| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10024992 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10016329 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10016328 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10016330 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10045176 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10051795 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10047023 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10047024 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10041477 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
| TVIS10041478 | HBV | ENSG00000198099.10 | protein_coding | ADH4 | No | No | 127 | P08319 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ADH4 |
|---|---|
| DrugBank ID | DB00157 |
| Drug Name | NADH |
| Target ID | BE0000360 |
| UniProt ID | P08319 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 1938903; 11306066; 3593480 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Thielen J, Ciriacy M: Biochemical basis of mitochondrial acetaldehyde dismutation in Saccharomyces cerevisiae. J Bacteriol. 1991 Nov;173(21):7012-7.@@Plapp BV, Mitchell JL, Berst KB: Mouse alcohol dehydrogenase 4: kinetic mechanism, substrate specificity and simulation of effects of ethanol on retinoid metabolism. Chem Biol Interact. 2001 Jan 30;130-132(1-3):445-56.@@Widenius TV: Ethanol-induced inhibition of testosterone biosynthesis in vitro: lack of acetaldehyde effect. Alcohol Alcohol. 1987;22(1):17-22. |
| Groups | Approved; Nutraceutical |
| Direct Classification | (5'->5')-dinucleotides |
| SMILES | NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O |
| Pathways | Ethylmalonic Encephalopathy; 3-Methylglutaconic Aciduria Type III; Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency); Caffeine Metabolism; Fructose and Mannose Degradation; Isovaleric Aciduria; Lysine Degradation; Methylmalonic Aciduria Due to Cobalamin-Related Disorders; Glycerol Phosphate Shuttle; Zellweger Syndrome; Propionic Acidemia; Glycolysis; Xanthine Dehydrogenase Deficiency (Xanthinuria); S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Tryptophan Metabolism; Glutaric Aciduria Type I; 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I; Glycine N-Methyltransferase Deficiency; Dimethylglycine Dehydrogenase Deficiency; Androgen and Estrogen Metabolism; Nucleotide Sugars Metabolism; 3-Methylglutaconic Aciduria Type IV; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Malate-Aspartate Shuttle; Folate Metabolism; Valine, Leucine, and Isoleucine Degradation; Maple Syrup Urine Disease; Glycerol Kinase Deficiency; Adenylosuccinate Lyase Deficiency; Cysteine Metabolism |
| PharmGKB | PA164755085 |
| ChEMBL | CHEMBL1234616 |
