| Basic Information ▶ | |
| VISDB ID | TVIS10048002 |
|---|---|
| Fusion Name | HBV-EPHB1 integration |
| Validated | No |
| Curated Way | Curated |
| Method | HBV capture sequencing |
| Wet Assay | Yes |
| Sample ID | 3651 |
| Sample Name | #3651N |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | - |
| Disease Abbreviation | - |
| Cancer | - |
| Literature ▶ | |
| PubMed ID | 33563643 |
| Journal | Gut |
| Published Year | 2021 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr3 |
| Cytogenetic Band | q22.2 |
| Human Strand | |
| Human Integration Location Type | intronic |
| Hg19 Start | 134920030 |
| Hg19 End | 134920030 |
| Hg38 Start | 135201188 |
| Hg38 End | 135201188 |
| Junction Sequence | TGGTTCAGCGGTAGTAGGTA |
| Target Gene ▶ | |
| Target Gene | EPHB1, ENSG00000240086 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV_A |
| Virus Genome Accession | X02763 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis b virus genome (serotype adw2) |
| Virus Genome Length | 3221 bp |
| Virus Breakpoint1 | 1832 |
| Virus Breakpoint2 | - |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000970111.1, Transcript 2: ENST00000398015.8, Transcript 3: ENST00000647596.1, Transcript 4: ENST00000928305.1, Transcript 5: ENST00000895120.1, Transcript 6: ENST00000493838.1, Transcript 7: ENST00000649588.1 |
| Transcript 1 Gene Id | ENSG00000154928.20 |
| Transcript 1 Gene Name | EPHB1 |
| Transcript 2 Gene Id | ENSG00000154928.20 |
| Transcript 2 Gene Name | EPHB1 |
| Transcript 3 Gene Id | ENSG00000154928.20 |
| Transcript 3 Gene Name | EPHB1 |
| Transcript 4 Gene Id | ENSG00000154928.20 |
| Transcript 4 Gene Name | EPHB1 |
| Transcript 5 Gene Id | ENSG00000154928.20 |
| Transcript 5 Gene Name | EPHB1 |
| Transcript 6 Gene Id | ENSG00000154928.20 |
| Transcript 6 Gene Name | EPHB1 |
| Transcript 7 Gene Id | ENSG00000240086.8 |
| Transcript 7 Gene Name | ENSG00000240086 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.000 | Donor Gain: 0.000 | Donor Loss: 0.020 |
| Delta Score Max | 0.020 |
| Delta Position at Max | -728 |
| Delta Score Flag | LOW |
| Gene | EPHB1 |
| AlphaGenome Analysis | |
| Window | chr3:135135652-135266724 |
| RNA-seq Change (±2kb) | Mean: -0.00019627215806394815 | Peak: 4.3701171875 |
| ATAC Change (±2kb) | Mean: 0.0002549564524088055 | Peak: 1.02587890625 |
| Interpretation | RNA-seq: minimal change -1.6% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 0.7% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D