| Basic Information ▶ | |
| VISDB ID | TVIS20004587 |
|---|---|
| Fusion Name | HPV-PRR30 integration |
| Validated | Yes |
| Curated Way | VISDB1.0 |
| Method | FISH, WGS, RNA-seq, qPCR |
| Wet Assay | Yes |
| Sample ID | Caski |
| Sample Name | Caski |
| Sample Type | Cell line |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Cervical carcinoma |
| Disease Abbreviation | CC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 24201445 |
| Journal | Genome Research |
| Published Year | 2014 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr2 |
| Cytogenetic Band | p23.3 |
| Human Strand | |
| Human Integration Location Type | Intronic |
| Hg19 Start | 27360017 |
| Hg19 End | 27360043 |
| Hg38 Start | 27137149 |
| Hg38 End | 27137175 |
| Junction Sequence | AAGGCCTGGGCTTCAGGGAGGTAGTG |
| Target Gene ▶ | |
| Target Gene | PRR30 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | NC_001526.2 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16, complete genome |
| Virus Genome Length | 7905 |
| Virus Breakpoint1 | 7876 |
| Virus Breakpoint2 | 7901 |
| Virus Gene Name | - |
| Virus Region Type | LCR |
| Integrated Virus Sequence | TTTACAAGCAACTTATATAATAATAC |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000186143.11 |
| Gene Name | PRR30 |
| Region | CDS |
| Impact | stop_gained |
| Frameshift | True |
| Stop Gained | True |
| Transcript | Transcript 1: ENST00000335524.7, Transcript 2: ENST00000432962.2 |
| Transcript 1 Protein Change From Aa0 | 393 |
| Transcript 2 Protein Change From Aa0 | 228 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.010 | Acceptor Loss: 0.030 | Donor Gain: 0.000 | Donor Loss: 0.010 |
| Delta Score Max | 0.030 |
| Delta Position at Max | 784 |
| Delta Score Flag | LOW |
| Gene | PRR30 |
| Altered Protein (FASTA) | |
| AlphaGenome Analysis | |
| Window | chr2:27071613-27202685 |
| RNA-seq Change (±2kb) | Mean: -0.00010088722774526104 | Peak: 6.6875 |
| ATAC Change (±2kb) | Mean: 0.00028074553119949996 | Peak: 2.6153564453125 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 0.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D