301652 10 373:375 0.0246913580246914 0.00306945358260616 2 BLCA FGFR3 FGFR3 Nilotinib 0.00617824540630737 -0.105268327499179 10 373:375 0.0246913580246914 0.0995383982127298 1 BLCA FGFR3 FGFR3 Nutlin3 0.0100192738110994 -0.0776156376370065 10 373:375 0.0246913580246914 0.0854585119182008 1 BLCA FGFR3 FGFR3 Panobinostat 0.000204766080582245 -0.291165300933829 10 373:375 0.0246913580246914 0.00722317728540929 1 BLCA FGFR3 FGFR3 PD0325901 0.00617824540630737 0.387151510981581 10 373:375 0.0246913580246914 0.0746537986595474 2 BLCA FGFR3 FGFR3 Sorafenib 0.0326546303548931 -0.0764401066967512 10 373:375 0.0246913580246914 0.175367459313315 1 BLCA FGFR3 FGFR3 TAE684 0.000438800985923679 -0.186490469756805 10 373:375 0.0246913580246914 0.0106043571598222 1 BLCA FGFR3 FGFR3 TKI258 0.019606677703729 -0.212481154492689 10 373:375 0.0246913580246914 0.104392576358009 1 BLCA FGFR3 FGFR3 Topotecan 0.0118828633140369 -0.29181546624364 10 373:375 0.0246913580246914 0.074913703501537 1 BLCA NFE2L2 NFE2L2 AEW541 0.00891078073302038 -0.0790035084199583 12 24:29:30:31:34 0.0296296296296296 0.0680033266467345 1 BLCA NFE2L2 NFE2L2 AZD6244 0.0226130460476501 -0.190598744890464 12 24:29:30:31:34 0.0296296296296296 0.136900600982901 1 BLCA NFE2L2 NFE2L2 Erlotinib 0.00502631595775484 0.126702055781814 12 24:29:30:31:34 0.0296296296296296 0.0607346511562043 2 BLCA NFE2L2 NFE2L2 Paclitaxel 0.000286393385612174 0.536159048561946 12 24:29:30:31:34 0.0296296296296296 0.00692117348562754 2 BLCA NFE2L2 NFE2L2 Panobinostat 0.0280438217806157 -0.172455135988606 12 24:29:30:31:34 0.0296296296296296 0.168888463846555 1 BLCA NFE2L2 NFE2L2 PD0332991 0.0255430797182069 -0.0843705593648857 12 24:29:30:31:34 0.0296296296296296 0.132276662826429 1 BLCA NFE2L2 NFE2L2 RAF265 0.000498349707509306 0.213707092375929 12 24:29:30:31:34 0.0296296296296296 0.00996836092647044 2 BLCA PIK3CA PIK3CA PHA665752 0.000912166090971948 0.0353741543944771 50 542:545:546 0.123456790123457 0.0132264083190932 2 BLCA RXRA RXRA AZD6244 0.0252783476078087 0.174454663292339 14 427 0.0345679012345679 0.138184273413645 2 BLCA RXRA RXRA PD0325901 0.0492192304653669 0.223747458074153 14 427 0.0345679012345679 0.198244122707728 2 BLCA TP53 TP53 17-AAG 0.00394986097615079 -0.124677986895172 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0409092743958475 1 BLCA TP53 TP53 AZD0530 0.00559804741629104 -0.109866530613117 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0477480514918942 1 BLCA TP53 TP53 AZD6244 0.00701827882035209 -0.188370843015323 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0726893163536467 1 BLCA TP53 TP53 Nilotinib 0.0222298425112159 0.0599817522013312 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.189607480242724 2 BLCA TP53 TP53 PD0325901 0.00745807012951878 -0.259203656987598 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0759942757476325 1 BLCA TP53 TP53 RAF265 0.0114023012144803 0.108613960388408 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0661333470439857 2 BLCA TP53 TP53 Sorafenib 0.00140540809976777 0.0577752943554404 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.0291120249237609 2 BLCA TP53 TP53 ZD6474 0.0309436970735161 0.0847738905204782 22 132:135:139:141:143:144:146:151:155:159:161 0.054320987654321 0.186951503152493 2 BLCA TP53 TP53 17-AAG 0.0236293903639482 -0.151279911986787 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.14276090011552 1 BLCA TP53 TP53 AZD6244 0.0464475384424374 -0.153792880988694 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.182024137139282 1 BLCA TP53 TP53 Erlotinib 0.0227145377423459 -0.162454873902935 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.109786932421339 1 BLCA TP53 TP53 Lapatinib 0.0413126706768911 -0.134370876035528 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.166398256893034 1 BLCA TP53 TP53 Panobinostat 0.039469996664498 0.11081659641003 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.19734998332249 2 BLCA TP53 TP53 PD0325901 0.0161039314980946 -0.274815999040956 18 192:193:194:199:204:208:213:214:218:220:221:224 0.0444444444444444 0.103595167522569 1 BLCA TP53 TP53 17-AAG 0.0258649530703574 -0.0663057554154265 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.144246853661609 1 BLCA TP53 TP53 AZD6244 0.0128139358728028 -0.125977237755792 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.115873204402054 1 BLCA TP53 TP53 Erlotinib 0.0282400594564217 -0.0596853685854593 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.127962769411911 1 BLCA TP53 TP53 PD0325901 0.00580298728325766 -0.193697363126893 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.0746537986595474 1 BLCA TP53 TP53 RAF265 0.0371436704635206 0.0748502097213624 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.141732426768697 2 BLCA TP53 TP53 Sorafenib 0.0041546038231821 0.0483045692929976 44 236:237:238:241:242:244:245:246:248:249 0.108641975308642 0.0463398118739542 2 BLCA TP53 TP53 17-AAG 0.0108727418956952 -0.101601206456906 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0829761881513581 1 BLCA TP53 TP53 AZD0530 0.0088124055430145 -0.0882167310574753 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0672525686177422 1 BLCA TP53 TP53 Erlotinib 0.00195321810815901 -0.116049872107231 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0354020782103821 1 BLCA TP53 TP53 Irinotecan 0.000701088531977431 0.234802426128389 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0145225481623896 2 BLCA TP53 TP53 Panobinostat 0.014568445525893 0.0769919813400683 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.105621230062724 2 BLCA TP53 TP53 PD0325901 0.0206877118913573 -0.158823322371072 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.111100674972104 1 BLCA TP53 TP53 RAF265 0.00423360379927922 0.0990749406012197 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0341040306053048 2 BLCA TP53 TP53 Sorafenib 0.00180382822415321 0.0600596417473581 57 271:273:275:277:278:279:280:282:283:285:286:287 0.140740740740741 0.0309840576886325 2 BLCA TP53 TP53 AZD0530 0.00199832600913289 -0.211049420719033 13 331:336:337 0.0320987654320988 0.022581280277263 1 BLCA TP53 TP53 Erlotinib 0.021201052338846 -0.174344960092838 13 331:336:337 0.0320987654320988 0.10600526169423 1 BLCA TP53 TP53 Panobinostat 0.00485545298657364 0.199983010900266 13 331:336:337 0.0320987654320988 0.0502886202180841 2 BLCA TP53 TP53 PF2341066 0.0105902722728442 0.0685006007211539 13 331:336:337 0.0320987654320988 0.0883764757820365 2 BLCA TP53 TP53 Sorafenib 0.0280506470072113 0.0869385710697184 13 331:336:337 0.0320987654320988 0.15643630061714 2 BLCA TP53 TP53 Topotecan 0.00648608993543202 0.285288478553077 13 331:336:337 0.0320987654320988 0.0553225318022143 2 CESC MAPK1 MAPK1 Nutlin3 0.0282846592878222 0.0442673946210949 10 321:322 0.0352112676056338 0.15456080002062 2 CESC PIK3CA PIK3CA RAF265 0.000549978533874231 -0.0670214460953595 59 542:545 0.207746478873239 0.00996836092647044 1 COAD APC APC AEW541 0.0353845652778186 0.0357932086546668 17 211:213:216 0.0636704119850187 0.183241498760132 2 COAD APC APC TKI258 0.0124387406118827 -0.191190833285007 17 211:213:216 0.0636704119850187 0.0858865423201425 1 COAD APC APC Nutlin3 0.0208424932793164 -0.0608946335707793 12 874:876 0.0449438202247191 0.12592339689587 1 COAD APC APC PLX4720 0.021598735411327 -0.126062608499942 12 874:876 0.0449438202247191 0.16896858483428 1 COAD APC APC Lapatinib 0.00310057032363832 -0.0815413749590235 12 935:940:941:943 0.0449438202247191 0.0345832843790428 1 COAD APC APC PHA665752 0.0155795423317107 -0.046520710667987 12 935:940:941:943 0.0449438202247191 0.0919743048739549 1 COAD APC APC Topotecan 0.0208424932793164 -0.276370581798936 12 935:940:941:943 0.0449438202247191 0.111931908351884 1 COAD APC APC AEW541 0.024798758456277 0.0395374171832659 11 1367:1370:1374:1378 0.0411985018726592 0.143832799046407 2 COAD APC APC Lapatinib 0.0213821758787866 -0.0642986961096128 11 1367:1370:1374:1378 0.0411985018726592 0.114830203793484 1 COAD APC APC PHA665752 0.016381885354572 -0.0460488974995514 11 1367:1370:1374:1378 0.0411985018726592 0.0919743048739549 1 COAD APC APC RAF265 0.03935746982736 -0.08281687935941 11 1367:1370:1374:1378 0.0411985018726592 0.146329054486338 1 COAD APC APC AEW541 0.00296334942147788 0.0505946833205317 22 1444:1447:1450:1451 0.0823970037453183 0.0332670521950657 2 COAD APC APC PHA665752 0.0440231868035308 -0.0316620009238296 22 1444:1447:1450:1451 0.0823970037453183 0.17584271195418 1 COAD APC APC RAF265 0.0245387999823882 -0.0708469105745149 22 1444:1447:1450:1451 0.0823970037453183 0.104650764630773 1 COAD BRAF BRAF AEW541 0.000373419787274809 -0.0463651882435059 38 594:597:600 0.142322097378277 0.00902431152580788 1 COAD BRAF BRAF AZD0530 0.00544655623701415 -0.0729656801300447 38 594:597:600 0.142322097378277 0.0477480514918942 1 COAD BRAF BRAF AZD6244 0.0141322658531801 -0.11039138089165 38 594:597:600 0.142322097378277 0.115873204402054 1 COAD BRAF BRAF Erlotinib 0.0103034122988557 -0.0394508857838574 38 594:597:600 0.142322097378277 0.078631304386004 1 COAD BRAF BRAF Nutlin3 0.0404270136928633 0.0340256072280024 38 594:597:600 0.142322097378277 0.166547664528704 2 COAD BRAF BRAF Panobinostat 0.0291187006631991 0.0887572109575148 38 594:597:600 0.142322097378277 0.168888463846555 2 COAD BRAF BRAF PD0325901 0.00175945391756989 -0.159771077965043 38 594:597:600 0.142322097378277 0.0500603406468697 1 COAD BRAF BRAF PHA665752 0.00257680273177791 0.0358486481595321 38 594:597:600 0.142322097378277 0.0287412612390613 2 COAD BRAF BRAF RAF265 2.24146071902462e-05 0.0993433222961557 38 594:597:600 0.142322097378277 0.00230595717325751 2 COAD BRAF BRAF Sorafenib 0.00458027594985907 0.0371237386752915 38 594:597:600 0.142322097378277 0.0474385723378261 2 COAD BRAF BRAF TKI258 0.0075829742452521 0.134927384882849 38 594:597:600 0.142322097378277 0.0578700666085029 2 COAD BRAF BRAF Topotecan 0.00969841812017782 0.194853767979191 38 594:597:600 0.142322097378277 0.0713415000667662 2 COAD CTNNB1 CTNNB1 17-AAG 0.00741631675701572 0.165241018843643 12 41:45 0.0449438202247191 0.0707685949891351 2 COAD CTNNB1 CTNNB1 Erlotinib 0.0101778532068034 0.0725405013387233 12 41:45 0.0449438202247191 0.078631304386004 2 COAD CTNNB1 CTNNB1 Lapatinib 0.000115451020917028 0.107492638928316 12 41:45 0.0449438202247191 0.00306945358260616 2 COAD CTNNB1 CTNNB1 Nutlin3 0.0318385839658619 0.051305852027914 12 41:45 0.0449438202247191 0.15456080002062 2 COAD CTNNB1 CTNNB1 Panobinostat 0.0222426236449321 0.164686552965638 12 41:45 0.0449438202247191 0.140225236022398 2 COAD CTNNB1 CTNNB1 PHA665752 0.00344305033068492 0.0570748916473492 12 41:45 0.0449438202247191 0.0332828198632876 2 COAD CTNNB1 CTNNB1 PLX4720 0.0308958612084381 0.103396613263427 12 41:45 0.0449438202247191 0.172410275043407 2 COAD KRAS KRAS Erlotinib 0.0137632810308025 0.0292810461560795 70 12:13 0.262172284644195 0.0907125340666528 2 COAD KRAS KRAS L685458 0.0209832575378389 -0.0278035395441291 70 12:13 0.262172284644195 0.138287293721145 1 