| Basic Information ▶ | |
| VISDB ID | TVIS10045213 |
|---|---|
| Fusion Name | HBV-MDGA2 integration |
| Validated | No |
| Curated Way | Curated |
| Method | HBV capture sequencing |
| Wet Assay | Yes |
| Sample ID | 1756 |
| Sample Name | #1756T |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Hepatocellular carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 33563643 |
| Journal | Gut |
| Published Year | 2021 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr14 |
| Cytogenetic Band | q21.3 |
| Human Strand | |
| Human Integration Location Type | intronic |
| Hg19 Start | 47629697 |
| Hg19 End | 47629697 |
| Hg38 Start | 47160494 |
| Hg38 End | 47160494 |
| Junction Sequence | TCCCAAAGCGATACAAGGAA |
| Target Gene ▶ | |
| Target Gene | MDGA2 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV_D |
| Virus Genome Accession | X85254 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus genome (PreS1, PreS2, S, PreC, C, X genes and polymerase) |
| Virus Genome Length | 3182 bp |
| Virus Breakpoint1 | 1703 |
| Virus Breakpoint2 | - |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000139915.22 |
| Gene Name | MDGA2 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000399232.8, Transcript 2: ENST00000357362.7, Transcript 3: ENST00000557238.5, Transcript 4: ENST00000482848.7 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.000 | Donor Gain: 0.000 | Donor Loss: 0.000 |
| Delta Score Max | 0.000 |
| Delta Position at Max | 168 |
| Delta Score Flag | LOW |
| Gene | MDGA2 |
| AlphaGenome Analysis | |
| Window | chr14:47094958-47226030 |
| RNA-seq Change (±2kb) | Mean: 7.035299631752423e-07 | Peak: 0.0380859375 |
| ATAC Change (±2kb) | Mean: 0.00011255040590185672 | Peak: 0.8710222244262695 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 0.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D