| Basic Information ▶ | |
| VISDB ID | TVIS20013299 |
|---|---|
| Fusion Name | HPV-DDHD1-DT integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput Viral Integration Detection method |
| Wet Assay | Yes |
| Sample ID | CES2 |
| Sample Name | CES2-P |
| Sample Type | Tumor |
| Age | 44 |
| Gender | Female |
| Disease Information ▶ | |
| Disease Name | Cervical Cancer |
| Disease Abbreviation | CC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 33017516 |
| Journal | Cancer Medicine |
| Published Year | 2020 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr14 |
| Cytogenetic Band | q22.1 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | 53974819 |
| Hg19 End | 53974819 |
| Hg38 Start | 53508101 |
| Hg38 End | 53508101 |
| Junction Sequence | GAATCTGTATTTAGCAGTGACGAAATATCCTTTGCTGGGATTGTTACAAAGCTACCAACAGCCAACAACACCACCACATCGAATTCCAAAACCTGCATTCAGCCAGCCCACCCCAAAACAGTAACTTTGGAATGATCATGCCTCTTATGCACGCTCCCACCGTCTGC |
| Target Gene ▶ | |
| Target Gene | DDHD1-DT |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV18 |
| Virus Genome Accession | AY262282 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 18 complete sequence |
| Virus Genome Length | 7857 bp |
| Virus Breakpoint1 | 1084 |
| Virus Breakpoint2 | - |
| Virus Gene Name | HpV18gp3_E1 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000258731.2 |
| Gene Name | DDHD1-DT |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000663444.2, Transcript 2: ENST00000728778.1, Transcript 3: ENST00000648066.2, Transcript 4: ENST00000456100.6, Transcript 5: ENST00000661514.1, Transcript 6: ENST00000668539.1, Transcript 7: ENST00000655713.1, Transcript 8: ENST00000653852.1, Transcript 9: ENST00000669612.1, Transcript 10: ENST00000425648.1 |
| AlphaGenome Analysis | |
| Window | chr14:53442565-53573637 |
| RNA-seq Change (±2kb) | Mean: -3.578071482479572e-05 | Peak: 0.01922607421875 |
| ATAC Change (±2kb) | Mean: -0.005066126585006714 | Peak: 21.43359375 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: DECREASED 11.7% (REF=0.04, ALT=0.04) |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D