COAD KRAS KRAS Lapatinib 0.00120004251609087 -0.0398686960297476 70 12:13 0.262172284644195 0.0187450052533217 1 COAD KRAS KRAS Panobinostat 0.00727662319677746 -0.0909607811843829 70 12:13 0.262172284644195 0.0674057128543235 1 COAD KRAS KRAS PD0325901 0.00518374001133924 0.118894073038394 70 12:13 0.262172284644195 0.0746537986595474 2 COAD KRAS KRAS Topotecan 0.00534131381768335 -0.150860365749909 70 12:13 0.262172284644195 0.0484056564727554 1 COAD PGM5 PGM5 AEW541 0.00578111941150234 -0.0492067725999203 13 98 0.048689138576779 0.0558841543111893 1 COAD PGM5 PGM5 Erlotinib 0.0302114780534433 -0.0631085170832381 13 98 0.048689138576779 0.128843068169096 1 COAD PGM5 PGM5 Nilotinib 0.00695145227362215 0.117571617029811 13 98 0.048689138576779 0.100022818944152 2 COAD PGM5 PGM5 Panobinostat 0.0173103627548043 0.19098798315144 13 98 0.048689138576779 0.119523933306982 2 COAD PGM5 PGM5 PD0325901 0.037184774458884 -0.164827670886235 13 98 0.048689138576779 0.170654095142905 1 COAD PGM5 PGM5 PHA665752 0.00526533496939062 0.0567251133419834 13 98 0.048689138576779 0.0424151983645355 2 COAD PGM5 PGM5 RAF265 0.00251050271108221 0.108796882102645 13 98 0.048689138576779 0.0242681928737947 2 COAD PGM5 PGM5 Sorafenib 0.00192314840825995 0.0787833466904955 13 98 0.048689138576779 0.0309840576886325 2 COAD PGM5 PGM5 TKI258 0.00467921723900384 0.251340680406546 13 98 0.048689138576779 0.0399109705679739 2 COAD PGM5 PGM5 Topotecan 0.00984024015272679 0.269276974270957 13 98 0.048689138576779 0.0713415000667662 2 COAD PIK3CA PIK3CA Erlotinib 0.000289241198893097 0.053012709917069 37 542:545:546 0.138576779026217 0.00838799476789981 2 COAD TP53 TP53 Erlotinib 0.0164308621911168 -0.0857882173752855 11 173:175:176:177:179:181 0.0411985018726592 0.0972525230793827 1 COAD TP53 TP53 ZD6474 0.0182348516446443 -0.104606366165288 11 173:175:176:177:179:181 0.0411985018726592 0.125907308974925 1 COAD TP53 TP53 AEW541 0.0180992553344419 0.0454825104989938 18 211:213:214:215:216:220 0.0674157303370786 0.119290546522458 2 COAD TP53 TP53 Erlotinib 0.054949956070507 -0.040021666865335 18 211:213:214:215:216:220 0.0674157303370786 0.194335210493256 1 COAD TP53 TP53 RAF265 0.0463590615042209 -0.0602094830169144 18 211:213:214:215:216:220 0.0674157303370786 0.163952778490537 1 COAD TP53 TP53 ZD6474 0.0270620062006644 -0.0751776613998283 18 211:213:214:215:216:220 0.0674157303370786 0.178363222686197 1 COAD TP53 TP53 Erlotinib 0.00227745340966152 -0.0639572273742897 24 232:236:240:245:248 0.0898876404494382 0.0366923049334356 1 COAD TP53 TP53 L685458 0.0023246122868233 -0.0440073242285732 24 232:236:240:245:248 0.0898876404494382 0.0350547508782544 1 COAD TP53 TP53 Lapatinib 0.0268348522256091 -0.047706585990315 24 232:236:240:245:248 0.0898876404494382 0.121595424147291 1 COAD TP53 TP53 Nutlin3 0.00522551722403981 -0.0410873732939813 24 232:236:240:245:248 0.0898876404494382 0.0607502083038393 1 COAD TP53 TP53 Panobinostat 0.00327585636927345 -0.13176738339374 24 232:236:240:245:248 0.0898876404494382 0.047499917354465 1 COAD TP53 TP53 PD0332991 0.0210946378124275 -0.059819502837173 24 232:236:240:245:248 0.0898876404494382 0.117643172415461 1 COAD TP53 TP53 PHA665752 0.00156532972547806 -0.0451572368680455 24 232:236:240:245:248 0.0898876404494382 0.0206338918358472 1 COAD TP53 TP53 PLX4720 0.0105041107935263 -0.0768789672976861 24 232:236:240:245:248 0.0898876404494382 0.0951935040663321 1 COAD TP53 TP53 Erlotinib 0.0114661196301293 -0.050949547664311 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.0791708260175595 1 COAD TP53 TP53 Nutlin3 0.0491175209337295 -0.0305661466230456 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.187422119352389 1 COAD TP53 TP53 Panobinostat 0.0215999247932683 -0.113971817017663 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.140225236022398 1 COAD TP53 TP53 ZD6474 0.00316382876743529 -0.0796742581821752 29 266:267:271:272:273:274:275:278:282:285:286 0.108614232209738 0.0352888593290859 1 ESCA TP53 TP53 Paclitaxel 0.037319735921205 0.548231820294997 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.180378723619157 2 ESCA TP53 TP53 PHA665752 0.0324478486917673 -0.0866019992185184 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.142573880615341 1 ESCA TP53 TP53 ZD6474 0.0153173611949596 0.131344350350068 15 124:126:130:134:135:138:143:146:147:151 0.0819672131147541 0.116895651224692 2 ESCA TP53 TP53 ZD6474 0.00796273771357656 0.166827891595174 18 157:158:163:167:168:172:173:174:175:176:177:179 0.0983606557377049 0.0721623105292876 2 ESCA TP53 TP53 AEW541 0.030564865348612 -0.15848601605415 11 213:216:220:224 0.0601092896174863 0.168867255122632 1 ESCA TP53 TP53 17-AAG 0.0466182364289904 -0.189720200579317 20 272:273:274:275:278:280:282:285 0.109289617486339 0.198813067123636 1 ESCA TP53 TP53 AEW541 0.000359879958166556 -0.190649443359424 20 272:273:274:275:278:280:282:285 0.109289617486339 0.00902431152580788 1 ESCA TP53 TP53 L685458 0.00580555678455469 -0.0966301624864853 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0495179843388488 1 ESCA TP53 TP53 PD0332991 0.0466182364289904 -0.141374998912046 20 272:273:274:275:278:280:282:285 0.109289617486339 0.187767896727878 1 ESCA TP53 TP53 PF2341066 0.0161642771643921 -0.0864673288585219 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0976591745348689 1 ESCA TP53 TP53 PHA665752 0.00196298183616346 -0.104527158649726 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0237193638536418 1 ESCA TP53 TP53 ZD6474 0.00118328027839505 0.162979927779846 20 272:273:274:275:278:280:282:285 0.109289617486339 0.0190639600408091 2 GBM EGFR EGFR 17-AAG 0.00994777596108504 -0.215664875682569 12 289 0.08 0.0801348619087406 1 GBM EGFR EGFR Paclitaxel 0.0360080810945265 -0.171488854184935 12 289 0.08 0.180378723619157 1 GBM EGFR EGFR RAF265 0.0337080035592337 -0.0956027665356531 12 289 0.08 0.135768347669136 1 GBM EGFR EGFR TAE684 0.0234509143402643 -0.0970900996641522 12 289 0.08 0.15748144968018 1 GBM EGFR EGFR Paclitaxel 0.0496136805898035 -0.134266979297247 12 596:598 0.08 0.199832880153375 1 GBM PTEN PTEN 17-AAG 0.0393729749787502 0.178009320859896 10 129:130:131:132:136 0.0666666666666667 0.184163915223186 2 GBM TP53 TP53 Nutlin3 0.00396062076964332 -0.0488128923108759 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.0607502083038393 1 GBM TP53 TP53 Panobinostat 0.0382763403468527 -0.0632604840722104 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.19734998332249 1 GBM TP53 TP53 PLX4720 0.0177396220127572 -0.131329302570282 14 234:238:239:242:245:248:249:254:255 0.0933333333333333 0.151308540697047 1 HNSC CDKN2A CDKN2A Erlotinib 0.00487558214680525 -0.0686181247854551 12 58 0.0240480961923848 0.0607346511562043 1 HNSC CDKN2A CDKN2A Lapatinib 0.0232448167292092 -0.0749062511789815 12 58 0.0240480961923848 0.116224083646046 1 HNSC CDKN2A CDKN2A AZD0530 0.0177878304831185 0.112596761095895 33 80:83:84:87:88:90 0.0661322645290581 0.0955272377797105 2 HNSC CDKN2A CDKN2A PLX4720 0.00468670615315181 0.0980215715505429 33 80:83:84:87:88:90 0.0661322645290581 0.0522747994005394 2 HNSC HRAS HRAS 17-AAG 0.0274972367443925 0.0758258834699461 25 12:13 0.0501002004008016 0.147246531215636 2 HNSC HRAS HRAS AZD6244 0.036222623471232 0.11647673363648 25 12:13 0.0501002004008016 0.159590117997514 2 HNSC HRAS HRAS Erlotinib 0.00854399719553809 -0.0393135376059919 25 12:13 0.0501002004008016 0.0728752701972366 1 HNSC HRAS HRAS Irinotecan 0.000176028724339069 0.332053686638767 25 12:13 0.0501002004008016 0.00850805500972167 2 HNSC HRAS HRAS Nutlin3 0.00195399900747659 0.0410620447164297 25 12:13 0.0501002004008016 0.0566659712168211 2 HNSC HRAS HRAS Paclitaxel 0.0227159369041313 0.139963269112006 25 12:13 0.0501002004008016 0.156848135766621 2 HNSC HRAS HRAS PD0325901 0.0462466658796718 0.110075936094211 25 12:13 0.0501002004008016 0.191593330072926 2 HNSC HRAS HRAS PF2341066 5.88490776676095e-05 0.064549275955108 25 12:13 0.0501002004008016 0.00426655813090169 2 HNSC HRAS HRAS PLX4720 3.03595375627369e-05 0.161261869702121 25 12:13 0.0501002004008016 0.00349235196641606 2 HNSC HRAS HRAS RAF265 0.0190405030226182 0.0636794288250597 25 12:13 0.0501002004008016 0.0869142697142903 2 HNSC HRAS HRAS TKI258 0.0105886877518349 0.147004276253518 25 12:13 0.0501002004008016 0.076767986200803 2 HNSC HRAS HRAS Topotecan 0.0449940181874372 0.163025052182729 25 12:13 0.0501002004008016 0.197700989005406 2 HNSC NFE2L2 NFE2L2 AZD0530 0.00366100065457706 0.159404784325661 13 24:28:29:30:32:34 0.0260521042084168 0.0370435174342952 2 HNSC NFE2L2 NFE2L2 Paclitaxel 0.0287533256233344 0.184693578552292 13 24:28:29:30:32:34 0.0260521042084168 0.173718008974312 2 HNSC NFE2L2 NFE2L2 Panobinostat 0.00870025697425151 -0.18884702204863 13 24:28:29:30:32:34 0.0260521042084168 0.0700854034036927 1 HNSC PIK3CA PIK3CA AEW541 0.00298256330024727 -0.0432209726221411 47 542:545:546 0.094188376753507 0.0332670521950657 1 HNSC PIK3CA PIK3CA Erlotinib 0.0112045811936321 0.038790109016418 47 542:545:546 0.094188376753507 0.0791708260175595 2 HNSC PIK3CA PIK3CA Lapatinib 0.00426345673782436 0.0581655654762525 47 542:545:546 0.094188376753507 0.0412134151323021 2 HNSC PIK3CA PIK3CA Paclitaxel 0.0441605619380593 0.1163884876082 47 542:545:546 0.094188376753507 0.188331808265253 2 HNSC PIK3CA PIK3CA PHA665752 0.0304617223268539 0.0267593508503352 47 542:545:546 0.094188376753507 0.138029679293557 2 HNSC TP53 TP53 L685458 0.0325954743912203 -0.0781274624629584 10 101:103:104:105:110 0.0200400801603206 0.175049769878776 1 HNSC TP53 TP53 Lapatinib 0.00583161383985842 -0.143495334318719 10 101:103:104:105:110 0.0200400801603206 0.04974023569291 1 HNSC TP53 TP53 Paclitaxel 0.00168397514089337 -0.358938354333985 10 101:103:104:105:110 0.0200400801603206 0.0241690496574986 1 HNSC TP53 TP53 PHA665752 0.0198613047816051 -0.0644544710421417 10 101:103:104:105:110 0.0200400801603206 0.0993065239080255 1 HNSC TP53 TP53 TKI258 0.0397987938384773 -0.260130708073464 10 101:103:104:105:110 0.0200400801603206 0.198993969192386 1 HNSC TP53 TP53 AZD0530 0.000614490402912619 0.216189398312863 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.014850184737055 2 HNSC TP53 TP53 L685458 0.000303223918160064 -0.0980185941865498 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.00732791135553488 1 HNSC TP53 TP53 Lapatinib 1.14328950424908e-05 -0.156011024087403 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.000552589927053722 1 HNSC TP53 TP53 Nutlin3 0.00494027742350776 -0.0587647164251964 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0607502083038393 1 HNSC TP53 TP53 Paclitaxel 0.0368560314678533 -0.174451279857689 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.180378723619157 1 HNSC TP53 TP53 Panobinostat 0.000580098436378463 -0.247092206662733 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0120163247535539 1 HNSC TP53 TP53 PD0332991 0.000506697975411541 -0.150888885885061 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.00865497417950243 1 HNSC TP53 TP53 PF2341066 0.00793692923532289 -0.052616675944911 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0767236492747879 1 HNSC TP53 TP53 PHA665752 0.000377589756207499 -0.0651741443699163 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.00912508577501456 1 HNSC TP53 TP53 Sorafenib 0.0226104083451293 -0.0601274851476072 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.13660455041849 1 HNSC TP53 TP53 TAE684 0.00426655396293196 -0.107088476369364 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0441893089017953 1 HNSC TP53 TP53 TKI258 0.00367723755407271 -0.247464165321885 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0333249653337839 1 HNSC TP53 TP53 Topotecan 0.00240748328740173 -0.320648291485217 19 125:126:127:132:134:136:137:139:141:143:144 0.0380761523046092 0.0290904230561042 1 HNSC TP53 TP53 AZD0530 0.00121090368030882 0.179146022882825 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0175660329374408 2 HNSC TP53 TP53 Irinotecan 0.00817238349331709 -0.199450951715384 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.118499560653098 1 HNSC TP53 TP53 L685458 0.000209701061770326 -0.0695301217587736 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00732791135553488 1 HNSC TP53 TP53 Lapatinib 6.26100630416088e-05 -0.0914246784260913 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00226961478525832 1 HNSC TP53 TP53 Nilotinib 0.0131788393174572 -0.0536278451349924 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.136495121502235 1 HNSC TP53 TP53 Nutlin3 0.0547749830840094 -0.027427666349917 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.196107212464119 1 HNSC TP53 TP53 Paclitaxel 0.00774545852619616 -0.164011607697448 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0748727657532295 1 HNSC TP53 TP53 Panobinostat 0.0114982533529005 -0.134447366596722 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0877498282195038 1 HNSC TP53 TP53 PD0332991 0.00458302811318126 -0.0836469748030502 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.039090533906546 1 HNSC TP53 TP53 PF2341066 0.0142166612305181 -0.0307298224360744 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0907580284145761 1 HNSC TP53 TP53 PHA665752 6.42271658644477e-05 -0.0476327017532366 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00310431301678164 1 HNSC TP53 TP53 Sorafenib 0.0224444939585724 -0.0412565850560542 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.13660455041849 1 HNSC TP53 TP53 TAE684 0.0122085810720987 -0.0597652668588318 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.093170750287069 1 HNSC TP53 TP53 TKI258 0.000295143888890758 -0.218065392077441 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.00501300613473629 1 HNSC TP53 TP53 Topotecan 0.00160593862835036 -0.254791499073441 48 151:155:157:158:159:161:163:166:167:171:172:173:176:177:179:180 0.0961923847695391 0.0211691910100729 1 HNSC TP53 TP53 AZD0530 9.16721061915045e-05 0.233997880051168 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.00372567810984827 2 HNSC TP53 TP53 L685458 0.00100179753981933 -0.0737192828643971 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.0207515204676861 1 HNSC TP53 TP53 Lapatinib 0.000646509396597675 -0.0841623726645693 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.0117179828133329 1 HNSC TP53 TP53 Nutlin3 0.004213593518496 -0.0463547567126311 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.0607502083038393 1 HNSC TP53 TP53 Paclitaxel 0.00378162846492943 -0.187491040104376 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.0421797021088283 1 HNSC TP53 TP53 Panobinostat 0.00222217855706945 -0.193788871045414 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.0402769863468838 1 HNSC TP53 TP53 PD0332991 7.34873122177295e-05 -0.129018256990375 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.00292505651276902 1 HNSC TP53 TP53 PF2341066 0.00369127756266553 -0.0449942033578544 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.048657749689682 1 HNSC TP53 TP53 PHA665752 1.37680301748575e-05 -0.0644894735149093 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.000998182187677169 1 HNSC TP53 TP53 TAE684 0.00275008309782726 -0.0940252372577661 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.0376459923820171 1 HNSC TP53 TP53 TKI258 0.000103892912234839 -0.239738556759914 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.00251074537900861 1 HNSC TP53 TP53 Topotecan 0.000131058812820326 -0.337166583394478 33 192:193:194:195:196:199:201:202:204:205 0.0661322645290581 0.00316725464315788 1 HNSC TP53 TP53 AZD0530 0.025540022680833 0.14915046791632 24 211:213:216:218:220:224 0.0480961923847695 0.119531777537222 2 HNSC TP53 TP53 Erlotinib 0.00190606418174014 -0.0887818659040618 24 211:213:216:218:220:224 0.0480961923847695 0.0354020782103821 1 HNSC TP53 TP53 Irinotecan 0.000251169483752972 -0.400199961926809 24 211:213:216:218:220:224 0.0480961923847695 0.00910489378604524 1 HNSC TP53 TP53 L685458 0.00498569365948603 -0.0664160362608117 24 211:213:216:218:220:224 0.0480961923847695 0.048195038708365 1 HNSC TP53 TP53 Lapatinib 0.00196569289347345 -0.124326151696312 24 211:213:216:218:220:224 0.0480961923847695 0.0259114063230591 1 HNSC TP53 TP53 Paclitaxel 0.0277218123186278 -0.137939691763774 24 211:213:216:218:220:224 0.0480961923847695 0.173718008974312 1 HNSC TP53 TP53 PF2341066 0.0394199129407688 -0.0326571614731501 24 211:213:216:218:220:224 0.0480961923847695 0.197099564703844 1 HNSC TP53 TP53 PHA665752 0.00623871991385498 -0.0442345172940057 24 211:213:216:218:220:224 0.0480961923847695 0.0476112835531038 1 HNSC TP53 TP53 TKI258 0.014383005090804 -0.187621576016609 24 211:213:216:218:220:224 0.0480961923847695 0.0947970790075718 1 HNSC TP53 TP53 Topotecan 0.0169290135978348 -0.213753120056769 24 211:213:216:218:220:224 0.0480961923847695 0.100526081063372 1 HNSC TP53 TP53 AZD0530 5.44623208958446e-05 0.155611030225548 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.00372567810984827 2 HNSC TP53 TP53 AZD6244 0.00680881336782093 -0.0850806578928753 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0726893163536467 1 HNSC TP53 TP53 Erlotinib 0.000674698030221386 -0.044749873167347 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0163052023970168 1 HNSC TP53 TP53 Irinotecan 0.000467864121356629 -0.184744886347251 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0113067162661185 1 HNSC TP53 TP53 L685458 1.46554698899383e-05 -0.0635628014545456 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.00212504313404105 1 HNSC TP53 TP53 Lapatinib 1.00771107803513e-09 -0.11201541390644 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 1.46118106315094e-07 1 HNSC TP53 TP53 Nilotinib 0.00583118114916536 -0.0478602509634375 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0995383982127298 1 HNSC TP53 TP53 Nutlin3 0.0369256347635602 -0.0220744621588573 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.157476971785771 1 HNSC TP53 TP53 Paclitaxel 2.69275515566545e-06 -0.189466381989553 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.00039044949757149 1 HNSC TP53 TP53 Panobinostat 3.38353676739497e-05 -0.158258503296592 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0016353761042409 1 HNSC TP53 TP53 PD0332991 0.000107725527218417 -0.0881643320532451 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.00312404028933409 1 HNSC TP53 TP53 PF2341066 0.00102224030589849 -0.0296734782115753 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0296449688710562 1 HNSC TP53 TP53 PHA665752 6.0870413460469e-08 -0.0479561493240288 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 8.82620995176801e-06 1 HNSC TP53 TP53 Sorafenib 0.00667489137460376 -0.0331762039892368 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0615910223867926 1 HNSC TP53 TP53 TAE684 0.00285590287035992 -0.0602135156094059 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 0.0376459923820171 1 HNSC TP53 TP53 TKI258 9.31926168262291e-07 -0.198059515868217 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 6.75646471990161e-05 1 HNSC TP53 TP53 Topotecan 2.27073652882757e-07 -0.270508795944353 118 234:236:237:238:239:241:242:244:245:246:248:249:251:256:258:262:265:266:267:268:270:271:272:273:274:275:276:278:280:281:282:283:285:286 0.236472945891784 3.29256796679998e-05 1 HNSC TP53 TP53 Erlotinib 0.0427336459570217 -0.0456791993184591 10 331:336:337:339:342:343:348 0.0200400801603206 0.158881504199183 1 HNSC TP53 TP53 L685458 0.0357181146868535 -0.091702700744475 10 331:336:337:339:342:343:348 0.0200400801603206 0.184968808199777 1 HNSC TP53 TP53 Lapatinib 0.0255493174162743 -0.110382219546876 10 331:336:337:339:342:343:348 0.0200400801603206 0.119504871785799 1 HNSC TP53 TP53 PHA665752 0.0302685615562495 -0.0629530306196784 10 331:336:337:339:342:343:348 0.0200400801603206 0.138029679293557 1 HNSC TP53 TP53 Sorafenib 0.0255493174162743 -0.0804800514502516 10 331:336:337:339:342:343:348 0.0200400801603206 0.148186041014391 1 HNSC TP53 TP53 Topotecan 0.00413298718018305 -0.433434509728489 10 331:336:337:339:342:343:348 0.0200400801603206 0.0399522094084361 1 KIRC VHL VHL PF2341066 0.0123057680563406 0.0651746362213518 15 107:112:115:116:117:118:120:121 0.040983606557377 0.0883764757820365 2 LAML FLT3 FLT3 AEW541 8.20411888098272e-05 -0.107163668061107 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00396532412580831 1 LAML FLT3 FLT3 AZD6244 0.00197306198531411 0.296493509402906 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.0357617484838182 2 LAML FLT3 FLT3 Erlotinib 0.029589639566379 0.0194610345566208 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.128843068169096 2 LAML FLT3 FLT3 Lapatinib 0.0467013197836907 0.0203144413290366 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.183018685638788 2 LAML FLT3 FLT3 Nilotinib 0.00758793798886671 0.00836346582480108 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.100022818944152 2 LAML FLT3 FLT3 Paclitaxel 0.00273256695381326 0.0985820817942686 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.0330185173585769 2 LAML FLT3 FLT3 Panobinostat 0.000249075078807217 0.120655316068331 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00722317728540929 2 LAML FLT3 FLT3 PD0325901 0.00313327110137612 0.315047630817949 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.0567905387124422 2 LAML FLT3 FLT3 PF2341066 0.00572471103549567 0.0631928146847398 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.063852546165144 2 LAML FLT3 FLT3 PHA665752 0.0451784095498292 0.0200735042068811 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.17584271195418 2 LAML FLT3 FLT3 RAF265 0.000109549717670959 0.13433751925509 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00317694181245781 2 LAML FLT3 FLT3 Sorafenib 0.000142887862832136 0.061585688004139 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00517968502766493 2 LAML FLT3 FLT3 TKI258 0.000473490679895259 0.114919146061011 30 594:595:596:598:599:600:601:602:603:605 0.176470588235294 0.00686561485848126 2 LIHC CTNNB1 CTNNB1 AZD0530 0.011917475221755 -0.0611605812867266 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0751319090067163 1 LIHC CTNNB1 CTNNB1 AZD6244 0.00237822382604426 -0.125777569370878 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0383158283084909 1 LIHC CTNNB1 CTNNB1 Erlotinib 0.000201805850773456 -0.0484163411184463 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0076262395382254 1 LIHC CTNNB1 CTNNB1 Lapatinib 0.0243250709473212 -0.0517512472882493 69 32:33:34:35:37:41:42:45 0.192737430167598 0.117571176245386 1 LIHC CTNNB1 CTNNB1 Nutlin3 0.0317113646196932 -0.0210902200233014 69 32:33:34:35:37:41:42:45 0.192737430167598 0.15456080002062 1 LIHC CTNNB1 CTNNB1 PD0325901 0.000696573462710588 -0.152376880276108 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0252507880232588 1 LIHC CTNNB1 CTNNB1 PF2341066 0.0119650254943576 -0.0311599626318665 69 32:33:34:35:37:41:42:45 0.192737430167598 0.0883764757820365 1 LIHC CTNNB1 CTNNB1 PLX4720 0.00013233335660759 0.0771969249303307 69 32:33:34:35:37:41:42:45 0.192737430167598 0.00383766734162011 2 LIHC CTNNB1 CTNNB1 RAF265 0.0562257148211773 -0.0466237598625258 69 32:33:34:35:37:41:42:45 0.192737430167598 0.194112586882636 1 LIHC CTNNB1 CTNNB1 ZD6474 0.000273164646105775 0.0887268868486122 69 32:33:34:35:37:41:42:45 0.192737430167598 0.00622799922840304 2 LIHC TP53 TP53 Nutlin3 0.0137798222575819 -0.0384015857698913 17 245:246:248:249 0.0474860335195531 0.0999037113674688 1 LIHC TP53 TP53 PLX4720 5.59217599856638e-05 -0.161386101111345 17 245:246:248:249 0.0474860335195531 0.00349235196641606 1 LIHC TP53 TP53 TAE684 0.00177016331898598 0.160441780325568 17 245:246:248:249 0.0474860335195531 0.0320842101566209 2 LIHC TP53 TP53 AEW541 0.00733246919714817 0.0933150915222767 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.0603418050494983 2 LIHC TP53 TP53 Erlotinib 0.0370240919355186 -0.0640302904618674 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.145094414341897 1 LIHC TP53 TP53 Paclitaxel 0.0313515834442159 0.301192545054864 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.180378723619157 2 LIHC TP53 TP53 PHA665752 0.0238755849528238 0.0553151843884544 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.115398660605315 2 LIHC TP53 TP53 RAF265 0.0191810802128089 0.133507713285211 12 266:271:273:275:276:277:280:281:286 0.0335195530726257 0.0869142697142903 2 LUAD BRAF BRAF PF2341066 0.0118587218094087 -0.0621073705661289 14 464:466:469 0.0275049115913556 0.0883764757820365 1 LUAD BRAF BRAF PLX4720 0.0245137729805003 -0.144797883964923 14 464:466:469 0.0275049115913556 0.172410275043407 1 LUAD BRAF BRAF AZD0530 0.0288894657453676 0.171997272243098 16 594:596:600:604 0.031434184675835 0.130905391658697 2 LUAD BRAF BRAF AZD6244 0.0410615558430778 0.228146533947085 16 594:596:600:604 0.031434184675835 0.16538682214573 2 LUAD BRAF BRAF PD0325901 0.0266943440775024 0.268581290178102 16 594:596:600:604 0.031434184675835 0.137852407807249 2 LUAD CTNNB1 CTNNB1 17-AAG 0.0133827755010716 0.171669953453247 11 33:34:37:41:45 0.0216110019646365 0.0970251223827691 2 LUAD CTNNB1 CTNNB1 L685458 0.0241709899379066 0.0578987377398591 11 33:34:37:41:45 0.0216110019646365 0.146033064208186 2 LUAD CTNNB1 CTNNB1 Lapatinib 0.0279818862657847 0.102636718121674 11 33:34:37:41:45 0.0216110019646365 0.122950712379963 2 LUAD CTNNB1 CTNNB1 Panobinostat 0.000529617831785219 0.25679752260404 11 33:34:37:41:45 0.0216110019646365 0.0120163247535539 2 LUAD CTNNB1 CTNNB1 PD0332991 0.0437550241498646 0.0787375261846724 11 33:34:37:41:45 0.0216110019646365 0.181270814335153 2 LUAD CTNNB1 CTNNB1 PHA665752 0.039335999737855 0.0529077681459706 11 33:34:37:41:45 0.0216110019646365 0.162963427485399 2 LUAD CTNNB1 CTNNB1 Sorafenib 0.00347812862575289 0.0863480717782941 11 33:34:37:41:45 0.0216110019646365 0.0420273875611808 2 LUAD CTNNB1 CTNNB1 ZD6474 0.00389948993807929 0.150158501780799 11 33:34:37:41:45 0.0216110019646365 0.0403875743586784 2 LUAD EGFR EGFR 17-AAG 0.00949403410940053 -0.128231115114196 24 746:747:751:754:759 0.0471512770137525 0.0801348619087406 1 LUAD EGFR EGFR AZD6244 0.0270726408722367 0.111360355120387 24 746:747:751:754:759 0.0471512770137525 0.138184273413645 2 LUAD EGFR EGFR PD0325901 0.0169083651262639 0.175407496018081 24 746:747:751:754:759 0.0471512770137525 0.103595167522569 2 LUAD EGFR EGFR AZD0530 0.0155987976614554 0.129007007684298 25 858:861:866 0.0491159135559921 0.0904730264364413 2 LUAD EGFR EGFR AZD6244 0.0115294912730808 0.153791271745531 25 858:861:866 0.0491159135559921 0.111451748973114 2 LUAD EGFR EGFR PD0325901 0.00399969929700829 0.208572522154698 25 858:861:866 0.0491159135559921 0.0644395997851336 2 LUAD EGFR EGFR PD0332991 0.0106489182965628 -0.0716835575085139 25 858:861:866 0.0491159135559921 0.0772046576500803 1 LUAD EGFR EGFR PHA665752 0.0184519083169315 -0.0355175474873688 25 858:861:866 0.0491159135559921 0.0990935817020395 1 LUAD EGFR EGFR TAE684 0.00366114633795959 -0.0995716705374781 25 858:861:866 0.0491159135559921 0.0409067065450795 1 LUAD KRAS KRAS 17-AAG 0.0284338129243987 0.0464405240816625 122 12:13 0.239685658153242 0.147246531215636 2 LUAD KRAS KRAS Lapatinib 0.00816475974429287 0.0478548814777902 122 12:13 0.239685658153242 0.0623100085748666 2 LUAD KRAS KRAS Paclitaxel 9.60220370876262e-05 -0.190375766348159 122 12:13 0.239685658153242 0.00464106512590193 1 LUAD KRAS KRAS RAF265 0.00617733819532606 -0.0607647599865282 122 12:13 0.239685658153242 0.0408094473117676 1 LUAD KRAS KRAS TKI258 0.00139395888853414 -0.107270425795115 122 12:13 0.239685658153242 0.0168436699031209 1 LUAD KRAS KRAS Topotecan 0.000201916473656128 -0.194116843391165 122 12:13 0.239685658153242 0.00418255552573408 1 LUAD STK11 STK11 Lapatinib 0.0012927589829877 0.146656977877692 11 56:60:62:65:69:70 0.0216110019646365 0.0187450052533217 2 LUAD STK11 STK11 Topotecan 0.0236465295397391 -0.270335665305548 11 56:60:62:65:69:70 0.0216110019646365 0.122455242259363 1 LUAD TP53 TP53 AEW541 0.0247883233153975 -0.0941215283142303 14 127:130:132:135:136:141:144:146 0.0275049115913556 0.143832799046407 1 LUAD TP53 TP53 AZD6244 0.00343340603630288 -0.320653326078437 14 127:130:132:135:136:141:144:146 0.0275049115913556 0.0452585341149016 1 LUAD TP53 TP53 PD0325901 0.0386485150347277 -0.263829580335471 14 127:130:132:135:136:141:144:146 0.0275049115913556 0.170654095142905 1 LUAD TP53 TP53 AEW541 0.00749070683373083 -0.0698885378518814 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.0603418050494983 1 LUAD TP53 TP53 AZD6244 0.0143842598568067 -0.17230068258184 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.115873204402054 1 LUAD TP53 TP53 L685458 0.00241756902608651 -0.0609505483103054 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.0350547508782544 1 LUAD TP53 TP53 Nutlin3 0.015350699208732 -0.0414379113619069 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.105992923107911 1 LUAD TP53 TP53 Paclitaxel 0.0119433039148415 0.201296824547288 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.108236191728251 2 LUAD TP53 TP53 PD0332991 8.06912141453523e-05 -0.0910111478408516 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.00292505651276902 1 LUAD TP53 TP53 PLX4720 0.000204398278439155 -0.145560542495409 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.00493962506227958 1 LUAD TP53 TP53 RAF265 7.51238684079618e-05 0.125865332367053 38 154:155:157:158:159:161:163:165:166:167:171:173:176:177:179:180:183 0.0746561886051081 0.00272324022978862 2 LUAD TP53 TP53 RAF265 0.00596460544752229 0.105016165556263 17 191:192:193:194:195:196:198 0.0333988212180747 0.0408094473117676 2 LUAD TP53 TP53 Sorafenib 0.0124017631291791 0.0484283602600403 17 191:192:193:194:195:196:198 0.0333988212180747 0.0856312216062366 2 LUAD TP53 TP53 RAF265 0.00619177821281991 0.147072365015006 12 205:209:213:214:216:220 0.0235756385068762 0.0408094473117676 2 LUAD TP53 TP53 AZD0530 0.0437589802362493 -0.0982632496139293 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.176251448173782 1 LUAD TP53 TP53 AZD6244 0.000901803195824824 -0.273909075641528 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.0217935772324332 1 LUAD TP53 TP53 Erlotinib 0.00745820529002293 -0.0805900229730092 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.0728752701972366 1 LUAD TP53 TP53 Lapatinib 0.00383111994588185 -0.0980859010645341 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.0396794565823477 1 LUAD TP53 TP53 Paclitaxel 0.000400147455753041 0.280546860846436 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.00828876872631299 2 LUAD TP53 TP53 PD0325901 0.0095454645484675 -0.284364890677721 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.076894019973766 1 LUAD TP53 TP53 PD0332991 0.0286422720478919 -0.0692816016307712 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.138758980731047 1 LUAD TP53 TP53 PLX4720 0.00849931813451018 -0.120761399735333 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.0821600753002651 1 LUAD TP53 TP53 RAF265 5.04071613651335e-05 0.119853875528393 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.00243634613264812 2 LUAD TP53 TP53 Topotecan 0.0103052366410076 0.229885212428361 36 232:236:237:238:239:241:242:244:245:247:248:249:250 0.0707269155206287 0.0713415000667662 2 LUAD TP53 TP53 AZD0530 0.0255550696803716 -0.0974336729561374 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.119531777537222 1 LUAD TP53 TP53 AZD6244 0.00176492690083959 -0.21027027411542 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.0357617484838182 1 LUAD TP53 TP53 Erlotinib 0.0382505239048699 -0.0541600908041938 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.145955946479109 1 LUAD TP53 TP53 L685458 0.00830543558473497 -0.0460216622102111 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.0602144079893285 1 LUAD TP53 TP53 Nutlin3 0.0180743443865151 -0.0370539700118179 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.113946953741073 1 LUAD TP53 TP53 Paclitaxel 0.0213763263001066 0.163705092269696 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.154978365675773 2 LUAD TP53 TP53 PD0325901 0.0275704815614497 -0.190213073429103 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.137852407807249 1 LUAD TP53 TP53 PD0332991 0.000164350280640791 -0.0785330335067945 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.00397179844881912 1 LUAD TP53 TP53 PLX4720 7.42235205161291e-05 -0.1489042640176 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.00349235196641606 1 LUAD TP53 TP53 RAF265 0.0159401384129872 0.0723776207328466 49 258:262:266:267:270:271:272:273:274:275:277:278:280:281:282:283:285:286 0.0962671905697446 0.079780384256353 2 LUAD TP53 TP53 AZD6244 0.0033634213046929 -0.272407544925192 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.0452585341149016 1 LUAD TP53 TP53 Erlotinib 0.00818514159756095 -0.105772368720869 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.0728752701972366 1 LUAD TP53 TP53 Lapatinib 0.00956684032091687 -0.0857312420252343 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.0693595923266473 1 LUAD