| Basic Information ▶ | |
| VISDB ID | TVIS10056588 |
|---|---|
| Fusion Name | HBV-NC_000007.14:2049664 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput HBV integration sequencing method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | Pt_0506_T |
| Sample Type | Tumor |
| Age | 54 |
| Gender | Male |
| Disease Information ▶ | |
| Disease Name | Hepatocellular Carcinoma |
| Disease Abbreviation | HCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 37400627 |
| Journal | Communications Biology |
| Published Year | 2023 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | NC_000007.14 |
| Cytogenetic Band | |
| Human Strand | - |
| Human Integration Location Type | |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 2049664 |
| Hg38 End | 2049533 |
| Junction Sequence | CCTTGGGTGGCTCCTGCCCTCCAGCAAGACATGGGGATGCTGCTGGACCCAGGTGTCTGTGAGGTCCAGGCACAGATCTTGCTTCTGCAGGAGGCCCCTGGGCGGACTAGGTGAGTCCTTCCTCCTACCGCC |
| Target Gene ▶ | |
| Target Gene | - |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Hepatitis B virus |
| Virus Subtype Name | HBV genotype D |
| Virus Genome Accession | NC_003977.2 |
| TaxonomyID | 10407 |
| Virus Abbreviation | HBV |
| Virus Genome | Hepatitis B virus (strain ayw) genome |
| Virus Genome Length | 3182 bp |
| Virus Breakpoint1 | 1818 |
| Virus Breakpoint2 | 1895 |
| Virus Gene Name | PreCore/Core,X/ENH2/BCP |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000853794.1, Transcript 2: ENST00000853792.1, Transcript 3: ENST00000853803.1, Transcript 4: ENST00000967146.1, Transcript 5: ENST00000853793.1, Transcript 6: ENST00000853804.1, Transcript 7: ENST00000932272.1, Transcript 8: ENST00000853801.1, Transcript 9: ENST00000853795.1, Transcript 10: ENST00000967148.1, Transcript 11: ENST00000402746.5, Transcript 12: ENST00000967143.1, Transcript 13: ENST00000853791.1, Transcript 14: ENST00000399654.6, Transcript 15: ENST00000406869.5, Transcript 16: ENST00000853805.1, Transcript 17: ENST00000967149.1, Transcript 18: ENST00000853798.1, Transcript 19: ENST00000853799.1, Transcript 20: ENST00000853797.1, Transcript 21: ENST00000265854.12, Transcript 22: ENST00000932271.1, Transcript 23: ENST00000853796.1, Transcript 24: ENST00000853806.1, Transcript 25: ENST00000853800.1, Transcript 26: ENST00000853802.1, Transcript 27: ENST00000853807.1, Transcript 28: ENST00000967144.1, Transcript 29: ENST00000853808.1, Transcript 30: ENST00000967150.1, Transcript 31: ENST00000438959.5, Transcript 32: ENST00000444373.6, Transcript 33: ENST00000421113.5, Transcript 34: ENST00000651235.1 |
| Transcript 1 Gene Id | ENSG00000002822.17 |
| Transcript 1 Gene Name | MAD1L1 |
| Transcript 2 Gene Id | ENSG00000002822.17 |
| Transcript 2 Gene Name | MAD1L1 |
| Transcript 3 Gene Id | ENSG00000002822.17 |
| Transcript 3 Gene Name | MAD1L1 |
| Transcript 4 Gene Id | ENSG00000002822.17 |
| Transcript 4 Gene Name | MAD1L1 |
| Transcript 5 Gene Id | ENSG00000002822.17 |
| Transcript 5 Gene Name | MAD1L1 |
