| Basic Information ▶ | |
| VISDB ID | TVIS10056086 |
|---|---|
| Fusion Name | HBV-NC_000004.12:1717755 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput HBV integration sequencing method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | Pt_0504_T |
| Sample Type | Tumor |
| Age | 75 |
| Gender | Male |
| Disease Information ▶ | |
| Disease Name | Hepatocellular Carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 37400627 |
| Journal | Communications Biology |
| Published Year | 2023 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | NC_000004.12 |
| Cytogenetic Band | NA |
| Human Strand | + |
| Human Integration Location Type | intergenic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 1717755 |
| Hg38 End | 1717887 |
| Junction Sequence | GGCAGCTGTCGCACCAGGACCAACCAGGAGAGATGGCCCTAAGGCCAGAGCCCACGGACCCAGTGCCAGACAGCCCAGCCTGGGCACGGGGCGGACCTAGGAGCAAGGCAGCTGTCCAGCCTGAGGGCTCCAC |
| Target Gene ▶ | |
| Target Gene | - |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV genotype D |
| Virus Genome Accession | NC_003977.2 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 bp |
| Virus Breakpoint1 | 6 |
| Virus Breakpoint2 | 78 |
| Virus Gene Name | preS1/preS2/S |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Transcript | Transcript 1: ENST00000458173.4, Transcript 2: ENST00000954371.1, Transcript 3: ENST00000382936.8, Transcript 4: ENST00000303277.6, Transcript 5: ENST00000874437.1, Transcript 6: ENST00000874438.1, Transcript 7: ENST00000460722.1, Transcript 8: ENST00000476253.1 |
| Transcript 1 Gene Id | ENSG00000013810.22 |
| Transcript 1 Gene Name | TACC3 |
| Transcript 1 Region | intron |
| Transcript 1 Impact | intronic_insertion |
| Transcript 2 Gene Id | ENSG00000168936.13 |
| Transcript 2 Gene Name | TMEM129 |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Gene Id | ENSG00000168936.13 |
| Transcript 3 Gene Name | TMEM129 |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Gene Id | ENSG00000168936.13 |
| Transcript 4 Gene Name | TMEM129 |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Gene Id | ENSG00000168936.13 |
| Transcript 5 Gene Name | TMEM129 |
| Transcript 5 Region | CDS |
| Transcript 5 Impact | stop_gained |
| Transcript 5 Frameshift | True |
| Transcript 5 Stop Gained | True |
| Transcript 5 Protein Change From Aa0 | 89 |
| Transcript 6 Gene Id | ENSG00000168936.13 |
| Transcript 6 Gene Name | TMEM129 |
| Transcript 6 Region | intron |
| Transcript 6 Impact | intronic_insertion |
| Transcript 7 Gene Id | ENSG00000168936.13 |
| Transcript 7 Gene Name | TMEM129 |
| Transcript 7 Region | intron |
| Transcript 7 Impact | intronic_insertion |
| Transcript 8 Gene Id | ENSG00000168936.13 |
| Transcript 8 Gene Name | TMEM129 |
| Transcript 8 Region | exon_non_coding |
| Transcript 8 Impact | noncoding_exon_insertion |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.020 | Acceptor Loss: 0.090 | Donor Gain: 0.070 | Donor Loss: 0.010 |
| Delta Score Max | 0.090 |
| Delta Position at Max | -52 |
| Delta Score Flag | LOW |
| Gene | TMEM129 |
| Altered Protein (FASTA) | |
| AlphaGenome Analysis | |
| Window | chr4:1652219-1783291 |
| RNA-seq Change (±2kb) | Mean: 0.004629701375961304 | Peak: 11.65625 |
| ATAC Change (±2kb) | Mean: -0.0022818492725491524 | Peak: 6.8125 |
| Interpretation | RNA-seq: minimal change 0.8% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -2.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D