TP53 TP53 Nutlin3 0.0413497649864369 -0.0439423338525318 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.166547664528704 1 LUAD TP53 TP53 PD0325901 0.00774190550519915 -0.299705723275969 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.0759942757476325 1 LUAD TP53 TP53 PD0332991 0.00368158718813576 -0.0891205900681102 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.035588676151979 1 LUAD TP53 TP53 PHA665752 0.0472956259738828 -0.0403514065184793 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.17584271195418 1 LUAD TP53 TP53 PLX4720 0.0303681318386893 -0.13634030480849 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.172410275043407 1 LUAD TP53 TP53 RAF265 0.0100110210258329 0.125199080421669 19 331:334:336:337:339:342:343:346:349:351:354 0.037328094302554 0.0604832520310738 2 LUSC CDKN2A CDKN2A ZD6474 0.00166532671356763 0.137642482589488 17 80:81:83:84:85:88 0.0356394129979036 0.0241472373467306 2 LUSC CDKN2A CDKN2A Paclitaxel 0.000147682572445451 0.43887996163211 15 108:109:110:114:118:120 0.0314465408805031 0.0053534932511476 2 LUSC CDKN2A CDKN2A ZD6474 0.00713756467816742 0.135233588490392 15 108:109:110:114:118:120 0.0314465408805031 0.0689964585556184 2 LUSC NFE2L2 NFE2L2 17-AAG 0.0155901759589255 -0.0832128582779057 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.107646453049724 1 LUSC NFE2L2 NFE2L2 AZD0530 0.00681222293723566 0.116615272212067 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.0548762403277317 2 LUSC NFE2L2 NFE2L2 Paclitaxel 0.00023281874095499 0.252326289500296 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.00675174348769471 2 LUSC NFE2L2 NFE2L2 Panobinostat 2.66801392169978e-06 -0.256960086028431 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.000193431009323234 1 LUSC NFE2L2 NFE2L2 PF2341066 0.00151062936065648 -0.043235241275394 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.0312916081850271 1 LUSC NFE2L2 NFE2L2 TAE684 0.0167462032770386 -0.0657503798077386 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.12140997375853 1 LUSC NFE2L2 NFE2L2 ZD6474 0.0120144276804966 0.0736718672297616 43 24:26:27:29:30:31:34:37:38:42 0.090146750524109 0.102476000804236 2 LUSC NFE2L2 NFE2L2 Nutlin3 0.0332147605782322 0.0475533915215324 17 77:79:80:81 0.0356394129979036 0.155359363994957 2 LUSC NFE2L2 NFE2L2 Paclitaxel 0.000620101725647972 0.389307137052748 17 77:79:80:81 0.0356394129979036 0.00999052780210622 2 LUSC NFE2L2 NFE2L2 ZD6474 0.00224674445145522 0.126867711125066 17 77:79:80:81 0.0356394129979036 0.0296161768600915 2 LUSC PIK3CA PIK3CA AEW541 0.0377143006614052 -0.0510666422752308 30 538:542:545 0.0628930817610063 0.188571503307026 1 LUSC PIK3CA PIK3CA Erlotinib 0.0459750463704332 0.0920667394004691 30 538:542:545 0.0628930817610063 0.16665954309282 2 LUSC TP53 TP53 17-AAG 0.0409306489644284 -0.151656952205499 11 100:103:104:105:109:110:111 0.0230607966457023 0.185467003120066 1 LUSC TP53 TP53 Nutlin3 0.00686798798608437 -0.0888790138707805 11 100:103:104:105:109:110:111 0.0230607966457023 0.0711327327130167 1 LUSC TP53 TP53 Erlotinib 0.0154998747182326 0.10029445320482 69 125:126:131:132:135:136:141:144:146:151:152:154:155:157:158:159:161:162:163:164 0.144654088050314 0.0972525230793827 2 LUSC TP53 TP53 Paclitaxel 0.0160853145106416 0.212162679531007 69 125:126:131:132:135:136:141:144:146:151:152:154:155:157:158:159:161:162:163:164 0.144654088050314 0.129576144669057 2 LUSC TP53 TP53 Panobinostat 0.0322511661077274 -0.147564563288499 69 125:126:131:132:135:136:141:144:146:151:152:154:155:157:158:159:161:162:163:164 0.144654088050314 0.179862272523864 1 LUSC TP53 TP53 RAF265 0.0356625066984113 0.0616180140608109 69 125:126:131:132:135:136:141:144:146:151:152:154:155:157:158:159:161:162:163:164 0.144654088050314 0.139758472196477 2 LUSC TP53 TP53 L685458 0.00653570332467484 -0.0926884037455613 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.0526487212265473 1 LUSC TP53 TP53 Lapatinib 0.0181165939968069 0.0637016339056555 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.10507624518148 2 LUSC TP53 TP53 Nilotinib 0.0130638392599781 -0.0921821276382059 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.136495121502235 1 LUSC TP53 TP53 Nutlin3 0.000371293604027747 -0.0869646848479312 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.0538375725840233 1 LUSC TP53 TP53 PD0332991 0.00761439800578801 -0.123268044069477 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.0581098795178559 1 LUSC TP53 TP53 PF2341066 0.0212323222070058 -0.0526412094320984 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.112462041705521 1 LUSC TP53 TP53 PHA665752 0.0466061218597478 -0.0506601490085109 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.17584271195418 1 LUSC TP53 TP53 PLX4720 0.00187115757279942 -0.172502176981851 28 171:172:173:174:175:176:179:180:181:183 0.0587002096436059 0.0301464275617684 1 LUSC TP53 TP53 Erlotinib 0.0571420730865714 0.123876401593434 19 211:213:214:215:216:218:220:221 0.039832285115304 0.197276204703639 2 LUSC TP53 TP53 AEW541 0.0314442475055935 -0.0397108834407779 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.168867255122632 1 LUSC TP53 TP53 Erlotinib 0.00799546673765181 0.107381264348151 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.0728752701972366 2 LUSC TP53 TP53 Nutlin3 0.00271483801937232 -0.0594239583150873 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.0607502083038393 1 LUSC TP53 TP53 Paclitaxel 0.0264388968080529 0.195412259818411 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.173718008974312 2 LUSC TP53 TP53 Panobinostat 0.0352154193417252 -0.137855068906068 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.189119844612969 1 LUSC TP53 TP53 PD0325901 0.0406894634887207 0.159879863896182 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.173528594290132 2 LUSC TP53 TP53 PD0332991 0.0360142827675657 -0.0874078577691053 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.15824457579688 1 LUSC TP53 TP53 PF2341066 0.0189153915191259 -0.0383513794486663 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.105489683472048 1 LUSC TP53 TP53 RAF265 0.00310317690969271 0.0712504681447594 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.0281225407440902 2 LUSC TP53 TP53 ZD6474 0.0286819224016854 0.0565274090745862 68 232:234:236:237:238:241:242:244:245:248:249:250:251:252 0.142557651991614 0.18082081514106 2 LUSC TP53 TP53 AEW541 0.0130873487578737 -0.0537077444628579 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.0948832784945843 1 LUSC TP53 TP53 Erlotinib 0.000210379021744149 0.167054899358723 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.0076262395382254 2 LUSC TP53 TP53 L685458 0.0378607379321382 -0.0582872406214635 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.189303689660691 1 LUSC TP53 TP53 Nutlin3 0.0554510049036474 -0.0428529548797745 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.196107212464119 1 LUSC TP53 TP53 Paclitaxel 0.0360929719522736 0.207391176633998 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.180378723619157 2 LUSC TP53 TP53 Panobinostat 0.0074378717632357 -0.179063714681128 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.0674057128543235 1 LUSC TP53 TP53 PF2341066 0.0143961010588638 -0.0410086817329937 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.0907580284145761 1 LUSC TP53 TP53 PLX4720 0.0308256585012058 -0.105016088928506 62 258:259:262:266:267:271:272:273:275:276:278:279:280:281:282:283:284:285:286:287 0.129979035639413 0.172410275043407 1 PAAD CDKN2A CDKN2A Lapatinib 0.00051819918815707 0.188095500705802 11 80:83:88 0.0647058823529412 0.0107341260403965 2 PAAD CDKN2A CDKN2A PF2341066 0.0100818856347733 0.074113518955745 11 80:83:88 0.0647058823529412 0.0883764757820365 2 PAAD KRAS KRAS 17-AAG 1.48503475524348e-05 0.314800083667929 33 12:13 0.194117647058824 0.000430660079020609 2 PAAD KRAS KRAS AZD0530 0.00167602028624132 0.203068114103115 33 12:13 0.194117647058824 0.0220929946822719 2 PAAD KRAS KRAS AZD6244 9.01360888403367e-05 0.502765939241859 33 12:13 0.194117647058824 0.00653486644092441 2 PAAD KRAS KRAS Erlotinib 9.01360888403367e-05 0.16507839687548 33 12:13 0.194117647058824 0.00653486644092441 2 PAAD KRAS KRAS L685458 4.37603180558869e-05 -0.106922410668201 33 12:13 0.194117647058824 0.0031726230590518 1 PAAD KRAS KRAS Lapatinib 5.77957746840609e-07 0.255591516872624 33 12:13 0.194117647058824 4.19019366459442e-05 2 PAAD KRAS KRAS Nilotinib 0.000103110453498004 -0.136245304008377 33 12:13 0.194117647058824 0.00747550787860529 1 PAAD KRAS KRAS Nutlin3 0.00473025088347172 -0.0596457464502254 33 12:13 0.194117647058824 0.0607502083038393 1 PAAD KRAS KRAS Panobinostat 0.00834916411935346 -0.172067395138589 33 12:13 0.194117647058824 0.0700854034036927 1 PAAD KRAS KRAS PD0325901 2.22181442422776e-05 0.702642861858155 33 12:13 0.194117647058824 0.00322163091513025 2 PAAD KRAS KRAS PF2341066 0.00197812218637191 0.0770455364417525 33 12:13 0.194117647058824 0.0318697463359919 2 PAAD KRAS KRAS PLX4720 0.00654753543996244 -0.157385762245163 33 12:13 0.194117647058824 0.0678137599138967 1 PAAD KRAS KRAS Sorafenib 7.10619126707641e-05 -0.0844757680081179 33 12:13 0.194117647058824 0.00343465911242026 1 PAAD KRAS KRAS TKI258 2.47655703589333e-05 -0.275926286239765 33 12:13 0.194117647058824 0.000897751925511332 1 PAAD KRAS KRAS ZD6474 0.00097717560658605 0.190423234614089 33 12:13 0.194117647058824 0.0177113078693722 2 PAAD TP53 TP53 Paclitaxel 0.0422983770384028 0.280683844319555 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.188331808265253 2 PAAD TP53 TP53 TAE684 0.0238937371928549 0.127321521205361 22 238:239:241:242:245:246:248:250:254:255:259 0.129411764705882 0.15748144968018 2 PAAD TP53 TP53 AZD0530 0.0020245285765822 0.234328761826387 11 272:273:275:278:282:283:286 0.0647058823529412 0.022581280277263 2 PAAD TP53 TP53 Erlotinib 0.0208125036900701 0.143881420901652 11 272:273:275:278:282:283:286 0.0647058823529412 0.10600526169423 2 PAAD TP53 TP53 L685458 0.00310242037898149 -0.106354534164831 11 272:273:275:278:282:283:286 0.0647058823529412 0.0374875795793597 1 PAAD TP53 TP53 Panobinostat 0.00447538327583761 -0.26279445516278 11 272:273:275:278:282:283:286 0.0647058823529412 0.0502886202180841 1 PAAD TP53 TP53 PD0332991 0.0312834075074718 -0.109949917506645 11 272:273:275:278:282:283:286 0.0647058823529412 0.146325615760755 1 PAAD TP53 TP53 Sorafenib 0.0216180694797919 -0.0717932797133742 11 272:273:275:278:282:283:286 0.0647058823529412 0.13660455041849 1 PRAD FOXA1 FOXA1 AZD0530 0.0155178778082316 -0.0894493721992234 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.0904730264364413 1 PRAD FOXA1 FOXA1 Nutlin3 0.031122635160933 -0.035280287543743 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.15456080002062 1 PRAD FOXA1 FOXA1 TKI258 0.0178520690587662 0.104649856326142 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.103542000540844 2 PRAD FOXA1 FOXA1 Topotecan 0.0427570013591951 -0.102831926048042 15 247:249:250:251:252:253:254:255 0.0303643724696356 