| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30068171 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS30068172 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS30068173 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS30068174 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS30068175 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS30068176 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS30068177 | HIV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS20061429 | HPV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS20031498 | HPV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
| TVIS20026571 | HPV | ENSG00000157764.14 | protein_coding | BRAF | Yes | No | 673 | P15056 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | BRAF |
|---|---|
| DrugBank ID | DB11718 |
| Drug Name | Encorafenib |
| Target ID | BE0000634 |
| UniProt ID | P15056 |
| Regulation Type | inhibitor |
| PubMed IDs | 26586345; 29356698; 25769717 |
| Citations | Li Z, Jiang K, Zhu X, Lin G, Song F, Zhao Y, Piao Y, Liu J, Cheng W, Bi X, Gong P, Song Z, Meng S: Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370(2):332-44. doi: 10.1016/j.canlet.2015.11.015. Epub 2015 Nov 14.@@Koelblinger P, Thuerigen O, Dummer R: Development of encorafenib for BRAF-mutated advanced melanoma. Curr Opin Oncol. 2018 Mar;30(2):125-133. doi: 10.1097/CCO.0000000000000426.@@Moschos SJ, Pinnamaneni R: Targeted therapies in melanoma. Surg Oncol Clin N Am. 2015 Apr;24(2):347-58. doi: 10.1016/j.soc.2014.12.011. Epub 2015 Jan 24. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpyrazoles |
| SMILES | COC(=O)N[C@@H](C)CNC1=NC=CC(=N1)C1=CN(N=C1C1=CC(Cl)=CC(NS(C)(=O)=O)=C1F)C(C)C |
| Pathways | |
| PharmGKB | PA166179872 |
| ChEMBL | CHEMBL3301612 |
