| Basic Information ▶ | |
| VISDB ID | TVIS20024573 |
|---|---|
| Fusion Name | HPV-ANKRD11 integration |
| Validated | No |
| Curated Way | Curated |
| Method | EBV capture sequencing, followed by Viral Integration Pathway Analysis (VIPA) pipeline |
| Wet Assay | No |
| Sample ID | SRR1611054.2 |
| Sample Name | SRA189003 |
| Sample Type | Tumor |
| Age | - |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Cervical cancer |
| Disease Abbreviation | CC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 35968887 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2022 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh38/hg38 |
| Human Genome RefSeq Accession | GCF_000001405.40 |
| Human Chromosome | chr16 |
| Cytogenetic Band | q24.3 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | - |
| Hg19 End | - |
| Hg38 Start | 89353786 |
| Hg38 End | 89353786 |
| Junction Sequence | cgtcgcaGTAACTGTTGCTTGCAGTACACACATTCTAATATTATTTCATGTATAGTTGTTTGCAGCTCTGTGCATAatatTCTTATGGAACATAATGTTTTTCATGATCAAcggccactatgggaacacaacacacatcagccctgagacac |
| Target Gene ▶ | |
| Target Gene | ANKRD11, ENSG00000288715 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | K02718 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16 (HPV16), complete genome |
| Virus Genome Length | 7,904 bp |
| Virus Breakpoint1 | 147 |
| Virus Breakpoint2 | - |
| Virus Gene Name | E6 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000642600.2, Transcript 2: ENST00000378330.7, Transcript 3: ENST00000301030.10, Transcript 4: ENST00000330736.10, Transcript 5: ENST00000642443.1, Transcript 6: ENST00000567699.2, Transcript 7: ENST00000562275.6, Transcript 8: ENST00000378332.7, Transcript 9: ENST00000644784.1, Transcript 10: ENST00000642695.1, Transcript 11: ENST00000643964.1, Transcript 12: ENST00000642333.1, Transcript 13: ENST00000646975.1, Transcript 14: ENST00000645278.1, Transcript 15: ENST00000646166.1, Transcript 16: ENST00000645844.1, Transcript 17: ENST00000647213.1, Transcript 18: ENST00000562816.5, Transcript 19: ENST00000647238.1, Transcript 20: ENST00000644045.1, Transcript 21: ENST00000643147.1, Transcript 22: ENST00000683497.1, Transcript 23: ENST00000711617.1 |
| Transcript 1 Gene Id | ENSG00000167522.18 |
| Transcript 1 Gene Name | ANKRD11 |
| Transcript 2 Gene Id | ENSG00000167522.18 |
| Transcript 2 Gene Name | ANKRD11 |
| Transcript 3 Gene Id | ENSG00000167522.18 |
| Transcript 3 Gene Name | ANKRD11 |
| Transcript 4 Gene Id | ENSG00000167522.18 |
| Transcript 4 Gene Name | ANKRD11 |
| Transcript 5 Gene Id | ENSG00000167522.18 |
| Transcript 5 Gene Name | ANKRD11 |
| Transcript 6 Gene Id | ENSG00000167522.18 |
| Transcript 6 Gene Name | ANKRD11 |
| Transcript 7 Gene Id | ENSG00000167522.18 |
| Transcript 7 Gene Name | ANKRD11 |
| Transcript 8 Gene Id | ENSG00000167522.18 |
| Transcript 8 Gene Name | ANKRD11 |
| Transcript 9 Gene Id | ENSG00000167522.18 |
| Transcript 9 Gene Name | ANKRD11 |
| Transcript 10 Gene Id | ENSG00000167522.18 |
| Transcript 10 Gene Name | ANKRD11 |
| Transcript 11 Gene Id | ENSG00000167522.18 |
| Transcript 11 Gene Name | ANKRD11 |
| Transcript 12 Gene Id | ENSG00000167522.18 |
| Transcript 12 Gene Name | ANKRD11 |
| Transcript 13 Gene Id | ENSG00000167522.18 |
| Transcript 13 Gene Name | ANKRD11 |
| Transcript 14 Gene Id | ENSG00000167522.18 |
| Transcript 14 Gene Name | ANKRD11 |
| Transcript 15 Gene Id | ENSG00000167522.18 |
| Transcript 15 Gene Name | ANKRD11 |
| Transcript 16 Gene Id | ENSG00000167522.18 |
| Transcript 16 Gene Name | ANKRD11 |
| Transcript 17 Gene Id | ENSG00000167522.18 |
| Transcript 17 Gene Name | ANKRD11 |
| Transcript 18 Gene Id | ENSG00000167522.18 |
| Transcript 18 Gene Name | ANKRD11 |
| Transcript 19 Gene Id | ENSG00000167522.18 |
| Transcript 19 Gene Name | ANKRD11 |
| Transcript 20 Gene Id | ENSG00000167522.18 |
| Transcript 20 Gene Name | ANKRD11 |
| Transcript 21 Gene Id | ENSG00000167522.18 |
| Transcript 21 Gene Name | ANKRD11 |
| Transcript 22 Gene Id | ENSG00000288715.2 |
| Transcript 22 Gene Name | ENSG00000288715 |
| Transcript 23 Gene Id | ENSG00000288715.2 |
| Transcript 23 Gene Name | ENSG00000288715 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.030 | Acceptor Loss: 0.020 | Donor Gain: 0.030 | Donor Loss: 0.020 |
| Delta Score Max | 0.030 |
| Delta Position at Max | -864 |
| Delta Score Flag | LOW |
| Gene | ANKRD11 |
| Altered Protein (FASTA) | |
| AlphaGenome Analysis | |
| Window | chr16:89288250-89419322 |
| RNA-seq Change (±2kb) | Mean: -0.00024703177041374147 | Peak: 0.1328125 |
| ATAC Change (±2kb) | Mean: -0.0009062148164957762 | Peak: 21.124195098876953 |
| Interpretation | RNA-seq: minimal change -2.5% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -1.6% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D