| Basic Information ▶ | |
| VISDB ID | TVIS46000263 |
|---|---|
| Fusion Name | BKPyv-CCBE1 integration |
| Validated | No |
| Curated Way | Curated |
| Method | Virome capture next-generation sequencing |
| Wet Assay | Yes |
| Sample ID | - |
| Sample Name | Case17_Urine |
| Sample Type | Tumor |
| Age | - |
| Gender | Female |
| Disease Information ▶ | |
| Disease Name | Urothelial carcinoma |
| Disease Abbreviation | UC |
| Cancer | Yes |
| Literature ▶ | |
| PubMed ID | 37507072 |
| Journal | American Journal of Transplantation |
| Published Year | 2023 |
| Human Genome ▶ | |
| Human Genome Version Description | GRCh37/hg19 |
| Human Genome RefSeq Accession | GCF_000001405.13 |
| Human Chromosome | chr18 |
| Cytogenetic Band | q21.32 |
| Human Strand | + |
| Human Integration Location Type | intronic |
| Hg19 Start | 57110467 |
| Hg19 End | 57110467 |
| Hg38 Start | 59443235 |
| Hg38 End | 59443235 |
| Junction Sequence | ACCTCAGGAAGGAAAGTGCATGACTGGGCAGCCAGCCAGTGGCAGTTAATAGTGAAACCCCGCCCCTAGAATTCTCAAATAAACACAAGAGGAAGTGGAAAGTAGCCAAAGGAGTGGAAAGCAGCCAGACAGACATGTTTTGACCCCCACTTGTGTGTGGAACACAGCATTTCTGCCCACACCGGGGACTCTAGCGGACACC |
| Target Gene ▶ | |
| Target Gene | CCBE1 |
| Nearby Gene | - |
| Distance | - |
| Virus Information ▶ | |
| Virus Name | BK polyomavirus |
| Virus Subtype Name | Genotype I, IV |
| Virus Genome Accession | AB217919.1 |
| TaxonomyID | 1417981 |
| Virus Abbreviation | BKPyV |
| Virus Genome | BK polyomavirus DNA, complete genome, isolate: TW-3a |
| Virus Genome Length | 5146 bp |
| Virus Breakpoint1 | 218 |
| Virus Breakpoint2 | - |
| Virus Gene Name | AB217919.1_Agno;AB217919.1_VP2;AB217919.1_VP3//upstream |
| Virus Region Type | - |
| Integrated Virus Sequence | - |
| ViMIC ID | - |
| Predicted VIS Effect ▶ | |
| Gene Id | ENSG00000183287.16 |
| Gene Name | CCBE1 |
| Region | intron |
| Impact | intronic_insertion |
| Transcript | Transcript 1: ENST00000439986.9, Transcript 2: ENST00000650467.2, Transcript 3: ENST00000649564.1, Transcript 4: ENST00000695903.1, Transcript 5: ENST00000695904.1, Transcript 6: ENST00000915151.1, Transcript 7: ENST00000589116.2, Transcript 8: ENST00000589419.2 |
| SpliceAI Score | |
| Delta Scores | Acceptor Gain: 0.000 | Acceptor Loss: 0.000 | Donor Gain: 0.000 | Donor Loss: 0.000 |
| Delta Score Max | 0.000 |
| Delta Position at Max | -1755 |
| Delta Score Flag | LOW |
| Gene | CCBE1 |
| AlphaGenome Analysis | |
| Window | chr18:59377699-59508771 |
| RNA-seq Change (±2kb) | Mean: 0.0004261864523869008 | Peak: 0.079498291015625 |
| ATAC Change (±2kb) | Mean: 0.03557799756526947 | Peak: 12.875 |
| Interpretation | RNA-seq: no signal in region (REF≈0, ALT≈0) | Splice sites: no signal in region (REF≈0, ALT≈0) | ATAC: INCREASED 186.2% (REF=0.02, ALT=0.05) |
| Visualization | |
Center for Precision Health
McWilliams School of Biomedical Informatics at UTHealth Houston
7000 Fannin Street, Suite 600, Houston, TX 77030
Email: Zhongming Zhao, Ph.D