| Basic Information ▶ | |
| VISDB ID | TVIS20063841 |
|---|---|
| Fusion Name | HPV-TMC1 integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput Viral Integration Detection method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | S109 |
| Sample Type | Tumor |
| Age | 57 = 59; >57 = 50 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Oropharyngeal squamous cell carcinoma |
| Disease Abbreviation | OPSCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 38279874 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2024 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr9 |
| Cytogenetic Band | q21.13 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | 75317676 |
| Hg19 End | 75317676 |
| Hg38 Start | 72702760 |
| Hg38 End | 72702760 |
| Junction Sequence | GTTCTTTGCATATCTTTTTTTGTTGTTGTTAAAAAGTGGACATTCTAGGTAATATATTGCATAATTCCATCGACCAAGTCTGTGCCCCCTGTATCACTGTCATTTTCGTTCTCGTCATCTGATATAGCATCCCCTGTTTTTTTTTCCACTACAGCCT |
| Target Gene ▶ | |
| Target Gene | TMC1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | AF534061 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16 East Asian type, complete genome |
| Virus Genome Length | 7905 bp |
| Virus Breakpoint1 | 997 |
| Virus Breakpoint2 | - |
| Virus Gene Name | HpV16gp3_E1 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000165091.18 |
| Gene Name | TMC1 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000297784.10, Transcript 2: ENST00000651183.1, Transcript 3: ENST00000650689.1, Transcript 4: ENST00000645208.2, Transcript 5: ENST00000645053.1, Transcript 6: ENST00000645773.1, Transcript 7: ENST00000340019.4, Transcript 8: ENST00000644967.1, Transcript 9: ENST00000645787.1, Transcript 10: ENST00000646619.1 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.010 | Donor Gain: 0.000 | Donor Loss: 0.120 |
| Delta Score Max | 0.120 |
| Delta Position at Max | -2117 |
| Delta Score Flag | LOW |
| Gene | TMC1 |
| AlphaGenome Analysis | |
| Window | chr9:72637224-72768296 |
| RNA-seq Change (±2kb) | Mean: 1.2860597962571774e-05 | Peak: 0.01190185546875 |
| ATAC Change (±2kb) | Mean: -0.0011177649721503258 | Peak: 6.3232421875 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -3.3% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D