| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS46001109 | BKPyv | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
| TVIS46001484 | BKPyv | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
| TVIS10044269 | HBV | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
| TVIS30051621 | HIV | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
| TVIS20008037 | HPV | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
| TVIS20055104 | HPV | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
| TVIS44006463 | HTLV-1 | ENSG00000169432.19 | protein_coding | SCN9A | No | No | 6335 | Q15858 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCN9A |
|---|---|
| DrugBank ID | DB00281 |
| Drug Name | Lidocaine |
| Target ID | BE0001143 |
| UniProt ID | Q15858 |
| Regulation Type | inhibitor |
| PubMed IDs | 17430993; 19088384; 20585544 |
| Citations | Sheets PL, Jackson JO 2nd, Waxman SG, Dib-Hajj SD, Cummins TR: A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol. 2007 Jun 15;581(Pt 3):1019-31. Epub 2007 Apr 12.@@Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15.@@Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. |
| Groups | Approved; Vet_approved |
| Direct Classification | m-Xylenes |
| SMILES | CCN(CC)CC(=O)NC1=C(C)C=CC=C1C |
| Pathways | Lidocaine (Antiarrhythmic) Action Pathway; Lidocaine (Local Anaesthetic) Metabolism Pathway; Lidocaine (Local Anaesthetic) Action Pathway |
| PharmGKB | PA450226 |
| ChEMBL | CHEMBL79 |
