| Basic Information ▶ | |
| VISDB ID | TVIS10016350 |
|---|---|
| Fusion Name | HBV-TTBK1 integration |
| Validated | No |
| Curated Way | VISDB1.0 |
| Method | Whole-genome sequencing |
| Wet Assay | No |
| Sample ID | 31656 |
| Sample Name | 31656N |
| Sample Type | Nontumor |
| Age | 45 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Hepatocellular carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 22267523 |
| Journal | Genome Research |
| Published Year | 2012 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr6 |
| Cytogenetic Band | p21.1 |
| Human Strand | + |
| Human Integration Location Type | Intronic |
| Hg19 Start | 43254922 |
| Hg19 End | 43254957 |
| Hg38 Start | 43287184 |
| Hg38 End | 43287219 |
| Junction Sequence | AGAGCCCTCCTTGTCAACTTGAGGCCCTCCCAAGG |
| Target Gene ▶ | |
| Target Gene | TTBK1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | - |
| Virus Genome Accession | NC_003977 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 |
| Virus Breakpoint1 | 1513 |
| Virus Breakpoint2 | 1548 |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | ACCGACCACGGGGCGCACCTCTCTTTACGCGGACTC |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000146216.14 |
| Gene Name | TTBK1 |
| Region | 3UTR |
| Impact | noncoding_exon_insertion |
| Transcript | Transcript 1: ENST00000259750.9 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.010 | Acceptor Loss: 0.010 | Donor Gain: 0.000 | Donor Loss: 0.000 |
| Delta Score Max | 0.010 |
| Delta Position at Max | -499 |
| Delta Score Flag | LOW |
| Gene | TTBK1 |
| Altered Protein (FASTA) | |
| AlphaGenome Analysis | |
| Window | chr6:43221648-43352720 |
| RNA-seq Change (±2kb) | Mean: -0.0003661013033706695 | Peak: 1.1484375 |
| ATAC Change (±2kb) | Mean: -0.0004176287620794028 | Peak: 7.265625 |
| Interpretation | RNA-seq: minimal change -1.3% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -0.9% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D