0.193742662408853 1 PRAD SPOP SPOP 17-AAG 0.022073446281697 0.0777981826242042 25 131:133 0.0506072874493927 0.139158683080264 2 PRAD SPOP SPOP Nutlin3 0.00135039164772212 -0.0446349583699381 25 131:133 0.0506072874493927 0.0566659712168211 1 PRAD TP53 TP53 Erlotinib 0.0370167327091144 -0.0677236099077412 11 245:248:249 0.0222672064777328 0.145094414341897 1 READ KRAS KRAS L685458 0.00307158102818551 -0.0372509286556365 27 11:12:13 0.3 0.0374875795793597 1 READ KRAS KRAS Lapatinib 0.0139109616454 -0.0484867177870933 27 11:12:13 0.3 0.0918748547435794 1 READ KRAS KRAS Nilotinib 0.0117466337118675 -0.0552580653334402 27 11:12:13 0.3 0.136495121502235 1 READ KRAS KRAS Nutlin3 0.0445668815633019 -0.0279398519797105 27 11:12:13 0.3 0.174653995315643 1 READ KRAS KRAS Panobinostat 0.0027848682204236 -0.129465537795472 27 11:12:13 0.3 0.0448673213290469 1 READ KRAS KRAS PD0332991 0.0139109616454 -0.0476938416124622 27 11:12:13 0.3 0.0916858835719545 1 READ KRAS KRAS PF2341066 0.00186606385662613 -0.0385491096799149 27 11:12:13 0.3 0.0318697463359919 1 READ KRAS KRAS PHA665752 0.0117466337118675 -0.0286127009895401 27 11:12:13 0.3 0.0774209949191267 1 READ KRAS KRAS TAE684 0.00960329446537725 -0.0864166911073139 27 11:12:13 0.3 0.0773598720822056 1 READ KRAS KRAS Topotecan 0.000834210392549538 -0.161576736233193 27 11:12:13 0.3 0.0120960506919683 1 READ TP53 TP53 AZD0530 0.0397950118262408 -0.0966340267553933 12 245:248:250 0.133333333333333 0.171288814221152 1 READ TP53 TP53 PF2341066 0.00518057718892286 0.0655992233135968 15 272:273:275:278:282:287 0.166666666666667 0.0625986410328179 2 SARC TP53 TP53 Lapatinib 0.0139396331335086 0.0899964580015643 14 234:237:238:241:242:244:248:252 0.0598290598290598 0.0918748547435794 2 SARC TP53 TP53 AZD0530 0.00983764376603282 -0.200711956358433 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.071322917303738 1 SARC TP53 TP53 Lapatinib 0.0324567160169822 0.110308094671014 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.134463537784641 2 SARC TP53 TP53 RAF265 0.0150355082148484 -0.132759088780258 10 259:262:266:268:270:272:275:278:281:286 0.0427350427350427 0.079780384256353 1 SKCM BRAF BRAF 17-AAG 0.000799974418703676 0.0975689613048956 159 594:597:600 0.439226519337017 0.0128884767457814 2 SKCM BRAF BRAF AZD0530 0.041345575846485 -0.0532944209681823 159 594:597:600 0.439226519337017 0.171288814221152 1 SKCM BRAF BRAF Nutlin3 0.0176685694894182 0.0270206309886514 159 594:597:600 0.439226519337017 0.113946953741073 2 SKCM BRAF BRAF PHA665752 0.000562153538039225 0.0372704856346386 159 594:597:600 0.439226519337017 0.0116446090022411 2 SKCM BRAF BRAF Topotecan 0.0003815935979778 0.180580721778337 159 594:597:600 0.439226519337017 0.00691638396334762 2 SKCM BRAF BRAF ZD6474 0.0175603285284132 -0.0576285371425644 159 594:597:600 0.439226519337017 0.125907308974925 1 SKCM IDH1 IDH1 Paclitaxel 0.0478497228117909 -0.224985121073974 13 132 0.0359116022099447 0.198234565934562 1 SKCM MAGEC1 MAGEC1 Paclitaxel 0.0434696571983662 0.285948348857 11 683:687:688:691:695 0.0303867403314917 0.188331808265253 2 SKCM MAGEC1 MAGEC1 PF2341066 0.0127993516649846 0.0887723896311021 11 683:687:688:691:695 0.0303867403314917 0.0883764757820365 2 SKCM MAGEC1 MAGEC1 PHA665752 0.00895232177887161 0.0820642348880151 11 683:687:688:691:695 0.0303867403314917 0.0645246258731337 2 SKCM MAGEC1 MAGEC1 RAF265 0.045166983894683 -0.117297210345193 11 683:687:688:691:695 0.0303867403314917 0.163730316618226 1 SKCM MAGEC1 MAGEC1 TAE684 0.0078589512843277 0.140406737634366 11 683:687:688:691:695 0.0303867403314917 0.0670322315427951 2 SKCM MAGEC1 MAGEC1 Topotecan 0.0250797215772481 0.361235146352493 11 683:687:688:691:695 0.0303867403314917 0.12539860788624 2 SKCM RAC1 RAC1 17-AAG 0.0246470424783627 0.117843204072056 19 29:34 0.0524861878453039 0.142952846374504 2 SKCM RAC1 RAC1 Paclitaxel 0.0395977163989604 0.169480123948329 19 29:34 0.0524861878453039 0.185215125091912 2 SKCM RAC1 RAC1 PF2341066 0.0217168080534799 0.0469242580397755 19 29:34 0.0524861878453039 0.112462041705521 2 SKCM SLC27A5 SLC27A5 AZD6244 0.027636854682729 0.261064401795499 10 550:554 0.0276243093922652 0.138184273413645 2 SKCM SLC27A5 SLC27A5 PD0325901 0.00786147680147922 0.426042442199486 10 550:554 0.0276243093922652 0.0759942757476325 2 STAD CTNNB1 CTNNB1 AEW541 0.0199373083595147 -0.0952468729903129 10 32:34:37:41 0.0242718446601942 0.125691726614332 1 STAD CTNNB1 CTNNB1 Nutlin3 0.011965332408263 -0.0836683611017581 10 32:34:37:41 0.0242718446601942 0.091314378905165 1 STAD DHX16 DHX16 17-AAG 0.0344362555124434 0.210729342550142 10 1033 0.0242718446601942 0.171110547504076 2 STAD DHX16 DHX16 AZD0530 0.0011402776657158 -0.172787728267138 10 1033 0.0242718446601942 0.0175660329374408 1 STAD DHX16 DHX16 Lapatinib 0.0317005326087269 0.0892709581714339 10 1033 0.0242718446601942 0.134463537784641 2 STAD DHX16 DHX16 PD0332991 0.0235428769888655 0.109679133126078 10 1033 0.0242718446601942 0.126433969014278 2 STAD DHX16 DHX16 PF2341066 0.000856855263140616 0.109245303494932 10 1033 0.0242718446601942 0.0296449688710562 2 STAD DHX16 DHX16 PHA665752 0.0358781450700409 0.0668307267868378 10 1033 0.0242718446601942 0.153009736328116 2 STAD DHX16 DHX16 RAF265 0.0064973629313525 0.120899989664968 10 1033 0.0242718446601942 0.0409616358715701 2 STAD DHX16 DHX16 Sorafenib 0.0113922138759696 0.0693971241158061 10 1033 0.0242718446601942 0.0856312216062366 2 STAD DHX16 DHX16 Topotecan 0.0113922138759696 0.335547506423123 10 1033 0.0242718446601942 0.074913703501537 2 STAD KRAS KRAS 17-AAG 0.0206729749106395 0.155455309831469 19 12:13 0.0461165048543689 0.136253698274669 2 STAD KRAS KRAS AEW541 0.000773198617802238 -0.0890370332223342 19 12:13 0.0461165048543689 0.0160162570830464 1 STAD KRAS KRAS Nutlin3 0.00544657039965456 -0.0687926681896762 19 12:13 0.0461165048543689 0.0607502083038393 1 STAD KRAS KRAS Paclitaxel 0.018313674211587 -0.259218929506583 19 12:13 0.0461165048543689 0.139762250562111 1 STAD KRAS KRAS PD0325901 0.0120881169235474 0.298896489927351 19 12:13 0.0461165048543689 0.0922514186270723 2 STAD KRAS KRAS RAF265 0.000903518907413797 0.119803078044849 19 12:13 0.0461165048543689 0.0145566935083334 2 STAD KRAS KRAS ZD6474 0.0153033298179807 -0.116894580651568 19 12:13 0.0461165048543689 0.116895651224692 1 STAD PGM5 PGM5 17-AAG 9.32266071929086e-07 0.313004768817122 22 98 0.0533980582524272 6.75892902148587e-05 2 STAD PGM5 PGM5 AZD0530 0.00121145054740971 -0.129093347064096 22 98 0.0533980582524272 0.0175660329374408 1 STAD PGM5 PGM5 AZD6244 0.0198456113927478 0.207435194607844 22 98 0.0533980582524272 0.136900600982901 2 STAD PGM5 PGM5 Erlotinib 0.0276955384654405 0.0708424440778513 22 98 0.0533980582524272 0.127962769411911 2 STAD PGM5 PGM5 Irinotecan 0.00148313937095887 0.31905560932794 22 98 0.0533980582524272 0.0238950231987818 2 STAD PGM5 PGM5 Lapatinib 0.0171392620136905 0.0816809037769815 22 98 0.0533980582524272 0.10507624518148 2 STAD PGM5 PGM5 Nilotinib 0.0219229273473496 0.0678460404165128 22 98 0.0533980582524272 0.189607480242724 2 STAD PGM5 PGM5 PD0325901 0.00903029550164655 0.299992077167607 22 98 0.0533980582524272 0.076894019973766 2 STAD PGM5 PGM5 PD0332991 0.0147622747439894 0.0769276401391528 22 98 0.0533980582524272 0.0920795152853798 2 STAD PGM5 PGM5 PF2341066 1.57641359227232e-07 0.12069093247058 22 98 0.0533980582524272 2.28579970879486e-05 2 STAD PGM5 PGM5 PHA665752 0.000779151606086323 0.0652087823940338 22 98 0.0533980582524272 0.0126790040380323 2 STAD PGM5 PGM5 PLX4720 0.022140711116216 -0.12069348282234 22 98 0.0533980582524272 0.16896858483428 1 STAD PGM5 PGM5 RAF265 0.00146404376477098 0.103211737402164 22 98 0.0533980582524272 0.0163297189147532 2 STAD PGM5 PGM5 Sorafenib 0.00679625074612884 0.0565477759454786 22 98 0.0533980582524272 0.0615910223867926 2 STAD PGM5 PGM5 TKI258 0.00353454450669879 0.203412084861627 22 98 0.0533980582524272 0.0333249653337839 2 STAD PGM5 PGM5 Topotecan 5.88731138888061e-05 0.370255457883917 22 98 0.0533980582524272 0.00213415037846922 2 STAD PIK3CA PIK3CA 17-AAG 0.00780894841259422 0.172958623856722 20 542:545:546:547 0.0485436893203883 0.0707685949891351 2 STAD PIK3CA PIK3CA Irinotecan 0.000439465810077692 0.357534840785948 20 542:545:546:547 0.0485436893203883 0.0113067162661185 2 STAD PIK3CA PIK3CA L685458 0.0254215465325538 0.0467035001055752 20 542:545:546:547 0.0485436893203883 0.147444969888812 2 STAD PIK3CA PIK3CA Lapatinib 0.0210393115444663 0.0749901310708152 20 542:545:546:547 0.0485436893203883 0.114830203793484 2 STAD PIK3CA PIK3CA PD0332991 0.00215519946581985 0.111686059259233 20 542:545:546:547 0.0485436893203883 0.0260419935453232 2 STAD PIK3CA PIK3CA PF2341066 0.00136623398886875 0.0868381938946543 20 542:545:546:547 0.0485436893203883 0.0312916081850271 2 STAD PIK3CA PIK3CA PHA665752 0.000786972664429593 0.0719756843308218 20 542:545:546:547 0.0485436893203883 0.0126790040380323 2 STAD PIK3CA PIK3CA RAF265 0.0265958682813944 0.0966627983280051 20 542:545:546:547 0.0485436893203883 0.110182882880063 2 STAD PIK3CA PIK3CA Sorafenib 0.00236995432215844 0.0729662293988784 20 542:545:546:547 0.0485436893203883 0.0343643376712974 2 STAD PIK3CA PIK3CA TKI258 0.00198758121566961 0.236275165995181 20 542:545:546:547 0.0485436893203883 0.0221691750978533 2 STAD PIK3CA PIK3CA Topotecan 0.00054828583826615 0.30412189482313 20 542:545:546:547 0.0485436893203883 0.00883349406095464 2 STAD TP53 TP53 Nutlin3 0.035208609484713 -0.0650738219153336 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.156137205198638 1 STAD TP53 TP53 PLX4720 0.00409140769954179 -0.184916197262047 16 125:126:130:131:134:135:136:141:144:146:151 0.0388349514563107 0.04943784303613 1 STAD TP53 TP53 PD0332991 0.040574798750961 -0.0920014911456732 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.17303958290851 1 STAD TP53 TP53 Topotecan 0.037046375691139 -0.242956737625363 18 162:167:168:171:173:175:176:178:179 0.0436893203883495 0.17328143468436 1 STAD TP53 TP53 Nilotinib 0.0222295165588269 -0.097498514810031 12 191:192:193:195:196:198 0.029126213592233 0.189607480242724 1 STAD TP53 TP53 Nutlin3 0.00754570082069384 -0.0970541803287064 12 191:192:193:195:196:198 0.029126213592233 0.0729417746000404 1 STAD TP53 TP53 PD0332991 0.00260688674583643 -0.148871370119118 12 191:192:193:195:196:198 0.029126213592233 0.0269998984390202 1 STAD TP53 TP53 PHA665752 0.0164919443222264 -0.0685912839447214 12 191:192:193:195:196:198 0.029126213592233 0.0919743048739549 1 STAD TP53 TP53 PLX4720 0.000851080656866218 -0.251123824120328 12 191:192:193:195:196:198 0.029126213592233 0.0176295278922288 1 STAD TP53 TP53 TKI258 0.0194136970978367 -0.238858769177344 12 191:192:193:195:196:198 0.029126213592233 0.104392576358009 1 STAD TP53 TP53 AZD6244 0.0219352259005954 -0.212129518961516 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.136900600982901 1 STAD TP53 TP53 L685458 0.0219352259005954 -0.0400573015176003 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.138287293721145 1 STAD TP53 TP53 Nutlin3 