| Transcript 6 Gene Id | ENSG00000002822.17 |
| Transcript 6 Gene Name | MAD1L1 |
| Transcript 7 Gene Id | ENSG00000002822.17 |
| Transcript 7 Gene Name | MAD1L1 |
| Transcript 8 Gene Id | ENSG00000002822.17 |
| Transcript 8 Gene Name | MAD1L1 |
| Transcript 9 Gene Id | ENSG00000002822.17 |
| Transcript 9 Gene Name | MAD1L1 |
| Transcript 10 Gene Id | ENSG00000002822.17 |
| Transcript 10 Gene Name | MAD1L1 |
| Transcript 11 Gene Id | ENSG00000002822.17 |
| Transcript 11 Gene Name | MAD1L1 |
| Transcript 12 Gene Id | ENSG00000002822.17 |
| Transcript 12 Gene Name | MAD1L1 |
| Transcript 13 Gene Id | ENSG00000002822.17 |
| Transcript 13 Gene Name | MAD1L1 |
| Transcript 14 Gene Id | ENSG00000002822.17 |
| Transcript 14 Gene Name | MAD1L1 |
| Transcript 15 Gene Id | ENSG00000002822.17 |
| Transcript 15 Gene Name | MAD1L1 |
| Transcript 16 Gene Id | ENSG00000002822.17 |
| Transcript 16 Gene Name | MAD1L1 |
| Transcript 17 Gene Id | ENSG00000002822.17 |
| Transcript 17 Gene Name | MAD1L1 |
| Transcript 18 Gene Id | ENSG00000002822.17 |
| Transcript 18 Gene Name | MAD1L1 |
| Transcript 19 Gene Id | ENSG00000002822.17 |
| Transcript 19 Gene Name | MAD1L1 |
| Transcript 20 Gene Id | ENSG00000002822.17 |
| Transcript 20 Gene Name | MAD1L1 |
| Transcript 21 Gene Id | ENSG00000002822.17 |
| Transcript 21 Gene Name | MAD1L1 |
| Transcript 22 Gene Id | ENSG00000002822.17 |
| Transcript 22 Gene Name | MAD1L1 |
| Transcript 23 Gene Id | ENSG00000002822.17 |
| Transcript 23 Gene Name | MAD1L1 |
| Transcript 24 Gene Id | ENSG00000002822.17 |
| Transcript 24 Gene Name | MAD1L1 |
| Transcript 25 Gene Id | ENSG00000002822.17 |
| Transcript 25 Gene Name | MAD1L1 |
| Transcript 26 Gene Id | ENSG00000002822.17 |
| Transcript 26 Gene Name | MAD1L1 |
| Transcript 27 Gene Id | ENSG00000002822.17 |
| Transcript 27 Gene Name | MAD1L1 |
| Transcript 28 Gene Id | ENSG00000002822.17 |
| Transcript 28 Gene Name | MAD1L1 |
| Transcript 29 Gene Id | ENSG00000002822.17 |
| Transcript 29 Gene Name | MAD1L1 |
| Transcript 30 Gene Id | ENSG00000002822.17 |
| Transcript 30 Gene Name | MAD1L1 |
| Transcript 31 Gene Id | ENSG00000002822.17 |
| Transcript 31 Gene Name | MAD1L1 |
| Transcript 32 Gene Id | ENSG00000002822.17 |
| Transcript 32 Gene Name | MAD1L1 |
| Transcript 33 Gene Id | ENSG00000002822.17 |
| Transcript 33 Gene Name | MAD1L1 |
| Transcript 34 Gene Id | ENSG00000286192.1 |
| Transcript 34 Gene Name | ENSG00000286192 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.020 | Donor Gain: 0.040 | Donor Loss: 0.010 |
| Delta Score Max | 0.040 |
| Delta Position at Max | -109 |
| Delta Score Flag | LOW |
| Gene | MAD1L1 |
| AlphaGenome Analysis | |
| Window | chr7:1984128-2115200 |
| RNA-seq Change (±2kb) | Mean: 0.0001864060468506068 | Peak: 0.1580810546875 |
| ATAC Change (±2kb) | Mean: 0.0006785682635381818 | Peak: 2.4031982421875 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 2.0% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D