| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30080013 | HIV | ENSG00000171298.15 | protein_coding | GAA | No | No | 2548 | P10253 |
| TVIS30045485 | HIV | ENSG00000171298.15 | protein_coding | GAA | No | No | 2548 | P10253 |
| TVIS20043365 | HPV | ENSG00000171298.15 | protein_coding | GAA | No | No | 2548 | P10253 |
| TVIS20020716 | HPV | ENSG00000171298.15 | protein_coding | GAA | No | No | 2548 | P10253 |
| TVIS20020717 | HPV | ENSG00000171298.15 | protein_coding | GAA | No | No | 2548 | P10253 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GAA |
|---|---|
| DrugBank ID | DB00284 |
| Drug Name | Acarbose |
| Target ID | BE0000876 |
| UniProt ID | P10253 |
| Regulation Type | inhibitor |
| PubMed IDs | 11404235; 16702880; 16763908; 3539207; 2776140; 32672281 |
| Citations | Salehi A, Fan BG, Ekelund M, Nordin G, Lundquist I: TPN-evoked dysfunction of islet lysosomal activity mediates impairment of glucose-stimulated insulin release. Am J Physiol Endocrinol Metab. 2001 Jul;281(1):E171-9.@@Zhang H, Kallwass H, Young SP, Carr C, Dai J, Kishnani PS, Millington DS, Keutzer J, Chen YT, Bali D: Comparison of maltose and acarbose as inhibitors of maltase-glucoamylase activity in assaying acid alpha-glucosidase activity in dried blood spots for the diagnosis of infantile Pompe disease. Genet Med. 2006 May;8(5):302-6.@@Gelb MH, Turecek F, Scott CR, Chamoles NA: Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders. J Inherit Metab Dis. 2006 Apr-Jun;29(2-3):397-404.@@Bourbon JR, Doucet E, Rieutort M: Role of alpha-glucosidase in fetal lung maturation. Biochim Biophys Acta. 1987 Jan 13;917(1):203-10.@@Calder PC, Geddes R: Acarbose is a competitive inhibitor of mammalian lysosomal acid alpha-D-glucosidases. Carbohydr Res. 1989 Aug 1;191(1):71-8. doi: 10.1016/0008-6215(89)85047-5.@@Wang M, Wang M, Zhang F, Su X: A ratiometric fluorescent biosensor for the sensitive determination of alpha-glucosidase activity and acarbose based on N-doped carbon dots. Analyst. 2020 Aug 24;145(17):5808-5815. doi: 10.1039/d0an01065k. |
| Groups | Approved; Investigational |
| Direct Classification | Aminocyclitol glycosides |
| SMILES | [H]C(=O)[C@H](O)[C@@H](O)[C@]([H])(O[C@@]1([H])O[C@H](CO)[C@@]([H])(O[C@H]2O[C@H](C)[C@@H](N[C@@]3([H])C=C(CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)CO |
| Pathways | |
| PharmGKB | PA448010 |
| ChEMBL | CHEMBL1566 |
