| Basic Information ▶ | |
| VISDB ID | TVIS20043401 |
|---|---|
| Fusion Name | HPV-PARD3 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput Viral Integration Detection method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | S108 |
| Sample Type | Tumor |
| Age | 57 = 59; >57 = 50 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Oropharyngeal squamous cell carcinoma |
| Disease Abbreviation | OPSCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 38279874 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2024 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr10 |
| Cytogenetic Band | p11.21 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | 34892314 |
| Hg19 End | 34892314 |
| Hg38 Start | 34603386 |
| Hg38 End | 34603386 |
| Junction Sequence | TAAACACCATGTAGTCAGTATAGTGGTGGAAGTGGGGGTGGTTGCAGTCAGTACAGTAGTGGAAGTGGGGGAGAGAAAACATCGAGGAAACAGAATGAGGAGGGGGCACAGTGGGAGATGCATGCTCATGGGAGGGAATA |
| Target Gene ▶ | |
| Target Gene | PARD3 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | AF534061 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16 East Asian type, complete genome |
| Virus Genome Length | 7905 bp |
| Virus Breakpoint1 | 1397 |
| Virus Breakpoint2 | - |
| Virus Gene Name | HpV16gp3_E1 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000148498.18 |
| Gene Name | PARD3 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000926304.1, Transcript 2: ENST00000545260.5, Transcript 3: ENST00000545693.5, Transcript 4: ENST00000963004.1, Transcript 5: ENST00000696673.1, Transcript 6: ENST00000926311.1, Transcript 7: ENST00000926312.1, Transcript 8: ENST00000346874.9, Transcript 9: ENST00000350537.9, Transcript 10: ENST00000374788.8, Transcript 11: ENST00000374789.8, Transcript 12: ENST00000374790.8, Transcript 13: ENST00000374794.8, Transcript 14: ENST00000926308.1, Transcript 15: ENST00000926305.1, Transcript 16: ENST00000926306.1, Transcript 17: ENST00000963005.1, Transcript 18: ENST00000926303.1, Transcript 19: ENST00000926302.1, Transcript 20: ENST00000926299.1, Transcript 21: ENST00000926300.1, Transcript 22: ENST00000963008.1, Transcript 23: ENST00000963007.1, Transcript 24: ENST00000963006.1, Transcript 25: ENST00000926301.1, Transcript 26: ENST00000926307.1, Transcript 27: ENST00000963009.1, Transcript 28: ENST00000926313.1, Transcript 29: ENST00000926314.1, Transcript 30: ENST00000926316.1, Transcript 31: ENST00000926315.1, Transcript 32: ENST00000926320.1, Transcript 33: ENST00000926334.1, Transcript 34: ENST00000926331.1, Transcript 35: ENST00000926332.1, Transcript 36: ENST00000926329.1, Transcript 37: ENST00000926328.1, Transcript 38: ENST00000926327.1, Transcript 39: ENST00000926323.1, Transcript 40: ENST00000926324.1, Transcript 41: ENST00000926325.1, Transcript 42: ENST00000926321.1, Transcript 43: ENST00000963011.1, Transcript 44: ENST00000926319.1, Transcript 45: ENST00000926317.1, Transcript 46: ENST00000926326.1, Transcript 47: ENST00000926322.1, Transcript 48: ENST00000926318.1, Transcript 49: ENST00000963016.1, Transcript 50: ENST00000926330.1, Transcript 51: ENST00000963015.1, Transcript 52: ENST00000963014.1, Transcript 53: ENST00000963010.1, Transcript 54: ENST00000926333.1, Transcript 55: ENST00000963012.1, Transcript 56: ENST00000963013.1, Transcript 57: ENST00000858358.1, Transcript 58: ENST00000374776.6, Transcript 59: ENST00000340077.9, Transcript 60: ENST00000374773.6 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.000 | Donor Gain: 0.000 | Donor Loss: 0.010 |
| Delta Score Max | 0.010 |
| Delta Position at Max | 407 |
| Delta Score Flag | LOW |
| Gene | PARD3 |
| AlphaGenome Analysis | |
| Window | chr10:34537850-34668922 |
| RNA-seq Change (±2kb) | Mean: -0.0008445274434052408 | Peak: 0.2890625 |
| ATAC Change (±2kb) | Mean: 0.0019460354233160615 | Peak: 2.3100128173828125 |
| Interpretation | RNA-seq: minimal change -7.8% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 9.3% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D