| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30021530 | HIV | ENSG00000100385.15 | protein_coding | IL2RB | No | No | 3560 | P14784 |
| TVIS20017292 | HPV | ENSG00000100385.15 | protein_coding | IL2RB | No | No | 3560 | P14784 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | IL2RB |
|---|---|
| DrugBank ID | DB00004 |
| Drug Name | Denileukin diftitox |
| Target ID | BE0000651 |
| UniProt ID | P14784 |
| Regulation Type | agonist |
| PubMed IDs | 15811959; 16516670; 18684057; 17187516; 11752352 |
| Citations | Foss F, Demierre MF, DiVenuti G: A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma. Blood. 2005 Jul 15;106(2):454-7. Epub 2005 Apr 5.@@Foss F: Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 2006 Feb;33(1 Suppl 3):S11-6.@@Duvic M, Talpur R: Optimizing denileukin diftitox (Ontak) therapy. Future Oncol. 2008 Aug;4(4):457-69. doi: 10.2217/14796694.4.4.457.@@Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Peptides |
| SMILES | |
| Pathways | |
| PharmGKB | PA164750594 |
| ChEMBL | CHEMBL1201550 |
