| Basic Information ▶ | |
| VISDB ID | TVIS10016535 |
|---|---|
| Fusion Name | HBV-chrX integration |
| Validated | No |
| Curated Way | VISDB1.0 |
| Method | Whole-genome sequencing |
| Wet Assay | No |
| Sample ID | 31656 |
| Sample Name | 31656T |
| Sample Type | Tumor |
| Age | 45 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Hepatocellular carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 22267523 |
| Journal | Genome Research |
| Published Year | 2012 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chrX |
| Cytogenetic Band | q28 |
| Human Strand | - |
| Human Integration Location Type | Intronic |
| Hg19 Start | 154003272 |
| Hg19 End | 154003307 |
| Hg38 Start | 154774997 |
| Hg38 End | 154775032 |
| Junction Sequence | CGGCAGACAGTTATCCCTTTCTAGTCTGGCTCGTG |
| Target Gene ▶ | |
| Target Gene | SNORA56, DKC1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | - |
| Virus Genome Accession | NC_003977 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 |
| Virus Breakpoint1 | 1212 |
| Virus Breakpoint2 | 1247 |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | GCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCT |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Transcript | Transcript 1: ENST00000620277.4, Transcript 2: ENST00000939406.1, Transcript 3: ENST00000413910.6, Transcript 4: ENST00000426673.6, Transcript 5: ENST00000953351.1, Transcript 6: ENST00000696575.1, Transcript 7: ENST00000696577.1, Transcript 8: ENST00000696578.1, Transcript 9: ENST00000696579.1, Transcript 10: ENST00000369550.10, Transcript 11: ENST00000939407.1, Transcript 12: ENST00000939408.1, Transcript 13: ENST00000696580.1, Transcript 14: ENST00000696581.1, Transcript 15: ENST00000696582.1, Transcript 16: ENST00000696583.1, Transcript 17: ENST00000696627.1, Transcript 18: ENST00000696628.1, Transcript 19: ENST00000696584.1, Transcript 20: ENST00000696585.1, Transcript 21: ENST00000696586.1, Transcript 22: ENST00000696587.1, Transcript 23: ENST00000696588.1, Transcript 24: ENST00000412124.5, Transcript 25: ENST00000484317.6, Transcript 26: ENST00000696589.1, Transcript 27: ENST00000696590.1, Transcript 28: ENST00000475966.1, Transcript 29: ENST00000696591.1, Transcript 30: ENST00000696592.1, Transcript 31: ENST00000481062.1, Transcript 32: ENST00000492372.2, Transcript 33: ENST00000383966.1 |
| Transcript 1 Gene Id | ENSG00000130826.20 |
| Transcript 1 Gene Name | DKC1 |
| Transcript 1 Region | exon_non_coding |
| Transcript 1 Impact | noncoding_exon_insertion |
| Transcript 2 Gene Id | ENSG00000130826.20 |
| Transcript 2 Gene Name | DKC1 |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Gene Id | ENSG00000130826.20 |
| Transcript 3 Gene Name | DKC1 |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Gene Id | ENSG00000130826.20 |
| Transcript 4 Gene Name | DKC1 |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Gene Id | ENSG00000130826.20 |
| Transcript 5 Gene Name | DKC1 |
| Transcript 5 Region | intron |
| Transcript 5 Impact | intronic_insertion |
| Transcript 6 Gene Id | ENSG00000130826.20 |
| Transcript 6 Gene Name | DKC1 |
| Transcript 6 Region | intron |
| Transcript 6 Impact | intronic_insertion |
| Transcript 7 Gene Id | ENSG00000130826.20 |
| Transcript 7 Gene Name | DKC1 |
| Transcript 7 Region | intron |
| Transcript 7 Impact | intronic_insertion |
| Transcript 8 Gene Id | ENSG00000130826.20 |
| Transcript 8 Gene Name | DKC1 |
| Transcript 8 Region | intron |
| Transcript 8 Impact | intronic_insertion |
| Transcript 9 Gene Id | ENSG00000130826.20 |
| Transcript 9 Gene Name | DKC1 |
| Transcript 9 Region | intron |
| Transcript 9 Impact | intronic_insertion |
| Transcript 10 Gene Id | ENSG00000130826.20 |
| Transcript 10 Gene Name | DKC1 |
| Transcript 10 Region | intron |
| Transcript 10 Impact | intronic_insertion |
| Transcript 11 Gene Id | ENSG00000130826.20 |
| Transcript 11 Gene Name | DKC1 |
| Transcript 11 Region | intron |
| Transcript 11 Impact | intronic_insertion |
| Transcript 12 Gene Id | ENSG00000130826.20 |
| Transcript 12 Gene Name | DKC1 |
| Transcript 12 Region | intron |
