| Basic Information ▶ | |
| VISDB ID | TVIS30016156 |
|---|---|
| Fusion Name | HIV-RBM15B integration |
| Validated | Yes |
| Curated Way | VISDB1.0 |
| Method | ligation mediated PCR |
| Wet Assay | Yes |
| Sample ID | PT1 |
| Sample Name | PT1 |
| Sample Type | PBMC |
| Age | 47 |
| Gender | - |
| Disease Information ▶ | |
| Disease Name | HIV-infected disease |
| Disease Abbreviation | HID |
| Cancer | No |
| Literature ▶ | |
| PubMed ID | 24968937 |
| Journal | Science |
| Published Year | 2014 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr3 |
| Cytogenetic Band | p21.2 |
| Human Strand | + |
| Human Integration Location Type | Exonic |
| Hg19 Start | 51434777 |
| Hg19 End | 51434948 |
| Hg38 Start | 51397346 |
| Hg38 End | 51397346 |
| Junction Sequence | CTTTCTACAAACGCAGACAAGCTCCACTACCCCTAACCTGCCAGGATGCTCAAGTCCACTGTCACAATCCCTTTCAGAAAACATTAGTGGCCGCTGCCCCAGCTACAGAGACGGCCGAAATGCTTTCACTCCTTAGCTTTGCCAACTCCATCCTCCAAAACTTCCCAGAAT |
| Target Gene ▶ | |
| Target Gene | RBM15B, DCAF1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | Human Immunodeficiency Virus |
| Virus Subtype Name | - |
| Virus Genome Accession | Not given |
| TaxonomyID | 11676 |
| Virus Abbreviation | HIV |
| Virus Genome | - |
| Virus Genome Length | 9719 |
| Virus Breakpoint1 | - |
| Virus Breakpoint2 | - |
| Virus Gene Name | - |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Transcript | Transcript 1: ENST00000563281.2, Transcript 2: ENST00000423656.5, Transcript 3: ENST00000926457.1, Transcript 4: ENST00000504652.5, Transcript 5: ENST00000855691.1, Transcript 6: ENST00000926456.1 |
| Transcript 1 Gene Id | ENSG00000259956.2 |
| Transcript 1 Gene Name | RBM15B |
| Transcript 1 Region | 3UTR |
| Transcript 1 Impact | noncoding_exon_insertion |
| Transcript 2 Gene Id | ENSG00000145041.18 |
| Transcript 2 Gene Name | DCAF1 |
| Transcript 2 Region | intron |
| Transcript 2 Impact | intronic_insertion |
| Transcript 3 Gene Id | ENSG00000145041.18 |
| Transcript 3 Gene Name | DCAF1 |
| Transcript 3 Region | intron |
| Transcript 3 Impact | intronic_insertion |
| Transcript 4 Gene Id | ENSG00000145041.18 |
| Transcript 4 Gene Name | DCAF1 |
| Transcript 4 Region | intron |
| Transcript 4 Impact | intronic_insertion |
| Transcript 5 Gene Id | ENSG00000145041.18 |
| Transcript 5 Gene Name | DCAF1 |
| Transcript 5 Region | 3UTR |
| Transcript 5 Impact | noncoding_exon_insertion |
| Transcript 6 Gene Id | ENSG00000145041.18 |
| Transcript 6 Gene Name | DCAF1 |
| Transcript 6 Region | 3UTR |
| Transcript 6 Impact | noncoding_exon_insertion |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.020 | Acceptor Loss: 0.000 | Donor Gain: 0.020 | Donor Loss: 0.000 |
| Delta Score Max | 0.020 |
| Delta Position at Max | 0 |
| Delta Score Flag | LOW |
| Gene | RBM15B |
| AlphaGenome Analysis | |
| Window | chr3:51331810-51462882 |
| RNA-seq Change (±2kb) | Mean: -0.008799034170806408 | Peak: 3.38037109375 |
| ATAC Change (±2kb) | Mean: -0.0010956685291603208 | Peak: 4.968735694885254 |
| Interpretation | RNA-seq: minimal change -2.9% | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: minimal change -2.0% |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D