0.0115385604664037 -0.0602890996938522 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.091314378905165 1 STAD TP53 TP53 PD0332991 0.0178053133750834 -0.07479745935413 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.103270817575484 1 STAD TP53 TP53 PLX4720 0.0300396830921418 -0.0960056883921933 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.172410275043407 1 STAD TP53 TP53 TKI258 0.0173587062054843 -0.190564171922628 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.103542000540844 1 STAD TP53 TP53 Topotecan 0.00386976444629204 -0.230232377178081 25 237:238:240:242:244:245:246:248:250:253:254:259 0.0606796116504854 0.0399522094084361 1 STAD TP53 TP53 Erlotinib 0.0316740847215045 -0.0885324938636405 17 265:267:270:271:272:273 0.0412621359223301 0.131221208131947 1 STAD TP53 TP53 Nutlin3 0.0355346742865866 -0.0616156320525045 17 265:267:270:271:272:273 0.0412621359223301 0.156137205198638 1 STAD TP53 TP53 PLX4720 0.00240000413201061 -0.187574792535255 17 265:267:270:271:272:273 0.0412621359223301 0.0348000599141539 1 STAD TP53 TP53 Lapatinib 0.050736697777241 -0.0718741682663022 13 282:285:286 0.0315533980582524 0.193600557307893 1 STAD TP53 TP53 Nutlin3 0.053979876564771 -0.0758554375317972 13 282:285:286 0.0315533980582524 0.196107212464119 1 STAD TP53 TP53 PLX4720 0.0298732553476715 -0.159778463077678 13 282:285:286 0.0315533980582524 0.172410275043407 1 STAD TP53 TP53 TKI258 0.0174785882029375 -0.231819264116647 13 282:285:286 0.0315533980582524 0.103542000540844 1 STAD TP53 TP53 Topotecan 0.0176905486359436 -0.308875856490685 13 282:285:286 0.0315533980582524 0.100526081063372 1 THYM GTF2I GTF2I AEW541 0.00732436824140214 -0.0463796394441442 56 424 0.474576271186441 0.0603418050494983 1 THYM GTF2I GTF2I AZD0530 0.0167319331575065 0.089400546438853 56 424 0.474576271186441 0.0933127041476324 2 THYM GTF2I GTF2I AZD6244 1.08036861955891e-05 0.224233291811236 56 424 0.474576271186441 0.00156653449836042 2 THYM GTF2I GTF2I Irinotecan 3.10245475022097e-05 -0.633118538147692 56 424 0.474576271186441 0.00449855938782041 1 THYM GTF2I GTF2I L685458 0.00421269766984375 -0.0829306125468123 56 424 0.474576271186441 0.0469877817021034 1 THYM GTF2I GTF2I Lapatinib 0.00686032013094414 -0.0966893401925488 56 424 0.474576271186441 0.0552636899437167 1 THYM GTF2I GTF2I Paclitaxel 0.0368882740782078 -0.221122348421817 56 424 0.474576271186441 0.180378723619157 1 THYM GTF2I GTF2I PD0325901 0.000135294768936371 0.277667945759327 56 424 0.474576271186441 0.0098088707478869 2 THYM GTF2I GTF2I TAE684 0.00366749782817954 0.123692492365413 56 424 0.474576271186441 0.0409067065450795 2 THYM GTF2I GTF2I ZD6474 1.25566286162985e-05 0.0696795684554201 56 424 0.474576271186441 0.000910355574681641 2 UCEC BCOR BCOR 17-AAG 0.00239094445781453 0.439879032407691 11 1459 0.0654761904761905 0.031516995125737 2 UCEC BCOR BCOR AZD6244 0.0290487935097078 0.237849981948945 11 1459 0.0654761904761905 0.140402501963588 2 UCEC CTNNB1 CTNNB1 17-AAG 0.00367685443323914 0.25359761054022 22 32:33:34:37:41:45 0.130952380952381 0.0409092743958475 2 UCEC CTNNB1 CTNNB1 AEW541 0.0156260097075939 -0.0668924959563681 22 32:33:34:37:41:45 0.130952380952381 0.107893876552434 1 UCEC CTNNB1 CTNNB1 AZD6244 0.000264192577310182 0.2919335630756 22 32:33:34:37:41:45 0.130952380952381 0.0127693079033255 2 UCEC CTNNB1 CTNNB1 PD0325901 0.00246432684707707 0.326537834112266 22 32:33:34:37:41:45 0.130952380952381 0.0510467704037393 2 UCEC CTNNB1 CTNNB1 PD0332991 0.033138183935836 0.0593737176622038 22 32:33:34:37:41:45 0.130952380952381 0.150157395959257 2 UCEC CTNNB1 CTNNB1 PLX4720 0.00146510738918465 0.149909500962084 22 32:33:34:37:41:45 0.130952380952381 0.0265550714289718 2 UCEC CTNNB1 CTNNB1 RAF265 0.0169970506642133 -0.109884714377267 22 32:33:34:37:41:45 0.130952380952381 0.0821524115436976 1 UCEC PIK3CA PIK3CA 17-AAG 0.0354021822422226 -0.283820653567821 11 539:542:545:546 0.0654761904761905 0.171110547504076 1 UCEC PIK3CA PIK3CA AZD6244 0.026256297815394 -0.299685766867365 11 539:542:545:546 0.0654761904761905 0.138184273413645 1 UCEC PIK3CA PIK3CA PD0325901 0.00875261159876096 -0.481075653077725 11 539:542:545:546 0.0654761904761905 0.076894019973766 1 UCEC POLE POLE 17-AAG 0.000954453853871131 0.40406533660502 10 286 0.0595238095238095 0.0138395808811314 2 UCEC POLE POLE AZD6244 0.0236035518936037 0.247895715301899 10 286 0.0595238095238095 0.136900600982901 2 UCEC POLE POLE PHA665752 0.0164753925827985 0.0649917594661596 10 286 0.0595238095238095 0.0919743048739549 2 UCEC POLE POLE TKI258 0.0201585664691328 0.232046123638994 10 286 0.0595238095238095 0.104392576358009 2 UCEC PPP2R1A PPP2R1A 17-AAG 0.00323760041031572 -0.276340372669978 21 177:179:183 0.125 0.0391210049579816 1 UCEC PPP2R1A PPP2R1A AZD0530 0.040739437607379 -0.129925966894309 21 177:179:183 0.125 0.171288814221152 1 UCEC PPP2R1A PPP2R1A AZD6244 0.0221279964123183 -0.223989571962598 21 177:179:183 0.125 0.136900600982901 1 UCEC PPP2R1A PPP2R1A RAF265 0.00604632423681395 0.118542932041205 21 177:179:183 0.125 0.0408094473117676 2 UCEC PTEN PTEN 17-AAG 7.53746050353353e-08 0.462820813357658 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 1.09293177301236e-05 2 UCEC PTEN PTEN AEW541 0.00127807845248283 -0.0860206669193653 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0205912639566678 1 UCEC PTEN PTEN PD0332991 0.00531802388204163 0.0765457131917094 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0428396368275576 2 UCEC PTEN PTEN RAF265 0.00335005042063392 -0.104984586150053 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0285739594701128 1 UCEC PTEN PTEN TKI258 0.00261380559455601 0.217128545116679 37 122:125:127:128:129:130:132:135:136:138:141:142 0.220238095238095 0.0270715579436158 2 UCEC TP53 TP53 17-AAG 0.000280198124385057 -0.378086645192997 18 236:237:238:241:245:246:248:249 0.107142857142857 0.00677145467263888 1 UCEC TP53 TP53 AZD6244 0.000399891454044171 -0.31235099324468 18 236:237:238:241:245:246:248:249 0.107142857142857 0.0144960652091012 1 UCEC TP53 TP53 Lapatinib 0.0177434017821692 -0.133874354017023 18 236:237:238:241:245:246:248:249 0.107142857142857 0.10507624518148 1 UCEC TP53 TP53 PD0325901 0.0324404823076069 -0.285577927427175 18 236:237:238:241:245:246:248:249 0.107142857142857 0.156795664486767 1 UCEC TP53 TP53 PD0332991 0.0152407473575801 -0.0819426460999836 18 236:237:238:241:245:246:248:249 0.107142857142857 0.0920795152853798 1 UCEC TP53 TP53 RAF265 0.0137501385022047 0.142231633758781 18 236:237:238:241:245:246:248:249 0.107142857142857 0.0766834647238339 2 UCEC TP53 TP53 17-AAG 0.000603735282054691 -0.41996542354116 13 273:276:278:281:282:286 0.0773809523809524 0.0109427019872413 1 UCEC TP53 TP53 AZD6244 0.0197293168052434 -0.256839527284728 13 273:276:278:281:282:286 0.0773809523809524 0.136900600982901 1 UCEC TP53 TP53 PD0332991 0.0124337089116178 -0.0883956113451286 13 273:276:278:281:282:286 0.0773809523809524 0.0858517996278372 1 UCEC TP53 TP53 RAF265 0.0159560768512706 0.148178909873357 13 273:276:278:281:282:286 0.0773809523809524 0.079780384256353 2 UVM GNA11 GNA11 AZD0530 0.0212760702539023 -0.0633696029035158 34 209 0.425 0.106380351269511 1 UVM GNA11 GNA11 AZD6244 0.0351149903428001 -0.134783475126102 34 209 0.425 0.159590117997514 1 UVM GNA11 GNA11 PD0325901 0.0388385182049369 -0.213451358412144 34 209 0.425 0.170654095142905 1 UVM SF3B1 SF3B1 AZD6244 0.000618095480779416 0.245373616216449 14 625 0.175 0.0179247689426031 2 UVM SF3B1 SF3B1 Irinotecan 0.000153504185869458 -0.295786649774999 14 625 0.175 0.00850805500972167 1 UVM SF3B1 SF3B1 L685458 0.00693437726036336 -0.0441414098928526 14 625 0.175 0.0529202475132993 1 UVM SF3B1 SF3B1 Nutlin3 0.00846387384999571 -0.0482736978778588 14 625 0.175 0.0767038567655861 1 UVM SF3B1 SF3B1 Panobinostat 0.00459731585814538 -0.151328295609001 14 625 0.175 0.0502886202180841 1 UVM SF3B1 SF3B1 PD0325901 0.000649277164828218 0.391024656874763 14 625 0.175 0.0252507880232588 2 UVM SF3B1 SF3B1 PF2341066 0.00274655262818052 -0.0561270713150195 14 625 0.175 0.0398250131086175 1 UVM SF3B1 SF3B1 RAF265 0.0200828631957629 -0.0782874023927154 14 625 0.175 0.0882428837389582 1 UVM SF3B1 SF3B1 Sorafenib 0.0078191432789209 -0.0450833587180495 14 625 0.175 0.0666926926731488 1 UVM SF3B1 SF3B1 TAE684 0.00589479033865476 -0.110191057293675 14 625 0.175 0.0548554285934821 1 UVM SF3B1 SF3B1 Topotecan 0.0348234239253194 -0.158002462842299 14 625 0.175 0.168313215639044 1 LGG-coc1 IDH1 IDH1 AEW541 1.79402115143587e-06 0.202414129275491 126 132 0.9 0.000260133066958201 2 LGG-coc1 IDH1 IDH1 AZD0530 0.000391262061622737 0.156101704734671 126 132 0.9 0.0113465997870594 2 LGG-coc1 IDH1 IDH1 AZD6244 0.0401182982231024 -0.152274787693642 126 132 0.9 0.16538682214573 1 LGG-coc1 IDH1 IDH1 Erlotinib 0.00821908784095086 -0.0459897840026483 126 132 0.9 0.0728752701972366 1 LGG-coc1 IDH1 IDH1 L685458 0.00495973166350337 0.0471914483016407 126 132 0.9 0.048195038708365 2 LGG-coc1 IDH1 IDH1 Nilotinib 0.00152005600494859 0.114350979094783 126 132 0.9 0.0518747850017199 2 LGG-coc1 IDH1 IDH1 Paclitaxel 0.00425972227544756 0.193568748751233 126 132 0.9 0.044118552138564 2 LGG-coc1 IDH1 IDH1 PD0325901 0.0149100656056909 -0.203400240923914 126 132 0.9 0.102950452991675 1 LGG-coc1 IDH1 IDH1 PD0332991 1.63281714183666e-05 0.101867236741531 126 132 0.9 0.00118379242783158 2 LGG-coc1 IDH1 IDH1 PF2341066 0.0187127340241949 0.0393806091346067 126 132 0.9 0.105489683472048 2 LGG-coc1 IDH1 IDH1 PHA665752 0.00312160100578082 0.0377754580444167 126 132 0.9 0.0323308675598728 2 LGG-coc1 IDH1 IDH1 RAF265 0.00138091416233166 0.12666222457815 126 132 0.9 0.0163297189147532 2 LGG-coc1 IDH1 IDH1 Sorafenib 0.00125360353446562 0.0525050602042493 126 132 0.9 0.0291120249237609 2 LGG-coc1 IDH1 IDH1 TAE684 9.20764189213247e-06 0.209310555073392 126 132 0.9 0.000496757081313102 2 LGG-coc1 IDH1 IDH1 TKI258 0.000535068447006326 0.2324188492743 126 132 0.9 0.00705317498326521 2 LGG-coc1 IDH1 IDH1 Topotecan 0.0180253662596392 0.159746343131007 126 132 0.9 0.100526081063372 2 LGG-coc1 IDH1 IDH1 ZD6474 3.89502354453323e-07 0.244282709779615 126 132 0.9 5.64778413957318e-05 2 LGG-coc1 TP53 TP53 AEW541 0.00501756958884432 0.16290592290829 10 173:176:179 0.0714285714285714 0.0519676850273162 2 LGG-coc1 TP53 TP53 AZD0530 0.0198003100681792 0.153383282859667 10 173:176:179 0.0714285714285714 0.102537319995928 2 LGG-coc1 TP53 TP53 Lapatinib 0.0230572496557151 0.0380971063792211 10 173:176:179 0.0714285714285714 0.116224083646046 2 LGG-coc1 TP53 TP53 Nilotinib 0.00276595123815477 0.193679918514709 10 173:176:179 0.0714285714285714 0.0668438215887403 2 LGG-coc1 TP53 TP53 Nutlin3 0.00180694255266876 0.0499882377928874 10 173:176:179 0.0714285714285714 0.0566659712168211 2 LGG-coc1 TP53 TP53 PD0325901 0.0144242888623021 -0.245998590390403 10 173:176:179 0.0714285714285714 0.102950452991675 1 LGG-coc1 TP53 TP53 PD0332991 0.00115103633746789 0.10291534036627 10 173:176:179 0.0714285714285714 0.0151727517211676 2 LGG-coc1 TP53 TP53 PHA665752 0.00501756958884432 