| Basic Information ▶ | |
| VISDB ID | TVIS20065365 |
|---|---|
| Fusion Name | HPV-PPP1R3B-DT integration |
| Validated | No |
| Curated Way | Curated |
| Method | High-throughput Viral Integration Detection method |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | S102 |
| Sample Type | Tumor |
| Age | 57 = 59; >57 = 50 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | Oropharyngeal squamous cell carcinoma |
| Disease Abbreviation | OPSCC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 38279874 |
| Journal | Clinical and Translational Medicine |
| Published Year | 2024 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr8 |
| Cytogenetic Band | p23.1 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | 9203989 |
| Hg19 End | 9203989 |
| Hg38 Start | 9346479 |
| Hg38 End | 9346479 |
| Junction Sequence | AAAGGAATATTGTATGCACCACCAAAAGGAATTGTTGTATTTGCAGGAATATAACCTGATAAAATATGTATGAGTGAGAAAAATGGTTTATAGAATATATGAGCCTGCCACCTCATAGGCCCAAGATATTTGTACTATAT |
| Target Gene ▶ | |
| Target Gene | PPP1R3B-DT |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Papillomavirus |
| Virus Subtype Name | HPV16 |
| Virus Genome Accession | HQ644236 |
| TaxonomyID | 10566 |
| Virus Abbreviation | HPV |
| Virus Genome | Human papillomavirus type 16 isolate AS411, complete genome |
| Virus Genome Length | 7905bp |
| Virus Breakpoint1 | 5401 |
| Virus Breakpoint2 | - |
| Virus Gene Name | HpV16gp7_L2 |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000248538.11 |
| Gene Name | PPP1R3B-DT |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000523246.2, Transcript 2: ENST00000520255.6, Transcript 3: ENST00000758838.1, Transcript 4: ENST00000647972.1, Transcript 5: ENST00000758839.1, Transcript 6: ENST00000758830.1, Transcript 7: ENST00000758864.1, Transcript 8: ENST00000758840.1, Transcript 9: ENST00000648532.2, Transcript 10: ENST00000649599.1, Transcript 11: ENST00000648214.1, Transcript 12: ENST00000758841.1, Transcript 13: ENST00000649984.4, Transcript 14: ENST00000758842.1, Transcript 15: ENST00000758866.1, Transcript 16: ENST00000758865.1, Transcript 17: ENST00000647924.2, Transcript 18: ENST00000758832.1, Transcript 19: ENST00000758831.1, Transcript 20: ENST00000758833.1, Transcript 21: ENST00000758860.1, Transcript 22: ENST00000701254.1, Transcript 23: ENST00000701328.2, Transcript 24: ENST00000758867.1, Transcript 25: ENST00000758880.1, Transcript 26: ENST00000649893.1, Transcript 27: ENST00000701083.2, Transcript 28: ENST00000687006.2, Transcript 29: ENST00000650228.2, Transcript 30: ENST00000758843.1, Transcript 31: ENST00000758882.1, Transcript 32: ENST00000758844.1, Transcript 33: ENST00000700982.1, Transcript 34: ENST00000758868.1, Transcript 35: ENST00000650028.3, Transcript 36: ENST00000758881.1, Transcript 37: ENST00000758869.1, Transcript 38: ENST00000701544.1, Transcript 39: ENST00000758883.1, Transcript 40: ENST00000686338.3, Transcript 41: ENST00000758870.1, Transcript 42: ENST00000649652.1, Transcript 43: ENST00000687373.3, Transcript 44: ENST00000758845.1, Transcript 45: ENST00000758846.1, Transcript 46: ENST00000758847.1, Transcript 47: ENST00000650282.2, Transcript 48: ENST00000758834.1, Transcript 49: ENST00000758871.1, Transcript 50: ENST00000758848.1, Transcript 51: ENST00000701270.1, Transcript 52: ENST00000758872.1, Transcript 53: ENST00000758849.1, Transcript 54: ENST00000702487.1, Transcript 55: ENST00000647577.1, Transcript 56: ENST00000758861.1, Transcript 57: ENST00000758850.1, Transcript 58: ENST00000758835.1, Transcript 59: ENST00000758852.1, Transcript 60: ENST00000758851.1, Transcript 61: ENST00000690418.1, Transcript 62: ENST00000758855.1, Transcript 63: ENST00000758854.1, Transcript 64: ENST00000691330.2, Transcript 65: ENST00000758853.1, Transcript 66: ENST00000758874.1, Transcript 67: ENST00000758873.1, Transcript 68: ENST00000649050.2, Transcript 69: ENST00000758862.1, Transcript 70: ENST00000758856.1, Transcript 71: ENST00000758875.1, Transcript 72: ENST00000758857.1, Transcript 73: ENST00000518619.1, Transcript 74: ENST00000758876.1, Transcript 75: ENST00000758877.1, Transcript 76: ENST00000758836.1, Transcript 77: ENST00000648337.1, Transcript 78: ENST00000649280.1, Transcript 79: ENST00000702089.1, Transcript 80: ENST00000758858.1, Transcript 81: ENST00000758837.1, Transcript 82: ENST00000758878.1, Transcript 83: ENST00000758863.1, Transcript 84: ENST00000758859.1 |
| AlphaGenome Analysis | |
| Window | chr8:9280943-9412015 |
| RNA-seq Change (±2kb) | Mean: 8.625577720522415e-06 | Peak: 0.03839111328125 |
| ATAC Change (±2kb) | Mean: -0.0006849563797004521 | Peak: 1.749612808227539 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -2.6% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D