| Basic Information ▶ | |
| VISDB ID | TVIS10041213 |
|---|---|
| Fusion Name | HBV-ZNF827 integration |
| Validated | No |
| Curated Way | Curated |
| Method | HBV capture sequencing |
| Wet Assay | Yes |
| Sample ID | 32 |
| Sample Name | #032T |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Hepatocellular carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 33563643 |
| Journal | Gut |
| Published Year | 2021 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr4 |
| Cytogenetic Band | q31.22 |
| Human Strand | |
| Human Integration Location Type | intronic |
| Hg19 Start | 146822391 |
| Hg19 End | 146822391 |
| Hg38 Start | 145901239 |
| Hg38 End | 145901239 |
| Junction Sequence | ACCTTTGTGGTAAAGAACAA |
| Target Gene ▶ | |
| Target Gene | ZNF827 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV_A |
| Virus Genome Accession | X02763 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis b virus genome (serotype adw2) |
| Virus Genome Length | 3221 bp |
| Virus Breakpoint1 | 2739 |
| Virus Breakpoint2 | - |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000151612.19 |
| Gene Name | ZNF827 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000655597.2, Transcript 2: ENST00000508784.6, Transcript 3: ENST00000503462.3, Transcript 4: ENST00000672795.1, Transcript 5: ENST00000884878.1, Transcript 6: ENST00000884879.1, Transcript 7: ENST00000513320.5, Transcript 8: ENST00000379448.9, Transcript 9: ENST00000672532.1, Transcript 10: ENST00000656985.1, Transcript 11: ENST00000511659.2, Transcript 12: ENST00000652097.1, Transcript 13: ENST00000513840.2, Transcript 14: ENST00000672123.1 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.000 | Donor Gain: 0.030 | Donor Loss: 0.030 |
| Delta Score Max | 0.030 |
| Delta Position at Max | 0 |
| Delta Score Flag | LOW |
| Gene | ZNF827 |
| AlphaGenome Analysis | |
| Window | chr4:145835703-145966775 |
| RNA-seq Change (±2kb) | Mean: 0.00037489261012524366 | Peak: 1.345703125 |
| ATAC Change (±2kb) | Mean: 0.00012278309441171587 | Peak: 1.6767578125 |
| Interpretation | RNA-seq: minimal change 0.6% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 0.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D