| Transcript 12 Impact | intronic_insertion |
| Transcript 13 Gene Id | ENSG00000130826.20 |
| Transcript 13 Gene Name | DKC1 |
| Transcript 13 Region | intron |
| Transcript 13 Impact | intronic_insertion |
| Transcript 14 Gene Id | ENSG00000130826.20 |
| Transcript 14 Gene Name | DKC1 |
| Transcript 14 Region | intron |
| Transcript 14 Impact | intronic_insertion |
| Transcript 15 Gene Id | ENSG00000130826.20 |
| Transcript 15 Gene Name | DKC1 |
| Transcript 15 Region | intron |
| Transcript 15 Impact | intronic_insertion |
| Transcript 16 Gene Id | ENSG00000130826.20 |
| Transcript 16 Gene Name | DKC1 |
| Transcript 16 Region | intron |
| Transcript 16 Impact | intronic_insertion |
| Transcript 17 Gene Id | ENSG00000130826.20 |
| Transcript 17 Gene Name | DKC1 |
| Transcript 17 Region | intron |
| Transcript 17 Impact | intronic_insertion |
| Transcript 18 Gene Id | ENSG00000130826.20 |
| Transcript 18 Gene Name | DKC1 |
| Transcript 18 Region | intron |
| Transcript 18 Impact | intronic_insertion |
| Transcript 19 Gene Id | ENSG00000130826.20 |
| Transcript 19 Gene Name | DKC1 |
| Transcript 19 Region | intron |
| Transcript 19 Impact | intronic_insertion |
| Transcript 20 Gene Id | ENSG00000130826.20 |
| Transcript 20 Gene Name | DKC1 |
| Transcript 20 Region | intron |
| Transcript 20 Impact | intronic_insertion |
| Transcript 21 Gene Id | ENSG00000130826.20 |
| Transcript 21 Gene Name | DKC1 |
| Transcript 21 Region | intron |
| Transcript 21 Impact | intronic_insertion |
| Transcript 22 Gene Id | ENSG00000130826.20 |
| Transcript 22 Gene Name | DKC1 |
| Transcript 22 Region | intron |
| Transcript 22 Impact | intronic_insertion |
| Transcript 23 Gene Id | ENSG00000130826.20 |
| Transcript 23 Gene Name | DKC1 |
| Transcript 23 Region | intron |
| Transcript 23 Impact | intronic_insertion |
| Transcript 24 Gene Id | ENSG00000130826.20 |
| Transcript 24 Gene Name | DKC1 |
| Transcript 24 Region | intron |
| Transcript 24 Impact | intronic_insertion |
| Transcript 25 Gene Id | ENSG00000130826.20 |
| Transcript 25 Gene Name | DKC1 |
| Transcript 25 Region | exon_non_coding |
| Transcript 25 Impact | noncoding_exon_insertion |
| Transcript 26 Gene Id | ENSG00000130826.20 |
| Transcript 26 Gene Name | DKC1 |
| Transcript 26 Region | intron |
| Transcript 26 Impact | intronic_insertion |
| Transcript 27 Gene Id | ENSG00000130826.20 |
| Transcript 27 Gene Name | DKC1 |
| Transcript 27 Region | exon_non_coding |
| Transcript 27 Impact | noncoding_exon_insertion |
| Transcript 28 Gene Id | ENSG00000130826.20 |
| Transcript 28 Gene Name | DKC1 |
| Transcript 28 Region | intron |
| Transcript 28 Impact | intronic_insertion |
| Transcript 29 Gene Id | ENSG00000130826.20 |
| Transcript 29 Gene Name | DKC1 |
| Transcript 29 Region | intron |
| Transcript 29 Impact | intronic_insertion |
| Transcript 30 Gene Id | ENSG00000130826.20 |
| Transcript 30 Gene Name | DKC1 |
| Transcript 30 Region | exon_non_coding |
| Transcript 30 Impact | noncoding_exon_insertion |
| Transcript 31 Gene Id | ENSG00000130826.20 |
| Transcript 31 Gene Name | DKC1 |
| Transcript 31 Region | exon_non_coding |
| Transcript 31 Impact | noncoding_exon_insertion |
| Transcript 32 Gene Id | ENSG00000130826.20 |
| Transcript 32 Gene Name | DKC1 |
| Transcript 32 Region | promoter |
| Transcript 32 Impact | promoter_insertion |
| Transcript 33 Gene Id | ENSG00000206693.1 |
| Transcript 33 Gene Name | SNORA56 |
| Transcript 33 Region | promoter |
| Transcript 33 Impact | promoter_insertion |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.090 | Acceptor Loss: 0.010 | Donor Gain: 0.060 | Donor Loss: 0.020 |
| Delta Score Max | 0.090 |
| Delta Position at Max | -211 |
| Delta Score Flag | LOW |
| Gene | DKC1 |
| AlphaGenome Analysis | |
| Window | chrX:154709461-154840533 |
| RNA-seq Change (±2kb) | Mean: -0.011263233609497547 | Peak: 18.3984375 |
| ATAC Change (±2kb) | Mean: 0.0004965885891579092 | Peak: 8.5859375 |
| Interpretation | RNA-seq: minimal change -3.2% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 0.9% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D