| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10004156 | HBV | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
| TVIS10033976 | HBV | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
| TVIS10030535 | HBV | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
| TVIS10052261 | HBV | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
| TVIS30064434 | HIV | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
| TVIS30064435 | HIV | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
| TVIS44039069 | HTLV-1 | ENSG00000112294.14 | protein_coding | ALDH5A1 | No | No | 7915 | P51649 X5D299 X5DQN2 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ALDH5A1 |
|---|---|
| DrugBank ID | DB00139 |
| Drug Name | Succinic acid |
| Target ID | BE0000152 |
| UniProt ID | P51649 |
| Regulation Type | inhibitor |
| PubMed IDs | 15853764; 17619587; 16942602; 17584458; 16689938; 11752352 |
| Citations | Yogeeswari P, Sriram D, Vaigundaragavendran J: The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders. Curr Drug Metab. 2005 Apr;6(2):127-39.@@Popov VN, Eprintsev AT, Fedorin DN, Fomenko OIu, Igamberdiev AU: [Role of transamination in the mobilization of respiratory substrates in germinating seeds of castor oil plants]. Prikl Biokhim Mikrobiol. 2007 May-Jun;43(3):376-81.@@Wang C, Zhang HB, Wang LH, Zhang LH: Succinic semialdehyde couples stress response to quorum-sensing signal decay in Agrobacterium tumefaciens. Mol Microbiol. 2006 Oct;62(1):45-56. Epub 2006 Aug 30.@@Ahn SJ, Yang CH, Cooksey DA: Pseudomonas putida 06909 genes expressed during colonization on mycelial surfaces and phenotypic characterization of mutants. J Appl Microbiol. 2007 Jul;103(1):120-32.@@Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R: Final steps in the catabolism of nicotine. FEBS J. 2006 Apr;273(7):1528-36.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Dicarboxylic acids and derivatives |
| SMILES | OC(=O)CCC(O)=O |
| Pathways | Mitochondrial Complex II Deficiency; 3-Methylglutaconic Aciduria Type III; 2-Ketoglutarate Dehydrogenase Complex Deficiency; 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency; Oxidation of Branched-Chain Fatty Acids; Isovaleric Aciduria; Warburg Effect; Refsum Disease; Isobutyryl-CoA Dehydrogenase Deficiency; Propionic Acidemia; 2-Hydroxyglutric Aciduria (D and L Form); Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]; 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I; Congenital Lactic Acidosis; 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency; Fumarase Deficiency; Succinic Semialdehyde Dehydrogenase Deficiency; Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency); Prolidase Deficiency (PD); Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency; Methylmalonic Aciduria; 3-Methylglutaconic Aciduria Type IV; Ornithine Aminotransferase Deficiency (OAT Deficiency); Ketone Body Metabolism; Homocarnosinosis; Methylmalonate Semialdehyde Dehydrogenase Deficiency; Prolinemia Type II; The Oncogenic Action of 2-Hydroxyglutarate; Valine, Leucine, and Isoleucine Degradation; Maple Syrup Urine Disease |
| PharmGKB | PA164747739 |
| ChEMBL | CHEMBL576 |
