| Basic Information ▶ | |
| VISDB ID | TVIS20034001 |
|---|---|
| Fusion Name | HPV-TEX41 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput Viral Integration Detection method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | S031 |
| Sample Type | Tumor |
| Age | 57 = 59; >57 = 50 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Oropharyngeal squamous cell carcinoma |
| Disease Abbreviation | OPSCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 38279874 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2024 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr2 |
| Cytogenetic Band | q22.3 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | 145584918 |
| Hg19 End | 145584918 |
| Hg38 Start | 144827351 |
| Hg38 End | 144827351 |
| Junction Sequence | GCCTTATCAAGGTGTAGAGTTTATGTCATTTTTAACTGCATTAAAAAGATTTTTGCAAGGCATACCTAAAAAAAATTGCATATTACTATATGGTGCAGCTAACACAGGTAAATCATTATTTGGTATGAGTTTAATAAAATAATCAAGAAGCTTGGAATTTGGATTGACTTGAGGTAC |
| Target Gene ▶ | |
| Target Gene | TEX41 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | AF534061 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16 East Asian type, complete genome |
| Virus Genome Length | 7905 bp |
| Virus Breakpoint1 | 2340 |
| Virus Breakpoint2 | - |
| Virus Gene Name | HpV16gp3_E1 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000226674.12 |
| Gene Name | TEX41 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000654442.1, Transcript 2: ENST00000653533.1, Transcript 3: ENST00000661187.1, Transcript 4: ENST00000667984.1, Transcript 5: ENST00000670681.1, Transcript 6: ENST00000654298.1, Transcript 7: ENST00000659773.1, Transcript 8: ENST00000598659.5, Transcript 9: ENST00000597655.6, Transcript 10: ENST00000631271.3, Transcript 11: ENST00000668424.1, Transcript 12: ENST00000671290.1, Transcript 13: ENST00000670099.1, Transcript 14: ENST00000671637.1, Transcript 15: ENST00000666650.1, Transcript 16: ENST00000661482.1, Transcript 17: ENST00000652981.1, Transcript 18: ENST00000657732.1, Transcript 19: ENST00000653630.1, Transcript 20: ENST00000653910.1, Transcript 21: ENST00000666949.1, Transcript 22: ENST00000662271.1, Transcript 23: ENST00000658352.1, Transcript 24: ENST00000659810.1, Transcript 25: ENST00000666917.1, Transcript 26: ENST00000665824.1, Transcript 27: ENST00000660660.1, Transcript 28: ENST00000665226.1, Transcript 29: ENST00000628985.2, Transcript 30: ENST00000600679.5, Transcript 31: ENST00000601277.5, Transcript 32: ENST00000625887.2, Transcript 33: ENST00000628688.2, Transcript 34: ENST00000629613.3, Transcript 35: ENST00000661327.1, Transcript 36: ENST00000626325.3, Transcript 37: ENST00000656353.1, Transcript 38: ENST00000656881.1, Transcript 39: ENST00000668319.1, Transcript 40: ENST00000668441.1, Transcript 41: ENST00000670869.1, Transcript 42: ENST00000758932.1, Transcript 43: ENST00000625651.2, Transcript 44: ENST00000659777.1, Transcript 45: ENST00000666180.1, Transcript 46: ENST00000666980.1, Transcript 47: ENST00000451027.5, Transcript 48: ENST00000664679.1, Transcript 49: ENST00000654410.1, Transcript 50: ENST00000445791.5, Transcript 51: ENST00000596540.5, Transcript 52: ENST00000594471.5, Transcript 53: ENST00000597469.5, Transcript 54: ENST00000598248.5, Transcript 55: ENST00000625362.3, Transcript 56: ENST00000596230.6, Transcript 57: ENST00000599072.6, Transcript 58: ENST00000599187.6, Transcript 59: ENST00000628136.3, Transcript 60: ENST00000631167.3, Transcript 61: ENST00000656317.1, Transcript 62: ENST00000656937.1, Transcript 63: ENST00000661920.1, Transcript 64: ENST00000665244.1, Transcript 65: ENST00000669172.1, Transcript 66: ENST00000670002.1, Transcript 67: ENST00000663282.1, Transcript 68: ENST00000657187.1, Transcript 69: ENST00000595686.5, Transcript 70: ENST00000626197.2, Transcript 71: ENST00000657526.1, Transcript 72: ENST00000653186.1, Transcript 73: ENST00000629631.2, Transcript 74: ENST00000661697.1, Transcript 75: ENST00000655563.2, Transcript 76: ENST00000657624.1, Transcript 77: ENST00000654361.1, Transcript 78: ENST00000660009.1, Transcript 79: ENST00000597670.5, Transcript 80: ENST00000600064.5, Transcript 81: ENST00000627991.3, Transcript 82: ENST00000657684.1, Transcript 83: ENST00000662863.1, Transcript 84: ENST00000664258.1, Transcript 85: ENST00000664937.1, Transcript 86: ENST00000665081.1, Transcript 87: ENST00000667704.1, Transcript 88: ENST00000667781.1, Transcript 89: ENST00000667905.1, Transcript 90: ENST00000668187.1, Transcript 91: ENST00000669646.1, Transcript 92: ENST00000666675.1, Transcript 93: ENST00000627675.2, Transcript 94: ENST00000414256.5, Transcript 95: ENST00000451774.5, Transcript 96: ENST00000630651.2, Transcript 97: ENST00000627195.2, Transcript 98: ENST00000626411.2, Transcript 99: ENST00000630122.2, Transcript 100: ENST00000630691.2, Transcript 101: ENST00000626133.2, Transcript 102: ENST00000627757.2, Transcript 103: ENST00000596589.5, Transcript 104: ENST00000597893.5, Transcript 105: ENST00000630709.2, Transcript 106: ENST00000630246.2, Transcript 107: ENST00000594626.5, Transcript 108: ENST00000628213.2, Transcript 109: ENST00000625671.2 |
| AlphaGenome Analysis | |
| Window | chr2:144761815-144892887 |
| RNA-seq Change (±2kb) | Mean: -4.4096393025938596e-07 | Peak: 0.009857177734375 |
| ATAC Change (±2kb) | Mean: 0.0004198410897515714 | Peak: 1.4085693359375 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 1.5% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D