| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20010873 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20012367 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20012707 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20050596 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20050636 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20045698 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20044520 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20038432 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS20043967 | HPV | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
| TVIS44031789 | HTLV-1 | ENSG00000273079.7 | protein_coding | GRIN2B | No | No | 2904 | Q13224 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GRIN2B |
|---|---|
| DrugBank ID | DB08954 |
| Drug Name | Ifenprodil |
| Target ID | BE0000417 |
| UniProt ID | Q13224 |
| Regulation Type | antagonist |
| PubMed IDs | 3365283; 27135925; 25462287; 7901753 |
| Citations | Seppala T, Stromberg C, Mattila MJ: Effects of the novel 5-hydroxytryptamine reuptake inhibitor indalpine and ethanol on psychomotor performance. Arzneimittelforschung. 1988 Jan;38(1):98-102.@@Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H: Activation of NMDA receptors and the mechanism of inhibition by ifenprodil. Nature. 2016 Jun 2;534(7605):63-8. doi: 10.1038/nature17679. Epub 2016 May 2.@@Zhu S, Paoletti P: Allosteric modulators of NMDA receptors: multiple sites and mechanisms. Curr Opin Pharmacol. 2015 Feb;20:14-23. doi: 10.1016/j.coph.2014.10.009. Epub 2014 Nov 12.@@Williams K: Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol. 1993 Oct;44(4):851-9. |
| Groups | Investigational; Withdrawn |
| Direct Classification | 4-benzylpiperidines |
| SMILES | CC(C(O)C1=CC=C(O)C=C1)N1CCC(CC2=CC=CC=C2)CC1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL305187 |
