| Basic Information ▶ | |
| VISDB ID | TVIS10054580 |
|---|---|
| Fusion Name | HBV-NC_000017.11:39626476 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput HBV integration sequencing method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | Pt_0501_T |
| Sample Type | Tumor |
| Age | 58 |
| Gender | Male |
| Disease Information ▶ | |
| Disease Name | Hepatocellular Carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 37400627 |
| Journal | Communications Biology |
| Published Year | 2023 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | NC_000017.11 |
| Cytogenetic Band | NA |
| Human Strand | + |
| Human Integration Location Type | intergenic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 39626476 |
| Hg38 End | 39626595 |
| Junction Sequence | CCCGGCACACCCCTGCACACTCTCCCTGCCACGATGACTGACACGTGTCCTCCCACACACAACTCGGTCACACTCGCTCCCTTTCCAGGACACCCCCATTCACAGCGTGACAGGCTGGTA |
| Target Gene ▶ | |
| Target Gene | - |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV genotype D |
| Virus Genome Accession | NC_003977.2 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 bp |
| Virus Breakpoint1 | 1260 |
| Virus Breakpoint2 | 1304 |
| Virus Gene Name | ENH1/promoterX |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Transcript | Transcript 1: ENST00000815502.1, Transcript 2: ENST00000815500.1, Transcript 3: ENST00000815501.1, Transcript 4: ENST00000815498.1, Transcript 5: ENST00000815499.1, Transcript 6: ENST00000815503.1, Transcript 7: ENST00000815504.1, Transcript 8: ENST00000580825.5, Transcript 9: ENST00000582680.5, Transcript 10: ENST00000254079.9, Transcript 11: ENST00000891107.1, Transcript 12: ENST00000579000.5, Transcript 13: ENST00000966853.1 |
| Transcript 1 Gene Id | ENSG00000306125.1 |
| Transcript 1 Gene Name | ENSG00000306125 |
| Transcript 1 Region | intron |
| Transcript 1 Impact | intronic_insertion |
| Transcript 2 Gene Id | ENSG00000306125.1 |
| Transcript 2 Gene Name | ENSG00000306125 |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Gene Id | ENSG00000306125.1 |
| Transcript 3 Gene Name | ENSG00000306125 |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Gene Id | ENSG00000306125.1 |
| Transcript 4 Gene Name | ENSG00000306125 |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Gene Id | ENSG00000306125.1 |
| Transcript 5 Gene Name | ENSG00000306125 |
| Transcript 5 Region | intron |
| Transcript 5 Impact | intronic_insertion |
| Transcript 6 Gene Id | ENSG00000306125.1 |
| Transcript 6 Gene Name | ENSG00000306125 |
| Transcript 6 Region | intron |
| Transcript 6 Impact | intronic_insertion |
| Transcript 7 Gene Id | ENSG00000306125.1 |
| Transcript 7 Gene Name | ENSG00000306125 |
| Transcript 7 Region | intron |
| Transcript 7 Impact | intronic_insertion |
| Transcript 8 Gene Id | ENSG00000131771.15 |
| Transcript 8 Gene Name | PPP1R1B |
| Transcript 8 Region | promoter |
| Transcript 8 Impact | promoter_insertion |
| Transcript 9 Gene Id | ENSG00000131771.15 |
| Transcript 9 Gene Name | PPP1R1B |
| Transcript 9 Region | promoter |
| Transcript 9 Impact | promoter_insertion |
| Transcript 10 Gene Id | ENSG00000131771.15 |
| Transcript 10 Gene Name | PPP1R1B |
| Transcript 10 Region | promoter |
| Transcript 10 Impact | promoter_insertion |
| Transcript 11 Gene Id | ENSG00000131771.15 |
| Transcript 11 Gene Name | PPP1R1B |
| Transcript 11 Region | promoter |
| Transcript 11 Impact | promoter_insertion |
| Transcript 12 Gene Id | ENSG00000131771.15 |
| Transcript 12 Gene Name | PPP1R1B |
| Transcript 12 Region | promoter |
| Transcript 12 Impact | promoter_insertion |
| Transcript 13 Gene Id | ENSG00000131771.15 |
| Transcript 13 Gene Name | PPP1R1B |
| Transcript 13 Region | promoter |
| Transcript 13 Impact | promoter_insertion |
| AlphaGenome Analysis | |
| Window | chr17:39560940-39692012 |
| RNA-seq Change (±2kb) | Mean: -0.001933210645802319 | Peak: 11.274658203125 |
| ATAC Change (±2kb) | Mean: 0.0029676828999072313 | Peak: 11.58544921875 |
| Interpretation | RNA-seq: minimal change -5.0% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 4.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D