| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30005504 | HIV | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS30026671 | HIV | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS30026672 | HIV | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS20000916 | HPV | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS20046556 | HPV | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS44012771 | HTLV-1 | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS44010815 | HTLV-1 | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
| TVIS44036114 | HTLV-1 | ENSG00000143799.14 | protein_coding | PARP1 | No | Yes | 142 | P09874 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PARP1 |
|---|---|
| DrugBank ID | DB09074 |
| Drug Name | Olaparib |
| Target ID | BE0001717 |
| UniProt ID | P09874 |
| Regulation Type | inhibitor |
| PubMed IDs | 25981132; 33114555; 30069770 |
| Citations | Verhagen CV, de Haan R, Hageman F, Oostendorp TP, Carli AL, O'Connor MJ, Jonkers J, Verheij M, van den Brekel MW, Vens C: Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. doi: 10.1016/j.radonc.2015.03.028. Epub 2015 May 13.@@Tavares TS, Hofman J, Lekesova A, Zelazkova J, Wsol V: Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3. Cancers (Basel). 2020 Oct 26;12(11). pii: cancers12113127. doi: 10.3390/cancers12113127.@@Bochum S, Berger S, Martens UM: Olaparib. Recent Results Cancer Res. 2018;211:217-233. doi: 10.1007/978-3-319-91442-8_15. |
| Groups | Approved |
| Direct Classification | Phthalazinones |
| SMILES | FC1=CC=C(CC2=NNC(=O)C3=CC=CC=C23)C=C1C(=O)N1CCN(CC1)C(=O)C1CC1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL521686 |
