| Basic Information ▶ | |
| VISDB ID | TVIS20023881 |
|---|---|
| Fusion Name | HPV-ENSG00000310264 integration |
| Validated | No |
| Curated Way | Curated |
| Method | HPV capture sequencing |
| Wet Assay | Yes |
| Sample ID | P2016105A.24 |
| Sample Name | New sample |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Cervical cancer |
| Disease Abbreviation | CC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 35968887 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2022 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | chr1 |
| Cytogenetic Band | q42.13 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 228818521 |
| Hg38 End | 228818521 |
| Junction Sequence | GCCAAGCAGCAGGAGCAGACACCCTGGAGCCTGGTCACGCACTATAGAGGCCaGTGCCATTCGTGCTGCAACCGAGCACGACAGGAACGACTCCAACGACGCAGAGAAACACAAGTATAATATTAAGTATGCATGGACCTAAGGCAACAT |
| Target Gene ▶ | |
| Target Gene | ENSG00000310264 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV18 |
| Virus Genome Accession | X05015 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 18 E6, E7, E1, E2, E4, E5, L1 & L2 genes |
| Virus Genome Length | 7,857 bp |
| Virus Breakpoint1 | 500 |
| Virus Breakpoint2 | - |
| Virus Gene Name | E6 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000310264.1 |
| Gene Name | ENSG00000310264 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000848621.1 |
| AlphaGenome Analysis | |
| Window | chr1:228752985-228884057 |
| RNA-seq Change (±2kb) | Mean: 1.778123805706855e-05 | Peak: 0.012603759765625 |
| ATAC Change (±2kb) | Mean: 0.001453000702895224 | Peak: 1.71484375 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 5.8% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D