| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20070312 | HPV | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS20039491 | HPV | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS20063739 | HPV | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44010630 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44008624 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44005724 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44026290 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44020165 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44017102 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
| TVIS44003711 | HTLV-1 | ENSG00000148053.18 | protein_coding | NTRK2 | Yes | No | 4915 | Q16620 Q548C2 Q5VWE5 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | NTRK2 |
|---|---|
| DrugBank ID | DB00321 |
| Drug Name | Amitriptyline |
| Target ID | BE0003605 |
| UniProt ID | Q16620 |
| Regulation Type | agonist |
| PubMed IDs | 19549602; 24818146; 27069625 |
| Citations | Jang SW, Liu X, Chan CB, Weinshenker D, Hall RA, Xiao G, Ye K: Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity. Chem Biol. 2009 Jun 26;16(6):644-56. doi: 10.1016/j.chembiol.2009.05.010.@@Cai J, Hua F, Yuan L, Tang W, Lu J, Yu S, Wang X, Hu Y: Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases. Biomed Res Int. 2014;2014:601084. doi: 10.1155/2014/601084. Epub 2014 Apr 9.@@O'Neill E, Kwok B, Day JS, Connor TJ, Harkin A: Amitriptyline protects against TNF-alpha-induced atrophy and reduction in synaptic markers via a Trk-dependent mechanism. Pharmacol Res Perspect. 2016 Mar 8;4(2):e00195. doi: 10.1002/prp2.195. eCollection 2016 Apr. |
| Groups | Approved |
| Direct Classification | Dibenzocycloheptenes |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA448385 |
| ChEMBL | CHEMBL629 |
