| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20011327 | HPV | ENSG00000156136.10 | protein_coding | DCK | No | No | 1633 | P27707 |
| TVIS20066768 | HPV | ENSG00000156136.10 | protein_coding | DCK | No | No | 1633 | P27707 |
| TVIS44015031 | HTLV-1 | ENSG00000156136.10 | protein_coding | DCK | No | No | 1633 | P27707 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | DCK |
|---|---|
| DrugBank ID | DB01073 |
| Drug Name | Fludarabine |
| Target ID | BE0002804 |
| UniProt ID | P27707 |
| Regulation Type | agonist |
| PubMed IDs | 15820918; 20137114; 16421443 |
| Citations | Jordheim LP, Galmarini CM, Dumontet C: [Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues]. Bull Cancer. 2005 Mar;92(3):239-48.@@Yao L, Xu W, Fan L, Miao KR, Wu YJ, Qiao C, Zhu DX, Zhu HY, Liu P, Li JY: [Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):36-9.@@Zhang Y, Secrist JA 3rd, Ealick SE: The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):133-9. Epub 2006 Jan 18. |
| Groups | Approved |
| Direct Classification | Purine nucleosides |
| SMILES | NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
| Pathways | |
| PharmGKB | PA449655 |
| ChEMBL | CHEMBL1568 |
