| Basic Information ▶ | |
| VISDB ID | TVIS30014702 |
|---|---|
| Fusion Name | HIV-EXOC6 integration |
| Validated | Yes |
| Curated Way | VISDB1.0 |
| Method | ligation mediated PCR |
| Wet Assay | Yes |
| Sample ID | PT1 |
| Sample Name | PT1 |
| Sample Type | PBMC |
| Age | 47 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | HIV-infected disease |
| Disease Abbreviation | HID |
| Cancer | No |
| Literature ▶ | |
| PubMed ID | 24968937 |
| Journal | Science |
| Published Year | 2014 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr10 |
| Cytogenetic Band | q23.33 |
| Human Strand | - |
| Human Integration Location Type | Intronic |
| Hg19 Start | 94687083 |
| Hg19 End | 94687024 |
| Hg38 Start | 92927326 |
| Hg38 End | 92927326 |
| Junction Sequence | ATGTTGGATGGGTTCTCTTTAAACAGTGAAGAAGACAGAGGGGATTGAGGTATAGTAAT |
| Target Gene ▶ | |
| Target Gene | EXOC6 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Immunodeficiency Virus |
| Virus Subtype Name | - |
| Virus Genome Accession | Not given |
| TaxonomyID | 11676 |
| Virus Abbreviation | HIV |
| Virus Genome | - |
| Virus Genome Length | 9719 |
| Virus Breakpoint1 | - |
| Virus Breakpoint2 | - |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000138190.17 |
| Gene Name | EXOC6 |
| Transcript | Transcript 1: ENST00000671701.1, Transcript 2: ENST00000672817.1, Transcript 3: ENST00000371552.8, Transcript 4: ENST00000443748.6, Transcript 5: ENST00000260762.10, Transcript 6: ENST00000495132.5 |
| Transcript 1 Region | intron |
| Transcript 1 Impact | intronic_insertion |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Region | intron |
| Transcript 5 Impact | intronic_insertion |
| Transcript 6 Region | promoter |
| Transcript 6 Impact | promoter_insertion |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.020 | Acceptor Loss: 0.230 | Donor Gain: 0.080 | Donor Loss: 0.300 |
| Delta Score Max | 0.300 |
| Delta Position at Max | -10 |
| Delta Score Flag | HIGH_RECALL |
| Gene | EXOC6 |
| AlphaGenome Analysis | |
| Window | chr10:92861790-92992862 |
| RNA-seq Change (±2kb) | Mean: -0.00045956397661939263 | Peak: 2.58056640625 |
| ATAC Change (±2kb) | Mean: 0.00039604795165359974 | Peak: 1.0702944993972778 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change 2.1% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D