| Basic Information ▶ | |
| VISDB ID | TVIS10049592 |
|---|---|
| Fusion Name | HBV-CCNE1 integration |
| Validated | No |
| Curated Way | Curated |
| Method | EBV capture sequencing, followed by Viral Integration Pathway Analysis (VIPA) pipeline |
| Wet Assay | No |
| Sample ID | SRR3104600.3 |
| Sample Name | SRA335342 |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Hepatocellular carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 35968887 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2022 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | chr19 |
| Cytogenetic Band | q12 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 29812424 |
| Hg38 End | 29812424 |
| Junction Sequence | tgGTGAACAGACCAATTTATGCCTACAGCCTCCTAGTACAAAGATCATTAACCTAATCTCCTCCCCCAGCCATCGGCCATCTTCCTGGCTCGCCCGGCCGcccgcgcgcaaagggggaaggggtactgggcccgcgg |
| Target Gene ▶ | |
| Target Gene | CCNE1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | - |
| Virus Genome Accession | AB014381 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus 22Y04HCC genomic DNA, complete sequence |
| Virus Genome Length | 3215 bp |
| Virus Breakpoint1 | 1741 |
| Virus Breakpoint2 | - |
| Virus Gene Name | X |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000105173.15 |
| Gene Name | CCNE1 |
| Transcript | Transcript 1: ENST00000937504.1, Transcript 2: ENST00000937503.1, Transcript 3: ENST00000937505.1, Transcript 4: ENST00000262643.8, Transcript 5: ENST00000937508.1, Transcript 6: ENST00000937506.1, Transcript 7: ENST00000937507.1, Transcript 8: ENST00000575243.5, Transcript 9: ENST00000855968.1, Transcript 10: ENST00000444983.6, Transcript 11: ENST00000357943.9, Transcript 12: ENST00000586912.1 |
| Transcript 1 Region | intron |
| Transcript 1 Impact | intronic_insertion |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Region | 5UTR |
| Transcript 5 Impact | noncoding_exon_insertion |
| Transcript 6 Region | intron |
| Transcript 6 Impact | intronic_insertion |
| Transcript 7 Region | intron |
| Transcript 7 Impact | intronic_insertion |
| Transcript 8 Region | intron |
| Transcript 8 Impact | intronic_insertion |
| Transcript 9 Region | intron |
| Transcript 9 Impact | intronic_insertion |
| Transcript 10 Region | promoter |
| Transcript 10 Impact | promoter_insertion |
| Transcript 11 Region | promoter |
| Transcript 11 Impact | promoter_insertion |
| Transcript 12 Region | promoter |
| Transcript 12 Impact | promoter_insertion |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.790 | Acceptor Loss: 0.230 | Donor Gain: 0.030 | Donor Loss: 0.000 |
| Delta Score Max | 0.790 |
| Delta Position at Max | 0 |
| Delta Score Flag | RECOMMENDED |
| Gene | CCNE1 |
| AlphaGenome Analysis | |
| Window | chr19:29746888-29877960 |
| RNA-seq Change (±2kb) | Mean: 0.008425961248576641 | Peak: 9.38916015625 |
| ATAC Change (±2kb) | Mean: 0.01832069270312786 | Peak: 7.552734375 |
| Interpretation | RNA-seq: INCREASED 32.8% (REF=0.03, ALT=0.03) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 4.7% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D