| Basic Information ▶ | |
| VISDB ID | TVIS10054554 |
|---|---|
| Fusion Name | HBV-NC_000016.10:68359970 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput HBV integration sequencing method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | Pt_0501_T |
| Sample Type | Tumor |
| Age | 58 |
| Gender | Male |
| Disease Information ▶ | |
| Disease Name | Hepatocellular Carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 37400627 |
| Journal | Communications Biology |
| Published Year | 2023 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | NC_000016.10 |
| Cytogenetic Band | NA |
| Human Strand | + |
| Human Integration Location Type | intergenic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 68359970 |
| Hg38 End | 68360025 |
| Junction Sequence | CAACTGTCAGCCTTGCTGCCCCAGCTTGCGCACTGGTGAGGGCCAGGCTGCTCTCT |
| Target Gene ▶ | |
| Target Gene | - |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV genotype D |
| Virus Genome Accession | NC_003977.2 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 bp |
| Virus Breakpoint1 | 1199 |
| Virus Breakpoint2 | 1087 |
| Virus Gene Name | ENH1/promoterX |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Region | 3UTR |
| Impact | noncoding_exon_insertion |
| Transcript | Transcript 1: ENST00000687654.1, Transcript 2: ENST00000879596.1, Transcript 3: ENST00000879597.1, Transcript 4: ENST00000879598.1, Transcript 5: ENST00000879595.1, Transcript 6: ENST00000879594.1, Transcript 7: ENST00000219334.10 |
| Transcript 1 Gene Id | ENSG00000132600.19 |
| Transcript 1 Gene Name | PRMT7 |
| Transcript 2 Gene Id | ENSG00000103056.13 |
| Transcript 2 Gene Name | SMPD3 |
| Transcript 3 Gene Id | ENSG00000103056.13 |
| Transcript 3 Gene Name | SMPD3 |
| Transcript 4 Gene Id | ENSG00000103056.13 |
| Transcript 4 Gene Name | SMPD3 |
| Transcript 5 Gene Id | ENSG00000103056.13 |
| Transcript 5 Gene Name | SMPD3 |
| Transcript 6 Gene Id | ENSG00000103056.13 |
| Transcript 6 Gene Name | SMPD3 |
| Transcript 7 Gene Id | ENSG00000103056.13 |
| Transcript 7 Gene Name | SMPD3 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.040 | Donor Gain: 0.010 | Donor Loss: 0.010 |
| Delta Score Max | 0.040 |
| Delta Position at Max | 1738 |
| Delta Score Flag | LOW |
| Gene | SMPD3 |
| AlphaGenome Analysis | |
| Window | chr16:68294434-68425506 |
| RNA-seq Change (±2kb) | Mean: -0.005254250485450029 | Peak: 6.5625 |
| ATAC Change (±2kb) | Mean: 0.011080914177000523 | Peak: 17.37109375 |
| Interpretation | RNA-seq: minimal change -4.0% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: INCREASED 14.6% (REF=0.08, ALT=0.09) |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D