0.0614385284013289 10 173:176:179 0.0714285714285714 0.0424151983645355 2 LGG-coc1 TP53 TP53 PLX4720 0.0309149458698523 0.168581503755144 10 173:176:179 0.0714285714285714 0.172410275043407 2 LGG-coc1 TP53 TP53 RAF265 0.00144773788602029 0.17871347254782 10 173:176:179 0.0714285714285714 0.0163297189147532 2 LGG-coc1 TP53 TP53 Sorafenib 0.00339248851834664 0.0879574551399026 10 173:176:179 0.0714285714285714 0.0420273875611808 2 LGG-coc1 TP53 TP53 TAE684 0.00605301281031527 0.157351321540688 10 173:176:179 0.0714285714285714 0.0548554285934821 2 LGG-coc1 TP53 TP53 TKI258 0.000137808079657588 0.361588726253407 10 173:176:179 0.0714285714285714 0.00285459593576432 2 LGG-coc1 TP53 TP53 Topotecan 0.0103322172510489 0.291004051921587 10 173:176:179 0.0714285714285714 0.0713415000667662 2 LGG-coc1 TP53 TP53 ZD6474 0.00276595123815477 0.182623295488811 10 173:176:179 0.0714285714285714 0.0334219107943701 2 LGG-coc1 TP53 TP53 AEW541 0.000300662031716009 0.205900146005564 11 190:193:194:195:196 0.0785714285714286 0.00902431152580788 2 LGG-coc1 TP53 TP53 AZD0530 0.000102777327168228 0.229227142605667 11 190:193:194:195:196 0.0785714285714286 0.00372567810984827 2 LGG-coc1 TP53 TP53 AZD6244 0.0228500076124252 -0.184427109176434 11 190:193:194:195:196 0.0785714285714286 0.136900600982901 1 LGG-coc1 TP53 TP53 Erlotinib 0.0171467863485632 -0.0676137342034054 11 190:193:194:195:196 0.0785714285714286 0.0972525230793827 1 LGG-coc1 TP53 TP53 L685458 0.000300662031716009 0.0673290572112956 11 190:193:194:195:196 0.0785714285714286 0.00732791135553488 2 LGG-coc1 TP53 TP53 Nilotinib 0.000777732908571514 0.157285593497389 11 190:193:194:195:196 0.0785714285714286 0.0375904239142898 2 LGG-coc1 TP53 TP53 Nutlin3 0.0300510166710194 0.037003295605465 11 190:193:194:195:196 0.0785714285714286 0.15456080002062 2 LGG-coc1 TP53 TP53 Paclitaxel 0.000619731942924836 0.340685608456182 11 190:193:194:195:196 0.0785714285714286 0.00999052780210622 2 LGG-coc1 TP53 TP53 PD0325901 0.0171467863485632 -0.22150056734732 11 190:193:194:195:196 0.0785714285714286 0.103595167522569 1 LGG-coc1 TP53 TP53 PD0332991 0.000385491676378741 0.117452160951233 11 190:193:194:195:196 0.0785714285714286 0.00798518472498821 2 LGG-coc1 TP53 TP53 PF2341066 0.000970708845254544 0.0728576432038998 11 190:193:194:195:196 0.0785714285714286 0.0296449688710562 2 LGG-coc1 TP53 TP53 PHA665752 0.000300662031716009 0.0657406578718305 11 190:193:194:195:196 0.0785714285714286 0.00871919891976426 2 LGG-coc1 TP53 TP53 RAF265 0.000178863229071871 0.221777478502566 11 190:193:194:195:196 0.0785714285714286 0.00432252803590355 2 LGG-coc1 TP53 TP53 Sorafenib 2.99128041758275e-05 0.101507024164317 11 190:193:194:195:196 0.0785714285714286 0.00216867830274749 2 LGG-coc1 TP53 TP53 TAE684 1.02777327168228e-05 0.276744391246428 11 190:193:194:195:196 0.0785714285714286 0.000496757081313102 2 LGG-coc1 TP53 TP53 TKI258 1.02777327168228e-05 0.356528469961016 11 190:193:194:195:196 0.0785714285714286 0.000496757081313102 2 LGG-coc1 TP53 TP53 Topotecan 4.60196987320423e-06 0.426890248472619 11 190:193:194:195:196 0.0785714285714286 0.000333642815807307 2 LGG-coc1 TP53 TP53 ZD6474 0.000300662031716009 0.242607524676584 11 190:193:194:195:196 0.0785714285714286 0.00622799922840304 2 LGG-coc1 TP53 TP53 AEW541 0.00124914691408534 0.179145486497445 13 205:208:213:214:216:220 0.0928571428571429 0.0205912639566678 2 LGG-coc1 TP53 TP53 AZD0530 0.011563405972084 0.135188989394241 13 205:208:213:214:216:220 0.0928571428571429 0.0751319090067163 2 LGG-coc1 TP53 TP53 L685458 0.0283306378654989 0.038262702675488 13 205:208:213:214:216:220 0.0928571428571429 0.157997788096052 2 LGG-coc1 TP53 TP53 Nilotinib 0.00178878568971448 0.135911279026342 13 205:208:213:214:216:220 0.0928571428571429 0.0518747850017199 2 LGG-coc1 TP53 TP53 PD0325901 0.0195961285169003 -0.21971816395906 13 205:208:213:214:216:220 0.0928571428571429 0.109286101344252 1 LGG-coc1 TP53 TP53 PD0332991 0.00103778274507152 0.089928535817881 13 205:208:213:214:216:220 0.0928571428571429 0.015047849803537 2 LGG-coc1 TP53 TP53 PHA665752 0.00481705188980034 0.0395053283301218 13 205:208:213:214:216:220 0.0928571428571429 0.0424151983645355 2 LGG-coc1 TP53 TP53 RAF265 0.00103778274507152 0.158960758241054 13 205:208:213:214:216:220 0.0928571428571429 0.015047849803537 2 LGG-coc1 TP53 TP53 Sorafenib 0.000580013693580749 0.0663531257954518 13 205:208:213:214:216:220 0.0928571428571429 0.0168203971138417 2 LGG-coc1 TP53 TP53 TAE684 0.00103778274507152 0.195862684731134 13 205:208:213:214:216:220 0.0928571428571429 0.0214969282907672 2 LGG-coc1 TP53 TP53 TKI258 0.000311152104914666 0.297670864544223 13 205:208:213:214:216:220 0.0928571428571429 0.00501300613473629 2 LGG-coc1 TP53 TP53 ZD6474 0.000250236079070888 0.234753822670711 13 205:208:213:214:216:220 0.0928571428571429 0.00622799922840304 2 LGG-coc1 TP53 TP53 AEW541 0.00160577828506074 0.13930417251085 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0213221054035784 2 LGG-coc1 TP53 TP53 AZD0530 0.00113011631731449 0.154978913969376 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0175660329374408 2 LGG-coc1 TP53 TP53 Erlotinib 0.0174383834487169 -0.0484094246162099 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0972525230793827 1 LGG-coc1 TP53 TP53 L685458 0.00578195412970176 0.0434012655386462 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0495179843388488 2 LGG-coc1 TP53 TP53 Nilotinib 0.00473139635709554 0.103596549904566 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0980074959684076 2 LGG-coc1 TP53 TP53 Paclitaxel 0.0160044719979473 0.188163502180127 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.129576144669057 2 LGG-coc1 TP53 TP53 PD0332991 0.000537205293900151 0.0764913085275216 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00865497417950243 2 LGG-coc1 TP53 TP53 PHA665752 0.00934494581610902 0.0234694152473274 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0645246258731337 2 LGG-coc1 TP53 TP53 RAF265 0.00201494476268604 0.12221435252558 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0208690707563911 2 LGG-coc1 TP53 TP53 Sorafenib 0.0122913456065516 0.0475805968404255 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.0856312216062366 2 LGG-coc1 TP53 TP53 TAE684 0.000117166771400825 0.183531891196013 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00345416954180369 2 LGG-coc1 TP53 TP53 TKI258 6.3533436355664e-05 0.252022308199971 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00184246965431426 2 LGG-coc1 TP53 TP53 Topotecan 0.000117166771400825 0.235452930545089 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.00316725464315788 2 LGG-coc1 TP53 TP53 ZD6474 1.99404006239228e-05 0.225377391871795 22 230:232:236:237:241:244:245:246:248:250:255 0.157142857142857 0.000963786030156269 2 LGG-coc1 TP53 TP53 AEW541 2.91197627436345e-05 0.172137455354529 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0021111827989135 2 LGG-coc1 TP53 TP53 AZD0530 1.86876087483311e-06 0.212589619298178 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000270970326850801 2 LGG-coc1 TP53 TP53 AZD6244 0.00646316947813552 -0.134096172923942 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0726893163536467 1 LGG-coc1 TP53 TP53 L685458 6.85351666349916e-05 0.0726343816204345 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00331253305402459 2 LGG-coc1 TP53 TP53 Nilotinib 4.90058315695754e-05 0.171622220344852 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00710584557758843 2 LGG-coc1 TP53 TP53 Nutlin3 0.00417226274590342 0.0381375203832441 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0607502083038393 2 LGG-coc1 TP53 TP53 Paclitaxel 0.00183351411194817 0.230538131356093 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0241690496574986 2 LGG-coc1 TP53 TP53 Panobinostat 0.0039438032733166 0.0993104885951865 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0502886202180841 2 LGG-coc1 TP53 TP53 PD0325901 0.00207146237159461 -0.188767640468643 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0500603406468697 1 LGG-coc1 TP53 TP53 PD0332991 1.40534108070927e-05 0.101038374809828 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00118379242783158 2 LGG-coc1 TP53 TP53 PF2341066 0.00646316947813552 0.0578764851364081 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.066939969594975 2 LGG-coc1 TP53 TP53 PHA665752 0.000152579506451223 0.0542501295598578 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00553100710885683 2 LGG-coc1 TP53 TP53 PLX4720 0.00372649925230416 0.1592032891696 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.0491220355985548 2 LGG-coc1 TP53 TP53 RAF265 3.18063058380346e-05 0.162286357408412 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00230595717325751 2 LGG-coc1 TP53 TP53 Sorafenib 1.40534108070927e-05 0.087293296010385 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.00203774456702844 2 LGG-coc1 TP53 TP53 TAE684 1.07320078160439e-06 0.209097089347316 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000155614113332637 2 LGG-coc1 TP53 TP53 TKI258 2.26694019667314e-07 0.350187953386379 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 3.28706328517605e-05 2 LGG-coc1 TP53 TP53 Topotecan 1.27926692675832e-05 0.290065305729859 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000618312347933188 2 LGG-coc1 TP53 TP53 ZD6474 2.66438278486468e-05 0.194124924748738 45 265:266:267:270:273:274:275:278:280:282:286 0.321428571428571 0.000965838759513446 2 LGG-coc2 IDH1 IDH1 Irinotecan 0.000973066604942381 0.35767908770092 10 132 0.181818181818182 0.0176368322145807 2 LGG-coc2 IDH1 IDH1 PD0332991 0.00257193537021378 0.091941652139906 10 132 0.181818181818182 0.0269998984390202 2 LGG-coc2 IDH1 IDH1 TAE684 0.000119109294544955 0.208342149318249 10 132 0.181818181818182 0.00345416954180369 2 BRCA-Basal TP53 TP53 17-AAG 0.0429637442021343 -0.220059202543676 10 193:194:195:196:198:199 0.153846153846154 0.188780088160893 1 THCA-Braf-like BRAF BRAF 17-AAG 4.90153988158706e-06 -0.15484778301649 224 600 0.842105263157895 0.000236907760943375 1 THCA-Braf-like BRAF BRAF AEW541 0.00161753903061629 -0.0383645995677155 224 600 0.842105263157895 0.0213221054035784 1 THCA-Braf-like BRAF BRAF AZD6244 0.0363205096132273 -0.065720591972211 224 600 0.842105263157895 0.159590117997514 1 THCA-Braf-like BRAF BRAF L685458 0.0017447210453629 -0.0569527041358083 224 600 0.842105263157895 0.0316230689472026 1 THCA-Braf-like BRAF BRAF Lapatinib 0.0055417066530154 -0.0483068963506268 224 600 0.842105263157895 0.04974023569291 1 THCA-Braf-like BRAF BRAF Nutlin3 0.00182537942685676 -0.0440743949176559 224 600 0.842105263157895 0.0566659712168211 1 THCA-Braf-like BRAF BRAF Paclitaxel 6.00382792445341e-05 -0.257843093736585 224 600 0.842105263157895 0.00435277524522872 1 THCA-Braf-like BRAF BRAF PD0332991 0.00397527447821632 -0.0757308216410975 224 600 0.842105263157895 0.0360259249588354 1 THCA-Braf-like BRAF BRAF PLX4720 9.63407439011328e-05 -0.0904205606562192 224 600 0.842105263157895 0.00349235196641606 1