| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017653 | HBV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS10017897 | HBV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS10007559 | HBV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30002340 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30018403 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30038730 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30038731 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30038732 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30038733 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
| TVIS30038734 | HIV | ENSG00000169032.11 | protein_coding | MAP2K1 | Yes | No | 5604 | A4QPA9 B4DFY5 Q02750 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MAP2K1 |
|---|---|
| DrugBank ID | DB08911 |
| Drug Name | Trametinib |
| Target ID | BE0000870 |
| UniProt ID | Q02750 |
| Regulation Type | inhibitor |
| PubMed IDs | 23432625; 23971497 |
| Citations | Salama AK, Kim KB: Trametinib (GSK1120212) in the treatment of melanoma. Expert Opin Pharmacother. 2013 Apr;14(5):619-27. doi: 10.1517/14656566.2013.770475. Epub 2013 Feb 23.@@Ho MY, Morris MJ, Pirhalla JL, Bauman JW, Pendry CB, Orford KW, Morrison RA, Cox DS: Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers. Xenobiotica. 2014 Apr;44(4):352-68. doi: 10.3109/00498254.2013.831143. Epub 2013 Aug 23. |
| Groups | Approved |
| Direct Classification | Pyridopyrimidines |
| SMILES | CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1 |
| Pathways | |
| PharmGKB | PA166115364 |
| ChEMBL | CHEMBL2103875 |
