| Basic Information ▶ | |
| VISDB ID | TVIS10017009 |
|---|---|
| Fusion Name | HBV-PPP1R1C integration |
| Validated | No |
| Curated Way | VISDB1.0 |
| Method | Capture based next-generation sequencing |
| Wet Assay | No |
| Sample ID | M18 |
| Sample Name | M18 |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Hepatocellular carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 30070724 |
| Journal | Hepatology |
| Published Year | 2019 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr2 |
| Cytogenetic Band | q31.3 |
| Human Strand | |
| Human Integration Location Type | Intron |
| Hg19 Start | 182826285 |
| Hg19 End | 182826372 |
| Hg38 Start | 181961558 |
| Hg38 End | 181961645 |
| Junction Sequence | TCTTTAAGGACTGGACTGTACGTCTCAGCTCCGTGAGCGTCATCTCAGCATCTCCAACCTTGGTGGACTGCGTAGTGACCACTGTGG |
| Target Gene ▶ | |
| Target Gene | KRT18P29, PPP1R1C |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | B |
| Virus Genome Accession | NC_003977 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 |
| Virus Breakpoint1 | 1935 |
| Virus Breakpoint2 | 1978 |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | ACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTC |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Transcript | Transcript 1: ENST00000495820.5, Transcript 2: ENST00000486067.5, Transcript 3: ENST00000475249.5, Transcript 4: ENST00000464264.6, Transcript 5: ENST00000490645.5, Transcript 6: ENST00000465612.5, Transcript 7: ENST00000397031.2 |
| Transcript 1 Gene Id | ENSG00000150722.12 |
| Transcript 1 Gene Name | PPP1R1C |
| Transcript 1 Region | intron |
| Transcript 1 Impact | intronic_insertion |
| Transcript 2 Gene Id | ENSG00000150722.12 |
| Transcript 2 Gene Name | PPP1R1C |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Gene Id | ENSG00000150722.12 |
| Transcript 3 Gene Name | PPP1R1C |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Gene Id | ENSG00000150722.12 |
| Transcript 4 Gene Name | PPP1R1C |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Gene Id | ENSG00000150722.12 |
| Transcript 5 Gene Name | PPP1R1C |
| Transcript 5 Region | intron |
| Transcript 5 Impact | intronic_insertion |
| Transcript 6 Gene Id | ENSG00000150722.12 |
| Transcript 6 Gene Name | PPP1R1C |
| Transcript 6 Region | intron |
| Transcript 6 Impact | intronic_insertion |
| Transcript 7 Gene Id | ENSG00000213958.2 |
| Transcript 7 Gene Name | KRT18P29 |
| Transcript 7 Region | exon_non_coding |
| Transcript 7 Impact | noncoding_exon_insertion |
| AlphaGenome Analysis | |
| Window | chr2:181896022-182027094 |
| RNA-seq Change (±2kb) | Mean: 3.344257129356265e-05 | Peak: 0.049560546875 |
| ATAC Change (±2kb) | Mean: -0.00015615721349604428 | Peak: 1.05853271484375 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -0.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D