| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20063059 | HPV | ENSG00000179142.2 | protein_coding | CYP11B2 | No | No | 1585 | P19099 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CYP11B2 |
|---|---|
| DrugBank ID | DB05667 |
| Drug Name | Levoketoconazole |
| Target ID | BE0003542 |
| UniProt ID | P19099 |
| Regulation Type | inhibitor |
| PubMed IDs | 34380370; 1495014 |
| Citations | Fleseriu M, Auchus RJ, Pivonello R, Salvatori R, Zacharieva S, Biller BMK: Levoketoconazole: a novel treatment for endogenous Cushing's syndrome. Expert Rev Endocrinol Metab. 2021 Jul;16(4):159-174. doi: 10.1080/17446651.2021.1945440. Epub 2021 Aug 12.@@Rotstein DM, Kertesz DJ, Walker KA, Swinney DC: Stereoisomers of ketoconazole: preparation and biological activity. J Med Chem. 1992 Jul 24;35(15):2818-25. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpiperazines |
| SMILES | CC(=O)N1CCN(CC1)C1=CC=C(OC[C@@H]2CO[C@](CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1 |
| Pathways | |
| PharmGKB | PA450146 |
| ChEMBL | CHEMBL295698 |
