| Basic Information ▶ | |
| VISDB ID | TVIS20022150 |
|---|---|
| Fusion Name | HPV-MAGI1 integration |
| Validated | No |
| Curated Way | Curated |
| Method | HPV capture sequencing |
| Wet Assay | Yes |
| Sample ID | D233031.10 |
| Sample Name | New sample |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Cervical cancer |
| Disease Abbreviation | CC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 35968887 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2022 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | chr3 |
| Cytogenetic Band | p14.1 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 65593869 |
| Hg38 End | 65593869 |
| Junction Sequence | taagcagtgtgcttacgactagatatagaaatacgggaaacatattgatatctCATTATATGGATATAGTTATATTGGGATATTGAAAGAGAAATAATTTAAAAATCTCCACAAACAAAAGCCTCACAGAGTGGTTGGCCAAGTGCTGCCTAATAGTTTCAGGAGAGGATACTTCGTTGCTGCTAAACACAGATGTAGGACATaatattacctgaccacccgcatgaacttcccatactttatttttactatat |
| Target Gene ▶ | |
| Target Gene | MAGI1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | K02718 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16 (HPV16), complete genome |
| Virus Genome Length | 7,904 bp |
| Virus Breakpoint1 | 3408 |
| Virus Breakpoint2 | - |
| Virus Gene Name | E2,E4 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000151276.24 |
| Gene Name | MAGI1 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000330909.12, Transcript 2: ENST00000402939.7, Transcript 3: ENST00000621418.4, Transcript 4: ENST00000611645.4, Transcript 5: ENST00000463103.6, Transcript 6: ENST00000483466.5, Transcript 7: ENST00000460329.6, Transcript 8: ENST00000497477.6, Transcript 9: ENST00000470990.5, Transcript 10: ENST00000464060.5 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.000 | Donor Gain: 0.010 | Donor Loss: 0.000 |
| Delta Score Max | 0.010 |
| Delta Position at Max | -1301 |
| Delta Score Flag | LOW |
| Gene | MAGI1 |
| AlphaGenome Analysis | |
| Window | chr3:65528333-65659405 |
| RNA-seq Change (±2kb) | Mean: 0.0008573250379413366 | Peak: 0.478515625 |
| ATAC Change (±2kb) | Mean: 0.00017142208525910974 | Peak: 3.372802734375 |
| Interpretation | RNA-seq: minimal change 4.3% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 0.8% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D